Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q556_LEIMA

TriTrypDb:

LmjF.32.2190 , LMJLV39_320028800 , LMJSD75_320028900

Length:

633

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q556

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q556

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.730
CLV_NRD_NRD_1	11	13	PF00675	0.641
CLV_NRD_NRD_1	136	138	PF00675	0.847
CLV_NRD_NRD_1	504	506	PF00675	0.759
CLV_PCSK_KEX2_1	10	12	PF00082	0.632
CLV_PCSK_KEX2_1	136	138	PF00082	0.816
CLV_PCSK_KEX2_1	504	506	PF00082	0.759
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.714
CLV_PCSK_SKI1_1	341	345	PF00082	0.694
CLV_PCSK_SKI1_1	538	542	PF00082	0.729
CLV_PCSK_SKI1_1	7	11	PF00082	0.808
DEG_SPOP_SBC_1	169	173	PF00917	0.596
DEG_SPOP_SBC_1	242	246	PF00917	0.814
DEG_SPOP_SBC_1	566	570	PF00917	0.737
DOC_CKS1_1	65	70	PF01111	0.622
DOC_MAPK_FxFP_2	456	459	PF00069	0.798
DOC_MAPK_gen_1	580	588	PF00069	0.732
DOC_MAPK_MEF2A_6	392	400	PF00069	0.749
DOC_PP2B_LxvP_1	357	360	PF13499	0.740
DOC_PP4_FxxP_1	393	396	PF00568	0.824
DOC_PP4_FxxP_1	456	459	PF00568	0.798
DOC_USP7_MATH_1	123	127	PF00917	0.802
DOC_USP7_MATH_1	146	150	PF00917	0.750
DOC_USP7_MATH_1	169	173	PF00917	0.698
DOC_USP7_MATH_1	224	228	PF00917	0.714
DOC_USP7_MATH_1	310	314	PF00917	0.777
DOC_USP7_MATH_1	321	325	PF00917	0.632
DOC_USP7_MATH_1	405	409	PF00917	0.745
DOC_USP7_MATH_1	449	453	PF00917	0.762
DOC_USP7_MATH_1	49	53	PF00917	0.821
DOC_WW_Pin1_4	129	134	PF00397	0.783
DOC_WW_Pin1_4	194	199	PF00397	0.610
DOC_WW_Pin1_4	271	276	PF00397	0.741
DOC_WW_Pin1_4	358	363	PF00397	0.814
DOC_WW_Pin1_4	489	494	PF00397	0.815
DOC_WW_Pin1_4	499	504	PF00397	0.660
DOC_WW_Pin1_4	521	526	PF00397	0.774
DOC_WW_Pin1_4	59	64	PF00397	0.699
LIG_APCC_ABBA_1	332	337	PF00400	0.821
LIG_BRCT_BRCA1_1	419	423	PF00533	0.567
LIG_BRCT_BRCA1_1	601	605	PF00533	0.708
LIG_CtBP_PxDLS_1	368	372	PF00389	0.820
LIG_CtBP_PxDLS_1	508	512	PF00389	0.636
LIG_deltaCOP1_diTrp_1	29	38	PF00928	0.544
LIG_eIF4E_1	522	528	PF01652	0.623
LIG_eIF4E_1	535	541	PF01652	0.667
LIG_FHA_1	229	235	PF00498	0.803
LIG_FHA_1	342	348	PF00498	0.732
LIG_FHA_1	354	360	PF00498	0.587
LIG_FHA_2	15	21	PF00498	0.728
LIG_FHA_2	200	206	PF00498	0.699
LIG_FHA_2	24	30	PF00498	0.593
LIG_FHA_2	297	303	PF00498	0.772
LIG_FHA_2	310	316	PF00498	0.621
LIG_FHA_2	54	60	PF00498	0.776
LIG_Integrin_isoDGR_2	89	91	PF01839	0.613
LIG_LIR_Apic_2	344	349	PF02991	0.810
LIG_LIR_Apic_2	390	396	PF02991	0.820
LIG_LIR_Gen_1	231	241	PF02991	0.597
LIG_LIR_Gen_1	333	343	PF02991	0.815
LIG_LIR_Nem_3	231	236	PF02991	0.600
LIG_LIR_Nem_3	333	338	PF02991	0.806
LIG_LIR_Nem_3	378	384	PF02991	0.742
LIG_LIR_Nem_3	427	432	PF02991	0.728
LIG_LIR_Nem_3	457	461	PF02991	0.718
LIG_LYPXL_S_1	428	432	PF13949	0.795
LIG_LYPXL_yS_3	429	432	PF13949	0.794
LIG_LYPXL_yS_3	458	461	PF13949	0.792
LIG_MYND_1	430	434	PF01753	0.796
LIG_Rb_pABgroove_1	599	607	PF01858	0.783
LIG_SH2_CRK	44	48	PF00017	0.735
LIG_SH2_CRK	522	526	PF00017	0.698
LIG_SH2_NCK_1	491	495	PF00017	0.820
LIG_SH2_NCK_1	522	526	PF00017	0.722
LIG_SH2_SRC	346	349	PF00017	0.811
LIG_SH2_STAP1	560	564	PF00017	0.623
LIG_SH2_STAT5	346	349	PF00017	0.811
LIG_SH2_STAT5	44	47	PF00017	0.770
LIG_SH2_STAT5	603	606	PF00017	0.756
LIG_SH3_2	65	70	PF14604	0.622
LIG_SH3_3	328	334	PF00018	0.748
LIG_SH3_3	356	362	PF00018	0.812
LIG_SH3_3	427	433	PF00018	0.794
LIG_SH3_3	456	462	PF00018	0.717
LIG_SH3_3	594	600	PF00018	0.710
LIG_SH3_3	62	68	PF00018	0.698
LIG_SUMO_SIM_par_1	155	162	PF11976	0.595
LIG_TRAF2_1	17	20	PF00917	0.577
LIG_WRC_WIRS_1	425	430	PF05994	0.796
MOD_CDC14_SPxK_1	361	364	PF00782	0.815
MOD_CDK_SPK_2	129	134	PF00069	0.783
MOD_CDK_SPK_2	499	504	PF00069	0.748
MOD_CDK_SPxK_1	358	364	PF00069	0.816
MOD_CDK_SPxK_1	499	505	PF00069	0.749
MOD_CDK_SPxK_1	64	70	PF00069	0.623
MOD_CDK_SPxxK_3	129	136	PF00069	0.747
MOD_CK1_1	101	107	PF00069	0.741
MOD_CK1_1	126	132	PF00069	0.813
MOD_CK1_1	149	155	PF00069	0.660
MOD_CK1_1	159	165	PF00069	0.683
MOD_CK1_1	171	177	PF00069	0.661
MOD_CK1_1	179	185	PF00069	0.650
MOD_CK1_1	197	203	PF00069	0.750
MOD_CK1_1	212	218	PF00069	0.607
MOD_CK1_1	263	269	PF00069	0.737
MOD_CK1_1	271	277	PF00069	0.721
MOD_CK1_1	313	319	PF00069	0.778
MOD_CK1_1	438	444	PF00069	0.686
MOD_CK1_1	587	593	PF00069	0.614
MOD_CK2_1	125	131	PF00069	0.803
MOD_CK2_1	14	20	PF00069	0.733
MOD_CK2_1	199	205	PF00069	0.770
MOD_CK2_1	23	29	PF00069	0.594
MOD_CK2_1	309	315	PF00069	0.785
MOD_CK2_1	53	59	PF00069	0.774
MOD_Cter_Amidation	134	137	PF01082	0.751
MOD_GlcNHglycan	164	167	PF01048	0.792
MOD_GlcNHglycan	178	181	PF01048	0.753
MOD_GlcNHglycan	222	225	PF01048	0.676
MOD_GlcNHglycan	284	287	PF01048	0.796
MOD_GlcNHglycan	315	318	PF01048	0.779
MOD_GlcNHglycan	400	403	PF01048	0.659
MOD_GlcNHglycan	409	412	PF01048	0.678
MOD_GlcNHglycan	450	454	PF01048	0.728
MOD_GlcNHglycan	551	554	PF01048	0.640
MOD_GlcNHglycan	569	572	PF01048	0.653
MOD_GlcNHglycan	582	585	PF01048	0.637
MOD_GlcNHglycan	77	80	PF01048	0.828
MOD_GSK3_1	119	126	PF00069	0.738
MOD_GSK3_1	152	159	PF00069	0.698
MOD_GSK3_1	168	175	PF00069	0.656
MOD_GSK3_1	220	227	PF00069	0.735
MOD_GSK3_1	237	244	PF00069	0.582
MOD_GSK3_1	259	266	PF00069	0.864
MOD_GSK3_1	291	298	PF00069	0.763
MOD_GSK3_1	309	316	PF00069	0.582
MOD_GSK3_1	333	340	PF00069	0.622
MOD_GSK3_1	403	410	PF00069	0.708
MOD_GSK3_1	435	442	PF00069	0.639
MOD_GSK3_1	485	492	PF00069	0.767
MOD_GSK3_1	49	56	PF00069	0.761
MOD_GSK3_1	495	502	PF00069	0.697
MOD_GSK3_1	530	537	PF00069	0.728
MOD_GSK3_1	580	587	PF00069	0.796
MOD_GSK3_1	92	99	PF00069	0.651
MOD_N-GLC_1	108	113	PF02516	0.756
MOD_N-GLC_1	263	268	PF02516	0.823
MOD_N-GLC_1	271	276	PF02516	0.702
MOD_N-GLC_1	310	315	PF02516	0.778
MOD_N-GLC_1	398	403	PF02516	0.635
MOD_N-GLC_1	580	585	PF02516	0.711
MOD_NEK2_1	43	48	PF00069	0.733
MOD_NEK2_1	543	548	PF00069	0.633
MOD_NEK2_1	558	563	PF00069	0.667
MOD_NEK2_1	567	572	PF00069	0.627
MOD_NEK2_1	604	609	PF00069	0.692
MOD_NEK2_2	424	429	PF00069	0.599
MOD_NEK2_2	485	490	PF00069	0.718
MOD_NMyristoyl	1	7	PF02799	0.792
MOD_PIKK_1	224	230	PF00454	0.770
MOD_PIKK_1	98	104	PF00454	0.658
MOD_PKA_1	96	102	PF00069	0.617
MOD_PKA_2	117	123	PF00069	0.691
MOD_PKA_2	23	29	PF00069	0.653
MOD_PKA_2	250	256	PF00069	0.686
MOD_PKA_2	260	266	PF00069	0.698
MOD_Plk_1	212	218	PF00069	0.622
MOD_Plk_1	310	316	PF00069	0.813
MOD_Plk_1	321	327	PF00069	0.703
MOD_Plk_1	442	448	PF00069	0.597
MOD_Plk_1	485	491	PF00069	0.723
MOD_Plk_1	584	590	PF00069	0.738
MOD_Plk_1	605	611	PF00069	0.766
MOD_Plk_2-3	14	20	PF00069	0.694
MOD_Plk_4	424	430	PF00069	0.766
MOD_Plk_4	507	513	PF00069	0.742
MOD_Plk_4	530	536	PF00069	0.790
MOD_Plk_4	599	605	PF00069	0.759
MOD_ProDKin_1	129	135	PF00069	0.785
MOD_ProDKin_1	194	200	PF00069	0.610
MOD_ProDKin_1	271	277	PF00069	0.740
MOD_ProDKin_1	358	364	PF00069	0.816
MOD_ProDKin_1	489	495	PF00069	0.816
MOD_ProDKin_1	499	505	PF00069	0.662
MOD_ProDKin_1	521	527	PF00069	0.775
MOD_ProDKin_1	59	65	PF00069	0.699
TRG_ENDOCYTIC_2	335	338	PF00928	0.825
TRG_ENDOCYTIC_2	429	432	PF00928	0.767
TRG_ENDOCYTIC_2	44	47	PF00928	0.732
TRG_ENDOCYTIC_2	458	461	PF00928	0.792
TRG_ENDOCYTIC_2	479	482	PF00928	0.837
TRG_ER_diArg_1	503	505	PF00400	0.747
TRG_NLS_MonoExtC_3	6	11	PF00514	0.730
TRG_Pf-PMV_PEXEL_1	623	628	PF00026	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7S3	Leishmania donovani	81%	99%
A4HKK9	Leishmania braziliensis	45%	100%
A4I842	Leishmania infantum	82%	99%
E9B300	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	99%