Phosphatidylethanolamine-binding protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylethanolamine-binding protein, putative

Species:

Leishmania major

UniProt:

Q4Q5A3_LEIMA

TriTrypDb:

LmjF.32.1770 , LMJLV39_320023900 , LMJSD75_320023900

Length:

513

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5A3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5A3

PDB structure(s): 7aih_X , 7ane_X

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	242	246	PF00656	0.627
CLV_C14_Caspase3-7	301	305	PF00656	0.430
CLV_C14_Caspase3-7	35	39	PF00656	0.612
CLV_NRD_NRD_1	148	150	PF00675	0.412
CLV_NRD_NRD_1	2	4	PF00675	0.600
CLV_NRD_NRD_1	48	50	PF00675	0.501
CLV_NRD_NRD_1	498	500	PF00675	0.506
CLV_PCSK_KEX2_1	2	4	PF00082	0.600
CLV_PCSK_KEX2_1	498	500	PF00082	0.506
CLV_PCSK_SKI1_1	2	6	PF00082	0.697
CLV_PCSK_SKI1_1	283	287	PF00082	0.421
CLV_PCSK_SKI1_1	352	356	PF00082	0.600
CLV_PCSK_SKI1_1	72	76	PF00082	0.423
DEG_MDM2_SWIB_1	414	422	PF02201	0.374
DEG_Nend_UBRbox_1	1	4	PF02207	0.599
DOC_ANK_TNKS_1	460	467	PF00023	0.473
DOC_CKS1_1	89	94	PF01111	0.397
DOC_CYCLIN_yCln2_LP_2	431	437	PF00134	0.510
DOC_MAPK_FxFP_2	66	69	PF00069	0.447
DOC_MAPK_FxFP_2	80	83	PF00069	0.433
DOC_MAPK_JIP1_4	452	458	PF00069	0.471
DOC_PP1_RVXF_1	490	497	PF00149	0.651
DOC_PP2B_LxvP_1	294	297	PF13499	0.543
DOC_PP2B_LxvP_1	383	386	PF13499	0.698
DOC_PP2B_LxvP_1	97	100	PF13499	0.522
DOC_PP4_FxxP_1	66	69	PF00568	0.447
DOC_PP4_FxxP_1	80	83	PF00568	0.433
DOC_USP7_MATH_1	232	236	PF00917	0.711
DOC_USP7_MATH_1	366	370	PF00917	0.486
DOC_USP7_MATH_1	387	391	PF00917	0.643
DOC_USP7_MATH_1	464	468	PF00917	0.502
DOC_WW_Pin1_4	131	136	PF00397	0.596
DOC_WW_Pin1_4	196	201	PF00397	0.563
DOC_WW_Pin1_4	262	267	PF00397	0.349
DOC_WW_Pin1_4	88	93	PF00397	0.380
DOC_WW_Pin1_4	95	100	PF00397	0.426
LIG_14-3-3_CanoR_1	498	503	PF00244	0.561
LIG_BRCT_BRCA1_1	167	171	PF00533	0.365
LIG_BRCT_BRCA1_1	222	226	PF00533	0.303
LIG_deltaCOP1_diTrp_1	23	30	PF00928	0.698
LIG_EVH1_1	117	121	PF00568	0.456
LIG_EVH1_2	221	225	PF00568	0.420
LIG_EVH1_2	99	103	PF00568	0.455
LIG_FHA_1	308	314	PF00498	0.516
LIG_FHA_1	333	339	PF00498	0.411
LIG_FHA_1	343	349	PF00498	0.440
LIG_FHA_1	389	395	PF00498	0.398
LIG_FHA_1	89	95	PF00498	0.403
LIG_FHA_2	108	114	PF00498	0.501
LIG_FHA_2	353	359	PF00498	0.524
LIG_FHA_2	414	420	PF00498	0.411
LIG_FHA_2	85	91	PF00498	0.551
LIG_LIR_Apic_2	23	28	PF02991	0.682
LIG_LIR_Apic_2	267	273	PF02991	0.419
LIG_LIR_Apic_2	65	69	PF02991	0.445
LIG_LIR_Apic_2	77	83	PF02991	0.437
LIG_LIR_Gen_1	260	269	PF02991	0.387
LIG_LIR_Gen_1	424	434	PF02991	0.526
LIG_LIR_Gen_1	447	456	PF02991	0.600
LIG_LIR_Nem_3	102	106	PF02991	0.438
LIG_LIR_Nem_3	115	120	PF02991	0.441
LIG_LIR_Nem_3	260	264	PF02991	0.386
LIG_LIR_Nem_3	424	429	PF02991	0.516
LIG_LIR_Nem_3	81	85	PF02991	0.553
LIG_LYPXL_yS_3	117	120	PF13949	0.437
LIG_MLH1_MIPbox_1	222	226	PF16413	0.303
LIG_Pex14_2	103	107	PF04695	0.442
LIG_Pex14_2	414	418	PF04695	0.372
LIG_REV1ctd_RIR_1	411	421	PF16727	0.388
LIG_SH2_CRK	25	29	PF00017	0.620
LIG_SH2_CRK	259	263	PF00017	0.350
LIG_SH2_CRK	270	274	PF00017	0.425
LIG_SH2_GRB2like	106	109	PF00017	0.440
LIG_SH2_NCK_1	426	430	PF00017	0.515
LIG_SH2_PTP2	323	326	PF00017	0.412
LIG_SH2_SRC	157	160	PF00017	0.447
LIG_SH2_STAP1	259	263	PF00017	0.350
LIG_SH2_STAP1	70	74	PF00017	0.434
LIG_SH2_STAP1	85	89	PF00017	0.414
LIG_SH2_STAT5	147	150	PF00017	0.393
LIG_SH2_STAT5	157	160	PF00017	0.390
LIG_SH2_STAT5	259	262	PF00017	0.353
LIG_SH2_STAT5	323	326	PF00017	0.396
LIG_SH3_1	402	408	PF00018	0.501
LIG_SH3_2	266	271	PF14604	0.385
LIG_SH3_3	115	121	PF00018	0.476
LIG_SH3_3	124	130	PF00018	0.420
LIG_SH3_3	166	172	PF00018	0.382
LIG_SH3_3	187	193	PF00018	0.513
LIG_SH3_3	215	221	PF00018	0.419
LIG_SH3_3	263	269	PF00018	0.358
LIG_SH3_3	316	322	PF00018	0.431
LIG_SH3_3	402	408	PF00018	0.417
LIG_SH3_3	426	432	PF00018	0.483
LIG_SH3_3	506	512	PF00018	0.574
LIG_TRAF2_1	356	359	PF00917	0.568
LIG_TRFH_1	95	99	PF08558	0.522
LIG_TYR_ITSM	113	120	PF00017	0.528
LIG_UBA3_1	144	150	PF00899	0.515
LIG_WRC_WIRS_1	258	263	PF05994	0.503
MOD_CDK_SPK_2	131	136	PF00069	0.520
MOD_CDK_SPK_2	196	201	PF00069	0.563
MOD_CK1_1	131	137	PF00069	0.546
MOD_CK1_1	235	241	PF00069	0.750
MOD_CK1_1	375	381	PF00069	0.674
MOD_CK1_1	388	394	PF00069	0.499
MOD_CK1_1	396	402	PF00069	0.386
MOD_CK1_1	412	418	PF00069	0.358
MOD_CK1_1	497	503	PF00069	0.527
MOD_CK2_1	352	358	PF00069	0.599
MOD_CK2_1	75	81	PF00069	0.557
MOD_GlcNHglycan	234	237	PF01048	0.700
MOD_GlcNHglycan	374	377	PF01048	0.602
MOD_GlcNHglycan	387	390	PF01048	0.640
MOD_GSK3_1	29	36	PF00069	0.589
MOD_GSK3_1	409	416	PF00069	0.396
MOD_GSK3_1	494	501	PF00069	0.515
MOD_GSK3_1	84	91	PF00069	0.473
MOD_N-GLC_1	107	112	PF02516	0.416
MOD_N-GLC_1	165	170	PF02516	0.365
MOD_N-GLC_1	95	100	PF02516	0.498
MOD_NEK2_1	112	117	PF00069	0.444
MOD_NEK2_1	203	208	PF00069	0.362
MOD_NEK2_1	342	347	PF00069	0.463
MOD_NEK2_1	413	418	PF00069	0.369
MOD_NEK2_1	486	491	PF00069	0.504
MOD_NEK2_1	494	499	PF00069	0.545
MOD_NEK2_1	75	80	PF00069	0.468
MOD_NEK2_2	393	398	PF00069	0.505
MOD_NEK2_2	409	414	PF00069	0.305
MOD_PIKK_1	129	135	PF00454	0.554
MOD_PIKK_1	29	35	PF00454	0.692
MOD_PKA_1	498	504	PF00069	0.576
MOD_PKA_2	179	185	PF00069	0.601
MOD_PKA_2	497	503	PF00069	0.484
MOD_Plk_1	112	118	PF00069	0.442
MOD_Plk_1	165	171	PF00069	0.353
MOD_Plk_1	70	76	PF00069	0.422
MOD_Plk_4	165	171	PF00069	0.381
MOD_Plk_4	220	226	PF00069	0.375
MOD_Plk_4	257	263	PF00069	0.366
MOD_Plk_4	409	415	PF00069	0.370
MOD_Plk_4	70	76	PF00069	0.429
MOD_ProDKin_1	131	137	PF00069	0.586
MOD_ProDKin_1	196	202	PF00069	0.554
MOD_ProDKin_1	262	268	PF00069	0.353
MOD_ProDKin_1	88	94	PF00069	0.385
MOD_ProDKin_1	95	101	PF00069	0.427
MOD_SUMO_rev_2	43	51	PF00179	0.510
TRG_DiLeu_BaEn_1	441	446	PF01217	0.570
TRG_DiLeu_BaLyEn_6	140	145	PF01217	0.393
TRG_DiLeu_BaLyEn_6	270	275	PF01217	0.485
TRG_ENDOCYTIC_2	117	120	PF00928	0.464
TRG_ENDOCYTIC_2	212	215	PF00928	0.362
TRG_ENDOCYTIC_2	258	261	PF00928	0.365
TRG_ENDOCYTIC_2	426	429	PF00928	0.526
TRG_ER_diArg_1	1	3	PF00400	0.594
TRG_ER_diArg_1	141	144	PF00400	0.441
TRG_ER_diArg_1	178	181	PF00400	0.486
TRG_ER_diArg_1	456	459	PF00400	0.481
TRG_ER_diArg_1	461	464	PF00400	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEF7	Leptomonas seymouri	71%	100%
A0A0S4JIJ2	Bodo saltans	47%	100%
A0A1X0NW02	Trypanosomatidae	59%	100%
A0A3Q8ITB2	Leishmania donovani	94%	100%
A0A422NH53	Trypanosoma rangeli	62%	100%
A4HKG4	Leishmania braziliensis	84%	100%
A4I7Z2	Leishmania infantum	94%	100%
D0AA60	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9B2V3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BP31	Trypanosoma cruzi	59%	100%