RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania major

UniProt:

Q4Q563_LEIMA

TriTrypDb:

LmjF.32.2130 , LMJLV39_320028100 , LMJSD75_320028200

Length:

404

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	4	2
GO:0005849	mRNA cleavage factor complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0140513	nuclear protein-containing complex	2	2

Expansion

Sequence features

Q4Q563

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q563

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006379	mRNA cleavage	7	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016071	mRNA metabolic process	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	2
GO:0090501	RNA phosphodiester bond hydrolysis	6	2
GO:0098787	mRNA cleavage involved in mRNA processing	8	2
GO:0098789	pre-mRNA cleavage required for polyadenylation	9	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0003729	mRNA binding	5	2
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.768
CLV_NRD_NRD_1	256	258	PF00675	0.716
CLV_NRD_NRD_1	316	318	PF00675	0.814
CLV_NRD_NRD_1	386	388	PF00675	0.604
CLV_NRD_NRD_1	67	69	PF00675	0.343
CLV_PCSK_KEX2_1	112	114	PF00082	0.662
CLV_PCSK_KEX2_1	220	222	PF00082	0.612
CLV_PCSK_KEX2_1	256	258	PF00082	0.642
CLV_PCSK_KEX2_1	318	320	PF00082	0.808
CLV_PCSK_KEX2_1	395	397	PF00082	0.572
CLV_PCSK_KEX2_1	67	69	PF00082	0.331
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.662
CLV_PCSK_PC1ET2_1	220	222	PF00082	0.612
CLV_PCSK_PC1ET2_1	318	320	PF00082	0.808
CLV_PCSK_PC1ET2_1	395	397	PF00082	0.613
CLV_PCSK_PC7_1	314	320	PF00082	0.775
CLV_PCSK_SKI1_1	220	224	PF00082	0.532
CLV_PCSK_SKI1_1	298	302	PF00082	0.708
CLV_PCSK_SKI1_1	369	373	PF00082	0.526
CLV_PCSK_SKI1_1	395	399	PF00082	0.612
DEG_APCC_DBOX_1	241	249	PF00400	0.608
DEG_APCC_DBOX_1	386	394	PF00400	0.523
DEG_COP1_1	374	384	PF00400	0.637
DEG_Nend_UBRbox_2	1	3	PF02207	0.705
DEG_SCF_FBW7_1	282	288	PF00400	0.728
DEG_SCF_FBW7_2	343	349	PF00400	0.733
DEG_SPOP_SBC_1	84	88	PF00917	0.678
DOC_CKS1_1	273	278	PF01111	0.743
DOC_CKS1_1	282	287	PF01111	0.699
DOC_CKS1_1	343	348	PF01111	0.742
DOC_CYCLIN_RxL_1	206	214	PF00134	0.483
DOC_CYCLIN_RxL_1	392	401	PF00134	0.616
DOC_CYCLIN_yCln2_LP_2	265	271	PF00134	0.674
DOC_CYCLIN_yCln2_LP_2	89	95	PF00134	0.751
DOC_MAPK_gen_1	165	173	PF00069	0.616
DOC_PP1_RVXF_1	142	148	PF00149	0.535
DOC_USP7_MATH_1	105	109	PF00917	0.741
DOC_USP7_MATH_1	117	121	PF00917	0.625
DOC_USP7_MATH_1	143	147	PF00917	0.750
DOC_USP7_MATH_1	228	232	PF00917	0.569
DOC_USP7_MATH_1	244	248	PF00917	0.538
DOC_USP7_MATH_1	252	256	PF00917	0.633
DOC_USP7_MATH_1	274	278	PF00917	0.778
DOC_USP7_MATH_1	293	297	PF00917	0.531
DOC_USP7_MATH_1	307	311	PF00917	0.700
DOC_USP7_MATH_1	322	326	PF00917	0.529
DOC_USP7_MATH_1	331	335	PF00917	0.783
DOC_USP7_MATH_1	83	87	PF00917	0.565
DOC_USP7_UBL2_3	298	302	PF12436	0.791
DOC_WW_Pin1_4	272	277	PF00397	0.792
DOC_WW_Pin1_4	281	286	PF00397	0.641
DOC_WW_Pin1_4	342	347	PF00397	0.759
LIG_14-3-3_CanoR_1	144	148	PF00244	0.533
LIG_14-3-3_CanoR_1	175	180	PF00244	0.618
LIG_14-3-3_CanoR_1	194	202	PF00244	0.343
LIG_14-3-3_CanoR_1	369	374	PF00244	0.529
LIG_14-3-3_CanoR_1	4	8	PF00244	0.667
LIG_14-3-3_CanoR_1	85	90	PF00244	0.714
LIG_BRCT_BRCA1_1	8	12	PF00533	0.464
LIG_FHA_1	176	182	PF00498	0.535
LIG_FHA_1	336	342	PF00498	0.802
LIG_FHA_2	346	352	PF00498	0.620
LIG_FHA_2	59	65	PF00498	0.561
LIG_FHA_2	71	77	PF00498	0.561
LIG_LIR_Gen_1	199	210	PF02991	0.473
LIG_LIR_Gen_1	37	45	PF02991	0.537
LIG_LIR_Gen_1	377	385	PF02991	0.592
LIG_LIR_Nem_3	10	16	PF02991	0.437
LIG_LIR_Nem_3	116	121	PF02991	0.601
LIG_LIR_Nem_3	170	176	PF02991	0.639
LIG_LIR_Nem_3	199	205	PF02991	0.467
LIG_LIR_Nem_3	37	41	PF02991	0.470
LIG_LIR_Nem_3	377	381	PF02991	0.584
LIG_LIR_Nem_3	48	54	PF02991	0.490
LIG_LYPXL_yS_3	118	121	PF13949	0.565
LIG_MLH1_MIPbox_1	9	13	PF16413	0.440
LIG_SH2_CRK	51	55	PF00017	0.452
LIG_SH2_NCK_1	202	206	PF00017	0.469
LIG_SH2_STAT5	177	180	PF00017	0.475
LIG_SH3_1	111	117	PF00018	0.723
LIG_SH3_3	111	117	PF00018	0.774
LIG_SH3_3	124	130	PF00018	0.704
LIG_SH3_3	265	271	PF00018	0.791
LIG_SH3_3	286	292	PF00018	0.704
LIG_SH3_3	340	346	PF00018	0.757
LIG_SH3_3	378	384	PF00018	0.670
LIG_SH3_4	298	305	PF00018	0.615
LIG_SUMO_SIM_anti_2	14	21	PF11976	0.444
LIG_SUMO_SIM_anti_2	353	361	PF11976	0.548
LIG_SUMO_SIM_par_1	209	214	PF11976	0.488
LIG_TRAF2_1	197	200	PF00917	0.559
LIG_TRAF2_1	61	64	PF00917	0.490
LIG_WRC_WIRS_1	35	40	PF05994	0.543
MOD_CK1_1	120	126	PF00069	0.796
MOD_CK1_1	277	283	PF00069	0.807
MOD_CK1_1	336	342	PF00069	0.707
MOD_CK1_1	6	12	PF00069	0.514
MOD_CK2_1	200	206	PF00069	0.600
MOD_CK2_1	345	351	PF00069	0.634
MOD_CK2_1	358	364	PF00069	0.546
MOD_CK2_1	58	64	PF00069	0.490
MOD_CK2_1	70	76	PF00069	0.490
MOD_DYRK1A_RPxSP_1	342	346	PF00069	0.549
MOD_GlcNHglycan	101	104	PF01048	0.756
MOD_GlcNHglycan	147	150	PF01048	0.581
MOD_GlcNHglycan	202	205	PF01048	0.591
MOD_GlcNHglycan	230	233	PF01048	0.554
MOD_GlcNHglycan	279	282	PF01048	0.587
MOD_GlcNHglycan	305	308	PF01048	0.764
MOD_GlcNHglycan	309	312	PF01048	0.769
MOD_GlcNHglycan	324	327	PF01048	0.694
MOD_GlcNHglycan	328	331	PF01048	0.718
MOD_GlcNHglycan	373	376	PF01048	0.618
MOD_GSK3_1	117	124	PF00069	0.796
MOD_GSK3_1	155	162	PF00069	0.713
MOD_GSK3_1	277	284	PF00069	0.763
MOD_GSK3_1	3	10	PF00069	0.551
MOD_GSK3_1	303	310	PF00069	0.802
MOD_GSK3_1	318	325	PF00069	0.673
MOD_GSK3_1	331	338	PF00069	0.668
MOD_GSK3_1	341	348	PF00069	0.618
MOD_GSK3_1	79	86	PF00069	0.539
MOD_N-GLC_1	121	126	PF02516	0.801
MOD_NEK2_1	121	126	PF00069	0.564
MOD_NEK2_1	358	363	PF00069	0.676
MOD_NEK2_1	371	376	PF00069	0.608
MOD_NEK2_1	69	74	PF00069	0.500
MOD_NEK2_1	79	84	PF00069	0.481
MOD_NEK2_2	293	298	PF00069	0.639
MOD_PIKK_1	155	161	PF00454	0.662
MOD_PIKK_1	274	280	PF00454	0.664
MOD_PIKK_1	333	339	PF00454	0.732
MOD_PKA_1	318	324	PF00069	0.770
MOD_PKA_2	143	149	PF00069	0.532
MOD_PKA_2	167	173	PF00069	0.596
MOD_PKA_2	3	9	PF00069	0.627
MOD_PKA_2	318	324	PF00069	0.750
MOD_PKA_2	341	347	PF00069	0.534
MOD_PKA_2	79	85	PF00069	0.596
MOD_Plk_1	105	111	PF00069	0.728
MOD_Plk_2-3	70	76	PF00069	0.591
MOD_Plk_4	14	20	PF00069	0.369
MOD_Plk_4	184	190	PF00069	0.533
MOD_Plk_4	336	342	PF00069	0.802
MOD_Plk_4	7	13	PF00069	0.461
MOD_ProDKin_1	272	278	PF00069	0.791
MOD_ProDKin_1	281	287	PF00069	0.643
MOD_ProDKin_1	342	348	PF00069	0.748
MOD_SUMO_for_1	300	303	PF00179	0.732
MOD_SUMO_rev_2	214	222	PF00179	0.636
TRG_DiLeu_BaEn_1	218	223	PF01217	0.490
TRG_DiLeu_BaEn_1	354	359	PF01217	0.640
TRG_DiLeu_BaLyEn_6	393	398	PF01217	0.469
TRG_DiLeu_LyEn_5	218	223	PF01217	0.593
TRG_ENDOCYTIC_2	118	121	PF00928	0.600
TRG_ENDOCYTIC_2	202	205	PF00928	0.464
TRG_ENDOCYTIC_2	51	54	PF00928	0.471
TRG_ER_diArg_1	110	113	PF00400	0.768
TRG_ER_diArg_1	66	68	PF00400	0.561
TRG_NES_CRM1_1	389	403	PF08389	0.394
TRG_NLS_MonoExtC_3	110	115	PF00514	0.807
TRG_Pf-PMV_PEXEL_1	209	214	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4N7	Leptomonas seymouri	57%	100%
A0A1X0NU71	Trypanosomatidae	31%	100%
A0A3Q8ITD1	Leishmania donovani	94%	100%
A0A3R7KNF2	Trypanosoma rangeli	34%	100%
A4HKK3	Leishmania braziliensis	83%	100%
A4I835	Leishmania infantum	94%	100%
E9B2Z3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BKQ1	Trypanosoma cruzi	36%	100%