HemK methyltransferase family member 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

eRF1 methyltransferase catalytic subunit, putative

Species:

Leishmania major

UniProt:

Q4Q567_LEIMA

TriTrypDb:

LmjF.32.2090 , LMJLV39_320027700 , LMJSD75_320027800

Length:

337

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	2
GO:0034708	methyltransferase complex	4	2
GO:0035657	eRF1 methyltransferase complex	5	2
GO:1902494	catalytic complex	2	2
GO:1990234	transferase complex	3	2

Expansion

Sequence features

Q4Q567

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q567

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0032259	methylation	2	9
GO:0043170	macromolecule metabolic process	3	9
GO:0043412	macromolecule modification	4	9
GO:0043414	macromolecule methylation	3	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0044260	obsolete cellular macromolecule metabolic process	3	9
GO:0071704	organic substance metabolic process	2	9

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0008168	methyltransferase activity	4	11
GO:0008276	protein methyltransferase activity	3	2
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	2
GO:0016740	transferase activity	2	11
GO:0016741	transferase activity, transferring one-carbon groups	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0140096	catalytic activity, acting on a protein	2	2
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.496
CLV_C14_Caspase3-7	227	231	PF00656	0.503
CLV_NRD_NRD_1	265	267	PF00675	0.402
CLV_PCSK_KEX2_1	265	267	PF00082	0.402
CLV_PCSK_SKI1_1	249	253	PF00082	0.425
CLV_PCSK_SKI1_1	71	75	PF00082	0.446
CLV_Separin_Metazoa	46	50	PF03568	0.363
DEG_APCC_KENBOX_2	274	278	PF00400	0.410
DOC_CYCLIN_RxL_1	68	77	PF00134	0.465
DOC_CYCLIN_yCln2_LP_2	155	161	PF00134	0.598
DOC_MAPK_gen_1	265	273	PF00069	0.381
DOC_MAPK_gen_1	49	59	PF00069	0.272
DOC_PP2B_LxvP_1	155	158	PF13499	0.583
DOC_PP2B_LxvP_1	73	76	PF13499	0.464
DOC_PP4_FxxP_1	216	219	PF00568	0.303
DOC_PP4_FxxP_1	334	337	PF00568	0.474
DOC_USP7_MATH_1	178	182	PF00917	0.644
DOC_WW_Pin1_4	164	169	PF00397	0.724
DOC_WW_Pin1_4	8	13	PF00397	0.423
DOC_WW_Pin1_4	87	92	PF00397	0.613
LIG_14-3-3_CanoR_1	145	155	PF00244	0.487
LIG_14-3-3_CanoR_1	203	208	PF00244	0.484
LIG_Actin_WH2_2	34	51	PF00022	0.421
LIG_BIR_II_1	1	5	PF00653	0.607
LIG_FHA_1	125	131	PF00498	0.481
LIG_FHA_1	13	19	PF00498	0.449
LIG_FHA_1	185	191	PF00498	0.578
LIG_FHA_1	278	284	PF00498	0.523
LIG_FHA_1	297	303	PF00498	0.480
LIG_FHA_1	81	87	PF00498	0.627
LIG_FHA_1	88	94	PF00498	0.463
LIG_FHA_2	123	129	PF00498	0.516
LIG_FHA_2	169	175	PF00498	0.497
LIG_FHA_2	231	237	PF00498	0.424
LIG_FHA_2	299	305	PF00498	0.532
LIG_LIR_Gen_1	33	41	PF02991	0.351
LIG_LIR_Nem_3	33	38	PF02991	0.313
LIG_NRBOX	69	75	PF00104	0.391
LIG_PCNA_TLS_4	249	256	PF02747	0.394
LIG_PTB_Apo_2	214	221	PF02174	0.305
LIG_PTB_Phospho_1	214	220	PF10480	0.302
LIG_SH2_NCK_1	143	147	PF00017	0.423
LIG_SH2_NCK_1	9	13	PF00017	0.494
LIG_SH2_PTP2	270	273	PF00017	0.395
LIG_SH2_STAP1	14	18	PF00017	0.481
LIG_SH2_STAP1	143	147	PF00017	0.447
LIG_SH2_STAT5	133	136	PF00017	0.391
LIG_SH2_STAT5	14	17	PF00017	0.364
LIG_SH2_STAT5	220	223	PF00017	0.328
LIG_SH2_STAT5	270	273	PF00017	0.302
LIG_SH2_STAT5	318	321	PF00017	0.426
LIG_SH2_STAT5	330	333	PF00017	0.352
LIG_SH3_3	101	107	PF00018	0.568
LIG_SH3_3	163	169	PF00018	0.753
LIG_SH3_3	216	222	PF00018	0.314
LIG_SH3_3	24	30	PF00018	0.356
LIG_SUMO_SIM_par_1	115	120	PF11976	0.324
LIG_SUMO_SIM_par_1	157	162	PF11976	0.620
LIG_SUMO_SIM_par_1	270	276	PF11976	0.348
LIG_TRAF2_1	82	85	PF00917	0.521
LIG_TYR_ITIM	268	273	PF00017	0.370
MOD_CK1_1	181	187	PF00069	0.623
MOD_CK1_1	2	8	PF00069	0.653
MOD_CK1_1	261	267	PF00069	0.394
MOD_CK2_1	122	128	PF00069	0.515
MOD_CK2_1	221	227	PF00069	0.404
MOD_CK2_1	294	300	PF00069	0.543
MOD_CK2_1	7	13	PF00069	0.499
MOD_GlcNHglycan	101	104	PF01048	0.644
MOD_GlcNHglycan	148	151	PF01048	0.475
MOD_GlcNHglycan	161	164	PF01048	0.691
MOD_GlcNHglycan	180	183	PF01048	0.670
MOD_GlcNHglycan	205	208	PF01048	0.529
MOD_GlcNHglycan	296	299	PF01048	0.468
MOD_GlcNHglycan	62	65	PF01048	0.300
MOD_GlcNHglycan	97	100	PF01048	0.664
MOD_GSK3_1	122	129	PF00069	0.322
MOD_GSK3_1	146	153	PF00069	0.480
MOD_GSK3_1	164	171	PF00069	0.649
MOD_GSK3_1	177	184	PF00069	0.694
MOD_GSK3_1	294	301	PF00069	0.591
MOD_GSK3_1	8	15	PF00069	0.527
MOD_GSK3_1	95	102	PF00069	0.651
MOD_N-GLC_1	277	282	PF02516	0.354
MOD_NEK2_1	119	124	PF00069	0.336
MOD_NEK2_1	134	139	PF00069	0.446
MOD_NEK2_1	183	188	PF00069	0.505
MOD_NEK2_1	294	299	PF00069	0.491
MOD_NEK2_1	47	52	PF00069	0.437
MOD_NEK2_2	298	303	PF00069	0.411
MOD_PIKK_1	230	236	PF00454	0.347
MOD_PIKK_1	80	86	PF00454	0.617
MOD_PKA_2	134	140	PF00069	0.541
MOD_PKA_2	18	24	PF00069	0.363
MOD_PKA_2	294	300	PF00069	0.558
MOD_PKA_2	316	322	PF00069	0.399
MOD_Plk_1	119	125	PF00069	0.363
MOD_Plk_4	126	132	PF00069	0.453
MOD_Plk_4	134	140	PF00069	0.407
MOD_Plk_4	258	264	PF00069	0.386
MOD_Plk_4	31	37	PF00069	0.364
MOD_Plk_4	321	327	PF00069	0.421
MOD_ProDKin_1	164	170	PF00069	0.729
MOD_ProDKin_1	8	14	PF00069	0.415
MOD_ProDKin_1	87	93	PF00069	0.614
MOD_SUMO_for_1	302	305	PF00179	0.472
TRG_DiLeu_BaEn_2	30	36	PF01217	0.333
TRG_ENDOCYTIC_2	143	146	PF00928	0.447
TRG_ENDOCYTIC_2	270	273	PF00928	0.426
TRG_ER_diArg_1	246	249	PF00400	0.334
TRG_ER_diArg_1	326	329	PF00400	0.383
TRG_Pf-PMV_PEXEL_1	254	258	PF00026	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6A8	Leptomonas seymouri	58%	94%
A0A0S4JAA0	Bodo saltans	38%	100%
A0A3Q8IFZ7	Leishmania donovani	91%	100%
A0A3R7LIX6	Trypanosoma rangeli	41%	100%
A4HKJ9	Leishmania braziliensis	80%	100%
A4I831	Leishmania infantum	92%	100%
D0AA96	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B2Y9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BBL2	Trypanosoma cruzi	39%	100%