Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania major

UniProt:

Q4Q581_LEIMA

TriTrypDb:

LmjF.32.1965 , LMJLV39_320026200 , LMJSD75_320026200

Length:

454

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q581

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q581

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	333	337	PF00656	0.731
CLV_NRD_NRD_1	362	364	PF00675	0.670
CLV_NRD_NRD_1	397	399	PF00675	0.758
CLV_NRD_NRD_1	45	47	PF00675	0.675
CLV_PCSK_FUR_1	395	399	PF00082	0.753
CLV_PCSK_KEX2_1	362	364	PF00082	0.804
CLV_PCSK_KEX2_1	397	399	PF00082	0.758
CLV_PCSK_KEX2_1	45	47	PF00082	0.656
CLV_PCSK_SKI1_1	183	187	PF00082	0.617
CLV_PCSK_SKI1_1	431	435	PF00082	0.745
DEG_Nend_UBRbox_2	1	3	PF02207	0.662
DEG_SCF_TRCP1_1	446	452	PF00400	0.734
DOC_ANK_TNKS_1	117	124	PF00023	0.619
DOC_CKS1_1	65	70	PF01111	0.820
DOC_MAPK_gen_1	240	248	PF00069	0.820
DOC_MAPK_RevD_3	383	398	PF00069	0.704
DOC_PP2B_LxvP_1	153	156	PF13499	0.592
DOC_PP4_FxxP_1	315	318	PF00568	0.678
DOC_USP7_MATH_1	116	120	PF00917	0.690
DOC_USP7_MATH_1	145	149	PF00917	0.745
DOC_USP7_MATH_1	196	200	PF00917	0.763
DOC_USP7_MATH_1	281	285	PF00917	0.781
DOC_USP7_MATH_1	288	292	PF00917	0.711
DOC_USP7_MATH_1	318	322	PF00917	0.789
DOC_USP7_MATH_1	387	391	PF00917	0.723
DOC_USP7_MATH_1	402	406	PF00917	0.560
DOC_USP7_MATH_1	66	70	PF00917	0.623
DOC_USP7_MATH_2	234	240	PF00917	0.629
DOC_WW_Pin1_4	102	107	PF00397	0.706
DOC_WW_Pin1_4	13	18	PF00397	0.808
DOC_WW_Pin1_4	147	152	PF00397	0.750
DOC_WW_Pin1_4	169	174	PF00397	0.764
DOC_WW_Pin1_4	252	257	PF00397	0.738
DOC_WW_Pin1_4	314	319	PF00397	0.727
DOC_WW_Pin1_4	64	69	PF00397	0.822
LIG_14-3-3_CanoR_1	211	216	PF00244	0.776
LIG_14-3-3_CanoR_1	240	248	PF00244	0.820
LIG_14-3-3_CanoR_1	287	293	PF00244	0.805
LIG_14-3-3_CanoR_1	316	326	PF00244	0.708
LIG_14-3-3_CanoR_1	376	380	PF00244	0.684
LIG_14-3-3_CanoR_1	391	395	PF00244	0.635
LIG_BRCT_BRCA1_1	113	117	PF00533	0.769
LIG_BRCT_BRCA1_1	309	313	PF00533	0.783
LIG_CaM_IQ_9	417	433	PF13499	0.735
LIG_eIF4E_1	20	26	PF01652	0.703
LIG_FHA_1	148	154	PF00498	0.752
LIG_FHA_1	223	229	PF00498	0.589
LIG_FHA_2	322	328	PF00498	0.783
LIG_FHA_2	55	61	PF00498	0.808
LIG_FHA_2	7	13	PF00498	0.811
LIG_GBD_Chelix_1	322	330	PF00786	0.708
LIG_IRF3_LxIS_1	326	333	PF10401	0.718
LIG_LIR_Apic_2	312	318	PF02991	0.674
LIG_LIR_Nem_3	109	113	PF02991	0.712
LIG_LIR_Nem_3	176	180	PF02991	0.716
LIG_LIR_Nem_3	77	82	PF02991	0.649
LIG_LYPXL_yS_3	110	113	PF13949	0.690
LIG_MAD2	226	234	PF02301	0.596
LIG_MYND_1	151	155	PF01753	0.715
LIG_PDZ_Class_1	449	454	PF00595	0.748
LIG_SH2_STAP1	416	420	PF00017	0.729
LIG_SH2_STAT5	370	373	PF00017	0.729
LIG_SH2_STAT5	56	59	PF00017	0.724
LIG_SH3_3	119	125	PF00018	0.685
LIG_SH3_3	148	154	PF00018	0.598
LIG_SH3_3	167	173	PF00018	0.488
LIG_SH3_3	235	241	PF00018	0.750
LIG_SH3_3	250	256	PF00018	0.549
LIG_SH3_3	289	295	PF00018	0.578
LIG_SH3_3	403	409	PF00018	0.620
LIG_SH3_5	106	110	PF00018	0.576
LIG_TRAF2_1	129	132	PF00917	0.775
LIG_TRAF2_1	234	237	PF00917	0.741
LIG_TYR_ITIM	108	113	PF00017	0.690
LIG_UBA3_1	127	135	PF00899	0.580
LIG_UBA3_1	78	87	PF00899	0.577
LIG_WRC_WIRS_1	185	190	PF05994	0.734
LIG_WRC_WIRS_1	322	327	PF05994	0.781
MOD_CDK_SPK_2	252	257	PF00069	0.582
MOD_CK1_1	160	166	PF00069	0.778
MOD_CK1_1	187	193	PF00069	0.751
MOD_CK1_1	314	320	PF00069	0.791
MOD_CK1_1	321	327	PF00069	0.664
MOD_CK1_1	378	384	PF00069	0.686
MOD_CK1_1	390	396	PF00069	0.734
MOD_CK1_1	69	75	PF00069	0.741
MOD_CK1_1	83	89	PF00069	0.573
MOD_CK2_1	229	235	PF00069	0.833
MOD_CK2_1	347	353	PF00069	0.761
MOD_CK2_1	54	60	PF00069	0.764
MOD_Cter_Amidation	360	363	PF01082	0.777
MOD_GlcNHglycan	118	121	PF01048	0.621
MOD_GlcNHglycan	194	197	PF01048	0.823
MOD_GlcNHglycan	213	216	PF01048	0.491
MOD_GlcNHglycan	242	245	PF01048	0.781
MOD_GlcNHglycan	265	268	PF01048	0.780
MOD_GlcNHglycan	278	281	PF01048	0.697
MOD_GlcNHglycan	292	295	PF01048	0.574
MOD_GlcNHglycan	336	339	PF01048	0.769
MOD_GlcNHglycan	364	367	PF01048	0.755
MOD_GlcNHglycan	380	383	PF01048	0.567
MOD_GlcNHglycan	446	449	PF01048	0.728
MOD_GSK3_1	156	163	PF00069	0.763
MOD_GSK3_1	169	176	PF00069	0.563
MOD_GSK3_1	184	191	PF00069	0.615
MOD_GSK3_1	192	199	PF00069	0.678
MOD_GSK3_1	236	243	PF00069	0.726
MOD_GSK3_1	286	293	PF00069	0.755
MOD_GSK3_1	303	310	PF00069	0.583
MOD_GSK3_1	31	38	PF00069	0.678
MOD_GSK3_1	314	321	PF00069	0.638
MOD_GSK3_1	330	337	PF00069	0.566
MOD_GSK3_1	347	354	PF00069	0.561
MOD_GSK3_1	370	377	PF00069	0.790
MOD_GSK3_1	46	53	PF00069	0.585
MOD_GSK3_1	6	13	PF00069	0.828
MOD_GSK3_1	60	67	PF00069	0.687
MOD_GSK3_1	98	105	PF00069	0.790
MOD_N-GLC_1	13	18	PF02516	0.594
MOD_N-GLC_1	222	227	PF02516	0.586
MOD_N-GLC_1	60	65	PF02516	0.599
MOD_NEK2_1	186	191	PF00069	0.812
MOD_NEK2_1	286	291	PF00069	0.722
MOD_NEK2_1	330	335	PF00069	0.741
MOD_NEK2_1	372	377	PF00069	0.771
MOD_NEK2_1	389	394	PF00069	0.567
MOD_NEK2_1	50	55	PF00069	0.663
MOD_PIKK_1	136	142	PF00454	0.702
MOD_PIKK_1	196	202	PF00454	0.740
MOD_PIKK_1	54	60	PF00454	0.762
MOD_PIKK_1	6	12	PF00454	0.717
MOD_PKA_1	362	368	PF00069	0.774
MOD_PKA_1	45	51	PF00069	0.684
MOD_PKA_2	281	287	PF00069	0.813
MOD_PKA_2	362	368	PF00069	0.787
MOD_PKA_2	375	381	PF00069	0.613
MOD_PKA_2	390	396	PF00069	0.579
MOD_PKA_2	444	450	PF00069	0.804
MOD_PKA_2	45	51	PF00069	0.643
MOD_Plk_1	20	26	PF00069	0.586
MOD_Plk_1	261	267	PF00069	0.797
MOD_Plk_1	311	317	PF00069	0.785
MOD_Plk_1	46	52	PF00069	0.791
MOD_Plk_1	60	66	PF00069	0.693
MOD_Plk_1	99	105	PF00069	0.673
MOD_Plk_2-3	351	357	PF00069	0.746
MOD_Plk_4	189	195	PF00069	0.790
MOD_Plk_4	318	324	PF00069	0.785
MOD_Plk_4	351	357	PF00069	0.780
MOD_Plk_4	375	381	PF00069	0.686
MOD_Plk_4	60	66	PF00069	0.803
MOD_Plk_4	74	80	PF00069	0.557
MOD_ProDKin_1	102	108	PF00069	0.704
MOD_ProDKin_1	13	19	PF00069	0.809
MOD_ProDKin_1	147	153	PF00069	0.752
MOD_ProDKin_1	169	175	PF00069	0.763
MOD_ProDKin_1	252	258	PF00069	0.740
MOD_ProDKin_1	314	320	PF00069	0.729
MOD_ProDKin_1	64	70	PF00069	0.821
MOD_SUMO_rev_2	131	137	PF00179	0.657
TRG_DiLeu_BaEn_1	21	26	PF01217	0.670
TRG_DiLeu_BaEn_1	351	356	PF01217	0.765
TRG_DiLeu_BaLyEn_6	108	113	PF01217	0.690
TRG_DiLeu_LyEn_5	21	26	PF01217	0.583
TRG_ENDOCYTIC_2	110	113	PF00928	0.728
TRG_ER_diArg_1	394	397	PF00400	0.748
TRG_ER_diArg_1	44	46	PF00400	0.657
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.601
TRG_Pf-PMV_PEXEL_1	24	28	PF00026	0.608
TRG_Pf-PMV_PEXEL_1	428	432	PF00026	0.746

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X5L4	Leishmania donovani	83%	95%
A4HKI6	Leishmania braziliensis	53%	95%
A4I817	Leishmania infantum	83%	95%
E9B2X5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%