18S rRNA aminocarboxypropyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribosome biogenesis protein TSR3, putative

Species:

Leishmania major

UniProt:

Q4Q580_LEIMA

TriTrypDb:

LmjF.32.1970 , LMJLV39_320026400 , LMJSD75_320026400

Length:

297

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q580

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q580

Function

Biological processes
Term	Name	Level	Count
GO:0000154	rRNA modification	6	12
GO:0000455	enzyme-directed rRNA pseudouridine synthesis	8	12
GO:0001522	pseudouridine synthesis	6	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0030490	maturation of SSU-rRNA	9	2
GO:0031118	rRNA pseudouridine synthesis	7	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0016740	transferase activity	2	12
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0106388	18S rRNA aminocarboxypropyltransferase activity	4	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140102	catalytic activity, acting on a rRNA	4	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901681	sulfur compound binding	2	12
GO:1904047	S-adenosyl-L-methionine binding	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.504
CLV_C14_Caspase3-7	269	273	PF00656	0.752
CLV_NRD_NRD_1	119	121	PF00675	0.408
CLV_NRD_NRD_1	217	219	PF00675	0.477
CLV_NRD_NRD_1	236	238	PF00675	0.601
CLV_NRD_NRD_1	243	245	PF00675	0.582
CLV_NRD_NRD_1	282	284	PF00675	0.680
CLV_PCSK_KEX2_1	217	219	PF00082	0.478
CLV_PCSK_KEX2_1	236	238	PF00082	0.521
CLV_PCSK_KEX2_1	243	245	PF00082	0.522
CLV_PCSK_KEX2_1	282	284	PF00082	0.680
CLV_PCSK_PC7_1	239	245	PF00082	0.609
CLV_PCSK_SKI1_1	184	188	PF00082	0.396
DEG_SCF_FBW7_1	81	88	PF00400	0.322
DEG_SPOP_SBC_1	25	29	PF00917	0.695
DOC_CKS1_1	82	87	PF01111	0.287
DOC_CYCLIN_RxL_1	215	226	PF00134	0.615
DOC_CYCLIN_RxL_1	65	76	PF00134	0.305
DOC_MAPK_gen_1	61	71	PF00069	0.287
DOC_USP7_MATH_1	249	253	PF00917	0.670
DOC_USP7_MATH_1	273	277	PF00917	0.636
DOC_USP7_MATH_1	289	293	PF00917	0.652
DOC_WW_Pin1_4	81	86	PF00397	0.287
DOC_WW_Pin1_4	89	94	PF00397	0.287
LIG_14-3-3_CanoR_1	123	127	PF00244	0.408
LIG_14-3-3_CanoR_1	73	77	PF00244	0.443
LIG_Actin_WH2_2	59	75	PF00022	0.387
LIG_BIR_III_2	115	119	PF00653	0.344
LIG_BIR_III_2	229	233	PF00653	0.515
LIG_BRCT_BRCA1_1	74	78	PF00533	0.471
LIG_FHA_1	154	160	PF00498	0.364
LIG_FHA_1	86	92	PF00498	0.372
LIG_LIR_Apic_2	245	249	PF02991	0.641
LIG_LIR_Nem_3	108	114	PF02991	0.287
LIG_LIR_Nem_3	178	182	PF02991	0.289
LIG_LIR_Nem_3	75	81	PF02991	0.361
LIG_MYND_1	127	131	PF01753	0.287
LIG_PDZ_Class_3	292	297	PF00595	0.659
LIG_Pex14_1	175	179	PF04695	0.250
LIG_Rb_LxCxE_1	145	164	PF01857	0.288
LIG_SH2_CRK	141	145	PF00017	0.287
LIG_SH2_SRC	206	209	PF00017	0.357
LIG_SH2_STAT5	172	175	PF00017	0.322
LIG_SH2_STAT5	206	209	PF00017	0.462
LIG_SH3_3	34	40	PF00018	0.628
LIG_SH3_3	79	85	PF00018	0.287
LIG_SUMO_SIM_anti_2	156	161	PF11976	0.402
LIG_TRAF2_1	292	295	PF00917	0.504
MOD_CDK_SPxxK_3	89	96	PF00069	0.408
MOD_CK2_1	107	113	PF00069	0.372
MOD_CK2_1	247	253	PF00069	0.644
MOD_CK2_1	289	295	PF00069	0.509
MOD_CK2_1	83	89	PF00069	0.292
MOD_Cter_Amidation	59	62	PF01082	0.287
MOD_GlcNHglycan	124	127	PF01048	0.443
MOD_GlcNHglycan	195	198	PF01048	0.363
MOD_GlcNHglycan	21	24	PF01048	0.604
MOD_GlcNHglycan	28	31	PF01048	0.613
MOD_GlcNHglycan	58	61	PF01048	0.298
MOD_GlcNHglycan	85	88	PF01048	0.394
MOD_GlcNHglycan	9	12	PF01048	0.730
MOD_GSK3_1	171	178	PF00069	0.322
MOD_GSK3_1	221	228	PF00069	0.581
MOD_GSK3_1	289	296	PF00069	0.508
MOD_GSK3_1	81	88	PF00069	0.305
MOD_N-GLC_2	56	58	PF02516	0.344
MOD_NEK2_1	122	127	PF00069	0.400
MOD_NEK2_1	153	158	PF00069	0.356
MOD_NEK2_2	175	180	PF00069	0.287
MOD_PKA_1	282	288	PF00069	0.565
MOD_PKA_2	122	128	PF00069	0.408
MOD_PKA_2	142	148	PF00069	0.104
MOD_PKA_2	273	279	PF00069	0.539
MOD_PKA_2	282	288	PF00069	0.497
MOD_PKA_2	72	78	PF00069	0.457
MOD_Plk_1	107	113	PF00069	0.287
MOD_Plk_2-3	221	227	PF00069	0.583
MOD_Plk_2-3	264	270	PF00069	0.647
MOD_Plk_4	175	181	PF00069	0.313
MOD_ProDKin_1	81	87	PF00069	0.287
MOD_ProDKin_1	89	95	PF00069	0.287
TRG_DiLeu_BaLyEn_6	125	130	PF01217	0.287
TRG_DiLeu_BaLyEn_6	67	72	PF01217	0.287
TRG_ER_diArg_1	236	239	PF00400	0.566
TRG_NES_CRM1_1	151	165	PF08389	0.408
TRG_NLS_MonoExtN_4	118	124	PF00514	0.408
TRG_Pf-PMV_PEXEL_1	218	223	PF00026	0.634
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKZ2	Leptomonas seymouri	83%	100%
A0A0S4JEU2	Bodo saltans	64%	100%
A0A1X0NUA5	Trypanosomatidae	69%	100%
A0A3S7X5P4	Leishmania donovani	93%	100%
A0A422NB90	Trypanosoma rangeli	67%	87%
A4I818	Leishmania infantum	94%	100%
D0AA84	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9AIV1	Leishmania braziliensis	81%	100%
E9B2X6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q10409	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	100%
Q12094	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	95%
V5BG92	Trypanosoma cruzi	65%	100%