Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q588_LEIMA

TriTrypDb:

LmjF.32.1900 , LMJLV39_320025500 , LMJSD75_320025500

Length:

605

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q588

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q588

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.732
CLV_C14_Caspase3-7	127	131	PF00656	0.645
CLV_C14_Caspase3-7	35	39	PF00656	0.657
CLV_C14_Caspase3-7	559	563	PF00656	0.665
CLV_NRD_NRD_1	134	136	PF00675	0.678
CLV_NRD_NRD_1	26	28	PF00675	0.616
CLV_NRD_NRD_1	36	38	PF00675	0.569
CLV_NRD_NRD_1	540	542	PF00675	0.725
CLV_NRD_NRD_1	592	594	PF00675	0.677
CLV_NRD_NRD_1	602	604	PF00675	0.627
CLV_PCSK_KEX2_1	26	28	PF00082	0.616
CLV_PCSK_KEX2_1	36	38	PF00082	0.569
CLV_PCSK_KEX2_1	540	542	PF00082	0.725
CLV_PCSK_KEX2_1	546	548	PF00082	0.635
CLV_PCSK_KEX2_1	592	594	PF00082	0.680
CLV_PCSK_KEX2_1	601	603	PF00082	0.640
CLV_PCSK_PC1ET2_1	546	548	PF00082	0.653
CLV_PCSK_SKI1_1	197	201	PF00082	0.730
CLV_PCSK_SKI1_1	29	33	PF00082	0.594
CLV_PCSK_SKI1_1	593	597	PF00082	0.628
DEG_APCC_DBOX_1	592	600	PF00400	0.632
DEG_SCF_FBW7_1	143	150	PF00400	0.651
DEG_SCF_FBW7_2	406	413	PF00400	0.729
DEG_SPOP_SBC_1	360	364	PF00917	0.781
DEG_SPOP_SBC_1	449	453	PF00917	0.681
DOC_CKS1_1	148	153	PF01111	0.727
DOC_MAPK_gen_1	135	141	PF00069	0.681
DOC_MAPK_gen_1	23	32	PF00069	0.562
DOC_MAPK_gen_1	574	582	PF00069	0.562
DOC_MAPK_MEF2A_6	274	282	PF00069	0.555
DOC_MAPK_MEF2A_6	92	101	PF00069	0.616
DOC_PP1_RVXF_1	519	526	PF00149	0.739
DOC_PP2B_LxvP_1	232	235	PF13499	0.694
DOC_PP2B_LxvP_1	493	496	PF13499	0.762
DOC_USP7_MATH_1	100	104	PF00917	0.716
DOC_USP7_MATH_1	106	110	PF00917	0.655
DOC_USP7_MATH_1	214	218	PF00917	0.735
DOC_USP7_MATH_1	221	225	PF00917	0.628
DOC_USP7_MATH_1	258	262	PF00917	0.715
DOC_USP7_MATH_1	303	307	PF00917	0.682
DOC_USP7_MATH_1	361	365	PF00917	0.764
DOC_USP7_MATH_1	386	390	PF00917	0.735
DOC_USP7_MATH_1	411	415	PF00917	0.695
DOC_USP7_MATH_1	71	75	PF00917	0.572
DOC_USP7_MATH_1	79	83	PF00917	0.571
DOC_WW_Pin1_4	139	144	PF00397	0.765
DOC_WW_Pin1_4	147	152	PF00397	0.812
DOC_WW_Pin1_4	153	158	PF00397	0.735
DOC_WW_Pin1_4	192	197	PF00397	0.582
DOC_WW_Pin1_4	399	404	PF00397	0.831
DOC_WW_Pin1_4	406	411	PF00397	0.734
DOC_WW_Pin1_4	479	484	PF00397	0.743
DOC_WW_Pin1_4	499	504	PF00397	0.564
DOC_WW_Pin1_4	563	568	PF00397	0.680
LIG_14-3-3_CanoR_1	262	270	PF00244	0.833
LIG_14-3-3_CanoR_1	304	308	PF00244	0.652
LIG_14-3-3_CanoR_1	329	338	PF00244	0.609
LIG_14-3-3_CanoR_1	348	354	PF00244	0.579
LIG_14-3-3_CanoR_1	450	455	PF00244	0.680
LIG_BRCT_BRCA1_1	117	121	PF00533	0.655
LIG_Clathr_ClatBox_1	65	69	PF01394	0.582
LIG_CSL_BTD_1	97	100	PF09270	0.635
LIG_CtBP_PxDLS_1	495	499	PF00389	0.783
LIG_deltaCOP1_diTrp_1	244	253	PF00928	0.582
LIG_EVH1_2	173	177	PF00568	0.670
LIG_FHA_1	144	150	PF00498	0.714
LIG_FHA_1	210	216	PF00498	0.714
LIG_FHA_1	361	367	PF00498	0.805
LIG_FHA_1	450	456	PF00498	0.782
LIG_FHA_1	460	466	PF00498	0.596
LIG_FHA_1	47	53	PF00498	0.632
LIG_FHA_2	125	131	PF00498	0.640
LIG_FHA_2	20	26	PF00498	0.667
LIG_FHA_2	206	212	PF00498	0.675
LIG_FHA_2	290	296	PF00498	0.699
LIG_FHA_2	33	39	PF00498	0.451
LIG_FHA_2	451	457	PF00498	0.791
LIG_LIR_Gen_1	57	66	PF02991	0.573
LIG_LIR_LC3C_4	283	287	PF02991	0.556
LIG_LIR_Nem_3	451	457	PF02991	0.699
LIG_LIR_Nem_3	511	515	PF02991	0.658
LIG_LIR_Nem_3	57	61	PF02991	0.602
LIG_MYND_1	147	151	PF01753	0.708
LIG_NRBOX	277	283	PF00104	0.552
LIG_PCNA_PIPBox_1	471	480	PF02747	0.719
LIG_PCNA_PIPBox_1	572	581	PF02747	0.694
LIG_Pex14_1	454	458	PF04695	0.684
LIG_SH2_CRK	478	482	PF00017	0.734
LIG_SH2_NCK_1	478	482	PF00017	0.785
LIG_SH2_PTP2	579	582	PF00017	0.556
LIG_SH2_SRC	579	582	PF00017	0.715
LIG_SH2_STAT5	478	481	PF00017	0.784
LIG_SH2_STAT5	579	582	PF00017	0.651
LIG_SH3_3	145	151	PF00018	0.584
LIG_SH3_3	243	249	PF00018	0.631
LIG_SH3_3	288	294	PF00018	0.755
LIG_SH3_3	335	341	PF00018	0.640
LIG_SH3_3	400	406	PF00018	0.831
LIG_SH3_3	477	483	PF00018	0.734
LIG_SH3_3	84	90	PF00018	0.591
LIG_SH3_3	94	100	PF00018	0.609
LIG_SUMO_SIM_anti_2	276	283	PF11976	0.712
LIG_SUMO_SIM_anti_2	584	592	PF11976	0.648
LIG_SUMO_SIM_anti_2	62	67	PF11976	0.572
LIG_SUMO_SIM_anti_2	9	15	PF11976	0.638
LIG_SUMO_SIM_par_1	59	64	PF11976	0.583
LIG_TRAF2_1	534	537	PF00917	0.723
LIG_TYR_ITIM	510	515	PF00017	0.592
LIG_UBA3_1	485	490	PF00899	0.671
MOD_CDC14_SPxK_1	142	145	PF00782	0.717
MOD_CDK_SPK_2	192	197	PF00069	0.566
MOD_CDK_SPxK_1	139	145	PF00069	0.715
MOD_CDK_SPxxK_3	567	574	PF00069	0.688
MOD_CK1_1	111	117	PF00069	0.631
MOD_CK1_1	223	229	PF00069	0.693
MOD_CK1_1	261	267	PF00069	0.789
MOD_CK1_1	276	282	PF00069	0.743
MOD_CK1_1	289	295	PF00069	0.583
MOD_CK1_1	391	397	PF00069	0.758
MOD_CK1_1	402	408	PF00069	0.649
MOD_CK1_1	412	418	PF00069	0.620
MOD_CK1_1	499	505	PF00069	0.812
MOD_CK1_1	531	537	PF00069	0.715
MOD_CK1_1	563	569	PF00069	0.767
MOD_CK2_1	106	112	PF00069	0.645
MOD_CK2_1	163	169	PF00069	0.622
MOD_CK2_1	183	189	PF00069	0.535
MOD_CK2_1	19	25	PF00069	0.666
MOD_CK2_1	289	295	PF00069	0.695
MOD_CK2_1	45	51	PF00069	0.634
MOD_CK2_1	531	537	PF00069	0.724
MOD_GlcNHglycan	104	107	PF01048	0.653
MOD_GlcNHglycan	108	111	PF01048	0.633
MOD_GlcNHglycan	112	116	PF01048	0.585
MOD_GlcNHglycan	165	168	PF01048	0.682
MOD_GlcNHglycan	189	192	PF01048	0.682
MOD_GlcNHglycan	256	259	PF01048	0.614
MOD_GlcNHglycan	295	299	PF01048	0.736
MOD_GlcNHglycan	349	352	PF01048	0.727
MOD_GlcNHglycan	363	366	PF01048	0.670
MOD_GlcNHglycan	413	417	PF01048	0.751
MOD_GlcNHglycan	430	433	PF01048	0.498
MOD_GlcNHglycan	498	501	PF01048	0.729
MOD_GlcNHglycan	531	534	PF01048	0.721
MOD_GlcNHglycan	547	550	PF01048	0.503
MOD_GlcNHglycan	567	570	PF01048	0.548
MOD_GlcNHglycan	585	588	PF01048	0.536
MOD_GSK3_1	102	109	PF00069	0.728
MOD_GSK3_1	111	118	PF00069	0.610
MOD_GSK3_1	139	146	PF00069	0.747
MOD_GSK3_1	147	154	PF00069	0.727
MOD_GSK3_1	183	190	PF00069	0.710
MOD_GSK3_1	202	209	PF00069	0.581
MOD_GSK3_1	254	261	PF00069	0.630
MOD_GSK3_1	276	283	PF00069	0.686
MOD_GSK3_1	325	332	PF00069	0.745
MOD_GSK3_1	386	393	PF00069	0.762
MOD_GSK3_1	394	401	PF00069	0.672
MOD_GSK3_1	402	409	PF00069	0.577
MOD_GSK3_1	41	48	PF00069	0.627
MOD_GSK3_1	561	568	PF00069	0.760
MOD_N-GLC_1	523	528	PF02516	0.682
MOD_NEK2_1	163	168	PF00069	0.733
MOD_NEK2_1	177	182	PF00069	0.572
MOD_NEK2_1	263	268	PF00069	0.723
MOD_NEK2_1	280	285	PF00069	0.768
MOD_NEK2_1	32	37	PF00069	0.646
MOD_NEK2_1	529	534	PF00069	0.625
MOD_PIKK_1	459	465	PF00454	0.733
MOD_PKA_2	258	264	PF00069	0.820
MOD_PKA_2	303	309	PF00069	0.816
MOD_PKA_2	347	353	PF00069	0.699
MOD_PKA_2	449	455	PF00069	0.681
MOD_Plk_1	168	174	PF00069	0.560
MOD_Plk_1	561	567	PF00069	0.672
MOD_Plk_4	273	279	PF00069	0.738
MOD_Plk_4	303	309	PF00069	0.714
MOD_Plk_4	450	456	PF00069	0.683
MOD_Plk_4	9	15	PF00069	0.638
MOD_ProDKin_1	139	145	PF00069	0.766
MOD_ProDKin_1	147	153	PF00069	0.796
MOD_ProDKin_1	158	164	PF00069	0.663
MOD_ProDKin_1	192	198	PF00069	0.583
MOD_ProDKin_1	399	405	PF00069	0.833
MOD_ProDKin_1	406	412	PF00069	0.733
MOD_ProDKin_1	479	485	PF00069	0.742
MOD_ProDKin_1	499	505	PF00069	0.561
MOD_ProDKin_1	563	569	PF00069	0.682
MOD_SUMO_rev_2	538	548	PF00179	0.656
TRG_DiLeu_BaLyEn_6	154	159	PF01217	0.656
TRG_DiLeu_BaLyEn_6	81	86	PF01217	0.702
TRG_ENDOCYTIC_2	512	515	PF00928	0.654
TRG_ENDOCYTIC_2	579	582	PF00928	0.683
TRG_ER_diArg_1	539	541	PF00400	0.661
TRG_ER_diArg_1	591	593	PF00400	0.652
TRG_ER_diArg_1	601	603	PF00400	0.627
TRG_NES_CRM1_1	59	69	PF08389	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X5N2	Leishmania donovani	87%	100%
A4HKH9	Leishmania braziliensis	63%	100%
A4I811	Leishmania infantum	86%	100%
E9B2W8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%