CBFD_NFYB_HMF domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q591_LEIMA

TriTrypDb:

LmjF.32.1875 , LMJLV39_320025200 , LMJSD75_320025200

Length:

158

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q591

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q591

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0005515	protein binding	2	9
GO:0046982	protein heterodimerization activity	4	9
GO:0046983	protein dimerization activity	3	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	117	119	PF00675	0.536
CLV_NRD_NRD_1	156	158	PF00675	0.512
CLV_NRD_NRD_1	31	33	PF00675	0.588
CLV_PCSK_KEX2_1	154	156	PF00082	0.586
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.586
CLV_PCSK_SKI1_1	101	105	PF00082	0.428
CLV_PCSK_SKI1_1	118	122	PF00082	0.569
CLV_PCSK_SKI1_1	96	100	PF00082	0.489
DEG_Nend_UBRbox_3	1	3	PF02207	0.622
DOC_USP7_MATH_1	120	124	PF00917	0.607
DOC_USP7_MATH_1	147	151	PF00917	0.532
DOC_USP7_MATH_1	47	51	PF00917	0.481
DOC_USP7_MATH_1	63	67	PF00917	0.516
LIG_14-3-3_CanoR_1	125	129	PF00244	0.505
LIG_FHA_1	102	108	PF00498	0.417
LIG_FHA_1	125	131	PF00498	0.588
LIG_LIR_Gen_1	24	31	PF02991	0.481
LIG_LIR_Nem_3	24	30	PF02991	0.485
LIG_SH2_NCK_1	27	31	PF00017	0.471
LIG_SH2_STAP1	27	31	PF00017	0.471
LIG_SH2_STAT5	109	112	PF00017	0.462
LIG_SUMO_SIM_anti_2	104	109	PF11976	0.422
LIG_UBA3_1	145	154	PF00899	0.519
MOD_CK1_1	123	129	PF00069	0.590
MOD_CK1_1	13	19	PF00069	0.718
MOD_CK1_1	35	41	PF00069	0.689
MOD_GlcNHglycan	101	104	PF01048	0.451
MOD_GlcNHglycan	14	18	PF01048	0.706
MOD_GlcNHglycan	35	38	PF01048	0.650
MOD_GlcNHglycan	49	52	PF01048	0.506
MOD_GlcNHglycan	59	62	PF01048	0.612
MOD_GSK3_1	114	121	PF00069	0.539
MOD_GSK3_1	17	24	PF00069	0.655
MOD_GSK3_1	6	13	PF00069	0.671
MOD_GSK3_1	99	106	PF00069	0.526
MOD_NEK2_1	148	153	PF00069	0.572
MOD_NEK2_1	6	11	PF00069	0.531
MOD_NEK2_1	99	104	PF00069	0.482
MOD_NEK2_2	63	68	PF00069	0.505
MOD_PIKK_1	19	25	PF00454	0.495
MOD_PIKK_1	6	12	PF00454	0.607
MOD_PKA_1	118	124	PF00069	0.562
MOD_PKA_1	32	38	PF00069	0.583
MOD_PKA_2	10	16	PF00069	0.646
MOD_PKA_2	124	130	PF00069	0.532
MOD_Plk_1	17	23	PF00069	0.682
TRG_ENDOCYTIC_2	27	30	PF00928	0.475
TRG_ER_diArg_1	155	157	PF00400	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICI0	Leptomonas seymouri	65%	100%
A0A0S4KIL7	Bodo saltans	35%	100%
A0A3S7X5N4	Leishmania donovani	92%	100%
A4HKH6	Leishmania braziliensis	73%	100%
A4I803	Leishmania infantum	92%	100%
D0AA70	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9B2W5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%