Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q558_LEIMA

TriTrypDb:

LmjF.32.2170 , LMJLV39_320028600 , LMJSD75_320028700

Length:

610

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q558

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q558

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	45	49	PF00656	0.458
CLV_MEL_PAP_1	337	343	PF00089	0.653
CLV_NRD_NRD_1	217	219	PF00675	0.698
CLV_NRD_NRD_1	226	228	PF00675	0.478
CLV_NRD_NRD_1	325	327	PF00675	0.665
CLV_NRD_NRD_1	434	436	PF00675	0.703
CLV_NRD_NRD_1	83	85	PF00675	0.651
CLV_PCSK_KEX2_1	217	219	PF00082	0.698
CLV_PCSK_KEX2_1	226	228	PF00082	0.478
CLV_PCSK_KEX2_1	434	436	PF00082	0.703
CLV_PCSK_KEX2_1	83	85	PF00082	0.637
CLV_PCSK_PC7_1	79	85	PF00082	0.614
CLV_PCSK_SKI1_1	226	230	PF00082	0.468
CLV_PCSK_SKI1_1	435	439	PF00082	0.681
CLV_PCSK_SKI1_1	540	544	PF00082	0.530
CLV_Separin_Metazoa	550	554	PF03568	0.526
DEG_APCC_DBOX_1	216	224	PF00400	0.595
DEG_APCC_DBOX_1	225	233	PF00400	0.401
DEG_COP1_1	105	112	PF00400	0.709
DEG_Nend_UBRbox_3	1	3	PF02207	0.755
DEG_SPOP_SBC_1	154	158	PF00917	0.684
DEG_SPOP_SBC_1	458	462	PF00917	0.667
DOC_CKS1_1	123	128	PF01111	0.819
DOC_CKS1_1	203	208	PF01111	0.666
DOC_CYCLIN_RxL_1	224	233	PF00134	0.528
DOC_CYCLIN_yCln2_LP_2	422	425	PF00134	0.614
DOC_MAPK_gen_1	254	264	PF00069	0.390
DOC_MAPK_MEF2A_6	598	605	PF00069	0.537
DOC_PP1_RVXF_1	405	411	PF00149	0.467
DOC_PP2B_LxvP_1	422	425	PF13499	0.614
DOC_PP2B_LxvP_1	496	499	PF13499	0.575
DOC_USP7_MATH_1	131	135	PF00917	0.769
DOC_USP7_MATH_1	136	140	PF00917	0.803
DOC_USP7_MATH_1	155	159	PF00917	0.700
DOC_USP7_MATH_1	195	199	PF00917	0.619
DOC_USP7_MATH_1	238	242	PF00917	0.460
DOC_USP7_MATH_1	24	28	PF00917	0.572
DOC_USP7_MATH_1	297	301	PF00917	0.600
DOC_USP7_MATH_1	339	343	PF00917	0.639
DOC_USP7_MATH_1	440	444	PF00917	0.632
DOC_USP7_MATH_1	485	489	PF00917	0.673
DOC_USP7_MATH_2	310	316	PF00917	0.692
DOC_USP7_UBL2_3	103	107	PF12436	0.794
DOC_WW_Pin1_4	122	127	PF00397	0.821
DOC_WW_Pin1_4	187	192	PF00397	0.745
DOC_WW_Pin1_4	202	207	PF00397	0.571
DOC_WW_Pin1_4	415	420	PF00397	0.532
LIG_14-3-3_CanoR_1	208	212	PF00244	0.625
LIG_14-3-3_CanoR_1	23	31	PF00244	0.653
LIG_14-3-3_CanoR_1	34	42	PF00244	0.459
LIG_14-3-3_CanoR_1	340	348	PF00244	0.525
LIG_14-3-3_CanoR_1	378	387	PF00244	0.432
LIG_14-3-3_CanoR_1	402	407	PF00244	0.521
LIG_14-3-3_CanoR_1	434	438	PF00244	0.584
LIG_14-3-3_CanoR_1	569	574	PF00244	0.586
LIG_Actin_WH2_2	291	309	PF00022	0.479
LIG_Actin_WH2_2	475	493	PF00022	0.432
LIG_BIR_III_2	467	471	PF00653	0.468
LIG_BIR_III_4	143	147	PF00653	0.654
LIG_BRCT_BRCA1_1	157	161	PF00533	0.574
LIG_Clathr_ClatBox_1	160	164	PF01394	0.576
LIG_Clathr_ClatBox_1	577	581	PF01394	0.499
LIG_CSL_BTD_1	409	412	PF09270	0.489
LIG_deltaCOP1_diTrp_1	10	18	PF00928	0.648
LIG_eIF4E_1	475	481	PF01652	0.413
LIG_FHA_1	24	30	PF00498	0.629
LIG_FHA_1	34	40	PF00498	0.507
LIG_FHA_1	491	497	PF00498	0.474
LIG_FHA_1	543	549	PF00498	0.424
LIG_FHA_2	287	293	PF00498	0.483
LIG_FHA_2	331	337	PF00498	0.659
LIG_FHA_2	460	466	PF00498	0.742
LIG_FHA_2	570	576	PF00498	0.460
LIG_LIR_Apic_2	65	70	PF02991	0.741
LIG_LIR_Gen_1	241	250	PF02991	0.560
LIG_LIR_Gen_1	251	259	PF02991	0.362
LIG_LIR_Gen_1	271	281	PF02991	0.405
LIG_LIR_Gen_1	381	388	PF02991	0.575
LIG_LIR_Gen_1	474	483	PF02991	0.504
LIG_LIR_Gen_1	91	101	PF02991	0.632
LIG_LIR_Nem_3	251	255	PF02991	0.477
LIG_LIR_Nem_3	256	262	PF02991	0.460
LIG_LIR_Nem_3	271	276	PF02991	0.408
LIG_LIR_Nem_3	381	386	PF02991	0.572
LIG_LIR_Nem_3	466	472	PF02991	0.520
LIG_LIR_Nem_3	474	478	PF02991	0.395
LIG_LIR_Nem_3	9	14	PF02991	0.665
LIG_LIR_Nem_3	91	96	PF02991	0.624
LIG_NRBOX	372	378	PF00104	0.554
LIG_PDZ_Class_3	605	610	PF00595	0.615
LIG_SH2_CRK	252	256	PF00017	0.478
LIG_SH2_CRK	67	71	PF00017	0.742
LIG_SH2_NCK_1	67	71	PF00017	0.742
LIG_SH2_NCK_1	93	97	PF00017	0.634
LIG_SH2_SRC	475	478	PF00017	0.545
LIG_SH2_STAP1	475	479	PF00017	0.541
LIG_SH2_STAT5	242	245	PF00017	0.398
LIG_SH2_STAT5	349	352	PF00017	0.528
LIG_SH2_STAT5	505	508	PF00017	0.603
LIG_SH2_STAT5	67	70	PF00017	0.742
LIG_SH3_1	107	113	PF00018	0.737
LIG_SH3_1	332	338	PF00018	0.545
LIG_SH3_2	174	179	PF14604	0.586
LIG_SH3_2	335	340	PF14604	0.608
LIG_SH3_3	107	113	PF00018	0.748
LIG_SH3_3	120	126	PF00018	0.629
LIG_SH3_3	171	177	PF00018	0.633
LIG_SH3_3	182	188	PF00018	0.734
LIG_SH3_3	332	338	PF00018	0.728
LIG_SH3_3	390	396	PF00018	0.516
LIG_SH3_3	467	473	PF00018	0.511
LIG_SH3_3	519	525	PF00018	0.692
LIG_SH3_3	587	593	PF00018	0.628
LIG_SH3_3	601	607	PF00018	0.398
LIG_SH3_5	89	93	PF00018	0.706
LIG_SUMO_SIM_par_1	227	233	PF11976	0.516
LIG_SUMO_SIM_par_1	575	581	PF11976	0.417
LIG_TRFH_1	469	473	PF08558	0.593
LIG_TYR_ITSM	89	96	PF00017	0.557
LIG_UBA3_1	42	47	PF00899	0.632
LIG_UBA3_1	422	427	PF00899	0.606
LIG_WRPW_2	588	591	PF00400	0.492
LIG_WW_3	205	209	PF00397	0.548
MOD_CDK_SPxK_1	202	208	PF00069	0.671
MOD_CK1_1	122	128	PF00069	0.781
MOD_CK1_1	167	173	PF00069	0.739
MOD_CK1_1	175	181	PF00069	0.615
MOD_CK1_1	241	247	PF00069	0.420
MOD_CK1_1	253	259	PF00069	0.457
MOD_CK1_1	272	278	PF00069	0.530
MOD_CK1_1	32	38	PF00069	0.646
MOD_CK1_1	330	336	PF00069	0.735
MOD_CK1_1	53	59	PF00069	0.793
MOD_CK1_1	78	84	PF00069	0.778
MOD_CK2_1	131	137	PF00069	0.705
MOD_CK2_1	245	251	PF00069	0.436
MOD_CK2_1	286	292	PF00069	0.474
MOD_CK2_1	459	465	PF00069	0.739
MOD_CK2_1	569	575	PF00069	0.468
MOD_Cter_Amidation	432	435	PF01082	0.558
MOD_GlcNHglycan	114	117	PF01048	0.716
MOD_GlcNHglycan	131	134	PF01048	0.585
MOD_GlcNHglycan	137	141	PF01048	0.664
MOD_GlcNHglycan	157	160	PF01048	0.738
MOD_GlcNHglycan	167	170	PF01048	0.640
MOD_GlcNHglycan	197	200	PF01048	0.630
MOD_GlcNHglycan	247	250	PF01048	0.629
MOD_GlcNHglycan	328	332	PF01048	0.744
MOD_GlcNHglycan	442	445	PF01048	0.593
MOD_GlcNHglycan	52	55	PF01048	0.784
MOD_GlcNHglycan	545	548	PF01048	0.631
MOD_GlcNHglycan	70	73	PF01048	0.529
MOD_GSK3_1	108	115	PF00069	0.726
MOD_GSK3_1	125	132	PF00069	0.612
MOD_GSK3_1	164	171	PF00069	0.693
MOD_GSK3_1	187	194	PF00069	0.670
MOD_GSK3_1	241	248	PF00069	0.409
MOD_GSK3_1	268	275	PF00069	0.557
MOD_GSK3_1	29	36	PF00069	0.614
MOD_GSK3_1	308	315	PF00069	0.633
MOD_GSK3_1	49	56	PF00069	0.764
MOD_LATS_1	21	27	PF00433	0.607
MOD_N-GLC_1	103	108	PF02516	0.695
MOD_N-GLC_1	24	29	PF02516	0.538
MOD_N-GLC_2	535	537	PF02516	0.683
MOD_NEK2_1	245	250	PF00069	0.573
MOD_NEK2_1	29	34	PF00069	0.520
MOD_NEK2_1	296	301	PF00069	0.514
MOD_NEK2_1	42	47	PF00069	0.495
MOD_NEK2_1	438	443	PF00069	0.525
MOD_NEK2_1	490	495	PF00069	0.480
MOD_NEK2_1	50	55	PF00069	0.634
MOD_NEK2_1	542	547	PF00069	0.461
MOD_NEK2_2	433	438	PF00069	0.590
MOD_PIKK_1	131	137	PF00454	0.754
MOD_PIKK_1	485	491	PF00454	0.510
MOD_PKA_2	172	178	PF00069	0.598
MOD_PKA_2	207	213	PF00069	0.728
MOD_PKA_2	253	259	PF00069	0.471
MOD_PKA_2	33	39	PF00069	0.622
MOD_PKA_2	339	345	PF00069	0.559
MOD_PKA_2	433	439	PF00069	0.570
MOD_PKA_2	490	496	PF00069	0.446
MOD_PKA_2	543	549	PF00069	0.539
MOD_PKA_2	552	558	PF00069	0.444
MOD_PKA_2	568	574	PF00069	0.458
MOD_PKA_2	6	12	PF00069	0.506
MOD_PKA_2	78	84	PF00069	0.826
MOD_Plk_1	119	125	PF00069	0.688
MOD_Plk_1	24	30	PF00069	0.624
MOD_Plk_1	250	256	PF00069	0.474
MOD_Plk_1	91	97	PF00069	0.627
MOD_Plk_4	238	244	PF00069	0.446
MOD_Plk_4	269	275	PF00069	0.535
MOD_Plk_4	418	424	PF00069	0.643
MOD_Plk_4	559	565	PF00069	0.420
MOD_ProDKin_1	122	128	PF00069	0.820
MOD_ProDKin_1	187	193	PF00069	0.743
MOD_ProDKin_1	202	208	PF00069	0.570
MOD_ProDKin_1	415	421	PF00069	0.531
MOD_SUMO_rev_2	99	109	PF00179	0.720
TRG_DiLeu_BaLyEn_6	25	30	PF01217	0.627
TRG_DiLeu_BaLyEn_6	369	374	PF01217	0.590
TRG_ENDOCYTIC_2	242	245	PF00928	0.379
TRG_ENDOCYTIC_2	252	255	PF00928	0.482
TRG_ENDOCYTIC_2	475	478	PF00928	0.402
TRG_ENDOCYTIC_2	588	591	PF00928	0.492
TRG_ENDOCYTIC_2	93	96	PF00928	0.627
TRG_ER_diArg_1	216	218	PF00400	0.699
TRG_ER_diArg_1	226	228	PF00400	0.463
TRG_ER_diArg_1	319	322	PF00400	0.584

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4W3	Leptomonas seymouri	31%	100%
A0A3S7X5P2	Leishmania donovani	90%	100%
A4HKK7	Leishmania braziliensis	70%	100%
A4I840	Leishmania infantum	90%	100%
E9B2Z8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%