CMP/dCMP-type deaminase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cytidine and deoxycytidylate deaminase zinc-binding region, putative

Species:

Leishmania major

UniProt:

Q4Q568_LEIMA

TriTrypDb:

LmjF.32.2080 , LMJLV39_320027600 , LMJSD75_320027700

Length:

542

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q568

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q568

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	54	56	PF00675	0.520
CLV_PCSK_FUR_1	52	56	PF00082	0.501
CLV_PCSK_KEX2_1	393	395	PF00082	0.640
CLV_PCSK_KEX2_1	49	51	PF00082	0.456
CLV_PCSK_KEX2_1	54	56	PF00082	0.521
CLV_PCSK_PC1ET2_1	393	395	PF00082	0.612
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.456
CLV_PCSK_PC7_1	50	56	PF00082	0.490
CLV_PCSK_SKI1_1	280	284	PF00082	0.413
CLV_PCSK_SKI1_1	404	408	PF00082	0.482
CLV_PCSK_SKI1_1	498	502	PF00082	0.269
CLV_PCSK_SKI1_1	55	59	PF00082	0.560
DEG_APCC_DBOX_1	513	521	PF00400	0.384
DEG_Nend_UBRbox_3	1	3	PF02207	0.345
DEG_SCF_FBW7_1	69	76	PF00400	0.624
DEG_SCF_FBW7_2	380	387	PF00400	0.508
DEG_SPOP_SBC_1	101	105	PF00917	0.520
DEG_SPOP_SBC_1	356	360	PF00917	0.434
DOC_ANK_TNKS_1	183	190	PF00023	0.533
DOC_CKS1_1	70	75	PF01111	0.640
DOC_CYCLIN_yClb5_NLxxxL_5	31	40	PF00134	0.511
DOC_CYCLIN_yCln2_LP_2	407	413	PF00134	0.395
DOC_MAPK_gen_1	52	62	PF00069	0.593
DOC_MAPK_MEF2A_6	184	192	PF00069	0.464
DOC_MAPK_MEF2A_6	32	40	PF00069	0.470
DOC_PP1_RVXF_1	127	133	PF00149	0.562
DOC_PP1_RVXF_1	386	393	PF00149	0.514
DOC_PP1_RVXF_1	496	502	PF00149	0.469
DOC_PP2B_LxvP_1	255	258	PF13499	0.496
DOC_PP2B_LxvP_1	36	39	PF13499	0.473
DOC_PP4_FxxP_1	442	445	PF00568	0.605
DOC_USP7_MATH_1	101	105	PF00917	0.603
DOC_USP7_MATH_1	118	122	PF00917	0.509
DOC_USP7_MATH_1	137	141	PF00917	0.671
DOC_USP7_MATH_1	155	159	PF00917	0.336
DOC_USP7_MATH_1	175	179	PF00917	0.406
DOC_USP7_MATH_1	214	218	PF00917	0.691
DOC_USP7_MATH_1	223	227	PF00917	0.540
DOC_USP7_MATH_1	357	361	PF00917	0.438
DOC_USP7_MATH_1	450	454	PF00917	0.605
DOC_USP7_MATH_2	243	249	PF00917	0.525
DOC_WW_Pin1_4	11	16	PF00397	0.623
DOC_WW_Pin1_4	203	208	PF00397	0.647
DOC_WW_Pin1_4	317	322	PF00397	0.651
DOC_WW_Pin1_4	380	385	PF00397	0.598
DOC_WW_Pin1_4	432	437	PF00397	0.518
DOC_WW_Pin1_4	69	74	PF00397	0.681
LIG_14-3-3_CanoR_1	304	308	PF00244	0.524
LIG_14-3-3_CanoR_1	388	393	PF00244	0.518
LIG_14-3-3_CanoR_1	429	433	PF00244	0.541
LIG_14-3-3_CanoR_1	462	471	PF00244	0.554
LIG_14-3-3_CanoR_1	59	65	PF00244	0.625
LIG_BIR_III_4	107	111	PF00653	0.613
LIG_BRCT_BRCA1_1	225	229	PF00533	0.460
LIG_deltaCOP1_diTrp_1	245	253	PF00928	0.457
LIG_FHA_1	12	18	PF00498	0.601
LIG_FHA_1	269	275	PF00498	0.379
LIG_FHA_1	350	356	PF00498	0.540
LIG_FHA_1	92	98	PF00498	0.719
LIG_FHA_2	133	139	PF00498	0.659
LIG_FHA_2	455	461	PF00498	0.537
LIG_IRF3_LxIS_1	15	22	PF10401	0.429
LIG_LIR_Gen_1	226	236	PF02991	0.480
LIG_LIR_Gen_1	537	542	PF02991	0.447
LIG_LIR_Nem_3	373	379	PF02991	0.491
LIG_LIR_Nem_3	537	542	PF02991	0.447
LIG_NRBOX	76	82	PF00104	0.626
LIG_PCNA_PIPBox_1	520	529	PF02747	0.422
LIG_PDZ_Class_1	537	542	PF00595	0.468
LIG_REV1ctd_RIR_1	498	508	PF16727	0.563
LIG_SH2_CRK	376	380	PF00017	0.636
LIG_SH2_STAT5	200	203	PF00017	0.637
LIG_SH2_STAT5	376	379	PF00017	0.599
LIG_SH2_STAT5	470	473	PF00017	0.404
LIG_SH2_STAT5	478	481	PF00017	0.461
LIG_SH2_STAT5	539	542	PF00017	0.496
LIG_SH3_3	254	260	PF00018	0.528
LIG_SH3_3	344	350	PF00018	0.365
LIG_SH3_3	364	370	PF00018	0.396
LIG_SH3_3	397	403	PF00018	0.564
LIG_SH3_3	67	73	PF00018	0.630
LIG_SH3_CIN85_PxpxPR_1	254	259	PF14604	0.561
LIG_SUMO_SIM_anti_2	342	349	PF11976	0.400
LIG_SUMO_SIM_anti_2	75	81	PF11976	0.497
LIG_SUMO_SIM_par_1	144	153	PF11976	0.424
LIG_SUMO_SIM_par_1	16	23	PF11976	0.411
LIG_TRAF2_1	326	329	PF00917	0.642
MOD_CDK_SPK_2	203	208	PF00069	0.569
MOD_CK1_1	171	177	PF00069	0.485
MOD_CK1_1	202	208	PF00069	0.632
MOD_CK1_1	303	309	PF00069	0.581
MOD_CK1_1	360	366	PF00069	0.528
MOD_CK1_1	386	392	PF00069	0.545
MOD_CK1_1	435	441	PF00069	0.551
MOD_CK1_1	454	460	PF00069	0.598
MOD_CK1_1	519	525	PF00069	0.395
MOD_CK1_1	96	102	PF00069	0.627
MOD_CK2_1	132	138	PF00069	0.670
MOD_CK2_1	321	327	PF00069	0.651
MOD_CK2_1	525	531	PF00069	0.386
MOD_CK2_1	72	78	PF00069	0.571
MOD_GlcNHglycan	115	118	PF01048	0.679
MOD_GlcNHglycan	120	123	PF01048	0.584
MOD_GlcNHglycan	155	158	PF01048	0.438
MOD_GlcNHglycan	170	173	PF01048	0.546
MOD_GlcNHglycan	176	180	PF01048	0.665
MOD_GlcNHglycan	247	250	PF01048	0.577
MOD_GlcNHglycan	266	269	PF01048	0.468
MOD_GlcNHglycan	323	326	PF01048	0.539
MOD_GlcNHglycan	336	340	PF01048	0.461
MOD_GlcNHglycan	359	362	PF01048	0.476
MOD_GlcNHglycan	453	456	PF01048	0.586
MOD_GlcNHglycan	527	530	PF01048	0.373
MOD_GlcNHglycan	99	102	PF01048	0.616
MOD_GSK3_1	109	116	PF00069	0.660
MOD_GSK3_1	145	152	PF00069	0.573
MOD_GSK3_1	171	178	PF00069	0.539
MOD_GSK3_1	194	201	PF00069	0.736
MOD_GSK3_1	210	217	PF00069	0.599
MOD_GSK3_1	230	237	PF00069	0.432
MOD_GSK3_1	264	271	PF00069	0.558
MOD_GSK3_1	312	319	PF00069	0.589
MOD_GSK3_1	356	363	PF00069	0.475
MOD_GSK3_1	428	435	PF00069	0.667
MOD_GSK3_1	440	447	PF00069	0.557
MOD_GSK3_1	450	457	PF00069	0.578
MOD_GSK3_1	60	67	PF00069	0.626
MOD_GSK3_1	69	76	PF00069	0.615
MOD_GSK3_1	93	100	PF00069	0.620
MOD_N-GLC_1	464	469	PF02516	0.571
MOD_NEK2_1	491	496	PF00069	0.304
MOD_NEK2_2	361	366	PF00069	0.527
MOD_PKA_2	300	306	PF00069	0.507
MOD_PKA_2	428	434	PF00069	0.591
MOD_Plk_1	137	143	PF00069	0.574
MOD_Plk_1	386	392	PF00069	0.599
MOD_Plk_4	145	151	PF00069	0.402
MOD_Plk_4	26	32	PF00069	0.448
MOD_Plk_4	93	99	PF00069	0.600
MOD_ProDKin_1	11	17	PF00069	0.616
MOD_ProDKin_1	203	209	PF00069	0.646
MOD_ProDKin_1	317	323	PF00069	0.654
MOD_ProDKin_1	380	386	PF00069	0.597
MOD_ProDKin_1	432	438	PF00069	0.522
MOD_ProDKin_1	69	75	PF00069	0.673
MOD_SUMO_rev_2	22	27	PF00179	0.448
TRG_DiLeu_BaEn_1	336	341	PF01217	0.586
TRG_DiLeu_BaLyEn_6	126	131	PF01217	0.574
TRG_DiLeu_BaLyEn_6	401	406	PF01217	0.531
TRG_ENDOCYTIC_2	376	379	PF00928	0.633
TRG_ENDOCYTIC_2	539	542	PF00928	0.496
TRG_ER_diArg_1	50	53	PF00400	0.470
TRG_NLS_MonoExtC_3	48	53	PF00514	0.470
TRG_Pf-PMV_PEXEL_1	404	408	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXU5	Leptomonas seymouri	43%	100%
A0A3Q8IL67	Leishmania donovani	90%	100%
A4HKJ8	Leishmania braziliensis	68%	100%
A4I830	Leishmania infantum	90%	100%
E9B2Y8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%