DUF3456 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TLR4 regulator and MIR-interacting MSAP, putative

Species:

Leishmania major

UniProt:

Q4Q576_LEIMA

TriTrypDb:

LmjF.32.2000 , LMJLV39_320026800 , LMJSD75_320026900

Length:

369

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 1
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q576

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q576

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	172	176	PF00656	0.327
CLV_C14_Caspase3-7	186	190	PF00656	0.222
CLV_C14_Caspase3-7	246	250	PF00656	0.560
CLV_C14_Caspase3-7	363	367	PF00656	0.593
CLV_NRD_NRD_1	100	102	PF00675	0.525
CLV_NRD_NRD_1	187	189	PF00675	0.520
CLV_NRD_NRD_1	278	280	PF00675	0.462
CLV_NRD_NRD_1	289	291	PF00675	0.375
CLV_NRD_NRD_1	293	295	PF00675	0.353
CLV_NRD_NRD_1	301	303	PF00675	0.415
CLV_PCSK_KEX2_1	187	189	PF00082	0.502
CLV_PCSK_KEX2_1	278	280	PF00082	0.458
CLV_PCSK_KEX2_1	289	291	PF00082	0.373
CLV_PCSK_KEX2_1	301	303	PF00082	0.419
CLV_PCSK_KEX2_1	99	101	PF00082	0.459
CLV_PCSK_PC7_1	183	189	PF00082	0.389
CLV_PCSK_PC7_1	274	280	PF00082	0.567
CLV_PCSK_SKI1_1	152	156	PF00082	0.528
CLV_PCSK_SKI1_1	245	249	PF00082	0.674
CLV_PCSK_SKI1_1	294	298	PF00082	0.555
CLV_PCSK_SKI1_1	69	73	PF00082	0.531
CLV_Separin_Metazoa	271	275	PF03568	0.505
DEG_Nend_UBRbox_1	1	4	PF02207	0.645
DOC_CYCLIN_RxL_1	66	73	PF00134	0.251
DOC_CYCLIN_yCln2_LP_2	32	38	PF00134	0.412
DOC_MAPK_gen_1	99	110	PF00069	0.281
DOC_PP2B_LxvP_1	32	35	PF13499	0.537
DOC_PP2B_LxvP_1	8	11	PF13499	0.518
DOC_USP7_MATH_1	310	314	PF00917	0.687
DOC_USP7_MATH_1	328	332	PF00917	0.766
DOC_USP7_MATH_1	334	338	PF00917	0.731
DOC_WW_Pin1_4	199	204	PF00397	0.352
DOC_WW_Pin1_4	340	345	PF00397	0.654
DOC_WW_Pin1_4	348	353	PF00397	0.580
DOC_WW_Pin1_4	38	43	PF00397	0.516
LIG_14-3-3_CanoR_1	104	110	PF00244	0.346
LIG_14-3-3_CanoR_1	2	8	PF00244	0.655
LIG_14-3-3_CanoR_1	74	80	PF00244	0.242
LIG_Actin_WH2_2	259	276	PF00022	0.510
LIG_BIR_III_2	164	168	PF00653	0.235
LIG_eIF4E_1	103	109	PF01652	0.331
LIG_FHA_1	236	242	PF00498	0.400
LIG_FHA_1	4	10	PF00498	0.555
LIG_FHA_1	83	89	PF00498	0.260
LIG_FHA_2	244	250	PF00498	0.754
LIG_FHA_2	363	369	PF00498	0.658
LIG_FHA_2	68	74	PF00498	0.350
LIG_FHA_2	76	82	PF00498	0.312
LIG_GBD_Chelix_1	67	75	PF00786	0.482
LIG_LIR_Gen_1	70	80	PF02991	0.341
LIG_LIR_Nem_3	347	353	PF02991	0.756
LIG_LIR_Nem_3	70	75	PF02991	0.357
LIG_LYPXL_SIV_4	349	357	PF13949	0.518
LIG_NRBOX	26	32	PF00104	0.387
LIG_SH2_CRK	350	354	PF00017	0.539
LIG_SH2_NCK_1	350	354	PF00017	0.605
LIG_SH2_SRC	86	89	PF00017	0.251
LIG_SH2_STAT3	139	142	PF00017	0.331
LIG_SH2_STAT5	86	89	PF00017	0.386
LIG_SH3_3	238	244	PF00018	0.578
LIG_SH3_3	346	352	PF00018	0.538
LIG_SH3_3	37	43	PF00018	0.523
LIG_SH3_3	44	50	PF00018	0.448
LIG_SUMO_SIM_anti_2	23	29	PF11976	0.363
LIG_SUMO_SIM_par_1	36	41	PF11976	0.604
LIG_TRAF2_1	226	229	PF00917	0.375
LIG_TRAF2_1	344	347	PF00917	0.626
LIG_TRFH_1	7	11	PF08558	0.480
LIG_UBA3_1	127	135	PF00899	0.335
MOD_CK1_1	223	229	PF00069	0.489
MOD_CK2_1	223	229	PF00069	0.386
MOD_CK2_1	312	318	PF00069	0.687
MOD_CK2_1	340	346	PF00069	0.748
MOD_CK2_1	67	73	PF00069	0.429
MOD_CK2_1	75	81	PF00069	0.376
MOD_Cter_Amidation	92	95	PF01082	0.270
MOD_GlcNHglycan	199	202	PF01048	0.444
MOD_GlcNHglycan	314	317	PF01048	0.587
MOD_GlcNHglycan	331	334	PF01048	0.786
MOD_GlcNHglycan	336	339	PF01048	0.710
MOD_GlcNHglycan	60	64	PF01048	0.271
MOD_GSK3_1	195	202	PF00069	0.366
MOD_GSK3_1	216	223	PF00069	0.434
MOD_GSK3_1	59	66	PF00069	0.404
MOD_GSK3_1	82	89	PF00069	0.278
MOD_N-GLC_1	75	80	PF02516	0.271
MOD_N-GLC_2	116	118	PF02516	0.313
MOD_N-GLC_2	265	267	PF02516	0.479
MOD_NEK2_1	144	149	PF00069	0.292
MOD_NEK2_1	20	25	PF00069	0.388
MOD_NEK2_1	220	225	PF00069	0.335
MOD_NEK2_1	26	31	PF00069	0.410
MOD_NEK2_1	329	334	PF00069	0.707
MOD_NEK2_1	59	64	PF00069	0.271
MOD_NEK2_1	75	80	PF00069	0.271
MOD_PKA_2	103	109	PF00069	0.360
MOD_Plk_1	230	236	PF00069	0.370
MOD_Plk_1	255	261	PF00069	0.605
MOD_Plk_1	75	81	PF00069	0.271
MOD_Plk_2-3	249	255	PF00069	0.738
MOD_Plk_2-3	362	368	PF00069	0.653
MOD_Plk_4	216	222	PF00069	0.311
MOD_Plk_4	26	32	PF00069	0.503
MOD_Plk_4	3	9	PF00069	0.633
MOD_Plk_4	82	88	PF00069	0.271
MOD_ProDKin_1	199	205	PF00069	0.432
MOD_ProDKin_1	340	346	PF00069	0.655
MOD_ProDKin_1	348	354	PF00069	0.581
MOD_ProDKin_1	38	44	PF00069	0.512
MOD_SUMO_rev_2	288	296	PF00179	0.353
TRG_DiLeu_BaEn_1	216	221	PF01217	0.404
TRG_DiLeu_BaLyEn_6	123	128	PF01217	0.335
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.454
TRG_ENDOCYTIC_2	350	353	PF00928	0.538
TRG_ENDOCYTIC_2	56	59	PF00928	0.315
TRG_ER_diArg_1	98	101	PF00400	0.313
TRG_Pf-PMV_PEXEL_1	225	229	PF00026	0.419
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCJ7	Leptomonas seymouri	52%	100%
A0A1X0NUB5	Trypanosomatidae	28%	100%
A0A3S7X5Q1	Leishmania donovani	93%	100%
A0A422NB75	Trypanosoma rangeli	30%	100%
A4HKJ0	Leishmania braziliensis	72%	100%
A4I822	Leishmania infantum	92%	100%
D0AA88	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B2Y0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5AW92	Trypanosoma cruzi	29%	100%