FCP1 homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q565_LEIMA

TriTrypDb:

LmjF.32.2110 , LMJLV39_320027900 , LMJSD75_320028000

Length:

871

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q565

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q565

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	547	551	PF00656	0.755
CLV_C14_Caspase3-7	630	634	PF00656	0.770
CLV_NRD_NRD_1	148	150	PF00675	0.700
CLV_NRD_NRD_1	253	255	PF00675	0.544
CLV_NRD_NRD_1	390	392	PF00675	0.615
CLV_NRD_NRD_1	434	436	PF00675	0.720
CLV_NRD_NRD_1	600	602	PF00675	0.751
CLV_NRD_NRD_1	672	674	PF00675	0.684
CLV_NRD_NRD_1	70	72	PF00675	0.815
CLV_NRD_NRD_1	869	871	PF00675	0.577
CLV_PCSK_KEX2_1	148	150	PF00082	0.707
CLV_PCSK_KEX2_1	253	255	PF00082	0.544
CLV_PCSK_KEX2_1	434	436	PF00082	0.728
CLV_PCSK_KEX2_1	600	602	PF00082	0.788
CLV_PCSK_KEX2_1	672	674	PF00082	0.684
CLV_PCSK_KEX2_1	72	74	PF00082	0.713
CLV_PCSK_KEX2_1	868	870	PF00082	0.731
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.544
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.676
CLV_PCSK_PC1ET2_1	868	870	PF00082	0.731
CLV_PCSK_SKI1_1	143	147	PF00082	0.546
CLV_PCSK_SKI1_1	193	197	PF00082	0.590
CLV_PCSK_SKI1_1	217	221	PF00082	0.717
CLV_PCSK_SKI1_1	255	259	PF00082	0.746
CLV_PCSK_SKI1_1	313	317	PF00082	0.698
CLV_PCSK_SKI1_1	465	469	PF00082	0.667
CLV_PCSK_SKI1_1	576	580	PF00082	0.757
CLV_PCSK_SKI1_1	590	594	PF00082	0.588
CLV_PCSK_SKI1_1	672	676	PF00082	0.691
CLV_PCSK_SKI1_1	716	720	PF00082	0.714
CLV_PCSK_SKI1_1	777	781	PF00082	0.675
CLV_PCSK_SKI1_1	831	835	PF00082	0.585
DEG_SCF_FBW7_1	127	132	PF00400	0.745
DEG_SCF_FBW7_1	84	90	PF00400	0.551
DEG_SCF_TRCP1_1	31	37	PF00400	0.672
DEG_SPOP_SBC_1	47	51	PF00917	0.688
DEG_SPOP_SBC_1	529	533	PF00917	0.797
DEG_SPOP_SBC_1	678	682	PF00917	0.681
DOC_CKS1_1	84	89	PF01111	0.551
DOC_CYCLIN_RxL_1	190	201	PF00134	0.581
DOC_CYCLIN_RxL_1	350	363	PF00134	0.605
DOC_CYCLIN_RxL_1	813	822	PF00134	0.591
DOC_CYCLIN_RxL_1	828	838	PF00134	0.586
DOC_CYCLIN_yCln2_LP_2	119	122	PF00134	0.648
DOC_CYCLIN_yCln2_LP_2	618	624	PF00134	0.539
DOC_MAPK_gen_1	146	155	PF00069	0.723
DOC_MAPK_HePTP_8	652	664	PF00069	0.678
DOC_MAPK_JIP1_4	149	155	PF00069	0.728
DOC_MAPK_MEF2A_6	655	664	PF00069	0.652
DOC_PP1_RVXF_1	775	781	PF00149	0.444
DOC_PP1_RVXF_1	829	835	PF00149	0.610
DOC_PP2B_LxvP_1	119	122	PF13499	0.751
DOC_PP2B_LxvP_1	664	667	PF13499	0.767
DOC_PP4_FxxP_1	118	121	PF00568	0.589
DOC_PP4_FxxP_1	375	378	PF00568	0.730
DOC_PP4_FxxP_1	820	823	PF00568	0.587
DOC_USP7_MATH_1	129	133	PF00917	0.797
DOC_USP7_MATH_1	244	248	PF00917	0.781
DOC_USP7_MATH_1	275	279	PF00917	0.741
DOC_USP7_MATH_1	29	33	PF00917	0.629
DOC_USP7_MATH_1	370	374	PF00917	0.670
DOC_USP7_MATH_1	400	404	PF00917	0.684
DOC_USP7_MATH_1	47	51	PF00917	0.488
DOC_USP7_MATH_1	504	508	PF00917	0.772
DOC_USP7_MATH_1	511	515	PF00917	0.664
DOC_USP7_MATH_1	529	533	PF00917	0.534
DOC_USP7_MATH_1	678	682	PF00917	0.720
DOC_USP7_MATH_1	93	97	PF00917	0.656
DOC_USP7_UBL2_3	388	392	PF12436	0.620
DOC_USP7_UBL2_3	716	720	PF12436	0.636
DOC_USP7_UBL2_3	777	781	PF12436	0.644
DOC_WW_Pin1_4	113	118	PF00397	0.665
DOC_WW_Pin1_4	123	128	PF00397	0.674
DOC_WW_Pin1_4	333	338	PF00397	0.750
DOC_WW_Pin1_4	500	505	PF00397	0.634
DOC_WW_Pin1_4	583	588	PF00397	0.709
DOC_WW_Pin1_4	591	596	PF00397	0.764
DOC_WW_Pin1_4	646	651	PF00397	0.614
DOC_WW_Pin1_4	66	71	PF00397	0.796
DOC_WW_Pin1_4	83	88	PF00397	0.666
LIG_14-3-3_CanoR_1	133	142	PF00244	0.760
LIG_14-3-3_CanoR_1	254	258	PF00244	0.566
LIG_14-3-3_CanoR_1	313	318	PF00244	0.677
LIG_14-3-3_CanoR_1	600	608	PF00244	0.791
LIG_14-3-3_CanoR_1	679	688	PF00244	0.806
LIG_14-3-3_CanoR_1	690	699	PF00244	0.774
LIG_14-3-3_CanoR_1	708	715	PF00244	0.527
LIG_14-3-3_CanoR_1	786	792	PF00244	0.573
LIG_APCC_ABBA_1	216	221	PF00400	0.723
LIG_APCC_ABBA_1	817	822	PF00400	0.595
LIG_BIR_II_1	1	5	PF00653	0.658
LIG_BRCT_BRCA1_1	31	35	PF00533	0.769
LIG_BRCT_BRCA1_1	372	376	PF00533	0.679
LIG_BRCT_BRCA1_1	406	410	PF00533	0.561
LIG_BRCT_BRCA1_1	726	730	PF00533	0.596
LIG_deltaCOP1_diTrp_1	404	410	PF00928	0.567
LIG_eIF4E_1	654	660	PF01652	0.672
LIG_FHA_1	1	7	PF00498	0.702
LIG_FHA_1	114	120	PF00498	0.693
LIG_FHA_1	307	313	PF00498	0.624
LIG_FHA_1	380	386	PF00498	0.602
LIG_FHA_1	47	53	PF00498	0.691
LIG_FHA_1	471	477	PF00498	0.649
LIG_FHA_1	541	547	PF00498	0.732
LIG_FHA_1	591	597	PF00498	0.843
LIG_FHA_1	642	648	PF00498	0.675
LIG_FHA_1	72	78	PF00498	0.745
LIG_FHA_1	753	759	PF00498	0.667
LIG_FHA_1	792	798	PF00498	0.476
LIG_FHA_1	824	830	PF00498	0.581
LIG_FHA_2	225	231	PF00498	0.570
LIG_FHA_2	314	320	PF00498	0.789
LIG_FHA_2	545	551	PF00498	0.735
LIG_IRF3_LxIS_1	421	428	PF10401	0.556
LIG_LIR_Apic_2	116	121	PF02991	0.581
LIG_LIR_Apic_2	373	378	PF02991	0.725
LIG_LIR_Gen_1	256	262	PF02991	0.657
LIG_LIR_Gen_1	402	411	PF02991	0.571
LIG_LIR_Gen_1	446	454	PF02991	0.614
LIG_LIR_Nem_3	256	261	PF02991	0.757
LIG_LIR_Nem_3	284	290	PF02991	0.583
LIG_LIR_Nem_3	402	408	PF02991	0.573
LIG_LIR_Nem_3	446	450	PF02991	0.656
LIG_LIR_Nem_3	605	611	PF02991	0.621
LIG_LIR_Nem_3	651	657	PF02991	0.626
LIG_LIR_Nem_3	668	674	PF02991	0.559
LIG_LIR_Nem_3	693	698	PF02991	0.782
LIG_LIR_Nem_3	712	718	PF02991	0.582
LIG_LIR_Nem_3	774	779	PF02991	0.483
LIG_LIR_Nem_3	96	101	PF02991	0.543
LIG_MLH1_MIPbox_1	372	376	PF16413	0.679
LIG_MLH1_MIPbox_1	406	410	PF16413	0.561
LIG_MYND_1	117	121	PF01753	0.580
LIG_PCNA_PIPBox_1	436	445	PF02747	0.718
LIG_PCNA_PIPBox_1	688	697	PF02747	0.563
LIG_PCNA_yPIPBox_3	193	206	PF02747	0.610
LIG_PCNA_yPIPBox_3	434	443	PF02747	0.720
LIG_Pex14_1	405	409	PF04695	0.563
LIG_Pex14_2	257	261	PF04695	0.527
LIG_Pex14_2	775	779	PF04695	0.587
LIG_REV1ctd_RIR_1	777	785	PF16727	0.445
LIG_SH2_CRK	671	675	PF00017	0.685
LIG_SH2_SRC	16	19	PF00017	0.617
LIG_SH2_SRC	43	46	PF00017	0.792
LIG_SH2_STAP1	16	20	PF00017	0.487
LIG_SH2_STAP1	48	52	PF00017	0.663
LIG_SH2_STAT3	423	426	PF00017	0.631
LIG_SH2_STAT3	698	701	PF00017	0.662
LIG_SH2_STAT3	812	815	PF00017	0.681
LIG_SH2_STAT5	236	239	PF00017	0.703
LIG_SH2_STAT5	43	46	PF00017	0.792
LIG_SH2_STAT5	447	450	PF00017	0.618
LIG_SH2_STAT5	48	51	PF00017	0.704
LIG_SH2_STAT5	698	701	PF00017	0.662
LIG_SH2_STAT5	721	724	PF00017	0.520
LIG_SH2_STAT5	812	815	PF00017	0.554
LIG_SH2_STAT5	824	827	PF00017	0.475
LIG_SH2_STAT5	837	840	PF00017	0.549
LIG_SH3_2	67	72	PF14604	0.796
LIG_SH3_3	144	150	PF00018	0.726
LIG_SH3_3	39	45	PF00018	0.678
LIG_SH3_3	560	566	PF00018	0.653
LIG_SH3_3	618	624	PF00018	0.663
LIG_SH3_3	64	70	PF00018	0.804
LIG_SH3_3	644	650	PF00018	0.741
LIG_SH3_3	696	702	PF00018	0.684
LIG_SH3_3	755	761	PF00018	0.647
LIG_SH3_3	81	87	PF00018	0.699
LIG_SUMO_SIM_anti_2	18	24	PF11976	0.485
LIG_SUMO_SIM_par_1	99	105	PF11976	0.782
LIG_TRAF2_1	321	324	PF00917	0.675
LIG_TRFH_1	620	624	PF08558	0.538
LIG_TYR_ITIM	652	657	PF00017	0.664
LIG_UBA3_1	430	438	PF00899	0.597
LIG_WRC_WIRS_1	372	377	PF05994	0.721
MOD_CDC14_SPxK_1	69	72	PF00782	0.803
MOD_CDK_SPK_2	66	71	PF00069	0.734
MOD_CDK_SPxK_1	66	72	PF00069	0.799
MOD_CDK_SPxxK_3	583	590	PF00069	0.721
MOD_CDK_SPxxK_3	66	73	PF00069	0.685
MOD_CK1_1	165	171	PF00069	0.755
MOD_CK1_1	198	204	PF00069	0.625
MOD_CK1_1	276	282	PF00069	0.738
MOD_CK1_1	371	377	PF00069	0.612
MOD_CK1_1	379	385	PF00069	0.605
MOD_CK1_1	46	52	PF00069	0.724
MOD_CK1_1	503	509	PF00069	0.731
MOD_CK1_1	532	538	PF00069	0.654
MOD_CK1_1	541	547	PF00069	0.736
MOD_CK1_1	639	645	PF00069	0.738
MOD_CK1_1	693	699	PF00069	0.710
MOD_CK1_1	75	81	PF00069	0.783
MOD_CK2_1	313	319	PF00069	0.706
MOD_CK2_1	511	517	PF00069	0.816
MOD_CK2_1	843	849	PF00069	0.723
MOD_CK2_1	99	105	PF00069	0.782
MOD_DYRK1A_RPxSP_1	66	70	PF00069	0.690
MOD_GlcNHglycan	164	167	PF01048	0.694
MOD_GlcNHglycan	186	189	PF01048	0.744
MOD_GlcNHglycan	241	244	PF01048	0.703
MOD_GlcNHglycan	275	278	PF01048	0.796
MOD_GlcNHglycan	306	309	PF01048	0.704
MOD_GlcNHglycan	31	34	PF01048	0.769
MOD_GlcNHglycan	324	329	PF01048	0.616
MOD_GlcNHglycan	45	48	PF01048	0.556
MOD_GlcNHglycan	452	455	PF01048	0.609
MOD_GlcNHglycan	506	509	PF01048	0.791
MOD_GlcNHglycan	526	529	PF01048	0.537
MOD_GlcNHglycan	532	535	PF01048	0.618
MOD_GlcNHglycan	543	546	PF01048	0.600
MOD_GlcNHglycan	58	61	PF01048	0.638
MOD_GlcNHglycan	682	685	PF01048	0.729
MOD_GlcNHglycan	79	82	PF01048	0.721
MOD_GlcNHglycan	797	800	PF01048	0.603
MOD_GSK3_1	123	130	PF00069	0.810
MOD_GSK3_1	134	141	PF00069	0.682
MOD_GSK3_1	158	165	PF00069	0.746
MOD_GSK3_1	184	191	PF00069	0.640
MOD_GSK3_1	220	227	PF00069	0.677
MOD_GSK3_1	230	237	PF00069	0.712
MOD_GSK3_1	239	246	PF00069	0.712
MOD_GSK3_1	275	282	PF00069	0.721
MOD_GSK3_1	335	342	PF00069	0.733
MOD_GSK3_1	395	402	PF00069	0.579
MOD_GSK3_1	43	50	PF00069	0.687
MOD_GSK3_1	495	502	PF00069	0.716
MOD_GSK3_1	513	520	PF00069	0.658
MOD_GSK3_1	524	531	PF00069	0.591
MOD_GSK3_1	532	539	PF00069	0.683
MOD_GSK3_1	540	547	PF00069	0.697
MOD_GSK3_1	62	69	PF00069	0.727
MOD_GSK3_1	638	645	PF00069	0.745
MOD_GSK3_1	646	653	PF00069	0.625
MOD_GSK3_1	673	680	PF00069	0.695
MOD_GSK3_1	71	78	PF00069	0.570
MOD_GSK3_1	787	794	PF00069	0.637
MOD_GSK3_1	83	90	PF00069	0.627
MOD_GSK3_1	835	842	PF00069	0.646
MOD_GSK3_1	851	858	PF00069	0.545
MOD_N-GLC_1	339	344	PF02516	0.689
MOD_N-GLC_1	413	418	PF02516	0.609
MOD_N-GLC_1	484	489	PF02516	0.701
MOD_NEK2_1	134	139	PF00069	0.813
MOD_NEK2_1	162	167	PF00069	0.661
MOD_NEK2_1	184	189	PF00069	0.623
MOD_NEK2_1	195	200	PF00069	0.605
MOD_NEK2_1	220	225	PF00069	0.737
MOD_NEK2_1	449	454	PF00069	0.613
MOD_NEK2_1	636	641	PF00069	0.816
MOD_NEK2_1	77	82	PF00069	0.672
MOD_NEK2_1	787	792	PF00069	0.629
MOD_NEK2_2	48	53	PF00069	0.685
MOD_NEK2_2	725	730	PF00069	0.699
MOD_PIKK_1	195	201	PF00454	0.604
MOD_PK_1	495	501	PF00069	0.695
MOD_PK_1	72	78	PF00069	0.706
MOD_PKA_1	253	259	PF00069	0.528
MOD_PKA_1	71	77	PF00069	0.749
MOD_PKA_2	134	140	PF00069	0.729
MOD_PKA_2	176	182	PF00069	0.715
MOD_PKA_2	221	227	PF00069	0.786
MOD_PKA_2	230	236	PF00069	0.666
MOD_PKA_2	253	259	PF00069	0.632
MOD_PKA_2	379	385	PF00069	0.605
MOD_PKA_2	485	491	PF00069	0.767
MOD_PKA_2	541	547	PF00069	0.713
MOD_PKA_2	602	608	PF00069	0.724
MOD_PKA_2	678	684	PF00069	0.722
MOD_PKA_2	72	78	PF00069	0.630
MOD_PKA_2	746	752	PF00069	0.753
MOD_PKA_2	764	770	PF00069	0.545
MOD_Plk_1	158	164	PF00069	0.626
MOD_Plk_1	324	330	PF00069	0.812
MOD_Plk_1	339	345	PF00069	0.551
MOD_Plk_1	465	471	PF00069	0.534
MOD_Plk_1	725	731	PF00069	0.703
MOD_Plk_2-3	295	301	PF00069	0.643
MOD_Plk_4	158	164	PF00069	0.626
MOD_Plk_4	253	259	PF00069	0.723
MOD_Plk_4	306	312	PF00069	0.614
MOD_Plk_4	371	377	PF00069	0.612
MOD_Plk_4	404	410	PF00069	0.567
MOD_Plk_4	559	565	PF00069	0.640
MOD_Plk_4	642	648	PF00069	0.753
MOD_Plk_4	72	78	PF00069	0.693
MOD_Plk_4	725	731	PF00069	0.643
MOD_Plk_4	764	770	PF00069	0.538
MOD_Plk_4	99	105	PF00069	0.704
MOD_ProDKin_1	113	119	PF00069	0.669
MOD_ProDKin_1	123	129	PF00069	0.672
MOD_ProDKin_1	333	339	PF00069	0.751
MOD_ProDKin_1	500	506	PF00069	0.636
MOD_ProDKin_1	583	589	PF00069	0.709
MOD_ProDKin_1	591	597	PF00069	0.763
MOD_ProDKin_1	646	652	PF00069	0.614
MOD_ProDKin_1	66	72	PF00069	0.799
MOD_ProDKin_1	83	89	PF00069	0.665
MOD_SUMO_rev_2	111	116	PF00179	0.729
MOD_SUMO_rev_2	28	37	PF00179	0.754
MOD_SUMO_rev_2	344	351	PF00179	0.665
MOD_SUMO_rev_2	573	578	PF00179	0.719
TRG_DiLeu_BaEn_3	324	330	PF01217	0.696
TRG_DiLeu_BaEn_4	517	523	PF01217	0.658
TRG_ENDOCYTIC_2	16	19	PF00928	0.617
TRG_ENDOCYTIC_2	390	393	PF00928	0.608
TRG_ENDOCYTIC_2	440	443	PF00928	0.718
TRG_ENDOCYTIC_2	447	450	PF00928	0.604
TRG_ENDOCYTIC_2	608	611	PF00928	0.616
TRG_ENDOCYTIC_2	654	657	PF00928	0.607
TRG_ENDOCYTIC_2	671	674	PF00928	0.686
TRG_ENDOCYTIC_2	715	718	PF00928	0.568
TRG_ENDOCYTIC_2	776	779	PF00928	0.614
TRG_ENDOCYTIC_2	811	814	PF00928	0.527
TRG_ER_diArg_1	133	136	PF00400	0.733
TRG_ER_diArg_1	147	149	PF00400	0.625
TRG_ER_diArg_1	433	435	PF00400	0.635
TRG_ER_diArg_1	600	603	PF00400	0.635
TRG_ER_diArg_1	671	673	PF00400	0.674
TRG_ER_diArg_1	70	73	PF00400	0.705
TRG_ER_diArg_1	762	765	PF00400	0.740
TRG_ER_diLys_1	867	871	PF00400	0.808
TRG_NES_CRM1_1	417	429	PF08389	0.592
TRG_NLS_Bipartite_1	852	871	PF00514	0.700
TRG_NLS_MonoCore_2	251	256	PF00514	0.544
TRG_NLS_MonoCore_2	866	871	PF00514	0.730
TRG_NLS_MonoExtN_4	252	257	PF00514	0.578
TRG_NLS_MonoExtN_4	68	75	PF00514	0.640
TRG_NLS_MonoExtN_4	864	871	PF00514	0.728
TRG_Pf-PMV_PEXEL_1	831	835	PF00026	0.585

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6P5	Leptomonas seymouri	47%	100%
A0A3Q8IG94	Leishmania donovani	91%	100%
A4HKK1	Leishmania braziliensis	67%	99%
A4I833	Leishmania infantum	91%	100%
E9B2Z1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%