CTP_transf_like domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphopantetheine adenylyltransferase, putative

Species:

Leishmania major

UniProt:

Q4Q569_LEIMA

TriTrypDb:

LmjF.32.2070 , LMJLV39_320027500 , LMJSD75_320027600

Length:

334

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q569

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q569

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006163	purine nucleotide metabolic process	5	2
GO:0006164	purine nucleotide biosynthetic process	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006753	nucleoside phosphate metabolic process	4	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009117	nucleotide metabolic process	5	2
GO:0009150	purine ribonucleotide metabolic process	6	2
GO:0009152	purine ribonucleotide biosynthetic process	7	2
GO:0009165	nucleotide biosynthetic process	6	2
GO:0009259	ribonucleotide metabolic process	5	2
GO:0009260	ribonucleotide biosynthetic process	6	2
GO:0009987	cellular process	1	2
GO:0015936	coenzyme A metabolic process	6	2
GO:0015937	coenzyme A biosynthetic process	7	2
GO:0018130	heterocycle biosynthetic process	4	2
GO:0019438	aromatic compound biosynthetic process	4	2
GO:0019637	organophosphate metabolic process	3	2
GO:0019693	ribose phosphate metabolic process	4	2
GO:0033865	nucleoside bisphosphate metabolic process	5	2
GO:0033866	nucleoside bisphosphate biosynthetic process	6	2
GO:0033875	ribonucleoside bisphosphate metabolic process	6	2
GO:0034030	ribonucleoside bisphosphate biosynthetic process	7	2
GO:0034032	purine nucleoside bisphosphate metabolic process	5	2
GO:0034033	purine nucleoside bisphosphate biosynthetic process	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034654	nucleobase-containing compound biosynthetic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0044281	small molecule metabolic process	2	2
GO:0046390	ribose phosphate biosynthetic process	5	2
GO:0046483	heterocycle metabolic process	3	2
GO:0055086	nucleobase-containing small molecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0072521	purine-containing compound metabolic process	4	2
GO:0072522	purine-containing compound biosynthetic process	5	2
GO:0090407	organophosphate biosynthetic process	4	2
GO:1901135	carbohydrate derivative metabolic process	3	2
GO:1901137	carbohydrate derivative biosynthetic process	4	2
GO:1901293	nucleoside phosphate biosynthetic process	5	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901362	organic cyclic compound biosynthetic process	4	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901566	organonitrogen compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004140	dephospho-CoA kinase activity	5	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	4
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	4
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	2
GO:0016779	nucleotidyltransferase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	227	229	PF00675	0.334
CLV_PCSK_SKI1_1	202	206	PF00082	0.282
CLV_PCSK_SKI1_1	26	30	PF00082	0.508
DEG_APCC_DBOX_1	25	33	PF00400	0.527
DEG_SCF_FBW7_1	28	34	PF00400	0.587
DEG_SPOP_SBC_1	127	131	PF00917	0.821
DOC_CKS1_1	28	33	PF01111	0.579
DOC_CYCLIN_RxL_1	23	30	PF00134	0.321
DOC_MAPK_gen_1	251	260	PF00069	0.484
DOC_MAPK_MEF2A_6	251	260	PF00069	0.487
DOC_MAPK_RevD_3	216	230	PF00069	0.534
DOC_USP7_MATH_1	126	130	PF00917	0.801
DOC_USP7_MATH_1	132	136	PF00917	0.784
DOC_USP7_MATH_1	39	43	PF00917	0.673
DOC_USP7_UBL2_3	168	172	PF12436	0.548
DOC_WW_Pin1_4	128	133	PF00397	0.805
DOC_WW_Pin1_4	27	32	PF00397	0.573
DOC_WW_Pin1_4	279	284	PF00397	0.482
DOC_WW_Pin1_4	312	317	PF00397	0.562
LIG_14-3-3_CanoR_1	217	226	PF00244	0.482
LIG_14-3-3_CanoR_1	53	63	PF00244	0.525
LIG_14-3-3_CanoR_1	78	82	PF00244	0.436
LIG_APCC_ABBA_1	154	159	PF00400	0.544
LIG_BIR_III_4	177	181	PF00653	0.555
LIG_DCNL_PONY_1	1	4	PF03556	0.368
LIG_deltaCOP1_diTrp_1	166	174	PF00928	0.515
LIG_eIF4E_1	23	29	PF01652	0.317
LIG_FHA_1	205	211	PF00498	0.485
LIG_FHA_1	23	29	PF00498	0.518
LIG_FHA_1	268	274	PF00498	0.562
LIG_FHA_1	315	321	PF00498	0.558
LIG_FHA_2	78	84	PF00498	0.499
LIG_HP1_1	3	7	PF01393	0.461
LIG_IRF3_LxIS_1	95	102	PF10401	0.504
LIG_LIR_Gen_1	68	74	PF02991	0.478
LIG_LIR_LC3C_4	277	281	PF02991	0.482
LIG_LIR_Nem_3	166	170	PF02991	0.484
LIG_LIR_Nem_3	193	197	PF02991	0.518
LIG_LIR_Nem_3	68	73	PF02991	0.450
LIG_PCNA_PIPBox_1	242	251	PF02747	0.530
LIG_Rb_pABgroove_1	151	159	PF01858	0.533
LIG_SH2_CRK	185	189	PF00017	0.432
LIG_SH2_NCK_1	157	161	PF00017	0.573
LIG_SH2_PTP2	187	190	PF00017	0.485
LIG_SH2_SRC	157	160	PF00017	0.572
LIG_SH2_SRC	87	90	PF00017	0.491
LIG_SH2_STAP1	157	161	PF00017	0.573
LIG_SH2_STAP1	89	93	PF00017	0.422
LIG_SH2_STAT5	187	190	PF00017	0.448
LIG_SH2_STAT5	70	73	PF00017	0.470
LIG_SH2_STAT5	87	90	PF00017	0.456
LIG_SH3_3	277	283	PF00018	0.471
LIG_SH3_3	310	316	PF00018	0.534
LIG_SUMO_SIM_anti_2	100	105	PF11976	0.412
LIG_SUMO_SIM_par_1	151	159	PF11976	0.575
LIG_SUMO_SIM_par_1	2	10	PF11976	0.454
LIG_TRAF2_1	119	122	PF00917	0.749
LIG_UBA3_1	28	35	PF00899	0.528
MOD_CK1_1	130	136	PF00069	0.740
MOD_CK1_1	206	212	PF00069	0.568
MOD_CK1_1	224	230	PF00069	0.529
MOD_CK1_1	234	240	PF00069	0.537
MOD_CK1_1	264	270	PF00069	0.506
MOD_CK1_1	27	33	PF00069	0.491
MOD_CK1_1	282	288	PF00069	0.489
MOD_CK1_1	322	328	PF00069	0.498
MOD_CK1_1	44	50	PF00069	0.520
MOD_CK2_1	116	122	PF00069	0.673
MOD_CK2_1	322	328	PF00069	0.452
MOD_CK2_1	52	58	PF00069	0.508
MOD_CK2_1	77	83	PF00069	0.506
MOD_GlcNHglycan	132	135	PF01048	0.749
MOD_GlcNHglycan	198	201	PF01048	0.362
MOD_GlcNHglycan	265	269	PF01048	0.296
MOD_GlcNHglycan	43	46	PF01048	0.702
MOD_GlcNHglycan	63	66	PF01048	0.287
MOD_GlcNHglycan	89	92	PF01048	0.488
MOD_GSK3_1	116	123	PF00069	0.655
MOD_GSK3_1	126	133	PF00069	0.742
MOD_GSK3_1	27	34	PF00069	0.510
MOD_NEK2_1	204	209	PF00069	0.485
MOD_NEK2_1	231	236	PF00069	0.534
MOD_NEK2_1	24	29	PF00069	0.521
MOD_NEK2_1	320	325	PF00069	0.528
MOD_NEK2_1	6	11	PF00069	0.410
MOD_NEK2_1	82	87	PF00069	0.448
MOD_NEK2_1	99	104	PF00069	0.461
MOD_PIKK_1	328	334	PF00454	0.702
MOD_PKA_2	328	334	PF00069	0.693
MOD_PKA_2	52	58	PF00069	0.528
MOD_PKA_2	77	83	PF00069	0.386
MOD_Plk_1	221	227	PF00069	0.577
MOD_Plk_1	82	88	PF00069	0.501
MOD_Plk_4	16	22	PF00069	0.414
MOD_Plk_4	221	227	PF00069	0.503
MOD_Plk_4	77	83	PF00069	0.413
MOD_ProDKin_1	128	134	PF00069	0.804
MOD_ProDKin_1	27	33	PF00069	0.585
MOD_ProDKin_1	279	285	PF00069	0.482
MOD_ProDKin_1	312	318	PF00069	0.562
TRG_ENDOCYTIC_2	185	188	PF00928	0.413
TRG_ENDOCYTIC_2	70	73	PF00928	0.446
TRG_ER_diArg_1	240	243	PF00400	0.518
TRG_NLS_MonoExtC_3	227	233	PF00514	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILA3	Leptomonas seymouri	58%	100%
A0A1X0NU95	Trypanosomatidae	35%	100%
A0A3Q8IFJ1	Leishmania donovani	93%	100%
A0A3R7M2F9	Trypanosoma rangeli	35%	100%
A4HKJ7	Leishmania braziliensis	74%	100%
A4I829	Leishmania infantum	93%	100%
D0AA94	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B2Y7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5DCC0	Trypanosoma cruzi	37%	100%