LeishMANIAdb
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Protein kinase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase
Gene product:
Serine/threonine-protein kinase NEK21, putative
Species:
Leishmania major
UniProt:
Q4Q598_LEIMA
TriTrypDb:
LmjF.32.1810 , LMJLV39_320024400 * , LMJSD75_320024400
Length:
655

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 33
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. yes yes: 15
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 5
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 65
NetGPI no yes: 0, no: 65
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

Q4Q598
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q598

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 66
GO:0006793 phosphorus metabolic process 3 66
GO:0006796 phosphate-containing compound metabolic process 4 66
GO:0006807 nitrogen compound metabolic process 2 66
GO:0008152 metabolic process 1 66
GO:0009987 cellular process 1 66
GO:0016310 phosphorylation 5 66
GO:0019538 protein metabolic process 3 66
GO:0036211 protein modification process 4 66
GO:0043170 macromolecule metabolic process 3 66
GO:0043412 macromolecule modification 4 66
GO:0044237 cellular metabolic process 2 66
GO:0044238 primary metabolic process 2 66
GO:0071704 organic substance metabolic process 2 66
GO:1901564 organonitrogen compound metabolic process 3 66
GO:0006996 organelle organization 4 1
GO:0016043 cellular component organization 3 1
GO:0032392 DNA geometric change 7 1
GO:0032508 DNA duplex unwinding 8 1
GO:0051276 chromosome organization 5 1
GO:0071103 DNA conformation change 6 1
GO:0071840 cellular component organization or biogenesis 2 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 66
GO:0003824 catalytic activity 1 66
GO:0004672 protein kinase activity 3 66
GO:0004674 protein serine/threonine kinase activity 4 40
GO:0005488 binding 1 66
GO:0005524 ATP binding 5 66
GO:0016301 kinase activity 4 66
GO:0016740 transferase activity 2 66
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 66
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 66
GO:0017076 purine nucleotide binding 4 66
GO:0030554 adenyl nucleotide binding 5 66
GO:0032553 ribonucleotide binding 3 66
GO:0032555 purine ribonucleotide binding 4 66
GO:0032559 adenyl ribonucleotide binding 5 66
GO:0035639 purine ribonucleoside triphosphate binding 4 66
GO:0036094 small molecule binding 2 66
GO:0043167 ion binding 2 66
GO:0043168 anion binding 3 66
GO:0097159 organic cyclic compound binding 2 66
GO:0097367 carbohydrate derivative binding 2 66
GO:0140096 catalytic activity, acting on a protein 2 66
GO:1901265 nucleoside phosphate binding 3 66
GO:1901363 heterocyclic compound binding 2 66
GO:0003676 nucleic acid binding 3 1
GO:0003677 DNA binding 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 29 33 PF00656 0.493
CLV_C14_Caspase3-7 46 50 PF00656 0.473
CLV_NRD_NRD_1 256 258 PF00675 0.432
CLV_NRD_NRD_1 312 314 PF00675 0.332
CLV_NRD_NRD_1 394 396 PF00675 0.333
CLV_NRD_NRD_1 75 77 PF00675 0.496
CLV_PCSK_FUR_1 581 585 PF00082 0.392
CLV_PCSK_KEX2_1 162 164 PF00082 0.470
CLV_PCSK_KEX2_1 256 258 PF00082 0.472
CLV_PCSK_KEX2_1 312 314 PF00082 0.336
CLV_PCSK_KEX2_1 371 373 PF00082 0.307
CLV_PCSK_KEX2_1 394 396 PF00082 0.308
CLV_PCSK_KEX2_1 456 458 PF00082 0.368
CLV_PCSK_KEX2_1 529 531 PF00082 0.519
CLV_PCSK_KEX2_1 583 585 PF00082 0.366
CLV_PCSK_PC1ET2_1 162 164 PF00082 0.430
CLV_PCSK_PC1ET2_1 371 373 PF00082 0.362
CLV_PCSK_PC1ET2_1 456 458 PF00082 0.342
CLV_PCSK_PC1ET2_1 529 531 PF00082 0.559
CLV_PCSK_PC1ET2_1 583 585 PF00082 0.383
CLV_PCSK_SKI1_1 143 147 PF00082 0.396
CLV_PCSK_SKI1_1 266 270 PF00082 0.388
CLV_PCSK_SKI1_1 317 321 PF00082 0.333
CLV_PCSK_SKI1_1 329 333 PF00082 0.328
CLV_PCSK_SKI1_1 443 447 PF00082 0.316
CLV_PCSK_SKI1_1 526 530 PF00082 0.584
CLV_PCSK_SKI1_1 556 560 PF00082 0.329
CLV_PCSK_SKI1_1 583 587 PF00082 0.416
DEG_APCC_DBOX_1 442 450 PF00400 0.309
DEG_APCC_DBOX_1 583 591 PF00400 0.304
DOC_CKS1_1 357 362 PF01111 0.394
DOC_CYCLIN_RxL_1 553 564 PF00134 0.308
DOC_CYCLIN_yCln2_LP_2 357 363 PF00134 0.403
DOC_MAPK_gen_1 138 147 PF00069 0.484
DOC_MAPK_gen_1 317 326 PF00069 0.339
DOC_MAPK_RevD_3 300 313 PF00069 0.352
DOC_PP4_FxxP_1 414 417 PF00568 0.418
DOC_PP4_FxxP_1 504 507 PF00568 0.537
DOC_USP7_MATH_1 118 122 PF00917 0.633
DOC_USP7_MATH_1 203 207 PF00917 0.429
DOC_USP7_UBL2_3 371 375 PF12436 0.285
DOC_USP7_UBL2_3 452 456 PF12436 0.445
DOC_WW_Pin1_4 112 117 PF00397 0.660
DOC_WW_Pin1_4 356 361 PF00397 0.350
DOC_WW_Pin1_4 412 417 PF00397 0.368
DOC_WW_Pin1_4 591 596 PF00397 0.380
DOC_WW_Pin1_4 607 612 PF00397 0.381
LIG_14-3-3_CanoR_1 202 211 PF00244 0.457
LIG_14-3-3_CanoR_1 584 593 PF00244 0.396
LIG_Actin_RPEL_3 306 325 PF02755 0.434
LIG_APCC_ABBA_1 265 270 PF00400 0.210
LIG_APCC_ABBAyCdc20_2 312 318 PF00400 0.332
LIG_BRCT_BRCA1_1 327 331 PF00533 0.348
LIG_BRCT_BRCA1_1 536 540 PF00533 0.652
LIG_BRCT_BRCA1_1 629 633 PF00533 0.376
LIG_BRCT_BRCA1_2 327 333 PF00533 0.348
LIG_EH1_1 297 305 PF00400 0.304
LIG_EH1_1 642 650 PF00400 0.195
LIG_eIF4E_1 298 304 PF01652 0.338
LIG_EVH1_2 617 621 PF00568 0.434
LIG_FHA_1 105 111 PF00498 0.765
LIG_FHA_1 21 27 PF00498 0.516
LIG_FHA_1 240 246 PF00498 0.269
LIG_FHA_1 295 301 PF00498 0.423
LIG_FHA_1 40 46 PF00498 0.464
LIG_FHA_1 423 429 PF00498 0.352
LIG_FHA_1 562 568 PF00498 0.320
LIG_FHA_2 16 22 PF00498 0.718
LIG_FHA_2 25 31 PF00498 0.727
LIG_FHA_2 289 295 PF00498 0.442
LIG_FHA_2 529 535 PF00498 0.497
LIG_FHA_2 536 542 PF00498 0.485
LIG_LIR_Apic_2 359 365 PF02991 0.341
LIG_LIR_Apic_2 412 417 PF02991 0.384
LIG_LIR_Apic_2 612 618 PF02991 0.434
LIG_LIR_Gen_1 142 150 PF02991 0.553
LIG_LIR_Gen_1 222 231 PF02991 0.332
LIG_LIR_Gen_1 297 306 PF02991 0.344
LIG_LIR_Gen_1 328 339 PF02991 0.297
LIG_LIR_Gen_1 555 565 PF02991 0.334
LIG_LIR_Nem_3 142 147 PF02991 0.536
LIG_LIR_Nem_3 222 228 PF02991 0.313
LIG_LIR_Nem_3 297 302 PF02991 0.350
LIG_LIR_Nem_3 328 334 PF02991 0.295
LIG_LIR_Nem_3 537 543 PF02991 0.410
LIG_LIR_Nem_3 555 560 PF02991 0.218
LIG_LIR_Nem_3 92 97 PF02991 0.602
LIG_LYPXL_SIV_4 618 626 PF13949 0.181
LIG_Pex14_1 553 557 PF04695 0.321
LIG_PTB_Apo_2 161 168 PF02174 0.441
LIG_PTB_Phospho_1 161 167 PF10480 0.436
LIG_SH2_CRK 615 619 PF00017 0.434
LIG_SH2_NCK_1 167 171 PF00017 0.591
LIG_SH2_NCK_1 486 490 PF00017 0.524
LIG_SH2_PTP2 128 131 PF00017 0.552
LIG_SH2_PTP2 144 147 PF00017 0.294
LIG_SH2_SRC 472 475 PF00017 0.237
LIG_SH2_SRC 479 482 PF00017 0.233
LIG_SH2_STAP1 167 171 PF00017 0.390
LIG_SH2_STAP1 231 235 PF00017 0.353
LIG_SH2_STAP1 343 347 PF00017 0.324
LIG_SH2_STAP1 387 391 PF00017 0.348
LIG_SH2_STAP1 486 490 PF00017 0.481
LIG_SH2_STAP1 619 623 PF00017 0.397
LIG_SH2_STAT3 298 301 PF00017 0.330
LIG_SH2_STAT5 128 131 PF00017 0.571
LIG_SH2_STAT5 144 147 PF00017 0.440
LIG_SH2_STAT5 194 197 PF00017 0.485
LIG_SH2_STAT5 234 237 PF00017 0.394
LIG_SH2_STAT5 24 27 PF00017 0.524
LIG_SH2_STAT5 298 301 PF00017 0.303
LIG_SH2_STAT5 362 365 PF00017 0.341
LIG_SH2_STAT5 472 475 PF00017 0.395
LIG_SH2_STAT5 479 482 PF00017 0.412
LIG_SH2_STAT5 503 506 PF00017 0.484
LIG_SH2_STAT5 557 560 PF00017 0.334
LIG_SH3_3 184 190 PF00018 0.628
LIG_SH3_3 261 267 PF00018 0.243
LIG_SH3_3 414 420 PF00018 0.253
LIG_SH3_4 466 473 PF00018 0.252
LIG_SUMO_SIM_anti_2 237 248 PF11976 0.314
LIG_SUMO_SIM_par_1 237 248 PF11976 0.320
LIG_SUMO_SIM_par_1 42 49 PF11976 0.482
LIG_SUMO_SIM_par_1 563 570 PF11976 0.411
LIG_TRAF2_1 459 462 PF00917 0.447
LIG_TRAF2_1 637 640 PF00917 0.276
LIG_TRFH_1 361 365 PF08558 0.325
LIG_TYR_ITIM 126 131 PF00017 0.595
LIG_TYR_ITIM 385 390 PF00017 0.371
LIG_UBA3_1 445 452 PF00899 0.305
LIG_UBA3_1 586 591 PF00899 0.406
MOD_CK1_1 105 111 PF00069 0.754
MOD_CK1_1 273 279 PF00069 0.469
MOD_CK1_1 345 351 PF00069 0.367
MOD_CK1_1 37 43 PF00069 0.593
MOD_CK1_1 482 488 PF00069 0.489
MOD_CK1_1 535 541 PF00069 0.540
MOD_CK1_1 589 595 PF00069 0.305
MOD_CK1_1 627 633 PF00069 0.423
MOD_CK2_1 15 21 PF00069 0.495
MOD_CK2_1 235 241 PF00069 0.434
MOD_CK2_1 288 294 PF00069 0.381
MOD_CK2_1 456 462 PF00069 0.398
MOD_CK2_1 528 534 PF00069 0.480
MOD_CK2_1 535 541 PF00069 0.469
MOD_CK2_1 591 597 PF00069 0.375
MOD_CK2_1 634 640 PF00069 0.310
MOD_Cter_Amidation 369 372 PF01082 0.301
MOD_Cter_Amidation 373 376 PF01082 0.278
MOD_Cter_Amidation 392 395 PF01082 0.331
MOD_GlcNHglycan 104 107 PF01048 0.685
MOD_GlcNHglycan 120 123 PF01048 0.565
MOD_GlcNHglycan 260 263 PF01048 0.406
MOD_GlcNHglycan 285 288 PF01048 0.181
MOD_GlcNHglycan 309 312 PF01048 0.392
MOD_GlcNHglycan 320 323 PF01048 0.356
MOD_GlcNHglycan 36 39 PF01048 0.705
MOD_GlcNHglycan 422 425 PF01048 0.311
MOD_GlcNHglycan 458 461 PF01048 0.283
MOD_GlcNHglycan 534 537 PF01048 0.506
MOD_GlcNHglycan 636 639 PF01048 0.320
MOD_GlcNHglycan 66 69 PF01048 0.814
MOD_GlcNHglycan 91 94 PF01048 0.763
MOD_GSK3_1 100 107 PF00069 0.741
MOD_GSK3_1 15 22 PF00069 0.750
MOD_GSK3_1 235 242 PF00069 0.492
MOD_GSK3_1 270 277 PF00069 0.410
MOD_GSK3_1 342 349 PF00069 0.357
MOD_GSK3_1 352 359 PF00069 0.339
MOD_GSK3_1 39 46 PF00069 0.723
MOD_GSK3_1 415 422 PF00069 0.470
MOD_GSK3_1 528 535 PF00069 0.557
MOD_GSK3_1 561 568 PF00069 0.382
MOD_GSK3_1 585 592 PF00069 0.378
MOD_N-GLC_1 112 117 PF02516 0.706
MOD_NEK2_1 219 224 PF00069 0.357
MOD_NEK2_1 325 330 PF00069 0.337
MOD_NEK2_1 337 342 PF00069 0.327
MOD_NEK2_1 5 10 PF00069 0.748
MOD_NEK2_1 560 565 PF00069 0.306
MOD_NEK2_1 586 591 PF00069 0.428
MOD_NEK2_1 625 630 PF00069 0.331
MOD_NMyristoyl 1 7 PF02799 0.648
MOD_PIKK_1 185 191 PF00454 0.598
MOD_PIKK_1 203 209 PF00454 0.401
MOD_PIKK_1 270 276 PF00454 0.428
MOD_PIKK_1 337 343 PF00454 0.347
MOD_PIKK_1 427 433 PF00454 0.461
MOD_PIKK_1 5 11 PF00454 0.721
MOD_PK_1 146 152 PF00069 0.547
MOD_PK_1 43 49 PF00069 0.483
MOD_PKA_1 456 462 PF00069 0.345
MOD_PKA_2 456 462 PF00069 0.340
MOD_Plk_1 20 26 PF00069 0.728
MOD_Plk_1 239 245 PF00069 0.326
MOD_Plk_1 343 349 PF00069 0.292
MOD_Plk_4 20 26 PF00069 0.728
MOD_Plk_4 239 245 PF00069 0.351
MOD_Plk_4 260 266 PF00069 0.297
MOD_Plk_4 294 300 PF00069 0.393
MOD_Plk_4 352 358 PF00069 0.321
MOD_Plk_4 43 49 PF00069 0.483
MOD_Plk_4 479 485 PF00069 0.425
MOD_Plk_4 627 633 PF00069 0.349
MOD_ProDKin_1 112 118 PF00069 0.658
MOD_ProDKin_1 356 362 PF00069 0.350
MOD_ProDKin_1 412 418 PF00069 0.368
MOD_ProDKin_1 591 597 PF00069 0.380
MOD_ProDKin_1 607 613 PF00069 0.381
TRG_DiLeu_BaEn_1 555 560 PF01217 0.360
TRG_DiLeu_BaEn_4 78 84 PF01217 0.504
TRG_ENDOCYTIC_2 128 131 PF00928 0.571
TRG_ENDOCYTIC_2 144 147 PF00928 0.525
TRG_ENDOCYTIC_2 387 390 PF00928 0.353
TRG_ENDOCYTIC_2 472 475 PF00928 0.374
TRG_ENDOCYTIC_2 557 560 PF00928 0.337
TRG_ER_diArg_1 255 257 PF00400 0.475
TRG_ER_diArg_1 312 314 PF00400 0.321
TRG_ER_diArg_1 394 396 PF00400 0.341
TRG_Pf-PMV_PEXEL_1 530 534 PF00026 0.581
TRG_Pf-PMV_PEXEL_1 556 561 PF00026 0.389
TRG_Pf-PMV_PEXEL_1 650 655 PF00026 0.586

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P953 Leptomonas seymouri 30% 100%
A0A0N1I9A0 Leptomonas seymouri 67% 100%
A0A0N1PD05 Leptomonas seymouri 34% 100%
A0A0S4IMB7 Bodo saltans 34% 100%
A0A0S4IRZ7 Bodo saltans 41% 100%
A0A0S4J804 Bodo saltans 30% 100%
A0A0S4JPZ1 Bodo saltans 28% 100%
A0A1X0NIX2 Trypanosomatidae 28% 100%
A0A1X0NUB2 Trypanosomatidae 46% 100%
A0A1X0P527 Trypanosomatidae 33% 100%
A0A1X0P549 Trypanosomatidae 30% 100%
A0A1X0P863 Trypanosomatidae 31% 100%
A0A1X0P8W3 Trypanosomatidae 26% 88%
A0A1X0P994 Trypanosomatidae 29% 100%
A0A3Q8IFK8 Leishmania donovani 31% 100%
A0A3Q8IHH8 Leishmania donovani 31% 100%
A0A3Q8IIH5 Leishmania donovani 27% 100%
A0A3Q8IJM9 Leishmania donovani 30% 100%
A0A3R7MKG5 Trypanosoma rangeli 27% 100%
A0A3S7X5M4 Leishmania donovani 93% 100%
A0A3S7X6T8 Leishmania donovani 35% 100%
A0A3S7XAL3 Leishmania donovani 31% 100%
A0A3S7XAT9 Leishmania donovani 31% 100%
A0A422NCP0 Trypanosoma rangeli 30% 100%
A0A422NH41 Trypanosoma rangeli 45% 100%
A4HHQ5 Leishmania braziliensis 33% 100%
A4HJT5 Leishmania braziliensis 30% 100%
A4HKG9 Leishmania braziliensis 72% 100%
A4HLR0 Leishmania braziliensis 35% 100%
A4HNI1 Leishmania braziliensis 29% 100%
A4HP12 Leishmania braziliensis 29% 100%
A4HP13 Leishmania braziliensis 30% 100%
A4HW88 Leishmania infantum 27% 100%
A4I4X0 Leishmania infantum 31% 100%
A4I7A1 Leishmania infantum 31% 100%
A4I7Z6 Leishmania infantum 93% 100%
A4I960 Leishmania infantum 35% 100%
A4IC37 Leishmania infantum 30% 100%
A4IDC1 Leishmania infantum 31% 100%
A4IDC2 Leishmania infantum 31% 100%
C9ZMH9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
C9ZWK2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
D0A2Z1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
D0A2Z6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
D0AA64 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
E9AEB9 Leishmania major 33% 100%
E9AFZ2 Leishmania major 30% 100%
E9ALG7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9ASS2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9ASS3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9B296 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9B2V8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
E9B436 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9B745 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
Q4Q1J2 Leishmania major 31% 100%
Q4Q1S3 Leishmania major 31% 100%
Q4Q1S4 Leishmania major 30% 100%
Q4Q3Y9 Leishmania major 32% 85%
Q4Q5W2 Leishmania major 31% 100%
Q4QFJ2 Leishmania major 27% 100%
Q8N5S9 Homo sapiens 24% 100%
Q8VBY2 Mus musculus 24% 100%
V5BC28 Trypanosoma cruzi 28% 100%
V5BPJ0 Trypanosoma cruzi 29% 100%
V5D7G4 Trypanosoma cruzi 31% 79%
V5DFW9 Trypanosoma cruzi 46% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS