Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q562_LEIMA

TriTrypDb:

LmjF.32.2140 , LMJLV39_320028200 , LMJSD75_320028300

Length:

133

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 8
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4Q562

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q562

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	86	90	PF00082	0.378
DOC_CKS1_1	15	20	PF01111	0.285
DOC_CYCLIN_RxL_1	83	91	PF00134	0.511
DOC_CYCLIN_yCln2_LP_2	81	87	PF00134	0.523
DOC_PP1_RVXF_1	84	90	PF00149	0.621
DOC_PP2B_LxvP_1	62	65	PF13499	0.477
DOC_PP2B_LxvP_1	81	84	PF13499	0.197
DOC_WW_Pin1_4	14	19	PF00397	0.294
LIG_Actin_WH2_2	25	40	PF00022	0.432
LIG_BRCT_BRCA1_1	25	29	PF00533	0.309
LIG_BRCT_BRCA1_1	75	79	PF00533	0.363
LIG_BRCT_BRCA1_1	90	94	PF00533	0.611
LIG_CAP-Gly_1	126	133	PF01302	0.708
LIG_eIF4E_1	43	49	PF01652	0.415
LIG_FHA_1	45	51	PF00498	0.412
LIG_FHA_1	72	78	PF00498	0.370
LIG_FHA_1	88	94	PF00498	0.571
LIG_IRF3_LxIS_1	33	40	PF10401	0.595
LIG_LIR_Apic_2	6	12	PF02991	0.444
LIG_LIR_Gen_1	107	114	PF02991	0.552
LIG_LIR_Gen_1	26	37	PF02991	0.407
LIG_LIR_Gen_1	40	51	PF02991	0.459
LIG_LIR_Nem_3	26	32	PF02991	0.307
LIG_LIR_Nem_3	40	46	PF02991	0.550
LIG_LIR_Nem_3	8	13	PF02991	0.437
LIG_NRBOX	47	53	PF00104	0.415
LIG_PDZ_Class_3	128	133	PF00595	0.712
LIG_Pex14_1	9	13	PF04695	0.436
LIG_SH2_CRK	43	47	PF00017	0.430
LIG_SH2_GRB2like	43	46	PF00017	0.494
LIG_SH2_NCK_1	43	47	PF00017	0.370
LIG_SH2_STAT5	106	109	PF00017	0.530
LIG_SH2_STAT5	120	123	PF00017	0.626
LIG_SH2_STAT5	43	46	PF00017	0.464
LIG_SH3_3	12	18	PF00018	0.211
LIG_SUMO_SIM_anti_2	44	50	PF11976	0.370
LIG_UBA3_1	77	86	PF00899	0.357
MOD_CK2_1	2	8	PF00069	0.498
MOD_GSK3_1	37	44	PF00069	0.462
MOD_GSK3_1	52	59	PF00069	0.333
MOD_GSK3_1	73	80	PF00069	0.370
MOD_N-GLC_1	2	7	PF02516	0.587
MOD_N-GLC_1	44	49	PF02516	0.453
MOD_NEK2_1	1	6	PF00069	0.614
MOD_NEK2_1	105	110	PF00069	0.461
MOD_NEK2_1	28	33	PF00069	0.413
MOD_NEK2_1	37	42	PF00069	0.429
MOD_NEK2_1	52	57	PF00069	0.307
MOD_NEK2_1	58	63	PF00069	0.421
MOD_NEK2_1	73	78	PF00069	0.267
MOD_NEK2_1	88	93	PF00069	0.458
MOD_NMyristoyl	1	7	PF02799	0.500
MOD_PKA_2	37	43	PF00069	0.400
MOD_Plk_1	44	50	PF00069	0.370
MOD_Plk_4	44	50	PF00069	0.318
MOD_Plk_4	73	79	PF00069	0.422
MOD_ProDKin_1	14	20	PF00069	0.294
TRG_DiLeu_BaLyEn_6	62	67	PF01217	0.479
TRG_ENDOCYTIC_2	109	112	PF00928	0.371
TRG_ENDOCYTIC_2	43	46	PF00928	0.350

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCE7	Leptomonas seymouri	59%	100%
A0A0S4IHK1	Bodo saltans	29%	100%
A0A1X0NU87	Trypanosomatidae	57%	100%
A0A3S7X5Q0	Leishmania donovani	98%	100%
A0A422MY14	Trypanosoma rangeli	42%	100%
A4HKK4	Leishmania braziliensis	88%	100%
A4I836	Leishmania infantum	98%	100%
D0AAA3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9B2Z4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%