Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q593_LEIMA

TriTrypDb:

LmjF.32.1860 , LMJLV39_320024900 , LMJSD75_320024900

Length:

414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q593

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q593

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.556
CLV_C14_Caspase3-7	332	336	PF00656	0.640
CLV_C14_Caspase3-7	375	379	PF00656	0.564
CLV_NRD_NRD_1	115	117	PF00675	0.544
CLV_NRD_NRD_1	262	264	PF00675	0.513
CLV_NRD_NRD_1	376	378	PF00675	0.640
CLV_NRD_NRD_1	408	410	PF00675	0.541
CLV_PCSK_KEX2_1	115	117	PF00082	0.524
CLV_PCSK_KEX2_1	261	263	PF00082	0.507
CLV_PCSK_KEX2_1	376	378	PF00082	0.622
CLV_PCSK_KEX2_1	408	410	PF00082	0.541
CLV_PCSK_SKI1_1	358	362	PF00082	0.644
CLV_PCSK_SKI1_1	81	85	PF00082	0.594
DEG_APCC_DBOX_1	357	365	PF00400	0.639
DEG_APCC_DBOX_1	94	102	PF00400	0.494
DOC_CYCLIN_RxL_1	355	365	PF00134	0.641
DOC_CYCLIN_yCln2_LP_2	154	160	PF00134	0.562
DOC_CYCLIN_yCln2_LP_2	85	91	PF00134	0.481
DOC_MAPK_MEF2A_6	367	374	PF00069	0.640
DOC_PP2B_LxvP_1	154	157	PF13499	0.559
DOC_PP2B_LxvP_1	24	27	PF13499	0.461
DOC_PP2B_LxvP_1	386	389	PF13499	0.543
DOC_PP4_FxxP_1	201	204	PF00568	0.645
DOC_PP4_FxxP_1	29	32	PF00568	0.503
DOC_PP4_FxxP_1	51	54	PF00568	0.669
DOC_USP7_MATH_1	129	133	PF00917	0.454
DOC_USP7_MATH_1	135	139	PF00917	0.428
DOC_USP7_MATH_1	220	224	PF00917	0.698
DOC_USP7_MATH_1	231	235	PF00917	0.689
DOC_USP7_MATH_1	25	29	PF00917	0.549
DOC_USP7_MATH_1	289	293	PF00917	0.661
DOC_USP7_MATH_1	346	350	PF00917	0.670
DOC_USP7_MATH_1	389	393	PF00917	0.646
DOC_WW_Pin1_4	227	232	PF00397	0.647
DOC_WW_Pin1_4	261	266	PF00397	0.522
DOC_WW_Pin1_4	279	284	PF00397	0.630
DOC_WW_Pin1_4	293	298	PF00397	0.619
LIG_14-3-3_CanoR_1	115	123	PF00244	0.527
LIG_14-3-3_CanoR_1	186	192	PF00244	0.638
LIG_14-3-3_CanoR_1	81	86	PF00244	0.564
LIG_14-3-3_CanoR_1	95	105	PF00244	0.420
LIG_Actin_WH2_2	121	139	PF00022	0.667
LIG_Actin_WH2_2	79	97	PF00022	0.471
LIG_APCC_ABBA_1	37	42	PF00400	0.538
LIG_BIR_II_1	1	5	PF00653	0.508
LIG_BRCT_BRCA1_1	391	395	PF00533	0.622
LIG_CtBP_PxDLS_1	75	79	PF00389	0.407
LIG_FHA_1	21	27	PF00498	0.414
LIG_FHA_1	310	316	PF00498	0.675
LIG_FHA_1	361	367	PF00498	0.658
LIG_FHA_1	77	83	PF00498	0.628
LIG_FHA_2	188	194	PF00498	0.572
LIG_FHA_2	82	88	PF00498	0.465
LIG_FXI_DFP_1	172	176	PF00024	0.610
LIG_IRF3_LxIS_1	289	296	PF10401	0.646
LIG_LIR_Apic_2	199	204	PF02991	0.646
LIG_LIR_Apic_2	28	32	PF02991	0.554
LIG_LIR_Apic_2	50	54	PF02991	0.597
LIG_LIR_Gen_1	190	197	PF02991	0.607
LIG_LIR_Nem_3	117	123	PF02991	0.486
LIG_LIR_Nem_3	173	178	PF02991	0.515
LIG_LIR_Nem_3	190	195	PF02991	0.516
LIG_LIR_Nem_3	267	271	PF02991	0.695
LIG_LIR_Nem_3	6	12	PF02991	0.543
LIG_Pex14_2	171	175	PF04695	0.608
LIG_SH2_CRK	10	14	PF00017	0.532
LIG_SH2_CRK	120	124	PF00017	0.487
LIG_SH2_NCK_1	347	351	PF00017	0.626
LIG_SH2_SRC	192	195	PF00017	0.603
LIG_SH2_STAP1	192	196	PF00017	0.607
LIG_SH2_STAP1	347	351	PF00017	0.598
LIG_SH2_STAP1	92	96	PF00017	0.398
LIG_SH2_STAT5	240	243	PF00017	0.626
LIG_SH2_STAT5	410	413	PF00017	0.571
LIG_SH3_1	179	185	PF00018	0.634
LIG_SH3_3	179	185	PF00018	0.634
LIG_SH3_3	201	207	PF00018	0.652
LIG_TRAF2_1	65	68	PF00917	0.466
LIG_TYR_ITSM	188	195	PF00017	0.571
LIG_WRC_WIRS_1	26	31	PF05994	0.541
LIG_WRC_WIRS_1	48	53	PF05994	0.512
MOD_CDK_SPK_2	279	284	PF00069	0.566
MOD_CDK_SPxxK_3	279	286	PF00069	0.557
MOD_CK1_1	187	193	PF00069	0.583
MOD_CK1_1	275	281	PF00069	0.630
MOD_CK1_1	307	313	PF00069	0.617
MOD_CK1_1	345	351	PF00069	0.691
MOD_CK1_1	97	103	PF00069	0.436
MOD_CK2_1	261	267	PF00069	0.580
MOD_CK2_1	279	285	PF00069	0.711
MOD_GlcNHglycan	130	134	PF01048	0.515
MOD_GlcNHglycan	137	140	PF01048	0.490
MOD_GlcNHglycan	217	220	PF01048	0.744
MOD_GlcNHglycan	222	225	PF01048	0.749
MOD_GlcNHglycan	279	282	PF01048	0.713
MOD_GlcNHglycan	325	328	PF01048	0.757
MOD_GlcNHglycan	344	347	PF01048	0.717
MOD_GlcNHglycan	348	351	PF01048	0.663
MOD_GlcNHglycan	5	8	PF01048	0.599
MOD_GSK3_1	215	222	PF00069	0.665
MOD_GSK3_1	227	234	PF00069	0.695
MOD_GSK3_1	275	282	PF00069	0.677
MOD_GSK3_1	284	291	PF00069	0.613
MOD_GSK3_1	342	349	PF00069	0.679
MOD_GSK3_1	389	396	PF00069	0.585
MOD_NEK2_1	1	6	PF00069	0.629
MOD_NEK2_1	164	169	PF00069	0.633
MOD_NEK2_1	33	38	PF00069	0.573
MOD_NEK2_1	360	365	PF00069	0.664
MOD_NEK2_1	393	398	PF00069	0.486
MOD_NEK2_1	47	52	PF00069	0.598
MOD_NEK2_1	94	99	PF00069	0.522
MOD_NEK2_2	389	394	PF00069	0.588
MOD_NEK2_2	76	81	PF00069	0.512
MOD_PIKK_1	11	17	PF00454	0.517
MOD_PIKK_1	114	120	PF00454	0.508
MOD_PIKK_1	272	278	PF00454	0.609
MOD_PKA_2	114	120	PF00069	0.521
MOD_PKA_2	225	231	PF00069	0.733
MOD_PKA_2	94	100	PF00069	0.443
MOD_Plk_1	20	26	PF00069	0.382
MOD_Plk_1	238	244	PF00069	0.619
MOD_Plk_4	187	193	PF00069	0.638
MOD_Plk_4	304	310	PF00069	0.652
MOD_Plk_4	47	53	PF00069	0.477
MOD_Plk_4	81	87	PF00069	0.506
MOD_Plk_4	97	103	PF00069	0.502
MOD_ProDKin_1	227	233	PF00069	0.647
MOD_ProDKin_1	261	267	PF00069	0.523
MOD_ProDKin_1	279	285	PF00069	0.633
MOD_ProDKin_1	293	299	PF00069	0.618
MOD_SUMO_rev_2	36	45	PF00179	0.545
MOD_SUMO_rev_2	369	375	PF00179	0.604
TRG_DiLeu_BaLyEn_6	356	361	PF01217	0.652
TRG_ENDOCYTIC_2	120	123	PF00928	0.497
TRG_ENDOCYTIC_2	192	195	PF00928	0.581
TRG_ENDOCYTIC_2	9	12	PF00928	0.453
TRG_ER_diArg_1	260	263	PF00400	0.486
TRG_ER_diArg_1	408	410	PF00400	0.598
TRG_Pf-PMV_PEXEL_1	358	362	PF00026	0.644
TRG_Pf-PMV_PEXEL_1	62	67	PF00026	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I475	Leptomonas seymouri	55%	100%
A0A1X0NUD6	Trypanosomatidae	29%	100%
A0A3Q8IGT2	Leishmania donovani	89%	100%
A4I801	Leishmania infantum	89%	100%
E9B2W3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5BF21	Trypanosoma cruzi	29%	100%