Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q587_LEIMA

TriTrypDb:

LmjF.32.1910 , LMJLV39_320025600 , LMJSD75_320025600

Length:

450

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q587

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q587

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	132	134	PF00675	0.646
CLV_NRD_NRD_1	31	33	PF00675	0.533
CLV_NRD_NRD_1	315	317	PF00675	0.626
CLV_NRD_NRD_1	36	38	PF00675	0.466
CLV_NRD_NRD_1	94	96	PF00675	0.646
CLV_PCSK_KEX2_1	132	134	PF00082	0.576
CLV_PCSK_KEX2_1	31	33	PF00082	0.529
CLV_PCSK_KEX2_1	315	317	PF00082	0.626
CLV_PCSK_KEX2_1	406	408	PF00082	0.752
CLV_PCSK_PC1ET2_1	406	408	PF00082	0.753
CLV_PCSK_SKI1_1	209	213	PF00082	0.547
CLV_PCSK_SKI1_1	221	225	PF00082	0.603
CLV_PCSK_SKI1_1	253	257	PF00082	0.647
CLV_PCSK_SKI1_1	37	41	PF00082	0.633
CLV_PCSK_SKI1_1	62	66	PF00082	0.639
CLV_PCSK_SKI1_1	67	71	PF00082	0.610
CLV_PCSK_SKI1_1	96	100	PF00082	0.513
DEG_APCC_DBOX_1	265	273	PF00400	0.626
DEG_APCC_DBOX_1	36	44	PF00400	0.413
DEG_COP1_1	394	403	PF00400	0.743
DOC_CDC14_PxL_1	285	293	PF14671	0.591
DOC_MAPK_DCC_7	266	274	PF00069	0.531
DOC_MAPK_gen_1	73	80	PF00069	0.600
DOC_MAPK_gen_1	82	89	PF00069	0.574
DOC_MAPK_RevD_3	25	38	PF00069	0.646
DOC_PP1_RVXF_1	207	214	PF00149	0.553
DOC_PP2B_LxvP_1	373	376	PF13499	0.713
DOC_SPAK_OSR1_1	75	79	PF12202	0.442
DOC_USP7_MATH_1	319	323	PF00917	0.618
DOC_USP7_MATH_1	359	363	PF00917	0.794
LIG_14-3-3_CanoR_1	266	270	PF00244	0.583
LIG_14-3-3_CanoR_1	321	327	PF00244	0.661
LIG_BIR_II_1	1	5	PF00653	0.583
LIG_BRCT_BRCA1_1	4	8	PF00533	0.502
LIG_FHA_1	100	106	PF00498	0.637
LIG_FHA_1	21	27	PF00498	0.561
LIG_FHA_2	19	25	PF00498	0.566
LIG_FHA_2	210	216	PF00498	0.446
LIG_FHA_2	403	409	PF00498	0.816
LIG_FHA_2	424	430	PF00498	0.750
LIG_FHA_2	432	438	PF00498	0.643
LIG_LIR_Gen_1	10	20	PF02991	0.570
LIG_LIR_Gen_1	171	182	PF02991	0.620
LIG_LIR_Gen_1	210	220	PF02991	0.559
LIG_LIR_Gen_1	234	243	PF02991	0.529
LIG_LIR_Gen_1	322	332	PF02991	0.628
LIG_LIR_Nem_3	10	15	PF02991	0.540
LIG_LIR_Nem_3	171	177	PF02991	0.622
LIG_LIR_Nem_3	180	185	PF02991	0.626
LIG_LIR_Nem_3	188	193	PF02991	0.459
LIG_LIR_Nem_3	210	216	PF02991	0.562
LIG_LIR_Nem_3	234	239	PF02991	0.574
LIG_LIR_Nem_3	268	273	PF02991	0.551
LIG_LIR_Nem_3	279	284	PF02991	0.465
LIG_LIR_Nem_3	322	327	PF02991	0.629
LIG_Pex14_1	232	236	PF04695	0.550
LIG_Pex14_1	326	330	PF04695	0.633
LIG_Pex14_2	281	285	PF04695	0.603
LIG_Rb_pABgroove_1	237	245	PF01858	0.507
LIG_REV1ctd_RIR_1	179	185	PF16727	0.616
LIG_SH2_CRK	190	194	PF00017	0.529
LIG_SH2_CRK	236	240	PF00017	0.546
LIG_SH2_CRK	286	290	PF00017	0.437
LIG_SH2_STAP1	12	16	PF00017	0.575
LIG_SH2_STAP1	243	247	PF00017	0.664
LIG_SH2_STAT3	243	246	PF00017	0.670
LIG_SH2_STAT3	81	84	PF00017	0.561
LIG_SH2_STAT5	238	241	PF00017	0.633
LIG_SH3_3	387	393	PF00018	0.805
LIG_SH3_3	397	403	PF00018	0.613
LIG_SH3_3	94	100	PF00018	0.658
LIG_TRAF2_1	212	215	PF00917	0.572
LIG_TRAF2_1	39	42	PF00917	0.626
LIG_TRAF2_1	426	429	PF00917	0.769
LIG_TRAF2_1	445	448	PF00917	0.695
LIG_WW_3	92	96	PF00397	0.602
MOD_CK1_1	231	237	PF00069	0.616
MOD_CK1_1	322	328	PF00069	0.688
MOD_CK2_1	18	24	PF00069	0.549
MOD_CK2_1	200	206	PF00069	0.507
MOD_CK2_1	209	215	PF00069	0.432
MOD_CK2_1	4	10	PF00069	0.507
MOD_CK2_1	402	408	PF00069	0.818
MOD_CK2_1	423	429	PF00069	0.731
MOD_CK2_1	431	437	PF00069	0.711
MOD_GlcNHglycan	202	205	PF01048	0.498
MOD_GlcNHglycan	233	236	PF01048	0.547
MOD_GlcNHglycan	349	353	PF01048	0.812
MOD_GlcNHglycan	416	419	PF01048	0.724
MOD_GSK3_1	155	162	PF00069	0.539
MOD_GSK3_1	423	430	PF00069	0.762
MOD_N-GLC_1	152	157	PF02516	0.394
MOD_N-GLC_1	295	300	PF02516	0.650
MOD_NEK2_1	295	300	PF00069	0.618
MOD_NEK2_1	317	322	PF00069	0.636
MOD_PIKK_1	2	8	PF00454	0.583
MOD_PIKK_1	295	301	PF00454	0.635
MOD_PIKK_1	353	359	PF00454	0.697
MOD_PIKK_1	412	418	PF00454	0.597
MOD_PKA_1	82	88	PF00069	0.662
MOD_PKA_2	265	271	PF00069	0.540
MOD_PKA_2	322	328	PF00069	0.603
MOD_Plk_1	172	178	PF00069	0.579
MOD_Plk_1	209	215	PF00069	0.512
MOD_Plk_1	228	234	PF00069	0.627
MOD_Plk_1	427	433	PF00069	0.735
MOD_Plk_4	177	183	PF00069	0.571
MOD_Plk_4	265	271	PF00069	0.494
MOD_Plk_4	385	391	PF00069	0.837
MOD_Plk_4	427	433	PF00069	0.673
MOD_SUMO_rev_2	214	220	PF00179	0.616
MOD_SUMO_rev_2	33	40	PF00179	0.566
TRG_DiLeu_BaLyEn_6	268	273	PF01217	0.531
TRG_ENDOCYTIC_2	12	15	PF00928	0.519
TRG_ENDOCYTIC_2	190	193	PF00928	0.615
TRG_ENDOCYTIC_2	236	239	PF00928	0.547
TRG_ER_diArg_1	132	135	PF00400	0.643
TRG_ER_diArg_1	163	166	PF00400	0.567
TRG_ER_diArg_1	314	316	PF00400	0.632
TRG_ER_diArg_1	321	324	PF00400	0.604
TRG_ER_diArg_1	73	76	PF00400	0.552
TRG_NES_CRM1_1	331	344	PF08389	0.534
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.624
TRG_Pf-PMV_PEXEL_1	132	136	PF00026	0.633
TRG_Pf-PMV_PEXEL_1	38	42	PF00026	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NU98	Trypanosomatidae	43%	75%
A0A3S7X5P1	Leishmania donovani	89%	100%
A0A422NBA5	Trypanosoma rangeli	36%	100%
A4HKI0	Leishmania braziliensis	63%	84%
A4I812	Leishmania infantum	89%	100%