WW domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5A4_LEIMA

TriTrypDb:

LmjF.32.1760 , LMJLV39_320023800 , LMJSD75_320023800

Length:

498

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5A4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5A4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	267	271	PF00656	0.577
CLV_C14_Caspase3-7	434	438	PF00656	0.753
CLV_C14_Caspase3-7	474	478	PF00656	0.612
CLV_NRD_NRD_1	205	207	PF00675	0.675
CLV_NRD_NRD_1	225	227	PF00675	0.446
CLV_NRD_NRD_1	348	350	PF00675	0.587
CLV_PCSK_FUR_1	349	353	PF00082	0.676
CLV_PCSK_KEX2_1	118	120	PF00082	0.521
CLV_PCSK_KEX2_1	205	207	PF00082	0.675
CLV_PCSK_KEX2_1	225	227	PF00082	0.428
CLV_PCSK_KEX2_1	351	353	PF00082	0.636
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.556
CLV_PCSK_PC1ET2_1	351	353	PF00082	0.636
CLV_PCSK_PC7_1	114	120	PF00082	0.576
CLV_PCSK_PC7_1	347	353	PF00082	0.670
CLV_PCSK_SKI1_1	217	221	PF00082	0.663
CLV_PCSK_SKI1_1	23	27	PF00082	0.693
CLV_PCSK_SKI1_1	368	372	PF00082	0.577
CLV_PCSK_SKI1_1	467	471	PF00082	0.714
DEG_APCC_DBOX_1	233	241	PF00400	0.692
DEG_APCC_KENBOX_2	180	184	PF00400	0.553
DEG_Nend_UBRbox_1	1	4	PF02207	0.639
DEG_SPOP_SBC_1	428	432	PF00917	0.703
DOC_ANK_TNKS_1	332	339	PF00023	0.542
DOC_USP7_MATH_1	221	225	PF00917	0.713
DOC_USP7_MATH_1	230	234	PF00917	0.564
DOC_USP7_MATH_1	24	28	PF00917	0.757
DOC_USP7_MATH_1	385	389	PF00917	0.746
DOC_USP7_MATH_1	428	432	PF00917	0.712
DOC_USP7_MATH_1	484	488	PF00917	0.544
DOC_USP7_UBL2_3	128	132	PF12436	0.511
DOC_USP7_UBL2_3	367	371	PF12436	0.683
DOC_WW_Pin1_4	11	16	PF00397	0.692
DOC_WW_Pin1_4	25	30	PF00397	0.630
DOC_WW_Pin1_4	424	429	PF00397	0.773
DOC_WW_Pin1_4	436	441	PF00397	0.659
LIG_14-3-3_CanoR_1	248	256	PF00244	0.598
LIG_14-3-3_CanoR_1	429	436	PF00244	0.724
LIG_Actin_WH2_2	453	469	PF00022	0.557
LIG_APCC_ABBA_1	136	141	PF00400	0.619
LIG_BRCT_BRCA1_1	27	31	PF00533	0.726
LIG_Clathr_ClatBox_1	146	150	PF01394	0.601
LIG_EH1_1	30	38	PF00400	0.678
LIG_FHA_1	131	137	PF00498	0.610
LIG_FHA_1	270	276	PF00498	0.647
LIG_FHA_1	468	474	PF00498	0.655
LIG_FHA_2	432	438	PF00498	0.771
LIG_FHA_2	449	455	PF00498	0.798
LIG_FHA_2	472	478	PF00498	0.722
LIG_LIR_Gen_1	150	157	PF02991	0.538
LIG_LIR_Gen_1	294	305	PF02991	0.543
LIG_LIR_Gen_1	462	473	PF02991	0.702
LIG_LIR_Gen_1	54	64	PF02991	0.566
LIG_LIR_Gen_1	85	96	PF02991	0.543
LIG_LIR_Nem_3	150	154	PF02991	0.540
LIG_LIR_Nem_3	294	300	PF02991	0.544
LIG_LIR_Nem_3	462	468	PF02991	0.690
LIG_LIR_Nem_3	54	60	PF02991	0.581
LIG_LIR_Nem_3	85	91	PF02991	0.545
LIG_NRBOX	236	242	PF00104	0.614
LIG_Pex14_2	57	61	PF04695	0.636
LIG_REV1ctd_RIR_1	58	66	PF16727	0.587
LIG_SH2_STAT3	236	239	PF00017	0.686
LIG_SH2_STAT3	340	343	PF00017	0.635
LIG_SH2_STAT5	236	239	PF00017	0.614
LIG_SH2_STAT5	297	300	PF00017	0.602
LIG_SH2_STAT5	465	468	PF00017	0.711
LIG_SH3_1	26	32	PF00018	0.640
LIG_SH3_2	29	34	PF14604	0.663
LIG_SH3_3	26	32	PF00018	0.663
LIG_SH3_3	379	385	PF00018	0.572
LIG_Sin3_3	109	116	PF02671	0.639
LIG_TRAF2_1	341	344	PF00917	0.647
LIG_TRAF2_1	403	406	PF00917	0.787
LIG_TRAF2_1	71	74	PF00917	0.588
LIG_TRAF2_1	82	85	PF00917	0.482
LIG_UBA3_1	126	132	PF00899	0.568
MOD_CDK_SPK_2	424	429	PF00069	0.629
MOD_CK1_1	199	205	PF00069	0.652
MOD_CK1_1	247	253	PF00069	0.622
MOD_CK1_1	400	406	PF00069	0.742
MOD_CK1_1	427	433	PF00069	0.708
MOD_CK2_1	400	406	PF00069	0.839
MOD_CK2_1	448	454	PF00069	0.765
MOD_CK2_1	68	74	PF00069	0.620
MOD_GlcNHglycan	249	252	PF01048	0.762
MOD_GlcNHglycan	353	357	PF01048	0.600
MOD_GlcNHglycan	386	390	PF01048	0.733
MOD_GlcNHglycan	399	402	PF01048	0.627
MOD_GlcNHglycan	482	485	PF01048	0.627
MOD_GlcNHglycan	70	73	PF01048	0.539
MOD_GlcNHglycan	8	11	PF01048	0.702
MOD_GSK3_1	221	228	PF00069	0.693
MOD_GSK3_1	243	250	PF00069	0.590
MOD_GSK3_1	397	404	PF00069	0.820
MOD_GSK3_1	424	431	PF00069	0.710
MOD_GSK3_1	467	474	PF00069	0.708
MOD_GSK3_1	480	487	PF00069	0.586
MOD_NEK2_1	213	218	PF00069	0.716
MOD_NEK2_1	269	274	PF00069	0.738
MOD_PKA_1	205	211	PF00069	0.683
MOD_PKA_1	225	231	PF00069	0.426
MOD_PKA_2	199	205	PF00069	0.670
MOD_PKA_2	225	231	PF00069	0.644
MOD_PKA_2	247	253	PF00069	0.556
MOD_PKA_2	397	403	PF00069	0.831
MOD_PKA_2	428	434	PF00069	0.726
MOD_Plk_1	130	136	PF00069	0.385
MOD_Plk_1	196	202	PF00069	0.644
MOD_Plk_4	264	270	PF00069	0.692
MOD_ProDKin_1	11	17	PF00069	0.690
MOD_ProDKin_1	25	31	PF00069	0.630
MOD_ProDKin_1	424	430	PF00069	0.775
MOD_ProDKin_1	436	442	PF00069	0.660
TRG_DiLeu_BaEn_1	107	112	PF01217	0.618
TRG_DiLeu_BaEn_1	150	155	PF01217	0.614
TRG_DiLeu_BaEn_4	168	174	PF01217	0.442
TRG_DiLeu_BaLyEn_6	370	375	PF01217	0.640
TRG_ENDOCYTIC_2	297	300	PF00928	0.539
TRG_ENDOCYTIC_2	465	468	PF00928	0.703
TRG_ER_diArg_1	286	289	PF00400	0.565
TRG_ER_diArg_1	375	378	PF00400	0.710
TRG_NES_CRM1_1	124	140	PF08389	0.543
TRG_Pf-PMV_PEXEL_1	164	168	PF00026	0.458
TRG_Pf-PMV_PEXEL_1	319	323	PF00026	0.408
TRG_Pf-PMV_PEXEL_1	373	377	PF00026	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMW1	Leptomonas seymouri	40%	85%
A0A3Q8IG72	Leishmania donovani	85%	100%
A0A3R7MFC1	Trypanosoma rangeli	28%	82%
A4HKG3	Leishmania braziliensis	59%	95%
A4I7Z1	Leishmania infantum	86%	100%
E9B2V2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%