3'-5' exonuclease domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3'-5' exonuclease, putative

Species:

Leishmania major

UniProt:

Q4Q590_LEIMA

TriTrypDb:

LmjF.32.1880 , LMJLV39_320025300 , LMJSD75_320025300

Length:

753

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q590

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q590

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	5
GO:0003824	catalytic activity	1	5
GO:0004518	nuclease activity	4	5
GO:0004527	exonuclease activity	5	5
GO:0005488	binding	1	5
GO:0008408	3'-5' exonuclease activity	6	5
GO:0016787	hydrolase activity	2	5
GO:0016788	hydrolase activity, acting on ester bonds	3	5
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	232	236	PF00656	0.626
CLV_C14_Caspase3-7	39	43	PF00656	0.700
CLV_C14_Caspase3-7	478	482	PF00656	0.728
CLV_NRD_NRD_1	138	140	PF00675	0.773
CLV_NRD_NRD_1	518	520	PF00675	0.404
CLV_NRD_NRD_1	521	523	PF00675	0.632
CLV_NRD_NRD_1	526	528	PF00675	0.649
CLV_PCSK_FUR_1	519	523	PF00082	0.460
CLV_PCSK_KEX2_1	137	139	PF00082	0.774
CLV_PCSK_KEX2_1	518	520	PF00082	0.404
CLV_PCSK_KEX2_1	521	523	PF00082	0.632
CLV_PCSK_KEX2_1	525	527	PF00082	0.645
CLV_PCSK_KEX2_1	595	597	PF00082	0.269
CLV_PCSK_KEX2_1	66	68	PF00082	0.714
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.754
CLV_PCSK_PC1ET2_1	595	597	PF00082	0.269
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.714
CLV_PCSK_PC7_1	521	527	PF00082	0.593
CLV_PCSK_SKI1_1	138	142	PF00082	0.637
CLV_PCSK_SKI1_1	509	513	PF00082	0.608
CLV_PCSK_SKI1_1	595	599	PF00082	0.338
CLV_PCSK_SKI1_1	605	609	PF00082	0.331
CLV_PCSK_SKI1_1	650	654	PF00082	0.380
CLV_PCSK_SKI1_1	671	675	PF00082	0.380
CLV_PCSK_SKI1_1	688	692	PF00082	0.226
CLV_PCSK_SKI1_1	703	707	PF00082	0.245
DEG_ODPH_VHL_1	168	180	PF01847	0.564
DEG_ODPH_VHL_1	447	458	PF01847	0.746
DEG_SCF_FBW7_1	242	249	PF00400	0.606
DEG_SPOP_SBC_1	302	306	PF00917	0.594
DOC_CDC14_PxL_1	172	180	PF14671	0.566
DOC_CKS1_1	243	248	PF01111	0.715
DOC_CKS1_1	420	425	PF01111	0.712
DOC_CKS1_1	86	91	PF01111	0.721
DOC_MAPK_DCC_7	138	148	PF00069	0.754
DOC_MAPK_MEF2A_6	542	551	PF00069	0.385
DOC_MAPK_MEF2A_6	601	608	PF00069	0.580
DOC_MAPK_MEF2A_6	650	658	PF00069	0.580
DOC_MAPK_NFAT4_5	601	609	PF00069	0.580
DOC_PP1_RVXF_1	481	488	PF00149	0.639
DOC_PP1_RVXF_1	603	609	PF00149	0.580
DOC_PP2B_LxvP_1	140	143	PF13499	0.748
DOC_PP2B_LxvP_1	421	424	PF13499	0.617
DOC_PP2B_LxvP_1	84	87	PF13499	0.740
DOC_PP2B_PxIxI_1	3	9	PF00149	0.740
DOC_PP4_FxxP_1	243	246	PF00568	0.793
DOC_PP4_MxPP_1	1	4	PF00568	0.800
DOC_USP7_MATH_1	186	190	PF00917	0.629
DOC_USP7_MATH_1	228	232	PF00917	0.700
DOC_USP7_MATH_1	238	242	PF00917	0.589
DOC_USP7_MATH_1	266	270	PF00917	0.671
DOC_USP7_MATH_1	278	282	PF00917	0.532
DOC_USP7_MATH_1	303	307	PF00917	0.724
DOC_USP7_MATH_1	387	391	PF00917	0.786
DOC_USP7_MATH_1	393	397	PF00917	0.624
DOC_USP7_MATH_1	414	418	PF00917	0.730
DOC_USP7_MATH_1	438	442	PF00917	0.736
DOC_WW_Pin1_4	123	128	PF00397	0.730
DOC_WW_Pin1_4	138	143	PF00397	0.634
DOC_WW_Pin1_4	194	199	PF00397	0.574
DOC_WW_Pin1_4	242	247	PF00397	0.723
DOC_WW_Pin1_4	249	254	PF00397	0.643
DOC_WW_Pin1_4	289	294	PF00397	0.749
DOC_WW_Pin1_4	328	333	PF00397	0.702
DOC_WW_Pin1_4	342	347	PF00397	0.572
DOC_WW_Pin1_4	416	421	PF00397	0.727
DOC_WW_Pin1_4	589	594	PF00397	0.580
DOC_WW_Pin1_4	59	64	PF00397	0.787
DOC_WW_Pin1_4	640	645	PF00397	0.622
DOC_WW_Pin1_4	85	90	PF00397	0.726
LIG_14-3-3_CanoR_1	132	140	PF00244	0.608
LIG_14-3-3_CanoR_1	179	185	PF00244	0.750
LIG_14-3-3_CanoR_1	529	534	PF00244	0.677
LIG_14-3-3_CanoR_1	542	549	PF00244	0.479
LIG_14-3-3_CanoR_1	688	697	PF00244	0.580
LIG_14-3-3_CanoR_1	726	731	PF00244	0.461
LIG_14-3-3_CanoR_1	740	745	PF00244	0.416
LIG_APCC_ABBA_1	656	661	PF00400	0.580
LIG_BIR_III_4	42	46	PF00653	0.697
LIG_BRCT_BRCA1_1	239	243	PF00533	0.808
LIG_BRCT_BRCA1_1	633	637	PF00533	0.580
LIG_BRCT_BRCA1_1	740	744	PF00533	0.555
LIG_FHA_1	102	108	PF00498	0.793
LIG_FHA_1	150	156	PF00498	0.745
LIG_FHA_1	265	271	PF00498	0.596
LIG_FHA_1	383	389	PF00498	0.593
LIG_FHA_1	47	53	PF00498	0.574
LIG_FHA_1	544	550	PF00498	0.511
LIG_FHA_1	572	578	PF00498	0.580
LIG_FHA_1	689	695	PF00498	0.580
LIG_FHA_2	230	236	PF00498	0.628
LIG_FHA_2	367	373	PF00498	0.724
LIG_FHA_2	473	479	PF00498	0.692
LIG_FHA_2	658	664	PF00498	0.580
LIG_FHA_2	89	95	PF00498	0.729
LIG_FXI_DFP_1	744	748	PF00024	0.544
LIG_IRF3_LxIS_1	628	634	PF10401	0.580
LIG_LIR_Apic_2	240	246	PF02991	0.798
LIG_LIR_Apic_2	249	253	PF02991	0.663
LIG_LIR_Gen_1	571	580	PF02991	0.580
LIG_LIR_Gen_1	634	644	PF02991	0.580
LIG_LIR_Gen_1	651	659	PF02991	0.580
LIG_LIR_Nem_3	571	575	PF02991	0.580
LIG_LIR_Nem_3	615	621	PF02991	0.580
LIG_LIR_Nem_3	634	640	PF02991	0.409
LIG_LIR_Nem_3	651	656	PF02991	0.580
LIG_LIR_Nem_3	741	747	PF02991	0.556
LIG_MYND_1	212	216	PF01753	0.811
LIG_PCNA_yPIPBox_3	230	243	PF02747	0.740
LIG_PDZ_Class_1	748	753	PF00595	0.442
LIG_Pex14_2	322	326	PF04695	0.626
LIG_PTB_Apo_2	729	736	PF02174	0.529
LIG_Rb_pABgroove_1	602	610	PF01858	0.580
LIG_SH2_CRK	250	254	PF00017	0.731
LIG_SH2_CRK	572	576	PF00017	0.580
LIG_SH2_NCK_1	310	314	PF00017	0.613
LIG_SH2_NCK_1	572	576	PF00017	0.580
LIG_SH2_SRC	256	259	PF00017	0.742
LIG_SH2_SRC	310	313	PF00017	0.617
LIG_SH2_SRC	463	466	PF00017	0.702
LIG_SH2_STAP1	543	547	PF00017	0.528
LIG_SH2_STAP1	572	576	PF00017	0.580
LIG_SH2_STAT5	250	253	PF00017	0.678
LIG_SH2_STAT5	256	259	PF00017	0.673
LIG_SH2_STAT5	272	275	PF00017	0.608
LIG_SH2_STAT5	576	579	PF00017	0.580
LIG_SH2_STAT5	697	700	PF00017	0.580
LIG_SH2_STAT5	704	707	PF00017	0.517
LIG_SH3_1	139	145	PF00018	0.752
LIG_SH3_2	127	132	PF14604	0.564
LIG_SH3_2	225	230	PF14604	0.590
LIG_SH3_2	420	425	PF14604	0.712
LIG_SH3_3	124	130	PF00018	0.717
LIG_SH3_3	139	145	PF00018	0.657
LIG_SH3_3	209	215	PF00018	0.781
LIG_SH3_3	222	228	PF00018	0.602
LIG_SH3_3	417	423	PF00018	0.719
LIG_SH3_3	426	432	PF00018	0.574
LIG_SH3_3	443	449	PF00018	0.529
LIG_SH3_3	638	644	PF00018	0.580
LIG_SH3_3	84	90	PF00018	0.729
LIG_SUMO_SIM_par_1	544	552	PF11976	0.449
LIG_SUMO_SIM_par_1	565	571	PF11976	0.568
LIG_TRFH_1	428	432	PF08558	0.564
LIG_TRFH_1	637	641	PF08558	0.580
LIG_TYR_ITIM	695	700	PF00017	0.580
LIG_WW_2	212	215	PF00397	0.691
LIG_WW_3	331	335	PF00397	0.685
LIG_WW_3	422	426	PF00397	0.713
MOD_CDC14_SPxK_1	129	132	PF00782	0.569
MOD_CDC14_SPxK_1	331	334	PF00782	0.685
MOD_CDC14_SPxK_1	592	595	PF00782	0.497
MOD_CDK_SPxK_1	126	132	PF00069	0.565
MOD_CDK_SPxK_1	328	334	PF00069	0.693
MOD_CDK_SPxK_1	419	425	PF00069	0.713
MOD_CDK_SPxK_1	589	595	PF00069	0.497
MOD_CDK_SPxxK_3	589	596	PF00069	0.552
MOD_CDK_SPxxK_3	59	66	PF00069	0.729
MOD_CK1_1	100	106	PF00069	0.780
MOD_CK1_1	11	17	PF00069	0.823
MOD_CK1_1	149	155	PF00069	0.590
MOD_CK1_1	189	195	PF00069	0.755
MOD_CK1_1	202	208	PF00069	0.658
MOD_CK1_1	241	247	PF00069	0.717
MOD_CK1_1	264	270	PF00069	0.595
MOD_CK1_1	292	298	PF00069	0.759
MOD_CK1_1	33	39	PF00069	0.744
MOD_CK1_1	340	346	PF00069	0.723
MOD_CK1_1	366	372	PF00069	0.722
MOD_CK1_1	396	402	PF00069	0.741
MOD_CK1_1	419	425	PF00069	0.752
MOD_CK1_1	433	439	PF00069	0.515
MOD_CK1_1	71	77	PF00069	0.773
MOD_CK1_1	738	744	PF00069	0.558
MOD_CK2_1	10	16	PF00069	0.676
MOD_CK2_1	366	372	PF00069	0.722
MOD_CK2_1	388	394	PF00069	0.745
MOD_CK2_1	472	478	PF00069	0.695
MOD_CK2_1	88	94	PF00069	0.726
MOD_DYRK1A_RPxSP_1	59	63	PF00069	0.722
MOD_GlcNHglycan	10	13	PF01048	0.759
MOD_GlcNHglycan	119	122	PF01048	0.707
MOD_GlcNHglycan	134	137	PF01048	0.575
MOD_GlcNHglycan	152	155	PF01048	0.788
MOD_GlcNHglycan	187	191	PF01048	0.790
MOD_GlcNHglycan	205	208	PF01048	0.690
MOD_GlcNHglycan	276	279	PF01048	0.657
MOD_GlcNHglycan	280	283	PF01048	0.625
MOD_GlcNHglycan	297	300	PF01048	0.555
MOD_GlcNHglycan	352	355	PF01048	0.723
MOD_GlcNHglycan	357	360	PF01048	0.750
MOD_GlcNHglycan	361	364	PF01048	0.713
MOD_GlcNHglycan	385	388	PF01048	0.808
MOD_GlcNHglycan	390	393	PF01048	0.720
MOD_GlcNHglycan	394	398	PF01048	0.596
MOD_GlcNHglycan	435	438	PF01048	0.682
MOD_GlcNHglycan	440	443	PF01048	0.624
MOD_GlcNHglycan	68	71	PF01048	0.592
MOD_GlcNHglycan	73	76	PF01048	0.733
MOD_GSK3_1	126	133	PF00069	0.718
MOD_GSK3_1	146	153	PF00069	0.594
MOD_GSK3_1	174	181	PF00069	0.660
MOD_GSK3_1	199	206	PF00069	0.768
MOD_GSK3_1	237	244	PF00069	0.802
MOD_GSK3_1	261	268	PF00069	0.715
MOD_GSK3_1	274	281	PF00069	0.533
MOD_GSK3_1	30	37	PF00069	0.746
MOD_GSK3_1	338	345	PF00069	0.729
MOD_GSK3_1	355	362	PF00069	0.495
MOD_GSK3_1	383	390	PF00069	0.748
MOD_GSK3_1	405	412	PF00069	0.759
MOD_GSK3_1	463	470	PF00069	0.742
MOD_GSK3_1	541	548	PF00069	0.562
MOD_GSK3_1	66	73	PF00069	0.751
MOD_GSK3_1	736	743	PF00069	0.598
MOD_GSK3_1	97	104	PF00069	0.800
MOD_N-GLC_1	207	212	PF02516	0.753
MOD_N-GLC_1	382	387	PF02516	0.688
MOD_N-GLC_2	627	629	PF02516	0.380
MOD_N-GLC_2	77	79	PF02516	0.748
MOD_NEK2_1	101	106	PF00069	0.675
MOD_NEK2_1	131	136	PF00069	0.716
MOD_NEK2_1	148	153	PF00069	0.535
MOD_NEK2_1	178	183	PF00069	0.741
MOD_NEK2_1	265	270	PF00069	0.713
MOD_NEK2_1	34	39	PF00069	0.745
MOD_NEK2_1	631	636	PF00069	0.580
MOD_NEK2_1	735	740	PF00069	0.560
MOD_NEK2_2	238	243	PF00069	0.696
MOD_NEK2_2	266	271	PF00069	0.693
MOD_NEK2_2	648	653	PF00069	0.580
MOD_OFUCOSY	629	636	PF10250	0.380
MOD_PIKK_1	312	318	PF00454	0.603
MOD_PK_1	409	415	PF00069	0.685
MOD_PK_1	529	535	PF00069	0.675
MOD_PK_1	560	566	PF00069	0.580
MOD_PK_1	726	732	PF00069	0.470
MOD_PKA_1	66	72	PF00069	0.711
MOD_PKA_2	131	137	PF00069	0.613
MOD_PKA_2	178	184	PF00069	0.698
MOD_PKA_2	261	267	PF00069	0.716
MOD_PKA_2	541	547	PF00069	0.507
MOD_PKA_2	66	72	PF00069	0.711
MOD_PKA_2	735	741	PF00069	0.541
MOD_PKB_1	527	535	PF00069	0.624
MOD_Plk_1	228	234	PF00069	0.606
MOD_Plk_1	372	378	PF00069	0.728
MOD_Plk_1	97	103	PF00069	0.723
MOD_Plk_2-3	229	235	PF00069	0.588
MOD_Plk_2-3	372	378	PF00069	0.728
MOD_Plk_4	229	235	PF00069	0.674
MOD_Plk_4	238	244	PF00069	0.692
MOD_Plk_4	430	436	PF00069	0.633
MOD_Plk_4	571	577	PF00069	0.580
MOD_Plk_4	648	654	PF00069	0.580
MOD_ProDKin_1	123	129	PF00069	0.730
MOD_ProDKin_1	138	144	PF00069	0.635
MOD_ProDKin_1	194	200	PF00069	0.576
MOD_ProDKin_1	242	248	PF00069	0.721
MOD_ProDKin_1	249	255	PF00069	0.647
MOD_ProDKin_1	289	295	PF00069	0.750
MOD_ProDKin_1	328	334	PF00069	0.704
MOD_ProDKin_1	342	348	PF00069	0.571
MOD_ProDKin_1	416	422	PF00069	0.725
MOD_ProDKin_1	589	595	PF00069	0.580
MOD_ProDKin_1	59	65	PF00069	0.788
MOD_ProDKin_1	640	646	PF00069	0.622
MOD_ProDKin_1	85	91	PF00069	0.726
MOD_SUMO_rev_2	528	538	PF00179	0.514
TRG_ENDOCYTIC_2	310	313	PF00928	0.617
TRG_ENDOCYTIC_2	572	575	PF00928	0.580
TRG_ENDOCYTIC_2	697	700	PF00928	0.580
TRG_ER_diArg_1	138	140	PF00400	0.772
TRG_ER_diArg_1	517	519	PF00400	0.440
TRG_ER_diArg_1	520	522	PF00400	0.469
TRG_ER_diArg_1	525	527	PF00400	0.475
TRG_ER_diArg_1	56	59	PF00400	0.622
TRG_NES_CRM1_1	615	626	PF08389	0.580
TRG_Pf-PMV_PEXEL_1	688	692	PF00026	0.380

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X5Q4	Leishmania donovani	86%	100%
A4I804	Leishmania infantum	86%	100%
E9B2W6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%