Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q572_LEIMA

TriTrypDb:

LmjF.32.2040 , LMJLV39_320027200 , LMJSD75_320027300

Length:

847

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q572

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q572

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	204	208	PF00656	0.613
CLV_C14_Caspase3-7	252	256	PF00656	0.426
CLV_C14_Caspase3-7	687	691	PF00656	0.618
CLV_C14_Caspase3-7	709	713	PF00656	0.799
CLV_C14_Caspase3-7	750	754	PF00656	0.577
CLV_NRD_NRD_1	192	194	PF00675	0.570
CLV_NRD_NRD_1	237	239	PF00675	0.627
CLV_NRD_NRD_1	26	28	PF00675	0.566
CLV_NRD_NRD_1	273	275	PF00675	0.653
CLV_NRD_NRD_1	41	43	PF00675	0.595
CLV_NRD_NRD_1	426	428	PF00675	0.611
CLV_NRD_NRD_1	438	440	PF00675	0.511
CLV_NRD_NRD_1	606	608	PF00675	0.581
CLV_NRD_NRD_1	637	639	PF00675	0.617
CLV_NRD_NRD_1	724	726	PF00675	0.598
CLV_PCSK_FUR_1	39	43	PF00082	0.603
CLV_PCSK_KEX2_1	192	194	PF00082	0.570
CLV_PCSK_KEX2_1	237	239	PF00082	0.627
CLV_PCSK_KEX2_1	26	28	PF00082	0.566
CLV_PCSK_KEX2_1	273	275	PF00082	0.653
CLV_PCSK_KEX2_1	41	43	PF00082	0.593
CLV_PCSK_KEX2_1	426	428	PF00082	0.611
CLV_PCSK_KEX2_1	438	440	PF00082	0.503
CLV_PCSK_KEX2_1	548	550	PF00082	0.592
CLV_PCSK_KEX2_1	637	639	PF00082	0.617
CLV_PCSK_KEX2_1	723	725	PF00082	0.684
CLV_PCSK_KEX2_1	785	787	PF00082	0.740
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.588
CLV_PCSK_PC1ET2_1	548	550	PF00082	0.580
CLV_PCSK_PC1ET2_1	785	787	PF00082	0.702
CLV_PCSK_PC7_1	422	428	PF00082	0.531
CLV_PCSK_SKI1_1	251	255	PF00082	0.609
CLV_PCSK_SKI1_1	530	534	PF00082	0.723
CLV_PCSK_SKI1_1	560	564	PF00082	0.650
CLV_PCSK_SKI1_1	701	705	PF00082	0.730
DEG_APCC_DBOX_1	246	254	PF00400	0.522
DEG_APCC_DBOX_1	700	708	PF00400	0.772
DEG_SCF_FBW7_1	567	573	PF00400	0.678
DEG_SPOP_SBC_1	231	235	PF00917	0.525
DEG_SPOP_SBC_1	561	565	PF00917	0.724
DOC_CKS1_1	111	116	PF01111	0.714
DOC_CKS1_1	466	471	PF01111	0.623
DOC_CKS1_1	567	572	PF01111	0.795
DOC_CKS1_1	584	589	PF01111	0.495
DOC_MAPK_DCC_7	580	590	PF00069	0.510
DOC_MAPK_gen_1	335	344	PF00069	0.553
DOC_MAPK_MEF2A_6	335	344	PF00069	0.538
DOC_PP4_FxxP_1	466	469	PF00568	0.662
DOC_USP7_MATH_1	195	199	PF00917	0.480
DOC_USP7_MATH_1	2	6	PF00917	0.703
DOC_USP7_MATH_1	231	235	PF00917	0.541
DOC_USP7_MATH_1	413	417	PF00917	0.639
DOC_USP7_MATH_1	471	475	PF00917	0.550
DOC_USP7_MATH_1	493	497	PF00917	0.720
DOC_USP7_MATH_1	645	649	PF00917	0.627
DOC_USP7_MATH_1	719	723	PF00917	0.823
DOC_USP7_MATH_1	797	801	PF00917	0.697
DOC_USP7_MATH_1	837	841	PF00917	0.710
DOC_USP7_UBL2_3	155	159	PF12436	0.583
DOC_USP7_UBL2_3	28	32	PF12436	0.653
DOC_USP7_UBL2_3	97	101	PF12436	0.761
DOC_WW_Pin1_4	107	112	PF00397	0.724
DOC_WW_Pin1_4	113	118	PF00397	0.685
DOC_WW_Pin1_4	119	124	PF00397	0.646
DOC_WW_Pin1_4	127	132	PF00397	0.681
DOC_WW_Pin1_4	134	139	PF00397	0.586
DOC_WW_Pin1_4	465	470	PF00397	0.623
DOC_WW_Pin1_4	5	10	PF00397	0.759
DOC_WW_Pin1_4	566	571	PF00397	0.764
DOC_WW_Pin1_4	583	588	PF00397	0.577
LIG_14-3-3_CanoR_1	247	251	PF00244	0.426
LIG_14-3-3_CanoR_1	258	263	PF00244	0.570
LIG_14-3-3_CanoR_1	449	455	PF00244	0.624
LIG_14-3-3_CanoR_1	535	541	PF00244	0.766
LIG_14-3-3_CanoR_1	552	561	PF00244	0.768
LIG_14-3-3_CanoR_1	596	602	PF00244	0.662
LIG_14-3-3_CanoR_1	637	641	PF00244	0.651
LIG_14-3-3_CanoR_1	642	648	PF00244	0.736
LIG_14-3-3_CanoR_1	664	670	PF00244	0.769
LIG_14-3-3_CanoR_1	828	837	PF00244	0.611
LIG_Actin_WH2_2	382	399	PF00022	0.628
LIG_APCC_ABBA_1	343	348	PF00400	0.609
LIG_APCC_ABBAyCdc20_2	439	445	PF00400	0.686
LIG_BIR_III_4	486	490	PF00653	0.730
LIG_CaM_IQ_9	807	822	PF13499	0.545
LIG_CtBP_PxDLS_1	587	591	PF00389	0.490
LIG_eIF4E_1	14	20	PF01652	0.646
LIG_FHA_1	185	191	PF00498	0.577
LIG_FHA_1	527	533	PF00498	0.703
LIG_FHA_1	562	568	PF00498	0.708
LIG_FHA_1	697	703	PF00498	0.643
LIG_FHA_1	739	745	PF00498	0.669
LIG_FHA_1	754	760	PF00498	0.635
LIG_FHA_2	104	110	PF00498	0.773
LIG_FHA_2	199	205	PF00498	0.681
LIG_FHA_2	247	253	PF00498	0.524
LIG_FHA_2	283	289	PF00498	0.534
LIG_FHA_2	399	405	PF00498	0.537
LIG_FHA_2	407	413	PF00498	0.541
LIG_FHA_2	517	523	PF00498	0.793
LIG_FHA_2	685	691	PF00498	0.649
LIG_FHA_2	716	722	PF00498	0.747
LIG_FHA_2	808	814	PF00498	0.542
LIG_FHA_2	833	839	PF00498	0.472
LIG_HP1_1	340	344	PF01393	0.525
LIG_IBAR_NPY_1	603	605	PF08397	0.541
LIG_IRF3_LxIS_1	493	500	PF10401	0.721
LIG_LIR_Apic_2	290	296	PF02991	0.649
LIG_LIR_Apic_2	600	604	PF02991	0.598
LIG_LIR_Gen_1	639	647	PF02991	0.671
LIG_LIR_Gen_1	672	679	PF02991	0.780
LIG_LIR_Nem_3	137	142	PF02991	0.692
LIG_LIR_Nem_3	217	221	PF02991	0.696
LIG_LIR_Nem_3	639	643	PF02991	0.665
LIG_LIR_Nem_3	672	676	PF02991	0.787
LIG_MYND_3	344	348	PF01753	0.495
LIG_NRBOX	759	765	PF00104	0.532
LIG_Pex14_1	601	605	PF04695	0.601
LIG_SH2_CRK	265	269	PF00017	0.634
LIG_SH2_CRK	293	297	PF00017	0.608
LIG_SH2_NCK_1	265	269	PF00017	0.634
LIG_SH2_STAP1	199	203	PF00017	0.635
LIG_SH2_STAT3	821	824	PF00017	0.386
LIG_SH2_STAT5	14	17	PF00017	0.664
LIG_SH2_STAT5	23	26	PF00017	0.533
LIG_SH2_STAT5	313	316	PF00017	0.578
LIG_SH2_STAT5	429	432	PF00017	0.474
LIG_SH2_STAT5	605	608	PF00017	0.588
LIG_SH2_STAT5	686	689	PF00017	0.595
LIG_SH2_STAT5	829	832	PF00017	0.658
LIG_SH3_3	108	114	PF00018	0.810
LIG_SH3_3	117	123	PF00018	0.661
LIG_SH3_3	292	298	PF00018	0.540
LIG_SH3_3	339	345	PF00018	0.560
LIG_SH3_3	470	476	PF00018	0.718
LIG_SH3_3	581	587	PF00018	0.516
LIG_SH3_3	6	12	PF00018	0.763
LIG_SH3_3	699	705	PF00018	0.749
LIG_SUMO_SIM_anti_2	339	345	PF11976	0.522
LIG_SUMO_SIM_anti_2	571	576	PF11976	0.561
LIG_SUMO_SIM_par_1	178	185	PF11976	0.640
LIG_SUMO_SIM_par_1	573	578	PF11976	0.759
LIG_TRAF2_1	202	205	PF00917	0.730
LIG_TRAF2_1	409	412	PF00917	0.615
LIG_TRAF2_1	519	522	PF00917	0.752
LIG_UBA3_1	242	251	PF00899	0.551
LIG_UBA3_1	343	352	PF00899	0.480
LIG_UBA3_1	763	770	PF00899	0.532
LIG_WRC_WIRS_1	673	678	PF05994	0.788
LIG_WW_1	11	14	PF00397	0.698
MOD_CDC14_SPxK_1	130	133	PF00782	0.821
MOD_CDK_SPxK_1	127	133	PF00069	0.830
MOD_CDK_SPxxK_3	465	472	PF00069	0.545
MOD_CK1_1	198	204	PF00069	0.603
MOD_CK1_1	3	9	PF00069	0.809
MOD_CK1_1	448	454	PF00069	0.632
MOD_CK1_1	566	572	PF00069	0.750
MOD_CK1_1	573	579	PF00069	0.683
MOD_CK1_1	672	678	PF00069	0.788
MOD_CK1_1	684	690	PF00069	0.555
MOD_CK1_1	714	720	PF00069	0.828
MOD_CK1_1	766	772	PF00069	0.686
MOD_CK1_1	840	846	PF00069	0.641
MOD_CK2_1	119	125	PF00069	0.656
MOD_CK2_1	198	204	PF00069	0.671
MOD_CK2_1	230	236	PF00069	0.622
MOD_CK2_1	246	252	PF00069	0.410
MOD_CK2_1	282	288	PF00069	0.547
MOD_CK2_1	385	391	PF00069	0.522
MOD_CK2_1	398	404	PF00069	0.535
MOD_CK2_1	406	412	PF00069	0.462
MOD_CK2_1	516	522	PF00069	0.794
MOD_CK2_1	643	649	PF00069	0.643
MOD_CK2_1	715	721	PF00069	0.751
MOD_CK2_1	807	813	PF00069	0.579
MOD_CK2_1	832	838	PF00069	0.464
MOD_Cter_Amidation	546	549	PF01082	0.580
MOD_Cter_Amidation	783	786	PF01082	0.743
MOD_GlcNHglycan	304	307	PF01048	0.368
MOD_GlcNHglycan	36	39	PF01048	0.644
MOD_GlcNHglycan	372	375	PF01048	0.396
MOD_GlcNHglycan	458	461	PF01048	0.741
MOD_GlcNHglycan	577	580	PF01048	0.627
MOD_GlcNHglycan	632	635	PF01048	0.611
MOD_GlcNHglycan	652	655	PF01048	0.568
MOD_GlcNHglycan	791	794	PF01048	0.759
MOD_GSK3_1	103	110	PF00069	0.727
MOD_GSK3_1	115	122	PF00069	0.628
MOD_GSK3_1	163	170	PF00069	0.466
MOD_GSK3_1	180	187	PF00069	0.488
MOD_GSK3_1	195	202	PF00069	0.459
MOD_GSK3_1	264	271	PF00069	0.705
MOD_GSK3_1	329	336	PF00069	0.599
MOD_GSK3_1	493	500	PF00069	0.702
MOD_GSK3_1	517	524	PF00069	0.675
MOD_GSK3_1	526	533	PF00069	0.702
MOD_GSK3_1	536	543	PF00069	0.521
MOD_GSK3_1	552	559	PF00069	0.708
MOD_GSK3_1	562	569	PF00069	0.702
MOD_GSK3_1	665	672	PF00069	0.692
MOD_GSK3_1	711	718	PF00069	0.745
MOD_GSK3_1	729	736	PF00069	0.657
MOD_GSK3_1	759	766	PF00069	0.544
MOD_GSK3_1	785	792	PF00069	0.710
MOD_GSK3_1	793	800	PF00069	0.648
MOD_GSK3_1	832	839	PF00069	0.617
MOD_N-GLC_1	493	498	PF02516	0.563
MOD_N-GLC_1	715	720	PF02516	0.597
MOD_NEK2_1	246	251	PF00069	0.503
MOD_NEK2_1	301	306	PF00069	0.574
MOD_NEK2_1	314	319	PF00069	0.419
MOD_NEK2_1	396	401	PF00069	0.636
MOD_NEK2_1	497	502	PF00069	0.769
MOD_NEK2_1	526	531	PF00069	0.649
MOD_NEK2_1	540	545	PF00069	0.654
MOD_NEK2_1	562	567	PF00069	0.767
MOD_NEK2_1	733	738	PF00069	0.677
MOD_NEK2_1	759	764	PF00069	0.573
MOD_NEK2_1	801	806	PF00069	0.633
MOD_NEK2_1	819	824	PF00069	0.423
MOD_NEK2_2	536	541	PF00069	0.698
MOD_NEK2_2	547	552	PF00069	0.567
MOD_PIKK_1	55	61	PF00454	0.577
MOD_PIKK_1	665	671	PF00454	0.630
MOD_PIKK_1	807	813	PF00454	0.661
MOD_PK_1	258	264	PF00069	0.473
MOD_PK_1	438	444	PF00069	0.599
MOD_PKA_1	438	444	PF00069	0.637
MOD_PKA_1	724	730	PF00069	0.574
MOD_PKA_1	785	791	PF00069	0.746
MOD_PKA_2	246	252	PF00069	0.489
MOD_PKA_2	396	402	PF00069	0.556
MOD_PKA_2	438	444	PF00069	0.702
MOD_PKA_2	448	454	PF00069	0.588
MOD_PKA_2	540	546	PF00069	0.754
MOD_PKA_2	636	642	PF00069	0.624
MOD_PKA_2	714	720	PF00069	0.770
MOD_PKA_2	724	730	PF00069	0.603
MOD_PKA_2	785	791	PF00069	0.746
MOD_PKA_2	819	825	PF00069	0.522
MOD_PKA_2	840	846	PF00069	0.719
MOD_PKB_1	420	428	PF00069	0.416
MOD_Plk_1	521	527	PF00069	0.566
MOD_Plk_2-3	385	391	PF00069	0.522
MOD_Plk_2-3	522	528	PF00069	0.564
MOD_Plk_4	282	288	PF00069	0.571
MOD_Plk_4	413	419	PF00069	0.620
MOD_Plk_4	438	444	PF00069	0.632
MOD_Plk_4	487	493	PF00069	0.622
MOD_Plk_4	570	576	PF00069	0.593
MOD_Plk_4	669	675	PF00069	0.739
MOD_Plk_4	681	687	PF00069	0.593
MOD_Plk_4	759	765	PF00069	0.542
MOD_Plk_4	797	803	PF00069	0.661
MOD_Plk_4	840	846	PF00069	0.641
MOD_ProDKin_1	107	113	PF00069	0.726
MOD_ProDKin_1	119	125	PF00069	0.649
MOD_ProDKin_1	127	133	PF00069	0.716
MOD_ProDKin_1	134	140	PF00069	0.582
MOD_ProDKin_1	465	471	PF00069	0.623
MOD_ProDKin_1	5	11	PF00069	0.755
MOD_ProDKin_1	566	572	PF00069	0.764
MOD_ProDKin_1	583	589	PF00069	0.570
MOD_SUMO_rev_2	398	407	PF00179	0.538
MOD_SUMO_rev_2	411	416	PF00179	0.538
MOD_SUMO_rev_2	808	817	PF00179	0.612
TRG_DiLeu_BaEn_1	391	396	PF01217	0.526
TRG_DiLeu_BaEn_1	52	57	PF01217	0.570
TRG_DiLeu_BaEn_4	52	58	PF01217	0.574
TRG_DiLeu_BaEn_4	521	527	PF01217	0.566
TRG_DiLeu_BaLyEn_6	511	516	PF01217	0.692
TRG_DiLeu_BaLyEn_6	588	593	PF01217	0.636
TRG_DiLeu_LyEn_5	52	57	PF01217	0.639
TRG_ENDOCYTIC_2	265	268	PF00928	0.633
TRG_ER_diArg_1	192	194	PF00400	0.568
TRG_ER_diArg_1	272	274	PF00400	0.654
TRG_ER_diArg_1	334	337	PF00400	0.570
TRG_ER_diArg_1	39	42	PF00400	0.677
TRG_ER_diArg_1	551	554	PF00400	0.743
TRG_ER_diArg_1	61	64	PF00400	0.586
TRG_ER_diArg_1	723	725	PF00400	0.598
TRG_NES_CRM1_1	143	156	PF08389	0.664
TRG_NLS_MonoExtN_4	604	611	PF00514	0.605
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.638
TRG_Pf-PMV_PEXEL_1	192	196	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.592
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.676
TRG_Pf-PMV_PEXEL_1	591	595	PF00026	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6A7	Leptomonas seymouri	37%	97%
A0A3Q8IH17	Leishmania donovani	89%	97%
A4HKJ4	Leishmania braziliensis	60%	92%
A4I826	Leishmania infantum	89%	97%
E9B2Y4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	90%