ABC transporter-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ABC transporter-like protein

Species:

Leishmania major

UniProt:

Q4Q570_LEIMA

TriTrypDb:

LmjF.32.2060 , LMJLV39_320027400 , LMJSD75_320027500

Length:

730

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4Q570

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q570

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0009987	cellular process	1	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0055085	transmembrane transport	2	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0005215	transporter activity	1	9
GO:0005488	binding	1	9
GO:0005524	ATP binding	5	9
GO:0015399	primary active transmembrane transporter activity	4	9
GO:0017076	purine nucleotide binding	4	9
GO:0022804	active transmembrane transporter activity	3	9
GO:0022857	transmembrane transporter activity	2	9
GO:0030554	adenyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032559	adenyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0042626	ATPase-coupled transmembrane transporter activity	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:0140359	ABC-type transporter activity	3	9
GO:0140657	ATP-dependent activity	1	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	555	557	PF00675	0.300
CLV_NRD_NRD_1	617	619	PF00675	0.275
CLV_PCSK_KEX2_1	555	557	PF00082	0.300
CLV_PCSK_KEX2_1	617	619	PF00082	0.244
CLV_PCSK_SKI1_1	122	126	PF00082	0.693
CLV_PCSK_SKI1_1	134	138	PF00082	0.601
CLV_PCSK_SKI1_1	172	176	PF00082	0.307
CLV_PCSK_SKI1_1	366	370	PF00082	0.364
CLV_PCSK_SKI1_1	47	51	PF00082	0.447
CLV_PCSK_SKI1_1	555	559	PF00082	0.250
CLV_PCSK_SKI1_1	617	621	PF00082	0.287
CLV_PCSK_SKI1_1	655	659	PF00082	0.287
CLV_PCSK_SKI1_1	701	705	PF00082	0.352
CLV_PCSK_SKI1_1	79	83	PF00082	0.643
DEG_APCC_DBOX_1	171	179	PF00400	0.364
DEG_APCC_DBOX_1	414	422	PF00400	0.555
DEG_APCC_DBOX_1	654	662	PF00400	0.500
DEG_SCF_FBW7_2	213	220	PF00400	0.522
DEG_SPOP_SBC_1	92	96	PF00917	0.436
DOC_ANK_TNKS_1	20	27	PF00023	0.589
DOC_CKS1_1	214	219	PF01111	0.560
DOC_CYCLIN_RxL_1	552	561	PF00134	0.384
DOC_MAPK_FxFP_2	469	472	PF00069	0.549
DOC_MAPK_gen_1	134	144	PF00069	0.412
DOC_MAPK_gen_1	552	560	PF00069	0.453
DOC_MAPK_MEF2A_6	134	142	PF00069	0.417
DOC_MAPK_MEF2A_6	172	180	PF00069	0.282
DOC_MAPK_MEF2A_6	366	375	PF00069	0.356
DOC_MAPK_MEF2A_6	682	689	PF00069	0.575
DOC_PP1_RVXF_1	120	126	PF00149	0.395
DOC_PP2B_LxvP_1	109	112	PF13499	0.449
DOC_PP2B_LxvP_1	603	606	PF13499	0.375
DOC_PP4_FxxP_1	469	472	PF00568	0.549
DOC_USP7_MATH_1	337	341	PF00917	0.555
DOC_USP7_MATH_1	358	362	PF00917	0.344
DOC_USP7_MATH_1	490	494	PF00917	0.671
DOC_USP7_MATH_1	588	592	PF00917	0.512
DOC_USP7_MATH_1	623	627	PF00917	0.500
DOC_USP7_MATH_1	92	96	PF00917	0.384
DOC_WW_Pin1_4	16	21	PF00397	0.702
DOC_WW_Pin1_4	160	165	PF00397	0.380
DOC_WW_Pin1_4	213	218	PF00397	0.556
DOC_WW_Pin1_4	8	13	PF00397	0.749
LIG_14-3-3_CanoR_1	239	248	PF00244	0.618
LIG_14-3-3_CanoR_1	301	309	PF00244	0.572
LIG_14-3-3_CanoR_1	319	324	PF00244	0.439
LIG_14-3-3_CanoR_1	36	42	PF00244	0.500
LIG_14-3-3_CanoR_1	415	419	PF00244	0.525
LIG_14-3-3_CanoR_1	420	425	PF00244	0.511
LIG_14-3-3_CanoR_1	429	434	PF00244	0.502
LIG_14-3-3_CanoR_1	617	624	PF00244	0.454
LIG_Actin_WH2_2	400	417	PF00022	0.346
LIG_Actin_WH2_2	681	698	PF00022	0.573
LIG_APCC_ABBA_1	162	167	PF00400	0.350
LIG_BIR_II_1	1	5	PF00653	0.757
LIG_BRCT_BRCA1_1	51	55	PF00533	0.364
LIG_BRCT_BRCA1_1	632	636	PF00533	0.484
LIG_Clathr_ClatBox_1	670	674	PF01394	0.458
LIG_EH_1	633	637	PF12763	0.484
LIG_eIF4E_1	183	189	PF01652	0.364
LIG_FHA_1	154	160	PF00498	0.345
LIG_FHA_1	184	190	PF00498	0.335
LIG_FHA_1	243	249	PF00498	0.510
LIG_FHA_1	272	278	PF00498	0.309
LIG_FHA_1	29	35	PF00498	0.582
LIG_FHA_1	320	326	PF00498	0.507
LIG_FHA_1	345	351	PF00498	0.553
LIG_FHA_1	363	369	PF00498	0.189
LIG_FHA_1	457	463	PF00498	0.546
LIG_FHA_1	514	520	PF00498	0.461
LIG_FHA_1	546	552	PF00498	0.503
LIG_FHA_1	675	681	PF00498	0.546
LIG_FHA_1	700	706	PF00498	0.494
LIG_FHA_1	80	86	PF00498	0.458
LIG_FHA_2	20	26	PF00498	0.645
LIG_FHA_2	242	248	PF00498	0.509
LIG_FHA_2	301	307	PF00498	0.583
LIG_FHA_2	436	442	PF00498	0.678
LIG_FHA_2	568	574	PF00498	0.433
LIG_FHA_2	609	615	PF00498	0.453
LIG_FHA_2	636	642	PF00498	0.458
LIG_FHA_2	676	682	PF00498	0.556
LIG_FHA_2	96	102	PF00498	0.583
LIG_LIR_Apic_2	468	472	PF02991	0.506
LIG_LIR_Gen_1	611	619	PF02991	0.453
LIG_LIR_Gen_1	633	643	PF02991	0.486
LIG_LIR_Nem_3	133	139	PF02991	0.391
LIG_LIR_Nem_3	468	474	PF02991	0.518
LIG_LIR_Nem_3	633	639	PF02991	0.459
LIG_LYPXL_yS_3	471	474	PF13949	0.530
LIG_SH2_CRK	357	361	PF00017	0.364
LIG_SH2_NCK_1	357	361	PF00017	0.364
LIG_SH2_SRC	165	168	PF00017	0.378
LIG_SH2_STAT3	378	381	PF00017	0.321
LIG_SH2_STAT5	165	168	PF00017	0.371
LIG_SH2_STAT5	258	261	PF00017	0.329
LIG_SH2_STAT5	312	315	PF00017	0.551
LIG_SH2_STAT5	393	396	PF00017	0.319
LIG_SH3_3	135	141	PF00018	0.426
LIG_SH3_3	469	475	PF00018	0.522
LIG_SH3_3	592	598	PF00018	0.487
LIG_SH3_3	640	646	PF00018	0.492
LIG_SUMO_SIM_anti_2	220	226	PF11976	0.566
LIG_SUMO_SIM_anti_2	274	279	PF11976	0.364
LIG_SUMO_SIM_anti_2	365	371	PF11976	0.364
LIG_SUMO_SIM_anti_2	447	453	PF11976	0.559
LIG_SUMO_SIM_anti_2	669	675	PF11976	0.458
LIG_SUMO_SIM_anti_2	683	690	PF11976	0.531
LIG_SUMO_SIM_par_1	450	457	PF11976	0.600
LIG_SUMO_SIM_par_1	47	52	PF11976	0.387
LIG_SUMO_SIM_par_1	60	65	PF11976	0.280
LIG_SUMO_SIM_par_1	669	675	PF11976	0.500
LIG_SUMO_SIM_par_1	701	707	PF11976	0.508
LIG_SUMO_SIM_par_1	717	723	PF11976	0.537
LIG_TRAF2_1	303	306	PF00917	0.588
LIG_UBA3_1	688	693	PF00899	0.504
LIG_WRC_WIRS_1	580	585	PF05994	0.453
LIG_WRC_WIRS_1	636	641	PF05994	0.487
MOD_CDK_SPK_2	16	21	PF00069	0.617
MOD_CDK_SPK_2	213	218	PF00069	0.455
MOD_CK1_1	158	164	PF00069	0.400
MOD_CK1_1	19	25	PF00069	0.699
MOD_CK1_1	242	248	PF00069	0.557
MOD_CK1_1	300	306	PF00069	0.581
MOD_CK1_1	362	368	PF00069	0.270
MOD_CK1_1	40	46	PF00069	0.503
MOD_CK1_1	406	412	PF00069	0.301
MOD_CK1_1	504	510	PF00069	0.662
MOD_CK1_1	511	517	PF00069	0.528
MOD_CK1_1	582	588	PF00069	0.486
MOD_CK1_1	95	101	PF00069	0.507
MOD_CK2_1	19	25	PF00069	0.651
MOD_CK2_1	241	247	PF00069	0.539
MOD_CK2_1	300	306	PF00069	0.587
MOD_CK2_1	435	441	PF00069	0.687
MOD_CK2_1	567	573	PF00069	0.446
MOD_CK2_1	583	589	PF00069	0.397
MOD_CK2_1	608	614	PF00069	0.453
MOD_CK2_1	635	641	PF00069	0.500
MOD_CK2_1	680	686	PF00069	0.614
MOD_CK2_1	722	728	PF00069	0.625
MOD_CK2_1	95	101	PF00069	0.451
MOD_GlcNHglycan	198	201	PF01048	0.369
MOD_GlcNHglycan	2	5	PF01048	0.614
MOD_GlcNHglycan	236	239	PF01048	0.321
MOD_GlcNHglycan	338	342	PF01048	0.386
MOD_GlcNHglycan	361	364	PF01048	0.349
MOD_GlcNHglycan	408	411	PF01048	0.298
MOD_GlcNHglycan	456	459	PF01048	0.365
MOD_GlcNHglycan	51	54	PF01048	0.260
MOD_GlcNHglycan	528	531	PF01048	0.233
MOD_GlcNHglycan	589	593	PF01048	0.240
MOD_GlcNHglycan	599	602	PF01048	0.184
MOD_GlcNHglycan	625	628	PF01048	0.300
MOD_GlcNHglycan	648	651	PF01048	0.260
MOD_GlcNHglycan	681	685	PF01048	0.348
MOD_GlcNHglycan	721	725	PF01048	0.386
MOD_GlcNHglycan	8	11	PF01048	0.531
MOD_GlcNHglycan	95	98	PF01048	0.716
MOD_GSK3_1	15	22	PF00069	0.792
MOD_GSK3_1	247	254	PF00069	0.484
MOD_GSK3_1	267	274	PF00069	0.141
MOD_GSK3_1	358	365	PF00069	0.314
MOD_GSK3_1	396	403	PF00069	0.377
MOD_GSK3_1	405	412	PF00069	0.344
MOD_GSK3_1	497	504	PF00069	0.735
MOD_GSK3_1	575	582	PF00069	0.498
MOD_GSK3_1	584	591	PF00069	0.504
MOD_GSK3_1	593	600	PF00069	0.517
MOD_GSK3_1	604	611	PF00069	0.384
MOD_GSK3_1	630	637	PF00069	0.479
MOD_GSK3_1	662	669	PF00069	0.495
MOD_GSK3_1	695	702	PF00069	0.531
MOD_GSK3_1	77	84	PF00069	0.395
MOD_GSK3_1	88	95	PF00069	0.477
MOD_N-GLC_1	350	355	PF02516	0.342
MOD_N-GLC_1	578	583	PF02516	0.236
MOD_N-GLC_1	666	671	PF02516	0.184
MOD_NEK2_1	241	246	PF00069	0.510
MOD_NEK2_1	267	272	PF00069	0.294
MOD_NEK2_1	273	278	PF00069	0.304
MOD_NEK2_1	317	322	PF00069	0.571
MOD_NEK2_1	350	355	PF00069	0.567
MOD_NEK2_1	37	42	PF00069	0.583
MOD_NEK2_1	373	378	PF00069	0.385
MOD_NEK2_1	387	392	PF00069	0.327
MOD_NEK2_1	400	405	PF00069	0.386
MOD_NEK2_1	414	419	PF00069	0.524
MOD_NEK2_1	435	440	PF00069	0.638
MOD_NEK2_1	567	572	PF00069	0.486
MOD_NEK2_1	583	588	PF00069	0.486
MOD_NEK2_1	62	67	PF00069	0.394
MOD_NEK2_1	680	685	PF00069	0.554
MOD_NEK2_1	695	700	PF00069	0.509
MOD_NEK2_1	722	727	PF00069	0.628
MOD_OFUCOSY	531	536	PF10250	0.287
MOD_PIKK_1	251	257	PF00454	0.346
MOD_PIKK_1	317	323	PF00454	0.558
MOD_PIKK_1	409	415	PF00454	0.437
MOD_PIKK_1	501	507	PF00454	0.670
MOD_PIKK_1	550	556	PF00454	0.500
MOD_PKA_1	617	623	PF00069	0.500
MOD_PKA_2	300	306	PF00069	0.556
MOD_PKA_2	344	350	PF00069	0.560
MOD_PKA_2	387	393	PF00069	0.327
MOD_PKA_2	414	420	PF00069	0.579
MOD_PKA_2	596	602	PF00069	0.384
MOD_PKA_2	617	623	PF00069	0.500
MOD_PKA_2	695	701	PF00069	0.647
MOD_Plk_1	305	311	PF00069	0.548
MOD_Plk_1	350	356	PF00069	0.529
MOD_Plk_1	511	517	PF00069	0.378
MOD_Plk_1	578	584	PF00069	0.444
MOD_Plk_1	588	594	PF00069	0.457
MOD_Plk_1	666	672	PF00069	0.487
MOD_Plk_1	680	686	PF00069	0.577
MOD_Plk_4	184	190	PF00069	0.329
MOD_Plk_4	273	279	PF00069	0.306
MOD_Plk_4	319	325	PF00069	0.532
MOD_Plk_4	37	43	PF00069	0.558
MOD_Plk_4	387	393	PF00069	0.327
MOD_Plk_4	396	402	PF00069	0.308
MOD_Plk_4	57	63	PF00069	0.342
MOD_Plk_4	635	641	PF00069	0.452
MOD_Plk_4	666	672	PF00069	0.456
MOD_Plk_4	699	705	PF00069	0.517
MOD_ProDKin_1	16	22	PF00069	0.700
MOD_ProDKin_1	160	166	PF00069	0.375
MOD_ProDKin_1	213	219	PF00069	0.556
MOD_ProDKin_1	8	14	PF00069	0.750
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.414
TRG_DiLeu_BaLyEn_6	363	368	PF01217	0.364
TRG_DiLeu_BaLyEn_6	535	540	PF01217	0.500
TRG_ENDOCYTIC_2	357	360	PF00928	0.364
TRG_ENDOCYTIC_2	39	42	PF00928	0.533
TRG_ENDOCYTIC_2	471	474	PF00928	0.530
TRG_ER_diArg_1	617	619	PF00400	0.509
TRG_Pf-PMV_PEXEL_1	239	243	PF00026	0.333
TRG_Pf-PMV_PEXEL_1	556	561	PF00026	0.184

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7P4	Leptomonas seymouri	63%	100%
A0A0S4J6G3	Bodo saltans	29%	100%
A0A1X0NU80	Trypanosomatidae	35%	100%
A0A3S5H7S2	Leishmania donovani	92%	99%
A4HKJ6	Leishmania braziliensis	78%	100%
A4I828	Leishmania infantum	92%	99%
E9B2Y6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q04473	Actinobacillus pleuropneumoniae	21%	100%
Q2NUA5	Sodalis glossinidius (strain morsitans)	24%	100%
Q2P3E7	Xanthomonas oryzae pv. oryzae (strain MAFF 311018)	21%	100%
Q56A55	Danio rerio	25%	100%
Q5E0F2	Aliivibrio fischeri (strain ATCC 700601 / ES114)	23%	100%
Q5H0H0	Xanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)	21%	100%
Q7MJ07	Vibrio vulnificus (strain YJ016)	23%	100%
Q7VL52	Haemophilus ducreyi (strain 35000HP / ATCC 700724)	21%	100%
Q9JI39	Mus musculus	28%	100%
Q9JJ59	Mus musculus	23%	96%
Q9NRK6	Homo sapiens	27%	99%
Q9PEE7	Xylella fastidiosa (strain 9a5c)	24%	100%
Q9QYJ4	Rattus norvegicus	23%	96%