DUF4200 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4200), putative

Species:

Leishmania major

UniProt:

Q4Q578_LEIMA

TriTrypDb:

LmjF.32.1980 , LMJLV39_320026600 , LMJSD75_320026600 , LMJSD75_320026700

Length:

744

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	4
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4Q578

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q578

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	63	67	PF00656	0.525
CLV_C14_Caspase3-7	731	735	PF00656	0.675
CLV_NRD_NRD_1	124	126	PF00675	0.343
CLV_NRD_NRD_1	168	170	PF00675	0.253
CLV_NRD_NRD_1	198	200	PF00675	0.252
CLV_NRD_NRD_1	282	284	PF00675	0.676
CLV_NRD_NRD_1	293	295	PF00675	0.684
CLV_NRD_NRD_1	34	36	PF00675	0.553
CLV_NRD_NRD_1	531	533	PF00675	0.671
CLV_NRD_NRD_1	663	665	PF00675	0.469
CLV_NRD_NRD_1	683	685	PF00675	0.462
CLV_NRD_NRD_1	716	718	PF00675	0.580
CLV_PCSK_FUR_1	681	685	PF00082	0.514
CLV_PCSK_KEX2_1	107	109	PF00082	0.252
CLV_PCSK_KEX2_1	136	138	PF00082	0.267
CLV_PCSK_KEX2_1	168	170	PF00082	0.266
CLV_PCSK_KEX2_1	282	284	PF00082	0.702
CLV_PCSK_KEX2_1	34	36	PF00082	0.512
CLV_PCSK_KEX2_1	365	367	PF00082	0.437
CLV_PCSK_KEX2_1	471	473	PF00082	0.740
CLV_PCSK_KEX2_1	662	664	PF00082	0.466
CLV_PCSK_KEX2_1	683	685	PF00082	0.513
CLV_PCSK_KEX2_1	716	718	PF00082	0.619
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.252
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.276
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.676
CLV_PCSK_PC1ET2_1	365	367	PF00082	0.437
CLV_PCSK_PC1ET2_1	471	473	PF00082	0.689
CLV_PCSK_SKI1_1	177	181	PF00082	0.344
CLV_PCSK_SKI1_1	212	216	PF00082	0.344
CLV_PCSK_SKI1_1	239	243	PF00082	0.503
CLV_PCSK_SKI1_1	27	31	PF00082	0.595
CLV_PCSK_SKI1_1	572	576	PF00082	0.754
CLV_PCSK_SKI1_1	683	687	PF00082	0.508
CLV_Separin_Metazoa	28	32	PF03568	0.380
DEG_Nend_UBRbox_2	1	3	PF02207	0.631
DEG_SPOP_SBC_1	429	433	PF00917	0.434
DOC_ANK_TNKS_1	531	538	PF00023	0.636
DOC_CYCLIN_RxL_1	236	246	PF00134	0.498
DOC_CYCLIN_RxL_1	24	32	PF00134	0.600
DOC_CYCLIN_yCln2_LP_2	639	645	PF00134	0.548
DOC_MAPK_gen_1	149	158	PF00069	0.523
DOC_MAPK_gen_1	175	184	PF00069	0.452
DOC_MAPK_gen_1	199	205	PF00069	0.452
DOC_MAPK_gen_1	365	371	PF00069	0.425
DOC_MAPK_gen_1	662	671	PF00069	0.465
DOC_PP4_FxxP_1	10	13	PF00568	0.623
DOC_USP7_MATH_1	20	24	PF00917	0.579
DOC_USP7_MATH_1	338	342	PF00917	0.422
DOC_USP7_MATH_1	429	433	PF00917	0.465
DOC_USP7_MATH_1	467	471	PF00917	0.713
DOC_USP7_MATH_1	475	479	PF00917	0.755
DOC_USP7_MATH_1	560	564	PF00917	0.755
DOC_USP7_MATH_1	57	61	PF00917	0.676
DOC_USP7_MATH_1	589	593	PF00917	0.715
DOC_USP7_MATH_1	77	81	PF00917	0.543
DOC_USP7_UBL2_3	126	130	PF12436	0.501
DOC_USP7_UBL2_3	652	656	PF12436	0.497
DOC_USP7_UBL2_3	714	718	PF12436	0.610
DOC_WW_Pin1_4	300	305	PF00397	0.610
LIG_14-3-3_CanoR_1	114	124	PF00244	0.544
LIG_14-3-3_CanoR_1	251	256	PF00244	0.442
LIG_14-3-3_CanoR_1	474	484	PF00244	0.707
LIG_14-3-3_CanoR_1	532	536	PF00244	0.764
LIG_14-3-3_CanoR_1	550	555	PF00244	0.746
LIG_14-3-3_CanoR_1	637	642	PF00244	0.568
LIG_14-3-3_CanoR_1	702	707	PF00244	0.636
LIG_Actin_WH2_2	501	518	PF00022	0.633
LIG_BIR_III_4	485	489	PF00653	0.504
LIG_EH_1	7	11	PF12763	0.570
LIG_FHA_1	179	185	PF00498	0.544
LIG_FHA_1	235	241	PF00498	0.492
LIG_FHA_1	301	307	PF00498	0.609
LIG_FHA_1	337	343	PF00498	0.472
LIG_FHA_1	422	428	PF00498	0.521
LIG_FHA_1	429	435	PF00498	0.525
LIG_FHA_2	254	260	PF00498	0.455
LIG_FHA_2	348	354	PF00498	0.518
LIG_FHA_2	370	376	PF00498	0.454
LIG_FHA_2	624	630	PF00498	0.455
LIG_HCF-1_HBM_1	321	324	PF13415	0.519
LIG_LIR_Gen_1	150	158	PF02991	0.454
LIG_LIR_Gen_1	213	221	PF02991	0.480
LIG_LIR_Gen_1	321	331	PF02991	0.501
LIG_LIR_Gen_1	379	389	PF02991	0.406
LIG_LIR_Gen_1	509	519	PF02991	0.578
LIG_LIR_LC3C_4	42	46	PF02991	0.399
LIG_LIR_Nem_3	150	155	PF02991	0.454
LIG_LIR_Nem_3	213	217	PF02991	0.458
LIG_LIR_Nem_3	321	327	PF02991	0.443
LIG_LIR_Nem_3	379	384	PF02991	0.387
LIG_LIR_Nem_3	509	515	PF02991	0.460
LIG_LIR_Nem_3	633	638	PF02991	0.458
LIG_RPA_C_Fungi	246	258	PF08784	0.477
LIG_SH2_CRK	225	229	PF00017	0.377
LIG_SH2_CRK	51	55	PF00017	0.576
LIG_SH2_NCK_1	324	328	PF00017	0.432
LIG_SH2_SRC	19	22	PF00017	0.544
LIG_SH2_STAP1	90	94	PF00017	0.670
LIG_SH2_STAT3	580	583	PF00017	0.570
LIG_SH2_STAT5	638	641	PF00017	0.469
LIG_SH3_3	43	49	PF00018	0.570
LIG_SH3_3	51	57	PF00018	0.607
LIG_SH3_3	697	703	PF00018	0.622
LIG_SH3_3	704	710	PF00018	0.676
LIG_SUMO_SIM_anti_2	213	219	PF11976	0.332
LIG_SUMO_SIM_anti_2	42	48	PF11976	0.454
LIG_SUMO_SIM_anti_2	623	629	PF11976	0.445
LIG_SUMO_SIM_anti_2	647	652	PF11976	0.574
LIG_SUMO_SIM_par_1	350	357	PF11976	0.324
LIG_SUMO_SIM_par_1	623	629	PF11976	0.441
LIG_TRAF2_1	256	259	PF00917	0.538
LIG_TRAF2_1	315	318	PF00917	0.581
LIG_TRAF2_1	326	329	PF00917	0.409
LIG_TRAF2_1	496	499	PF00917	0.636
LIG_TRAF2_1	672	675	PF00917	0.588
LIG_UBA3_1	624	631	PF00899	0.436
LIG_UBA3_1	693	699	PF00899	0.537
LIG_WRC_WIRS_1	152	157	PF05994	0.301
MOD_CK1_1	116	122	PF00069	0.412
MOD_CK1_1	23	29	PF00069	0.516
MOD_CK1_1	579	585	PF00069	0.744
MOD_CK1_1	592	598	PF00069	0.717
MOD_CK1_1	60	66	PF00069	0.703
MOD_CK1_1	705	711	PF00069	0.728
MOD_CK1_1	75	81	PF00069	0.538
MOD_CK2_1	156	162	PF00069	0.350
MOD_CK2_1	189	195	PF00069	0.371
MOD_CK2_1	253	259	PF00069	0.533
MOD_CK2_1	323	329	PF00069	0.465
MOD_CK2_1	430	436	PF00069	0.573
MOD_CK2_1	623	629	PF00069	0.478
MOD_Cter_Amidation	280	283	PF01082	0.532
MOD_GlcNHglycan	187	190	PF01048	0.293
MOD_GlcNHglycan	251	254	PF01048	0.503
MOD_GlcNHglycan	279	282	PF01048	0.703
MOD_GlcNHglycan	414	419	PF01048	0.355
MOD_GlcNHglycan	490	493	PF01048	0.685
MOD_GlcNHglycan	586	589	PF01048	0.730
MOD_GlcNHglycan	591	594	PF01048	0.674
MOD_GlcNHglycan	62	65	PF01048	0.732
MOD_GlcNHglycan	70	73	PF01048	0.600
MOD_GlcNHglycan	80	83	PF01048	0.557
MOD_GlcNHglycan	86	89	PF01048	0.518
MOD_GSK3_1	185	192	PF00069	0.371
MOD_GSK3_1	19	26	PF00069	0.603
MOD_GSK3_1	249	256	PF00069	0.445
MOD_GSK3_1	463	470	PF00069	0.694
MOD_GSK3_1	542	549	PF00069	0.735
MOD_GSK3_1	561	568	PF00069	0.796
MOD_GSK3_1	572	579	PF00069	0.727
MOD_GSK3_1	589	596	PF00069	0.635
MOD_GSK3_1	68	75	PF00069	0.641
MOD_GSK3_1	94	101	PF00069	0.608
MOD_N-GLC_1	300	305	PF02516	0.684
MOD_N-GLC_1	542	547	PF02516	0.716
MOD_N-GLC_1	726	731	PF02516	0.651
MOD_NEK2_1	115	120	PF00069	0.488
MOD_NEK2_1	156	161	PF00069	0.293
MOD_NEK2_1	198	203	PF00069	0.437
MOD_NEK2_1	224	229	PF00069	0.443
MOD_NEK2_1	369	374	PF00069	0.563
MOD_NEK2_1	430	435	PF00069	0.490
MOD_NEK2_1	522	527	PF00069	0.696
MOD_NEK2_1	561	566	PF00069	0.616
MOD_NEK2_1	686	691	PF00069	0.463
MOD_NEK2_2	338	343	PF00069	0.409
MOD_PIKK_1	579	585	PF00454	0.770
MOD_PIKK_1	607	613	PF00454	0.705
MOD_PIKK_1	686	692	PF00454	0.495
MOD_PKA_1	185	191	PF00069	0.293
MOD_PKA_2	113	119	PF00069	0.404
MOD_PKA_2	198	204	PF00069	0.269
MOD_PKA_2	531	537	PF00069	0.738
MOD_PKA_2	583	589	PF00069	0.774
MOD_PKA_2	75	81	PF00069	0.568
MOD_PKB_1	548	556	PF00069	0.623
MOD_Plk_1	20	26	PF00069	0.567
MOD_Plk_1	414	420	PF00069	0.372
MOD_Plk_1	504	510	PF00069	0.521
MOD_Plk_1	615	621	PF00069	0.732
MOD_Plk_2-3	623	629	PF00069	0.459
MOD_Plk_4	151	157	PF00069	0.301
MOD_Plk_4	347	353	PF00069	0.335
MOD_Plk_4	623	629	PF00069	0.445
MOD_Plk_4	94	100	PF00069	0.498
MOD_ProDKin_1	300	306	PF00069	0.609
MOD_SUMO_rev_2	123	131	PF00179	0.384
MOD_SUMO_rev_2	307	314	PF00179	0.583
MOD_SUMO_rev_2	357	367	PF00179	0.431
MOD_SUMO_rev_2	623	632	PF00179	0.440
MOD_SUMO_rev_2	708	715	PF00179	0.648
TRG_DiLeu_BaEn_3	385	391	PF01217	0.395
TRG_DiLeu_BaEn_3	414	420	PF01217	0.431
TRG_ENDOCYTIC_2	211	214	PF00928	0.293
TRG_ENDOCYTIC_2	225	228	PF00928	0.361
TRG_ENDOCYTIC_2	324	327	PF00928	0.494
TRG_ENDOCYTIC_2	51	54	PF00928	0.573
TRG_ER_diArg_1	167	169	PF00400	0.312
TRG_ER_diArg_1	283	286	PF00400	0.672
TRG_ER_diArg_1	33	35	PF00400	0.569
TRG_ER_diArg_1	662	664	PF00400	0.486
TRG_ER_diArg_1	681	684	PF00400	0.492
TRG_ER_diArg_1	701	704	PF00400	0.364
TRG_NES_CRM1_1	397	411	PF08389	0.432
TRG_NLS_Bipartite_1	185	203	PF00514	0.421
TRG_NLS_Bipartite_1	282	298	PF00514	0.611
TRG_NLS_MonoCore_2	281	286	PF00514	0.486
TRG_NLS_MonoExtC_3	281	286	PF00514	0.486
TRG_NLS_MonoExtN_4	282	287	PF00514	0.617
TRG_Pf-PMV_PEXEL_1	125	129	PF00026	0.293
TRG_Pf-PMV_PEXEL_1	637	641	PF00026	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEP4	Leptomonas seymouri	54%	97%
A0A1X0NUV9	Trypanosomatidae	39%	100%
A0A3Q8IG83	Leishmania donovani	93%	100%
A0A422NB67	Trypanosoma rangeli	40%	100%
A4HKI8	Leishmania braziliensis	74%	100%
A4I820	Leishmania infantum	93%	100%
D0AA86	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9B2X8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5DCC5	Trypanosoma cruzi	38%	100%