Importin N-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q561_LEIMA

TriTrypDb:

LmjF.32.2150 , LMJLV39_320028300 , LMJSD75_320028400

Length:

1082

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 3

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0005737	cytoplasm	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4Q561

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q561

Function

Biological processes
Term	Name	Level	Count
GO:0006606	protein import into nucleus	5	12
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0006913	nucleocytoplasmic transport	5	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0033365	protein localization to organelle	5	12
GO:0034504	protein localization to nucleus	6	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0051169	nuclear transport	4	12
GO:0051170	import into nucleus	6	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0072594	establishment of protein localization to organelle	4	12

Molecular functions
Term	Name	Level	Count
GO:0005048	signal sequence binding	4	2
GO:0005488	binding	1	2
GO:0008139	nuclear localization sequence binding	5	2
GO:0033218	amide binding	2	2
GO:0042277	peptide binding	3	2
GO:0061608	nuclear import signal receptor activity	3	2
GO:0140104	molecular carrier activity	1	2
GO:0140142	nucleocytoplasmic carrier activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	466	470	PF00656	0.494
CLV_C14_Caspase3-7	659	663	PF00656	0.660
CLV_C14_Caspase3-7	832	836	PF00656	0.528
CLV_NRD_NRD_1	1032	1034	PF00675	0.456
CLV_NRD_NRD_1	20	22	PF00675	0.470
CLV_NRD_NRD_1	290	292	PF00675	0.255
CLV_NRD_NRD_1	351	353	PF00675	0.266
CLV_NRD_NRD_1	63	65	PF00675	0.432
CLV_NRD_NRD_1	817	819	PF00675	0.301
CLV_PCSK_KEX2_1	1032	1034	PF00082	0.456
CLV_PCSK_KEX2_1	816	818	PF00082	0.302
CLV_PCSK_PC1ET2_1	816	818	PF00082	0.360
CLV_PCSK_SKI1_1	188	192	PF00082	0.407
CLV_PCSK_SKI1_1	389	393	PF00082	0.462
CLV_PCSK_SKI1_1	455	459	PF00082	0.472
CLV_PCSK_SKI1_1	488	492	PF00082	0.492
CLV_PCSK_SKI1_1	530	534	PF00082	0.369
CLV_PCSK_SKI1_1	576	580	PF00082	0.403
CLV_PCSK_SKI1_1	64	68	PF00082	0.370
CLV_PCSK_SKI1_1	677	681	PF00082	0.439
CLV_PCSK_SKI1_1	824	828	PF00082	0.360
CLV_PCSK_SKI1_1	863	867	PF00082	0.341
DEG_Nend_UBRbox_2	1	3	PF02207	0.455
DEG_SPOP_SBC_1	924	928	PF00917	0.542
DOC_CKS1_1	551	556	PF01111	0.516
DOC_CYCLIN_RxL_1	61	70	PF00134	0.413
DOC_CYCLIN_yCln2_LP_2	101	107	PF00134	0.517
DOC_MAPK_gen_1	1032	1039	PF00069	0.485
DOC_MAPK_gen_1	560	569	PF00069	0.452
DOC_MAPK_HePTP_8	803	815	PF00069	0.541
DOC_MAPK_MEF2A_6	272	280	PF00069	0.519
DOC_MAPK_MEF2A_6	488	497	PF00069	0.502
DOC_MAPK_MEF2A_6	806	815	PF00069	0.541
DOC_PP2B_PxIxI_1	492	498	PF00149	0.431
DOC_PP4_FxxP_1	669	672	PF00568	0.626
DOC_PP4_FxxP_1	866	869	PF00568	0.541
DOC_SPAK_OSR1_1	668	672	PF12202	0.617
DOC_USP7_MATH_1	1010	1014	PF00917	0.234
DOC_USP7_MATH_1	107	111	PF00917	0.353
DOC_USP7_MATH_1	44	48	PF00917	0.525
DOC_USP7_MATH_1	69	73	PF00917	0.322
DOC_USP7_MATH_1	924	928	PF00917	0.537
DOC_USP7_UBL2_3	288	292	PF12436	0.466
DOC_USP7_UBL2_3	408	412	PF12436	0.511
DOC_USP7_UBL2_3	558	562	PF12436	0.474
DOC_WW_Pin1_4	100	105	PF00397	0.537
DOC_WW_Pin1_4	1064	1069	PF00397	0.509
DOC_WW_Pin1_4	32	37	PF00397	0.434
DOC_WW_Pin1_4	365	370	PF00397	0.432
DOC_WW_Pin1_4	550	555	PF00397	0.398
DOC_WW_Pin1_4	67	72	PF00397	0.496
DOC_WW_Pin1_4	793	798	PF00397	0.484
LIG_14-3-3_CanoR_1	21	28	PF00244	0.508
LIG_14-3-3_CanoR_1	389	399	PF00244	0.457
LIG_14-3-3_CanoR_1	415	420	PF00244	0.344
LIG_14-3-3_CanoR_1	455	464	PF00244	0.400
LIG_14-3-3_CanoR_1	56	61	PF00244	0.474
LIG_14-3-3_CanoR_1	610	619	PF00244	0.347
LIG_14-3-3_CanoR_1	786	791	PF00244	0.552
LIG_Actin_WH2_2	171	189	PF00022	0.311
LIG_APCC_ABBA_1	114	119	PF00400	0.526
LIG_APCC_ABBA_1	491	496	PF00400	0.484
LIG_APCC_ABBA_1	533	538	PF00400	0.441
LIG_APCC_ABBA_1	541	546	PF00400	0.345
LIG_BRCT_BRCA1_1	297	301	PF00533	0.483
LIG_BRCT_BRCA1_1	425	429	PF00533	0.355
LIG_deltaCOP1_diTrp_1	121	127	PF00928	0.382
LIG_DLG_GKlike_1	56	63	PF00625	0.317
LIG_EH1_1	937	945	PF00400	0.345
LIG_eIF4E_1	973	979	PF01652	0.508
LIG_FHA_1	1002	1008	PF00498	0.388
LIG_FHA_1	1010	1016	PF00498	0.396
LIG_FHA_1	192	198	PF00498	0.432
LIG_FHA_1	55	61	PF00498	0.513
LIG_FHA_1	603	609	PF00498	0.422
LIG_FHA_1	611	617	PF00498	0.313
LIG_FHA_1	681	687	PF00498	0.480
LIG_FHA_1	798	804	PF00498	0.499
LIG_FHA_1	986	992	PF00498	0.388
LIG_FHA_2	169	175	PF00498	0.437
LIG_FHA_2	279	285	PF00498	0.466
LIG_FHA_2	318	324	PF00498	0.490
LIG_FHA_2	47	53	PF00498	0.498
LIG_FHA_2	470	476	PF00498	0.648
LIG_FHA_2	597	603	PF00498	0.521
LIG_FHA_2	825	831	PF00498	0.541
LIG_IRF3_LxIS_1	844	849	PF10401	0.505
LIG_LIR_Apic_2	864	869	PF02991	0.541
LIG_LIR_Gen_1	121	131	PF02991	0.384
LIG_LIR_Gen_1	225	233	PF02991	0.517
LIG_LIR_Gen_1	298	309	PF02991	0.460
LIG_LIR_Gen_1	993	1002	PF02991	0.384
LIG_LIR_Nem_3	121	126	PF02991	0.388
LIG_LIR_Nem_3	225	229	PF02991	0.522
LIG_LIR_Nem_3	298	304	PF02991	0.469
LIG_LIR_Nem_3	485	490	PF02991	0.494
LIG_LIR_Nem_3	577	582	PF02991	0.387
LIG_LIR_Nem_3	872	878	PF02991	0.399
LIG_LIR_Nem_3	993	998	PF02991	0.350
LIG_MLH1_MIPbox_1	297	301	PF16413	0.560
LIG_NRBOX	5	11	PF00104	0.464
LIG_Pex14_2	296	300	PF04695	0.466
LIG_Pex14_2	301	305	PF04695	0.466
LIG_Pex14_2	866	870	PF04695	0.455
LIG_PTB_Apo_2	307	314	PF02174	0.541
LIG_PTB_Phospho_1	307	313	PF10480	0.541
LIG_Rb_LxCxE_1	739	758	PF01857	0.515
LIG_REV1ctd_RIR_1	510	519	PF16727	0.421
LIG_SH2_GRB2like	220	223	PF00017	0.511
LIG_SH2_PTP2	494	497	PF00017	0.477
LIG_SH2_PTP2	995	998	PF00017	0.436
LIG_SH2_SRC	494	497	PF00017	0.349
LIG_SH2_SRC	536	539	PF00017	0.434
LIG_SH2_SRC	544	547	PF00017	0.470
LIG_SH2_STAP1	582	586	PF00017	0.354
LIG_SH2_STAP1	962	966	PF00017	0.506
LIG_SH2_STAT3	220	223	PF00017	0.511
LIG_SH2_STAT3	589	592	PF00017	0.508
LIG_SH2_STAT5	1078	1081	PF00017	0.532
LIG_SH2_STAT5	161	164	PF00017	0.399
LIG_SH2_STAT5	220	223	PF00017	0.511
LIG_SH2_STAT5	282	285	PF00017	0.455
LIG_SH2_STAT5	307	310	PF00017	0.466
LIG_SH2_STAT5	413	416	PF00017	0.365
LIG_SH2_STAT5	494	497	PF00017	0.347
LIG_SH2_STAT5	536	539	PF00017	0.367
LIG_SH2_STAT5	589	592	PF00017	0.361
LIG_SH2_STAT5	626	629	PF00017	0.469
LIG_SH2_STAT5	710	713	PF00017	0.386
LIG_SH2_STAT5	938	941	PF00017	0.371
LIG_SH2_STAT5	973	976	PF00017	0.465
LIG_SH2_STAT5	984	987	PF00017	0.409
LIG_SH2_STAT5	995	998	PF00017	0.377
LIG_SH3_1	205	211	PF00018	0.524
LIG_SH3_3	205	211	PF00018	0.477
LIG_SH3_3	548	554	PF00018	0.424
LIG_SH3_3	908	914	PF00018	0.505
LIG_Sin3_3	377	384	PF02671	0.455
LIG_SUMO_SIM_anti_2	1012	1019	PF11976	0.374
LIG_SUMO_SIM_anti_2	565	571	PF11976	0.411
LIG_SUMO_SIM_anti_2	59	64	PF11976	0.439
LIG_SUMO_SIM_par_1	212	218	PF11976	0.436
LIG_SUMO_SIM_par_1	676	684	PF11976	0.529
LIG_TRAF2_1	23	26	PF00917	0.540
LIG_TRFH_1	307	311	PF08558	0.466
LIG_UBA3_1	854	863	PF00899	0.540
LIG_WRC_WIRS_1	464	469	PF05994	0.373
MOD_CK1_1	1013	1019	PF00069	0.481
MOD_CK1_1	129	135	PF00069	0.446
MOD_CK1_1	228	234	PF00069	0.479
MOD_CK1_1	242	248	PF00069	0.479
MOD_CK1_1	47	53	PF00069	0.541
MOD_CK1_1	523	529	PF00069	0.352
MOD_CK1_1	54	60	PF00069	0.435
MOD_CK1_1	733	739	PF00069	0.405
MOD_CK1_1	772	778	PF00069	0.426
MOD_CK1_1	919	925	PF00069	0.520
MOD_CK1_1	949	955	PF00069	0.592
MOD_CK2_1	168	174	PF00069	0.475
MOD_CK2_1	20	26	PF00069	0.565
MOD_CK2_1	212	218	PF00069	0.521
MOD_CK2_1	228	234	PF00069	0.503
MOD_CK2_1	278	284	PF00069	0.466
MOD_CK2_1	296	302	PF00069	0.466
MOD_CK2_1	469	475	PF00069	0.540
MOD_CK2_1	681	687	PF00069	0.491
MOD_CK2_1	733	739	PF00069	0.363
MOD_CK2_1	772	778	PF00069	0.473
MOD_Cter_Amidation	350	353	PF01082	0.266
MOD_GlcNHglycan	109	112	PF01048	0.277
MOD_GlcNHglycan	14	17	PF01048	0.468
MOD_GlcNHglycan	22	25	PF01048	0.461
MOD_GlcNHglycan	339	342	PF01048	0.266
MOD_GlcNHglycan	45	49	PF01048	0.489
MOD_GlcNHglycan	732	735	PF01048	0.427
MOD_GlcNHglycan	94	97	PF01048	0.504
MOD_GSK3_1	1009	1016	PF00069	0.387
MOD_GSK3_1	125	132	PF00069	0.515
MOD_GSK3_1	138	145	PF00069	0.400
MOD_GSK3_1	161	168	PF00069	0.448
MOD_GSK3_1	191	198	PF00069	0.447
MOD_GSK3_1	238	245	PF00069	0.474
MOD_GSK3_1	391	398	PF00069	0.486
MOD_GSK3_1	43	50	PF00069	0.420
MOD_GSK3_1	463	470	PF00069	0.497
MOD_GSK3_1	520	527	PF00069	0.345
MOD_GSK3_1	546	553	PF00069	0.493
MOD_GSK3_1	677	684	PF00069	0.501
MOD_GSK3_1	70	77	PF00069	0.409
MOD_GSK3_1	793	800	PF00069	0.517
MOD_GSK3_1	896	903	PF00069	0.445
MOD_GSK3_1	905	912	PF00069	0.391
MOD_GSK3_1	919	926	PF00069	0.349
MOD_GSK3_1	946	953	PF00069	0.488
MOD_GSK3_1	990	997	PF00069	0.333
MOD_LATS_1	406	412	PF00433	0.500
MOD_N-GLC_1	67	72	PF02516	0.507
MOD_N-GLC_2	819	821	PF02516	0.360
MOD_NEK2_1	1	6	PF00069	0.557
MOD_NEK2_1	1001	1006	PF00069	0.387
MOD_NEK2_1	126	131	PF00069	0.383
MOD_NEK2_1	191	196	PF00069	0.432
MOD_NEK2_1	240	245	PF00069	0.556
MOD_NEK2_1	278	283	PF00069	0.533
MOD_NEK2_1	296	301	PF00069	0.357
MOD_NEK2_1	305	310	PF00069	0.442
MOD_NEK2_1	31	36	PF00069	0.542
MOD_NEK2_1	354	359	PF00069	0.485
MOD_NEK2_1	43	48	PF00069	0.433
MOD_NEK2_1	467	472	PF00069	0.544
MOD_NEK2_1	846	851	PF00069	0.551
MOD_NEK2_1	854	859	PF00069	0.514
MOD_NEK2_1	889	894	PF00069	0.444
MOD_NEK2_1	946	951	PF00069	0.470
MOD_NEK2_1	994	999	PF00069	0.349
MOD_PIKK_1	391	397	PF00454	0.504
MOD_PIKK_1	423	429	PF00454	0.368
MOD_PIKK_1	47	53	PF00454	0.564
MOD_PIKK_1	506	512	PF00454	0.481
MOD_PIKK_1	94	100	PF00454	0.571
MOD_PK_1	212	218	PF00069	0.436
MOD_PK_1	786	792	PF00069	0.560
MOD_PKA_1	824	830	PF00069	0.541
MOD_PKA_2	195	201	PF00069	0.426
MOD_PKA_2	20	26	PF00069	0.518
MOD_PKA_2	343	349	PF00069	0.516
MOD_PKA_2	506	512	PF00069	0.520
MOD_PKA_2	730	736	PF00069	0.369
MOD_Plk_1	1	7	PF00069	0.560
MOD_Plk_1	191	197	PF00069	0.438
MOD_Plk_1	233	239	PF00069	0.530
MOD_Plk_1	51	57	PF00069	0.447
MOD_Plk_1	772	778	PF00069	0.500
MOD_Plk_2-3	225	231	PF00069	0.519
MOD_Plk_2-3	546	552	PF00069	0.527
MOD_Plk_4	1002	1008	PF00069	0.377
MOD_Plk_4	1010	1016	PF00069	0.339
MOD_Plk_4	126	132	PF00069	0.429
MOD_Plk_4	212	218	PF00069	0.476
MOD_Plk_4	228	234	PF00069	0.440
MOD_Plk_4	296	302	PF00069	0.471
MOD_Plk_4	357	363	PF00069	0.464
MOD_Plk_4	395	401	PF00069	0.442
MOD_Plk_4	463	469	PF00069	0.368
MOD_Plk_4	56	62	PF00069	0.419
MOD_Plk_4	565	571	PF00069	0.312
MOD_Plk_4	626	632	PF00069	0.452
MOD_Plk_4	681	687	PF00069	0.440
MOD_Plk_4	720	726	PF00069	0.525
MOD_Plk_4	733	739	PF00069	0.409
MOD_Plk_4	772	778	PF00069	0.456
MOD_Plk_4	854	860	PF00069	0.513
MOD_Plk_4	905	911	PF00069	0.461
MOD_Plk_4	994	1000	PF00069	0.341
MOD_ProDKin_1	100	106	PF00069	0.532
MOD_ProDKin_1	1064	1070	PF00069	0.502
MOD_ProDKin_1	32	38	PF00069	0.433
MOD_ProDKin_1	365	371	PF00069	0.427
MOD_ProDKin_1	550	556	PF00069	0.389
MOD_ProDKin_1	67	73	PF00069	0.490
MOD_ProDKin_1	793	799	PF00069	0.484
MOD_SUMO_for_1	407	410	PF00179	0.513
MOD_SUMO_rev_2	15	24	PF00179	0.579
MOD_SUMO_rev_2	182	189	PF00179	0.492
MOD_SUMO_rev_2	409	414	PF00179	0.387
MOD_SUMO_rev_2	684	691	PF00179	0.463
MOD_SUMO_rev_2	746	751	PF00179	0.572
TRG_DiLeu_BaEn_1	331	336	PF01217	0.541
TRG_DiLeu_BaEn_1	565	570	PF01217	0.327
TRG_DiLeu_BaEn_2	664	670	PF01217	0.592
TRG_ENDOCYTIC_2	28	31	PF00928	0.433
TRG_ENDOCYTIC_2	494	497	PF00928	0.503
TRG_ENDOCYTIC_2	544	547	PF00928	0.508
TRG_ENDOCYTIC_2	745	748	PF00928	0.529
TRG_ENDOCYTIC_2	995	998	PF00928	0.391
TRG_ER_diArg_1	1032	1034	PF00400	0.456
TRG_ER_diArg_1	205	208	PF00400	0.539
TRG_ER_diArg_1	603	606	PF00400	0.391
TRG_Pf-PMV_PEXEL_1	1032	1036	PF00026	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZF6	Leptomonas seymouri	77%	100%
A0A0S4JKP1	Bodo saltans	38%	100%
A0A1X0NU68	Trypanosomatidae	41%	100%
A0A3Q8ID72	Leishmania donovani	99%	100%
A0A3R7MFW4	Trypanosoma rangeli	43%	100%
A4HKK5	Leishmania braziliensis	90%	100%
A4I837	Leishmania infantum	99%	100%
D0AAA4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9B2Z5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O00410	Homo sapiens	22%	99%
O60518	Homo sapiens	21%	98%
O74476	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	99%
P32337	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	99%
Q8BIV3	Mus musculus	21%	98%
Q8BKC5	Mus musculus	23%	99%
V5BG77	Trypanosoma cruzi	42%	100%