LeishMANIAdb
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Cation efflux family-domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Cation efflux family-domain-containing protein
Gene product:
Cation efflux family, putative
Species:
Leishmania major
UniProt:
Q4Q592_LEIMA
TriTrypDb:
LmjF.32.1870 , LMJLV39_320025000 , LMJSD75_320025000 *
Length:
625

Annotations

LeishMANIAdb annotations

Similar to Zn transporters found in animals.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

Q4Q592
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q592

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 2
GO:0008324 monoatomic cation transmembrane transporter activity 4 2
GO:0015075 monoatomic ion transmembrane transporter activity 3 2
GO:0022857 transmembrane transporter activity 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 331 335 PF00656 0.466
CLV_C14_Caspase3-7 575 579 PF00656 0.514
CLV_NRD_NRD_1 177 179 PF00675 0.523
CLV_NRD_NRD_1 19 21 PF00675 0.456
CLV_NRD_NRD_1 220 222 PF00675 0.491
CLV_NRD_NRD_1 287 289 PF00675 0.671
CLV_NRD_NRD_1 342 344 PF00675 0.631
CLV_NRD_NRD_1 439 441 PF00675 0.729
CLV_NRD_NRD_1 613 615 PF00675 0.755
CLV_PCSK_FUR_1 175 179 PF00082 0.460
CLV_PCSK_KEX2_1 177 179 PF00082 0.489
CLV_PCSK_KEX2_1 19 21 PF00082 0.456
CLV_PCSK_KEX2_1 220 222 PF00082 0.491
CLV_PCSK_KEX2_1 287 289 PF00082 0.671
CLV_PCSK_KEX2_1 439 441 PF00082 0.725
CLV_PCSK_KEX2_1 503 505 PF00082 0.789
CLV_PCSK_KEX2_1 613 615 PF00082 0.780
CLV_PCSK_PC1ET2_1 503 505 PF00082 0.789
CLV_PCSK_SKI1_1 272 276 PF00082 0.657
CLV_PCSK_SKI1_1 281 285 PF00082 0.582
CLV_PCSK_SKI1_1 297 301 PF00082 0.499
DEG_APCC_DBOX_1 271 279 PF00400 0.456
DEG_APCC_DBOX_1 342 350 PF00400 0.452
DEG_MDM2_SWIB_1 28 36 PF02201 0.466
DEG_Nend_Nbox_1 1 3 PF02207 0.665
DOC_CKS1_1 487 492 PF01111 0.599
DOC_CKS1_1 597 602 PF01111 0.487
DOC_CKS1_1 9 14 PF01111 0.629
DOC_CYCLIN_yClb5_NLxxxL_5 288 296 PF00134 0.387
DOC_CYCLIN_yCln2_LP_2 580 586 PF00134 0.556
DOC_MAPK_gen_1 269 277 PF00069 0.378
DOC_MAPK_HePTP_8 91 103 PF00069 0.483
DOC_MAPK_MEF2A_6 272 279 PF00069 0.460
DOC_MAPK_MEF2A_6 88 95 PF00069 0.602
DOC_MAPK_NFAT4_5 272 280 PF00069 0.462
DOC_PP2B_LxvP_1 536 539 PF13499 0.457
DOC_PP4_FxxP_1 189 192 PF00568 0.784
DOC_PP4_FxxP_1 487 490 PF00568 0.622
DOC_USP7_MATH_1 471 475 PF00917 0.529
DOC_USP7_MATH_1 492 496 PF00917 0.557
DOC_USP7_MATH_1 529 533 PF00917 0.527
DOC_USP7_MATH_1 576 580 PF00917 0.611
DOC_USP7_MATH_1 584 588 PF00917 0.567
DOC_WW_Pin1_4 188 193 PF00397 0.749
DOC_WW_Pin1_4 202 207 PF00397 0.688
DOC_WW_Pin1_4 478 483 PF00397 0.549
DOC_WW_Pin1_4 486 491 PF00397 0.585
DOC_WW_Pin1_4 503 508 PF00397 0.471
DOC_WW_Pin1_4 537 542 PF00397 0.592
DOC_WW_Pin1_4 596 601 PF00397 0.555
DOC_WW_Pin1_4 8 13 PF00397 0.621
LIG_14-3-3_CanoR_1 88 92 PF00244 0.602
LIG_14-3-3_CanoR_1 94 100 PF00244 0.398
LIG_Actin_WH2_2 129 145 PF00022 0.416
LIG_Actin_WH2_2 315 330 PF00022 0.282
LIG_APCC_ABBA_1 598 603 PF00400 0.558
LIG_BRCT_BRCA1_1 121 125 PF00533 0.399
LIG_BRCT_BRCA1_1 34 38 PF00533 0.483
LIG_BRCT_BRCA1_1 40 44 PF00533 0.398
LIG_BRCT_BRCA1_1 424 428 PF00533 0.599
LIG_BRCT_BRCA1_1 441 445 PF00533 0.437
LIG_BRCT_BRCA1_1 494 498 PF00533 0.506
LIG_BRCT_BRCA1_1 96 100 PF00533 0.363
LIG_CaM_NSCaTE_8 374 381 PF13499 0.496
LIG_EH_1 122 126 PF12763 0.344
LIG_EVH1_1 487 491 PF00568 0.622
LIG_EVH1_2 594 598 PF00568 0.558
LIG_FHA_1 146 152 PF00498 0.670
LIG_FHA_1 233 239 PF00498 0.431
LIG_FHA_1 383 389 PF00498 0.477
LIG_FHA_1 40 46 PF00498 0.456
LIG_FHA_1 452 458 PF00498 0.554
LIG_FHA_1 60 66 PF00498 0.199
LIG_FHA_1 96 102 PF00498 0.483
LIG_FHA_2 106 112 PF00498 0.483
LIG_FHA_2 570 576 PF00498 0.510
LIG_Integrin_isoDGR_2 270 272 PF01839 0.639
LIG_LIR_Apic_2 187 192 PF02991 0.782
LIG_LIR_Gen_1 351 360 PF02991 0.452
LIG_LIR_Gen_1 619 625 PF02991 0.575
LIG_LIR_Gen_1 97 107 PF02991 0.483
LIG_LIR_Nem_3 122 128 PF02991 0.283
LIG_LIR_Nem_3 310 316 PF02991 0.441
LIG_LIR_Nem_3 35 40 PF02991 0.396
LIG_LIR_Nem_3 351 355 PF02991 0.481
LIG_LIR_Nem_3 442 448 PF02991 0.613
LIG_LIR_Nem_3 540 545 PF02991 0.602
LIG_LIR_Nem_3 619 625 PF02991 0.575
LIG_LIR_Nem_3 97 103 PF02991 0.483
LIG_MLH1_MIPbox_1 34 38 PF16413 0.416
LIG_NRBOX 164 170 PF00104 0.620
LIG_NRBOX 4 10 PF00104 0.526
LIG_PDZ_Class_3 620 625 PF00595 0.574
LIG_Pex14_1 258 262 PF04695 0.363
LIG_Pex14_2 185 189 PF04695 0.736
LIG_Pex14_2 28 32 PF04695 0.483
LIG_PTB_Apo_2 120 127 PF02174 0.419
LIG_SH2_CRK 263 267 PF00017 0.429
LIG_SH2_NCK_1 527 531 PF00017 0.558
LIG_SH2_PTP2 352 355 PF00017 0.442
LIG_SH2_SRC 263 266 PF00017 0.420
LIG_SH2_SRC 352 355 PF00017 0.442
LIG_SH2_SRC 622 625 PF00017 0.576
LIG_SH2_STAT3 463 466 PF00017 0.574
LIG_SH2_STAT5 229 232 PF00017 0.483
LIG_SH2_STAT5 265 268 PF00017 0.444
LIG_SH2_STAT5 352 355 PF00017 0.474
LIG_SH3_3 280 286 PF00018 0.427
LIG_SH3_3 485 491 PF00018 0.620
LIG_SH3_3 580 586 PF00018 0.608
LIG_SH3_3 588 594 PF00018 0.555
LIG_SUMO_SIM_anti_2 240 249 PF11976 0.503
LIG_SUMO_SIM_anti_2 273 279 PF11976 0.459
LIG_SUMO_SIM_par_1 240 249 PF11976 0.534
LIG_SUMO_SIM_par_1 51 57 PF11976 0.483
LIG_TRFH_1 229 233 PF08558 0.483
LIG_TYR_ITIM 261 266 PF00017 0.437
LIG_UBA3_1 274 281 PF00899 0.463
MOD_CDK_SPxK_1 596 602 PF00069 0.557
MOD_CDK_SPxK_1 8 14 PF00069 0.626
MOD_CK1_1 191 197 PF00069 0.817
MOD_CK1_1 506 512 PF00069 0.499
MOD_CK1_1 532 538 PF00069 0.540
MOD_CK1_1 540 546 PF00069 0.560
MOD_CK1_1 69 75 PF00069 0.580
MOD_CK2_1 105 111 PF00069 0.483
MOD_CK2_1 569 575 PF00069 0.506
MOD_GlcNHglycan 171 174 PF01048 0.450
MOD_GlcNHglycan 193 196 PF01048 0.603
MOD_GlcNHglycan 221 224 PF01048 0.397
MOD_GlcNHglycan 28 31 PF01048 0.383
MOD_GlcNHglycan 330 333 PF01048 0.666
MOD_GlcNHglycan 494 497 PF01048 0.806
MOD_GlcNHglycan 499 503 PF01048 0.780
MOD_GlcNHglycan 508 511 PF01048 0.709
MOD_GlcNHglycan 518 521 PF01048 0.664
MOD_GlcNHglycan 532 535 PF01048 0.660
MOD_GlcNHglycan 618 621 PF01048 0.774
MOD_GSK3_1 105 112 PF00069 0.483
MOD_GSK3_1 145 152 PF00069 0.682
MOD_GSK3_1 215 222 PF00069 0.675
MOD_GSK3_1 32 39 PF00069 0.316
MOD_GSK3_1 330 337 PF00069 0.420
MOD_GSK3_1 366 373 PF00069 0.590
MOD_GSK3_1 374 381 PF00069 0.520
MOD_GSK3_1 4 11 PF00069 0.627
MOD_GSK3_1 555 562 PF00069 0.574
MOD_GSK3_1 69 76 PF00069 0.576
MOD_N-GLC_1 316 321 PF02516 0.621
MOD_N-GLC_1 530 535 PF02516 0.715
MOD_N-GLC_2 280 282 PF02516 0.631
MOD_NEK2_1 109 114 PF00069 0.366
MOD_NEK2_1 169 174 PF00069 0.640
MOD_NEK2_1 219 224 PF00069 0.610
MOD_NEK2_1 366 371 PF00069 0.566
MOD_NEK2_1 378 383 PF00069 0.477
MOD_NEK2_1 38 43 PF00069 0.458
MOD_NEK2_1 45 50 PF00069 0.379
MOD_NEK2_1 498 503 PF00069 0.493
MOD_NEK2_1 54 59 PF00069 0.278
MOD_NEK2_1 95 100 PF00069 0.483
MOD_NEK2_2 215 220 PF00069 0.747
MOD_NEK2_2 32 37 PF00069 0.402
MOD_NEK2_2 576 581 PF00069 0.561
MOD_PIKK_1 134 140 PF00454 0.483
MOD_PIKK_1 196 202 PF00454 0.755
MOD_PIKK_1 221 227 PF00454 0.649
MOD_PIKK_1 336 342 PF00454 0.338
MOD_PIKK_1 367 373 PF00454 0.521
MOD_PIKK_1 73 79 PF00454 0.667
MOD_PK_1 453 459 PF00069 0.510
MOD_PKA_1 439 445 PF00069 0.524
MOD_PKA_2 114 120 PF00069 0.438
MOD_PKA_2 149 155 PF00069 0.704
MOD_PKA_2 219 225 PF00069 0.583
MOD_PKA_2 439 445 PF00069 0.540
MOD_PKA_2 515 521 PF00069 0.545
MOD_PKA_2 87 93 PF00069 0.602
MOD_PKB_1 326 334 PF00069 0.426
MOD_Plk_1 246 252 PF00069 0.405
MOD_Plk_1 432 438 PF00069 0.508
MOD_Plk_4 105 111 PF00069 0.227
MOD_Plk_4 237 243 PF00069 0.410
MOD_Plk_4 308 314 PF00069 0.442
MOD_Plk_4 318 324 PF00069 0.337
MOD_Plk_4 348 354 PF00069 0.452
MOD_Plk_4 374 380 PF00069 0.495
MOD_Plk_4 4 10 PF00069 0.602
MOD_Plk_4 40 46 PF00069 0.423
MOD_Plk_4 87 93 PF00069 0.602
MOD_Plk_4 95 101 PF00069 0.369
MOD_ProDKin_1 188 194 PF00069 0.750
MOD_ProDKin_1 202 208 PF00069 0.690
MOD_ProDKin_1 478 484 PF00069 0.549
MOD_ProDKin_1 486 492 PF00069 0.585
MOD_ProDKin_1 503 509 PF00069 0.471
MOD_ProDKin_1 537 543 PF00069 0.594
MOD_ProDKin_1 596 602 PF00069 0.557
MOD_ProDKin_1 8 14 PF00069 0.626
TRG_DiLeu_BaEn_1 320 325 PF01217 0.423
TRG_DiLeu_BaEn_1 4 9 PF01217 0.619
TRG_DiLeu_BaLyEn_6 325 330 PF01217 0.277
TRG_ENDOCYTIC_2 263 266 PF00928 0.432
TRG_ENDOCYTIC_2 352 355 PF00928 0.442
TRG_ENDOCYTIC_2 622 625 PF00928 0.576
TRG_ER_diArg_1 18 20 PF00400 0.614
TRG_ER_diArg_1 219 221 PF00400 0.714
TRG_ER_diArg_1 286 288 PF00400 0.473
TRG_ER_diArg_1 325 328 PF00400 0.406
TRG_ER_diArg_1 612 614 PF00400 0.555
TRG_ER_FFAT_2 187 194 PF00635 0.736
TRG_NES_CRM1_1 138 149 PF08389 0.483
TRG_NES_CRM1_1 345 356 PF08389 0.449
TRG_Pf-PMV_PEXEL_1 344 348 PF00026 0.640

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7X5K5 Leishmania donovani 89% 100%
A4HKH5 Leishmania braziliensis 60% 100%
A4I802 Leishmania infantum 88% 100%
E9B2W4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS