Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q585_LEIMA

TriTrypDb:

LmjF.32.1930 , LMJLV39_320025800 , LMJSD75_320025800

Length:

781

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q585

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q585

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	289	293	PF00656	0.580
CLV_C14_Caspase3-7	363	367	PF00656	0.504
CLV_C14_Caspase3-7	546	550	PF00656	0.661
CLV_C14_Caspase3-7	710	714	PF00656	0.646
CLV_NRD_NRD_1	121	123	PF00675	0.640
CLV_NRD_NRD_1	296	298	PF00675	0.646
CLV_NRD_NRD_1	329	331	PF00675	0.496
CLV_NRD_NRD_1	392	394	PF00675	0.527
CLV_NRD_NRD_1	408	410	PF00675	0.387
CLV_NRD_NRD_1	470	472	PF00675	0.540
CLV_NRD_NRD_1	491	493	PF00675	0.643
CLV_NRD_NRD_1	520	522	PF00675	0.474
CLV_NRD_NRD_1	527	529	PF00675	0.497
CLV_NRD_NRD_1	543	545	PF00675	0.538
CLV_PCSK_KEX2_1	121	123	PF00082	0.640
CLV_PCSK_KEX2_1	296	298	PF00082	0.646
CLV_PCSK_KEX2_1	328	330	PF00082	0.505
CLV_PCSK_KEX2_1	392	394	PF00082	0.527
CLV_PCSK_KEX2_1	407	409	PF00082	0.407
CLV_PCSK_KEX2_1	428	430	PF00082	0.477
CLV_PCSK_KEX2_1	439	441	PF00082	0.447
CLV_PCSK_KEX2_1	470	472	PF00082	0.523
CLV_PCSK_KEX2_1	520	522	PF00082	0.544
CLV_PCSK_KEX2_1	527	529	PF00082	0.499
CLV_PCSK_KEX2_1	543	545	PF00082	0.538
CLV_PCSK_PC1ET2_1	428	430	PF00082	0.477
CLV_PCSK_PC1ET2_1	439	441	PF00082	0.447
CLV_PCSK_PC7_1	324	330	PF00082	0.503
CLV_PCSK_SKI1_1	324	328	PF00082	0.488
CLV_PCSK_SKI1_1	341	345	PF00082	0.349
CLV_PCSK_SKI1_1	376	380	PF00082	0.465
CLV_PCSK_SKI1_1	392	396	PF00082	0.408
CLV_Separin_Metazoa	325	329	PF03568	0.392
CLV_Separin_Metazoa	590	594	PF03568	0.547
DEG_APCC_DBOX_1	329	337	PF00400	0.502
DEG_APCC_DBOX_1	391	399	PF00400	0.518
DEG_APCC_DBOX_1	469	477	PF00400	0.554
DEG_SPOP_SBC_1	67	71	PF00917	0.673
DOC_ANK_TNKS_1	223	230	PF00023	0.495
DOC_MAPK_gen_1	341	352	PF00069	0.468
DOC_MAPK_RevD_3	316	330	PF00069	0.503
DOC_PP2B_LxvP_1	117	120	PF13499	0.620
DOC_USP7_MATH_1	107	111	PF00917	0.646
DOC_USP7_MATH_1	120	124	PF00917	0.580
DOC_USP7_MATH_1	135	139	PF00917	0.559
DOC_USP7_MATH_1	144	148	PF00917	0.567
DOC_USP7_MATH_1	202	206	PF00917	0.631
DOC_USP7_MATH_1	279	283	PF00917	0.666
DOC_USP7_MATH_1	491	495	PF00917	0.561
DOC_USP7_MATH_1	566	570	PF00917	0.642
DOC_USP7_MATH_1	624	628	PF00917	0.634
DOC_USP7_MATH_1	65	69	PF00917	0.687
DOC_USP7_MATH_1	703	707	PF00917	0.668
DOC_USP7_MATH_1	711	715	PF00917	0.639
DOC_USP7_MATH_1	735	739	PF00917	0.659
DOC_USP7_MATH_1	762	766	PF00917	0.631
DOC_USP7_MATH_1	78	82	PF00917	0.613
DOC_USP7_UBL2_3	341	345	PF12436	0.469
DOC_USP7_UBL2_3	434	438	PF12436	0.373
DOC_WW_Pin1_4	549	554	PF00397	0.653
DOC_WW_Pin1_4	560	565	PF00397	0.599
DOC_WW_Pin1_4	58	63	PF00397	0.656
DOC_WW_Pin1_4	72	77	PF00397	0.589
DOC_WW_Pin1_4	760	765	PF00397	0.662
LIG_14-3-3_CanoR_1	15	21	PF00244	0.577
LIG_14-3-3_CanoR_1	48	57	PF00244	0.608
LIG_14-3-3_CanoR_1	492	500	PF00244	0.553
LIG_14-3-3_CanoR_1	593	598	PF00244	0.647
LIG_AP2alpha_1	21	25	PF02296	0.692
LIG_APCC_ABBAyCdc20_2	92	98	PF00400	0.573
LIG_BIR_III_2	676	680	PF00653	0.572
LIG_deltaCOP1_diTrp_1	777	781	PF00928	0.683
LIG_FHA_1	286	292	PF00498	0.636
LIG_FHA_1	313	319	PF00498	0.622
LIG_FHA_1	614	620	PF00498	0.608
LIG_FHA_2	1	7	PF00498	0.654
LIG_FHA_2	135	141	PF00498	0.645
LIG_FHA_2	146	152	PF00498	0.623
LIG_FHA_2	228	234	PF00498	0.730
LIG_FHA_2	506	512	PF00498	0.591
LIG_FHA_2	695	701	PF00498	0.656
LIG_LIR_Gen_1	302	312	PF02991	0.475
LIG_LIR_Gen_1	348	357	PF02991	0.423
LIG_LIR_Gen_1	777	781	PF02991	0.683
LIG_LIR_Nem_3	302	308	PF02991	0.487
LIG_LIR_Nem_3	344	349	PF02991	0.489
LIG_LIR_Nem_3	777	781	PF02991	0.683
LIG_NRBOX	744	750	PF00104	0.541
LIG_PDZ_Class_2	776	781	PF00595	0.682
LIG_Pex14_2	21	25	PF04695	0.692
LIG_PTAP_UEV_1	763	768	PF05743	0.600
LIG_SH2_NCK_1	507	511	PF00017	0.592
LIG_SH2_NCK_1	759	763	PF00017	0.660
LIG_SH2_PTP2	349	352	PF00017	0.443
LIG_SH2_SRC	349	352	PF00017	0.443
LIG_SH2_STAP1	707	711	PF00017	0.631
LIG_SH2_STAT3	163	166	PF00017	0.666
LIG_SH2_STAT5	209	212	PF00017	0.658
LIG_SH2_STAT5	349	352	PF00017	0.443
LIG_SH2_STAT5	507	510	PF00017	0.624
LIG_SH2_STAT5	517	520	PF00017	0.489
LIG_SH3_3	222	228	PF00018	0.762
LIG_SH3_3	585	591	PF00018	0.576
LIG_SH3_3	653	659	PF00018	0.638
LIG_SH3_3	761	767	PF00018	0.665
LIG_SUMO_SIM_anti_2	356	363	PF11976	0.497
LIG_SUMO_SIM_anti_2	375	382	PF11976	0.322
LIG_TRAF2_1	137	140	PF00917	0.645
LIG_TRAF2_1	230	233	PF00917	0.592
LIG_TRAF2_1	236	239	PF00917	0.510
LIG_TRAF2_1	577	580	PF00917	0.670
LIG_TRAF2_1	714	717	PF00917	0.648
MOD_CDC14_SPxK_1	552	555	PF00782	0.572
MOD_CDK_SPK_2	560	565	PF00069	0.672
MOD_CDK_SPxK_1	549	555	PF00069	0.573
MOD_CK1_1	109	115	PF00069	0.688
MOD_CK1_1	123	129	PF00069	0.562
MOD_CK1_1	17	23	PF00069	0.657
MOD_CK1_1	261	267	PF00069	0.573
MOD_CK1_1	27	33	PF00069	0.642
MOD_CK1_1	282	288	PF00069	0.654
MOD_CK1_1	51	57	PF00069	0.631
MOD_CK1_1	542	548	PF00069	0.686
MOD_CK1_1	583	589	PF00069	0.636
MOD_CK1_1	63	69	PF00069	0.654
MOD_CK1_1	635	641	PF00069	0.686
MOD_CK1_1	650	656	PF00069	0.558
MOD_CK1_1	72	78	PF00069	0.623
MOD_CK1_1	81	87	PF00069	0.538
MOD_CK2_1	133	139	PF00069	0.667
MOD_CK2_1	227	233	PF00069	0.595
MOD_CK2_1	240	246	PF00069	0.468
MOD_CK2_1	41	47	PF00069	0.606
MOD_CK2_1	566	572	PF00069	0.678
MOD_CK2_1	711	717	PF00069	0.646
MOD_CK2_1	723	729	PF00069	0.571
MOD_GlcNHglycan	125	128	PF01048	0.788
MOD_GlcNHglycan	130	133	PF01048	0.712
MOD_GlcNHglycan	180	183	PF01048	0.692
MOD_GlcNHglycan	265	268	PF01048	0.586
MOD_GlcNHglycan	35	38	PF01048	0.688
MOD_GlcNHglycan	386	389	PF01048	0.487
MOD_GlcNHglycan	417	420	PF01048	0.517
MOD_GlcNHglycan	486	489	PF01048	0.650
MOD_GlcNHglycan	52	56	PF01048	0.588
MOD_GlcNHglycan	558	561	PF01048	0.673
MOD_GlcNHglycan	582	585	PF01048	0.668
MOD_GlcNHglycan	600	603	PF01048	0.523
MOD_GlcNHglycan	622	625	PF01048	0.628
MOD_GlcNHglycan	626	629	PF01048	0.608
MOD_GlcNHglycan	71	74	PF01048	0.624
MOD_GlcNHglycan	737	740	PF01048	0.664
MOD_GlcNHglycan	764	767	PF01048	0.616
MOD_GSK3_1	102	109	PF00069	0.510
MOD_GSK3_1	121	128	PF00069	0.519
MOD_GSK3_1	172	179	PF00069	0.727
MOD_GSK3_1	208	215	PF00069	0.679
MOD_GSK3_1	24	31	PF00069	0.698
MOD_GSK3_1	256	263	PF00069	0.632
MOD_GSK3_1	279	286	PF00069	0.665
MOD_GSK3_1	287	294	PF00069	0.551
MOD_GSK3_1	308	315	PF00069	0.441
MOD_GSK3_1	480	487	PF00069	0.624
MOD_GSK3_1	539	546	PF00069	0.654
MOD_GSK3_1	556	563	PF00069	0.589
MOD_GSK3_1	579	586	PF00069	0.684
MOD_GSK3_1	620	627	PF00069	0.648
MOD_GSK3_1	63	70	PF00069	0.666
MOD_GSK3_1	632	639	PF00069	0.601
MOD_GSK3_1	74	81	PF00069	0.594
MOD_GSK3_1	82	89	PF00069	0.567
MOD_LATS_1	38	44	PF00433	0.584
MOD_N-GLC_1	212	217	PF02516	0.678
MOD_N-GLC_1	240	245	PF02516	0.602
MOD_N-GLC_1	272	277	PF02516	0.682
MOD_N-GLC_1	63	68	PF02516	0.652
MOD_N-GLC_1	82	87	PF02516	0.594
MOD_N-GLC_2	647	649	PF02516	0.655
MOD_NEK2_1	174	179	PF00069	0.628
MOD_NEK2_1	260	265	PF00069	0.588
MOD_NEK2_1	384	389	PF00069	0.495
MOD_PIKK_1	202	208	PF00454	0.632
MOD_PIKK_1	258	264	PF00454	0.617
MOD_PIKK_1	397	403	PF00454	0.512
MOD_PIKK_1	534	540	PF00454	0.581
MOD_PIKK_1	566	572	PF00454	0.665
MOD_PIKK_1	632	638	PF00454	0.663
MOD_PIKK_1	694	700	PF00454	0.656
MOD_PK_1	543	549	PF00069	0.659
MOD_PK_1	593	599	PF00069	0.645
MOD_PKA_1	121	127	PF00069	0.632
MOD_PKA_1	341	347	PF00069	0.493
MOD_PKA_1	543	549	PF00069	0.659
MOD_PKA_2	120	126	PF00069	0.791
MOD_PKA_2	14	20	PF00069	0.618
MOD_PKA_2	172	178	PF00069	0.629
MOD_PKA_2	182	188	PF00069	0.658
MOD_PKA_2	298	304	PF00069	0.463
MOD_PKA_2	480	486	PF00069	0.606
MOD_PKA_2	491	497	PF00069	0.579
MOD_PKA_2	542	548	PF00069	0.651
MOD_PKA_2	554	560	PF00069	0.589
MOD_PKA_2	636	642	PF00069	0.686
MOD_PKB_1	297	305	PF00069	0.434
MOD_Plk_1	110	116	PF00069	0.544
MOD_Plk_1	151	157	PF00069	0.631
MOD_Plk_1	17	23	PF00069	0.624
MOD_Plk_1	212	218	PF00069	0.675
MOD_Plk_1	240	246	PF00069	0.517
MOD_Plk_1	272	278	PF00069	0.681
MOD_Plk_1	291	297	PF00069	0.583
MOD_Plk_1	51	57	PF00069	0.585
MOD_Plk_1	613	619	PF00069	0.631
MOD_Plk_1	630	636	PF00069	0.544
MOD_Plk_1	82	88	PF00069	0.709
MOD_Plk_2-3	14	20	PF00069	0.574
MOD_Plk_2-3	233	239	PF00069	0.519
MOD_Plk_2-3	240	246	PF00069	0.474
MOD_Plk_2-3	723	729	PF00069	0.642
MOD_Plk_4	152	158	PF00069	0.669
MOD_Plk_4	583	589	PF00069	0.654
MOD_Plk_4	82	88	PF00069	0.709
MOD_ProDKin_1	549	555	PF00069	0.656
MOD_ProDKin_1	560	566	PF00069	0.590
MOD_ProDKin_1	58	64	PF00069	0.658
MOD_ProDKin_1	72	78	PF00069	0.583
MOD_ProDKin_1	760	766	PF00069	0.664
MOD_SUMO_for_1	433	436	PF00179	0.453
MOD_SUMO_for_1	564	567	PF00179	0.657
TRG_DiLeu_BaEn_1	322	327	PF01217	0.624
TRG_DiLeu_BaEn_1	375	380	PF01217	0.456
TRG_DiLeu_BaEn_1	744	749	PF01217	0.541
TRG_DiLeu_BaLyEn_6	390	395	PF01217	0.518
TRG_ENDOCYTIC_2	349	352	PF00928	0.481
TRG_ENDOCYTIC_2	610	613	PF00928	0.614
TRG_ER_diArg_1	120	122	PF00400	0.632
TRG_ER_diArg_1	219	222	PF00400	0.617
TRG_ER_diArg_1	295	297	PF00400	0.658
TRG_ER_diArg_1	327	330	PF00400	0.454
TRG_ER_diArg_1	392	394	PF00400	0.527
TRG_ER_diArg_1	407	409	PF00400	0.407
TRG_ER_diArg_1	454	457	PF00400	0.467
TRG_ER_diArg_1	469	471	PF00400	0.484
TRG_ER_diArg_1	520	522	PF00400	0.478
TRG_ER_diArg_1	527	529	PF00400	0.493
TRG_NLS_Bipartite_1	428	442	PF00514	0.379
TRG_Pf-PMV_PEXEL_1	392	396	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	471	475	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	520	524	PF00026	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X5K7	Leishmania donovani	87%	100%
A4HKI2	Leishmania braziliensis	57%	99%
A4I814	Leishmania infantum	87%	100%
E9B2X1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%