Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5A2_LEIMA

TriTrypDb:

LmjF.32.1780 , LMJLV39_320024000 , LMJSD75_320024000

Length:

189

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5A2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5A2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	29	31	PF00675	0.548
CLV_NRD_NRD_1	61	63	PF00675	0.555
CLV_NRD_NRD_1	66	68	PF00675	0.585
CLV_PCSK_KEX2_1	151	153	PF00082	0.586
CLV_PCSK_KEX2_1	29	31	PF00082	0.548
CLV_PCSK_KEX2_1	61	63	PF00082	0.551
CLV_PCSK_KEX2_1	66	68	PF00082	0.588
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.586
CLV_PCSK_PC7_1	62	68	PF00082	0.530
CLV_PCSK_SKI1_1	176	180	PF00082	0.635
DEG_Nend_Nbox_1	1	3	PF02207	0.515
DOC_MAPK_gen_1	27	37	PF00069	0.561
DOC_PP2B_LxvP_1	168	171	PF13499	0.548
DOC_PP2B_LxvP_1	35	38	PF13499	0.523
DOC_USP7_MATH_1	181	185	PF00917	0.599
DOC_USP7_UBL2_3	182	186	PF12436	0.599
LIG_14-3-3_CanoR_1	128	136	PF00244	0.570
LIG_deltaCOP1_diTrp_1	131	141	PF00928	0.532
LIG_EVH1_2	38	42	PF00568	0.501
LIG_FHA_2	144	150	PF00498	0.568
LIG_FHA_2	44	50	PF00498	0.573
LIG_LIR_Gen_1	19	28	PF02991	0.533
LIG_LIR_Gen_1	40	50	PF02991	0.599
LIG_LIR_Gen_1	75	86	PF02991	0.511
LIG_LIR_Nem_3	116	122	PF02991	0.486
LIG_LIR_Nem_3	19	25	PF02991	0.553
LIG_LIR_Nem_3	40	45	PF02991	0.596
LIG_LIR_Nem_3	75	81	PF02991	0.468
LIG_REV1ctd_RIR_1	177	187	PF16727	0.587
LIG_SH2_CRK	98	102	PF00017	0.562
LIG_SH2_STAT5	110	113	PF00017	0.624
LIG_SUMO_SIM_anti_2	31	36	PF11976	0.552
LIG_SUMO_SIM_anti_2	49	54	PF11976	0.520
LIG_TRAF2_1	46	49	PF00917	0.548
LIG_UBA3_1	77	82	PF00899	0.393
MOD_CK1_1	140	146	PF00069	0.479
MOD_CK2_1	143	149	PF00069	0.590
MOD_CK2_1	161	167	PF00069	0.710
MOD_CK2_1	43	49	PF00069	0.568
MOD_GlcNHglycan	142	145	PF01048	0.483
MOD_GlcNHglycan	6	9	PF01048	0.502
MOD_GSK3_1	44	51	PF00069	0.564
MOD_LATS_1	102	108	PF00433	0.597
MOD_NEK2_1	2	7	PF00069	0.522
MOD_PIKK_1	44	50	PF00454	0.444
MOD_PKA_2	127	133	PF00069	0.555
MOD_PKA_2	72	78	PF00069	0.599
MOD_Plk_1	48	54	PF00069	0.598
MOD_Plk_1	73	79	PF00069	0.644
MOD_Plk_2-3	88	94	PF00069	0.494
MOD_Plk_4	137	143	PF00069	0.572
MOD_Plk_4	73	79	PF00069	0.416
MOD_Plk_4	96	102	PF00069	0.570
TRG_ENDOCYTIC_2	119	122	PF00928	0.506
TRG_ENDOCYTIC_2	22	25	PF00928	0.564
TRG_ENDOCYTIC_2	98	101	PF00928	0.561
TRG_ER_diArg_1	152	155	PF00400	0.532
TRG_ER_diLys_1	185	189	PF00400	0.611
TRG_NLS_MonoExtC_3	181	186	PF00514	0.594
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMN5	Leptomonas seymouri	41%	100%
A0A3R7NMC2	Trypanosoma rangeli	35%	80%
A0A3S7X5J7	Leishmania donovani	87%	100%
A4HKG5	Leishmania braziliensis	66%	100%
A4I7Z3	Leishmania infantum	88%	100%
E9B2V4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%