Lipase_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q564_LEIMA

TriTrypDb:

LmjF.32.2120 , LMJLV39_320028000 , LMJSD75_320028100

Length:

501

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	16
GO:0110165	cellular anatomical entity	1	16

Expansion

Sequence features

Q4Q564

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q564

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.557
CLV_NRD_NRD_1	349	351	PF00675	0.471
CLV_PCSK_KEX2_1	204	206	PF00082	0.408
CLV_PCSK_KEX2_1	349	351	PF00082	0.400
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.364
CLV_PCSK_PC7_1	345	351	PF00082	0.393
CLV_PCSK_SKI1_1	245	249	PF00082	0.444
CLV_PCSK_SKI1_1	317	321	PF00082	0.398
CLV_PCSK_SKI1_1	39	43	PF00082	0.398
DEG_Nend_UBRbox_3	1	3	PF02207	0.602
DOC_CDC14_PxL_1	114	122	PF14671	0.603
DOC_CYCLIN_RxL_1	356	365	PF00134	0.530
DOC_MAPK_DCC_7	457	465	PF00069	0.296
DOC_MAPK_MEF2A_6	219	226	PF00069	0.563
DOC_MAPK_MEF2A_6	419	428	PF00069	0.567
DOC_MAPK_MEF2A_6	457	465	PF00069	0.296
DOC_PP1_RVXF_1	315	321	PF00149	0.499
DOC_PP1_RVXF_1	357	364	PF00149	0.530
DOC_PP1_RVXF_1	92	98	PF00149	0.601
DOC_PP4_FxxP_1	168	171	PF00568	0.430
DOC_PP4_FxxP_1	413	416	PF00568	0.510
DOC_USP7_MATH_1	86	90	PF00917	0.423
LIG_14-3-3_CanoR_1	489	495	PF00244	0.639
LIG_14-3-3_CanoR_1	53	58	PF00244	0.626
LIG_14-3-3_CanoR_1	94	98	PF00244	0.617
LIG_Actin_WH2_2	4	19	PF00022	0.620
LIG_APCC_ABBA_1	38	43	PF00400	0.530
LIG_BRCT_BRCA1_1	162	166	PF00533	0.364
LIG_BRCT_BRCA1_1	4	8	PF00533	0.612
LIG_FHA_1	155	161	PF00498	0.419
LIG_FHA_1	25	31	PF00498	0.605
LIG_FHA_1	307	313	PF00498	0.338
LIG_FHA_1	342	348	PF00498	0.684
LIG_FHA_1	356	362	PF00498	0.444
LIG_FHA_1	371	377	PF00498	0.423
LIG_FHA_1	387	393	PF00498	0.264
LIG_FHA_1	476	482	PF00498	0.435
LIG_FHA_1	90	96	PF00498	0.613
LIG_FHA_2	1	7	PF00498	0.611
LIG_FHA_2	442	448	PF00498	0.320
LIG_GBD_Chelix_1	473	481	PF00786	0.460
LIG_IRF3_LxIS_1	276	283	PF10401	0.290
LIG_LIR_Apic_2	456	461	PF02991	0.426
LIG_LIR_Gen_1	106	115	PF02991	0.509
LIG_LIR_Gen_1	128	137	PF02991	0.577
LIG_LIR_Gen_1	153	164	PF02991	0.402
LIG_LIR_Gen_1	232	240	PF02991	0.547
LIG_LIR_Gen_1	26	36	PF02991	0.558
LIG_LIR_Gen_1	278	285	PF02991	0.459
LIG_LIR_Gen_1	288	299	PF02991	0.425
LIG_LIR_Gen_1	5	16	PF02991	0.603
LIG_LIR_Gen_1	96	105	PF02991	0.563
LIG_LIR_LC3C_4	373	378	PF02991	0.309
LIG_LIR_Nem_3	106	111	PF02991	0.545
LIG_LIR_Nem_3	116	120	PF02991	0.544
LIG_LIR_Nem_3	128	132	PF02991	0.595
LIG_LIR_Nem_3	146	150	PF02991	0.262
LIG_LIR_Nem_3	215	221	PF02991	0.629
LIG_LIR_Nem_3	232	236	PF02991	0.438
LIG_LIR_Nem_3	246	250	PF02991	0.494
LIG_LIR_Nem_3	26	31	PF02991	0.558
LIG_LIR_Nem_3	278	282	PF02991	0.395
LIG_LIR_Nem_3	288	294	PF02991	0.385
LIG_LIR_Nem_3	365	370	PF02991	0.368
LIG_LIR_Nem_3	483	488	PF02991	0.616
LIG_LIR_Nem_3	5	11	PF02991	0.567
LIG_LYPXL_yS_3	117	120	PF13949	0.539
LIG_MAD2	345	353	PF02301	0.580
LIG_NRBOX	476	482	PF00104	0.459
LIG_PCNA_PIPBox_1	273	282	PF02747	0.485
LIG_PCNA_yPIPBox_3	273	287	PF02747	0.502
LIG_PCNA_yPIPBox_3	34	46	PF02747	0.596
LIG_PCNA_yPIPBox_3	486	499	PF02747	0.663
LIG_PCNA_yPIPBox_3	53	66	PF02747	0.532
LIG_PDZ_Class_2	496	501	PF00595	0.569
LIG_Pex14_1	162	166	PF04695	0.366
LIG_Pex14_2	129	133	PF04695	0.646
LIG_Pex14_2	364	368	PF04695	0.444
LIG_Pex14_2	413	417	PF04695	0.575
LIG_Pex14_2	451	455	PF04695	0.489
LIG_PTB_Apo_2	262	269	PF02174	0.439
LIG_PTB_Apo_2	411	418	PF02174	0.354
LIG_REV1ctd_RIR_1	245	255	PF16727	0.535
LIG_SH2_CRK	269	273	PF00017	0.428
LIG_SH2_CRK	315	319	PF00017	0.456
LIG_SH2_CRK	397	401	PF00017	0.345
LIG_SH2_CRK	438	442	PF00017	0.478
LIG_SH2_GRB2like	206	209	PF00017	0.651
LIG_SH2_GRB2like	412	415	PF00017	0.529
LIG_SH2_GRB2like	438	441	PF00017	0.546
LIG_SH2_NCK_1	269	273	PF00017	0.374
LIG_SH2_NCK_1	438	442	PF00017	0.325
LIG_SH2_PTP2	110	113	PF00017	0.608
LIG_SH2_PTP2	140	143	PF00017	0.470
LIG_SH2_PTP2	233	236	PF00017	0.518
LIG_SH2_SRC	238	241	PF00017	0.536
LIG_SH2_SRC	291	294	PF00017	0.399
LIG_SH2_SRC	438	441	PF00017	0.599
LIG_SH2_STAP1	206	210	PF00017	0.566
LIG_SH2_STAP1	227	231	PF00017	0.603
LIG_SH2_STAP1	238	242	PF00017	0.635
LIG_SH2_STAT3	206	209	PF00017	0.651
LIG_SH2_STAT5	110	113	PF00017	0.606
LIG_SH2_STAT5	119	122	PF00017	0.578
LIG_SH2_STAT5	140	143	PF00017	0.379
LIG_SH2_STAT5	184	187	PF00017	0.331
LIG_SH2_STAT5	188	191	PF00017	0.330
LIG_SH2_STAT5	233	236	PF00017	0.495
LIG_SH2_STAT5	291	294	PF00017	0.403
LIG_SH2_STAT5	367	370	PF00017	0.356
LIG_SH2_STAT5	412	415	PF00017	0.667
LIG_SH2_STAT5	498	501	PF00017	0.606
LIG_SH2_STAT5	83	86	PF00017	0.509
LIG_SH3_1	219	225	PF00018	0.554
LIG_SH3_3	219	225	PF00018	0.544
LIG_SH3_3	447	453	PF00018	0.424
LIG_SUMO_SIM_anti_2	109	116	PF11976	0.572
LIG_SUMO_SIM_anti_2	304	309	PF11976	0.309
LIG_SUMO_SIM_anti_2	373	378	PF11976	0.426
LIG_SUMO_SIM_anti_2	404	410	PF11976	0.374
LIG_SUMO_SIM_par_1	150	155	PF11976	0.400
LIG_SUMO_SIM_par_1	377	382	PF11976	0.543
LIG_TYR_ITIM	115	120	PF00017	0.604
LIG_TYR_ITIM	138	143	PF00017	0.444
LIG_TYR_ITIM	231	236	PF00017	0.508
LIG_TYR_ITIM	410	415	PF00017	0.408
LIG_TYR_ITIM	436	441	PF00017	0.309
LIG_TYR_ITSM	363	370	PF00017	0.444
LIG_UBA3_1	12	17	PF00899	0.624
LIG_UBA3_1	120	126	PF00899	0.627
LIG_WRC_WIRS_1	276	281	PF05994	0.351
MOD_CK1_1	232	238	PF00069	0.460
MOD_CK1_1	334	340	PF00069	0.665
MOD_CK1_1	89	95	PF00069	0.614
MOD_CK2_1	441	447	PF00069	0.327
MOD_GlcNHglycan	105	108	PF01048	0.345
MOD_GlcNHglycan	239	243	PF01048	0.421
MOD_GlcNHglycan	31	34	PF01048	0.387
MOD_GlcNHglycan	43	46	PF01048	0.328
MOD_GlcNHglycan	76	79	PF01048	0.432
MOD_GSK3_1	12	19	PF00069	0.606
MOD_GSK3_1	139	146	PF00069	0.410
MOD_GSK3_1	150	157	PF00069	0.402
MOD_GSK3_1	188	195	PF00069	0.440
MOD_GSK3_1	331	338	PF00069	0.634
MOD_GSK3_1	351	358	PF00069	0.613
MOD_GSK3_1	382	389	PF00069	0.405
MOD_GSK3_1	86	93	PF00069	0.524
MOD_N-GLC_1	255	260	PF02516	0.290
MOD_N-GLC_2	265	267	PF02516	0.345
MOD_N-GLC_2	326	328	PF02516	0.356
MOD_NEK2_1	103	108	PF00069	0.566
MOD_NEK2_1	154	159	PF00069	0.385
MOD_NEK2_1	192	197	PF00069	0.437
MOD_NEK2_1	301	306	PF00069	0.304
MOD_NEK2_1	321	326	PF00069	0.484
MOD_NEK2_1	401	406	PF00069	0.411
MOD_NEK2_1	41	46	PF00069	0.534
MOD_NEK2_1	469	474	PF00069	0.438
MOD_NEK2_2	86	91	PF00069	0.513
MOD_PIKK_1	332	338	PF00454	0.654
MOD_PIKK_1	488	494	PF00454	0.603
MOD_PK_1	53	59	PF00069	0.513
MOD_PKA_2	103	109	PF00069	0.548
MOD_PKA_2	351	357	PF00069	0.615
MOD_PKA_2	488	494	PF00069	0.653
MOD_PKA_2	90	96	PF00069	0.610
MOD_Plk_1	341	347	PF00069	0.617
MOD_Plk_2-3	24	30	PF00069	0.610
MOD_Plk_4	188	194	PF00069	0.332
MOD_Plk_4	229	235	PF00069	0.527
MOD_Plk_4	243	249	PF00069	0.568
MOD_Plk_4	255	261	PF00069	0.520
MOD_Plk_4	275	281	PF00069	0.204
MOD_Plk_4	303	309	PF00069	0.321
MOD_Plk_4	372	378	PF00069	0.362
MOD_Plk_4	396	402	PF00069	0.365
MOD_Plk_4	469	475	PF00069	0.369
MOD_Plk_4	53	59	PF00069	0.551
MOD_SUMO_rev_2	199	203	PF00179	0.643
TRG_DiLeu_BaEn_1	26	31	PF01217	0.656
TRG_ENDOCYTIC_2	105	108	PF00928	0.546
TRG_ENDOCYTIC_2	110	113	PF00928	0.536
TRG_ENDOCYTIC_2	117	120	PF00928	0.552
TRG_ENDOCYTIC_2	140	143	PF00928	0.392
TRG_ENDOCYTIC_2	178	181	PF00928	0.370
TRG_ENDOCYTIC_2	227	230	PF00928	0.513
TRG_ENDOCYTIC_2	233	236	PF00928	0.488
TRG_ENDOCYTIC_2	291	294	PF00928	0.399
TRG_ENDOCYTIC_2	297	300	PF00928	0.382
TRG_ENDOCYTIC_2	315	318	PF00928	0.342
TRG_ENDOCYTIC_2	367	370	PF00928	0.396
TRG_ENDOCYTIC_2	397	400	PF00928	0.460
TRG_ENDOCYTIC_2	412	415	PF00928	0.662
TRG_ENDOCYTIC_2	438	441	PF00928	0.466
TRG_ER_diArg_1	349	352	PF00400	0.657

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6A4	Leptomonas seymouri	56%	71%
A0A1X0NUP0	Trypanosomatidae	32%	79%
A0A1X0P3P0	Trypanosomatidae	22%	73%
A0A3Q8IDV0	Leishmania donovani	22%	77%
A0A3R7R847	Trypanosoma rangeli	23%	75%
A0A3S7X5M8	Leishmania donovani	94%	100%
A0A422MY34	Trypanosoma rangeli	32%	79%
A4HKK2	Leishmania braziliensis	74%	100%
A4HLQ6	Leishmania braziliensis	23%	80%
A4I834	Leishmania infantum	94%	100%
A4I956	Leishmania infantum	22%	77%
D0AAA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	84%
E9B2Z2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	74%
Q4Q3Z3	Leishmania major	23%	77%
V5B8R5	Trypanosoma cruzi	21%	76%
V5BBK9	Trypanosoma cruzi	30%	80%