DUF647-domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vitamin B6 photo-protection and homoeostasis, putative

Species:

Leishmania major

UniProt:

Q4Q586_LEIMA

TriTrypDb:

LmjF.32.1920 , LMJLV39_320025700 , LMJSD75_320025700

Length:

468

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4Q586

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q586

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	22	24	PF00675	0.283
CLV_NRD_NRD_1	253	255	PF00675	0.369
CLV_NRD_NRD_1	348	350	PF00675	0.476
CLV_NRD_NRD_1	355	357	PF00675	0.415
CLV_NRD_NRD_1	370	372	PF00675	0.324
CLV_NRD_NRD_1	407	409	PF00675	0.384
CLV_NRD_NRD_1	460	462	PF00675	0.426
CLV_PCSK_KEX2_1	22	24	PF00082	0.282
CLV_PCSK_KEX2_1	253	255	PF00082	0.365
CLV_PCSK_KEX2_1	354	356	PF00082	0.499
CLV_PCSK_KEX2_1	370	372	PF00082	0.321
CLV_PCSK_KEX2_1	407	409	PF00082	0.383
CLV_PCSK_KEX2_1	460	462	PF00082	0.426
CLV_PCSK_SKI1_1	242	246	PF00082	0.357
CLV_PCSK_SKI1_1	254	258	PF00082	0.289
CLV_PCSK_SKI1_1	371	375	PF00082	0.303
CLV_PCSK_SKI1_1	429	433	PF00082	0.338
CLV_PCSK_SKI1_1	461	465	PF00082	0.337
DEG_APCC_DBOX_1	28	36	PF00400	0.425
DOC_CDC14_PxL_1	341	349	PF14671	0.568
DOC_CKS1_1	255	260	PF01111	0.526
DOC_CYCLIN_RxL_1	423	435	PF00134	0.444
DOC_CYCLIN_yCln2_LP_2	90	96	PF00134	0.291
DOC_MAPK_DCC_7	324	332	PF00069	0.624
DOC_MAPK_gen_1	109	118	PF00069	0.441
DOC_MAPK_gen_1	276	284	PF00069	0.656
DOC_MAPK_gen_1	370	376	PF00069	0.484
DOC_MAPK_MEF2A_6	111	120	PF00069	0.452
DOC_MAPK_MEF2A_6	324	332	PF00069	0.603
DOC_MAPK_RevD_3	241	254	PF00069	0.568
DOC_PP2B_LxvP_1	453	456	PF13499	0.549
DOC_PP4_FxxP_1	33	36	PF00568	0.453
DOC_USP7_UBL2_3	379	383	PF12436	0.602
DOC_WW_Pin1_4	254	259	PF00397	0.494
DOC_WW_Pin1_4	289	294	PF00397	0.486
DOC_WW_Pin1_4	323	328	PF00397	0.528
DOC_WW_Pin1_4	78	83	PF00397	0.232
LIG_14-3-3_CanoR_1	161	168	PF00244	0.533
LIG_14-3-3_CanoR_1	349	354	PF00244	0.718
LIG_14-3-3_CanoR_1	355	363	PF00244	0.649
LIG_14-3-3_CanoR_1	449	457	PF00244	0.536
LIG_Actin_WH2_2	260	278	PF00022	0.639
LIG_BRCT_BRCA1_1	73	77	PF00533	0.367
LIG_Clathr_ClatBox_1	235	239	PF01394	0.484
LIG_deltaCOP1_diTrp_1	334	341	PF00928	0.564
LIG_deltaCOP1_diTrp_1	418	427	PF00928	0.595
LIG_EH1_1	447	455	PF00400	0.600
LIG_EVH1_1	341	345	PF00568	0.558
LIG_FHA_1	10	16	PF00498	0.595
LIG_FHA_1	144	150	PF00498	0.300
LIG_FHA_1	205	211	PF00498	0.288
LIG_FHA_1	230	236	PF00498	0.488
LIG_FHA_1	238	244	PF00498	0.445
LIG_FHA_1	270	276	PF00498	0.603
LIG_FHA_1	284	290	PF00498	0.495
LIG_FHA_1	392	398	PF00498	0.501
LIG_FHA_2	255	261	PF00498	0.508
LIG_FHA_2	302	308	PF00498	0.617
LIG_FHA_2	329	335	PF00498	0.603
LIG_FHA_2	400	406	PF00498	0.536
LIG_Integrin_isoDGR_2	368	370	PF01839	0.250
LIG_LIR_Gen_1	178	189	PF02991	0.443
LIG_LIR_Gen_1	3	10	PF02991	0.653
LIG_LIR_Gen_1	66	77	PF02991	0.297
LIG_LIR_Nem_3	178	184	PF02991	0.440
LIG_LIR_Nem_3	232	236	PF02991	0.531
LIG_LIR_Nem_3	3	9	PF02991	0.601
LIG_LIR_Nem_3	334	339	PF02991	0.601
LIG_LIR_Nem_3	340	344	PF02991	0.612
LIG_LIR_Nem_3	458	462	PF02991	0.488
LIG_LIR_Nem_3	66	72	PF02991	0.297
LIG_MAD2	102	110	PF02301	0.466
LIG_MLH1_MIPbox_1	73	77	PF16413	0.374
LIG_PCNA_PIPBox_1	70	79	PF02747	0.268
LIG_PCNA_yPIPBox_3	447	461	PF02747	0.606
LIG_Pex14_2	47	51	PF04695	0.441
LIG_Pex14_2	59	63	PF04695	0.268
LIG_SH2_CRK	393	397	PF00017	0.460
LIG_SH2_CRK	69	73	PF00017	0.316
LIG_SH2_GRB2like	311	314	PF00017	0.584
LIG_SH2_NCK_1	189	193	PF00017	0.421
LIG_SH2_STAP1	393	397	PF00017	0.460
LIG_SH2_STAT5	157	160	PF00017	0.421
LIG_SH2_STAT5	189	192	PF00017	0.281
LIG_SH2_STAT5	199	202	PF00017	0.249
LIG_SH2_STAT5	311	314	PF00017	0.484
LIG_SH2_STAT5	389	392	PF00017	0.456
LIG_SH2_STAT5	393	396	PF00017	0.469
LIG_SH2_STAT5	421	424	PF00017	0.470
LIG_SH2_STAT5	52	55	PF00017	0.436
LIG_SH3_1	339	345	PF00018	0.653
LIG_SH3_3	12	18	PF00018	0.642
LIG_SH3_3	252	258	PF00018	0.498
LIG_SH3_3	288	294	PF00018	0.481
LIG_SH3_3	339	345	PF00018	0.607
LIG_SH3_3	435	441	PF00018	0.567
LIG_SUMO_SIM_par_1	328	334	PF11976	0.595
LIG_TRAF2_1	257	260	PF00917	0.534
LIG_TRAF2_1	304	307	PF00917	0.554
LIG_TRAF2_1	402	405	PF00917	0.605
LIG_TYR_ITIM	391	396	PF00017	0.454
LIG_TYR_ITIM	67	72	PF00017	0.316
LIG_UBA3_1	317	324	PF00899	0.574
LIG_UBA3_1	32	37	PF00899	0.508
LIG_WRC_WIRS_1	181	186	PF05994	0.432
LIG_WRC_WIRS_1	203	208	PF05994	0.382
LIG_WW_2	342	345	PF00397	0.554
MOD_CK1_1	105	111	PF00069	0.586
MOD_CK1_1	224	230	PF00069	0.272
MOD_CK1_1	54	60	PF00069	0.287
MOD_CK1_1	71	77	PF00069	0.209
MOD_CK2_1	254	260	PF00069	0.513
MOD_CK2_1	301	307	PF00069	0.593
MOD_CK2_1	328	334	PF00069	0.569
MOD_CK2_1	399	405	PF00069	0.536
MOD_Cter_Amidation	368	371	PF01082	0.353
MOD_DYRK1A_RPxSP_1	254	258	PF00069	0.503
MOD_GlcNHglycan	152	155	PF01048	0.272
MOD_GlcNHglycan	162	165	PF01048	0.260
MOD_GlcNHglycan	73	76	PF01048	0.445
MOD_GSK3_1	145	152	PF00069	0.387
MOD_GSK3_1	198	205	PF00069	0.307
MOD_GSK3_1	51	58	PF00069	0.442
MOD_N-GLC_1	121	126	PF02516	0.287
MOD_NEK2_1	114	119	PF00069	0.281
MOD_NEK2_1	198	203	PF00069	0.365
MOD_NEK2_1	221	226	PF00069	0.284
MOD_NEK2_1	409	414	PF00069	0.509
MOD_NEK2_1	51	56	PF00069	0.438
MOD_NEK2_1	63	68	PF00069	0.268
MOD_NEK2_1	77	82	PF00069	0.220
MOD_PIKK_1	269	275	PF00454	0.485
MOD_PIKK_1	354	360	PF00454	0.722
MOD_PKA_1	22	28	PF00069	0.386
MOD_PKA_1	349	355	PF00069	0.719
MOD_PKA_2	160	166	PF00069	0.533
MOD_PKA_2	22	28	PF00069	0.512
MOD_PKA_2	354	360	PF00069	0.656
MOD_PKA_2	448	454	PF00069	0.526
MOD_Plk_1	121	127	PF00069	0.287
MOD_Plk_1	259	265	PF00069	0.523
MOD_Plk_4	114	120	PF00069	0.296
MOD_Plk_4	121	127	PF00069	0.255
MOD_Plk_4	130	136	PF00069	0.187
MOD_Plk_4	198	204	PF00069	0.300
MOD_Plk_4	224	230	PF00069	0.391
MOD_Plk_4	260	266	PF00069	0.559
MOD_Plk_4	55	61	PF00069	0.317
MOD_Plk_4	68	74	PF00069	0.210
MOD_ProDKin_1	254	260	PF00069	0.496
MOD_ProDKin_1	289	295	PF00069	0.489
MOD_ProDKin_1	323	329	PF00069	0.532
MOD_ProDKin_1	78	84	PF00069	0.232
MOD_SUMO_rev_2	359	367	PF00179	0.628
TRG_DiLeu_BaEn_1	260	265	PF01217	0.585
TRG_DiLeu_BaEn_3	404	410	PF01217	0.513
TRG_DiLeu_BaEn_3	425	431	PF01217	0.524
TRG_DiLeu_BaLyEn_6	231	236	PF01217	0.541
TRG_DiLeu_BaLyEn_6	438	443	PF01217	0.513
TRG_ENDOCYTIC_2	389	392	PF00928	0.456
TRG_ENDOCYTIC_2	393	396	PF00928	0.451
TRG_ENDOCYTIC_2	52	55	PF00928	0.457
TRG_ENDOCYTIC_2	69	72	PF00928	0.255
TRG_ER_diArg_1	253	255	PF00400	0.579
TRG_ER_diArg_1	29	32	PF00400	0.462
TRG_ER_diArg_1	353	356	PF00400	0.683
TRG_ER_diArg_1	370	372	PF00400	0.534
TRG_ER_diArg_1	406	408	PF00400	0.573
TRG_ER_diArg_1	459	461	PF00400	0.638
TRG_NES_CRM1_1	239	252	PF08389	0.484
TRG_NES_CRM1_1	260	273	PF08389	0.520
TRG_Pf-PMV_PEXEL_1	234	239	PF00026	0.341
TRG_Pf-PMV_PEXEL_1	268	273	PF00026	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I637	Leptomonas seymouri	71%	77%
A0A0N1I7Q2	Leptomonas seymouri	60%	89%
A0A0S4JVE4	Bodo saltans	41%	81%
A0A1X0NUW8	Trypanosomatidae	52%	74%
A0A3Q8IFI0	Leishmania donovani	95%	100%
A0A422NB59	Trypanosoma rangeli	51%	80%
A4HKI1	Leishmania braziliensis	83%	100%
A4I813	Leishmania infantum	95%	100%
D0AA76	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	79%
E9B2X0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5ALC0	Trypanosoma cruzi	51%	74%