Complex1_LYR_dom domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NADH-ubiquinone oxidoreductase complex I subunit, putative

Species:

Leishmania major

UniProt:

Q4Q554_LEIMA

TriTrypDb:

LmjF.32.2210 , LMJLV39_320029000 , LMJSD75_320029100

Length:

206

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005747	mitochondrial respiratory chain complex I	4	2
GO:0030964	NADH dehydrogenase complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0045271	respiratory chain complex I	4	2
GO:0098796	membrane protein complex	2	2
GO:0098798	mitochondrial protein-containing complex	2	2
GO:0098800	inner mitochondrial membrane protein complex	3	2
GO:0098803	respiratory chain complex	3	2
GO:1902494	catalytic complex	2	2
GO:1902495	transmembrane transporter complex	3	2
GO:1990204	oxidoreductase complex	3	2
GO:1990351	transporter complex	2	2
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4Q554

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q554

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	130	132	PF00675	0.438
CLV_NRD_NRD_1	15	17	PF00675	0.461
CLV_NRD_NRD_1	92	94	PF00675	0.596
CLV_PCSK_KEX2_1	130	132	PF00082	0.467
CLV_PCSK_KEX2_1	15	17	PF00082	0.461
CLV_PCSK_KEX2_1	92	94	PF00082	0.599
CLV_PCSK_PC7_1	126	132	PF00082	0.467
CLV_PCSK_SKI1_1	16	20	PF00082	0.461
CLV_PCSK_SKI1_1	30	34	PF00082	0.461
CLV_PCSK_SKI1_1	45	49	PF00082	0.461
DEG_SCF_FBW7_1	186	192	PF00400	0.668
DOC_CKS1_1	186	191	PF01111	0.669
DOC_MAPK_DCC_7	19	29	PF00069	0.261
DOC_MAPK_MEF2A_6	23	31	PF00069	0.275
DOC_MAPK_RevD_3	117	131	PF00069	0.569
DOC_USP7_MATH_1	189	193	PF00917	0.718
DOC_USP7_MATH_1	196	200	PF00917	0.734
DOC_WW_Pin1_4	146	151	PF00397	0.618
DOC_WW_Pin1_4	185	190	PF00397	0.721
LIG_14-3-3_CanoR_1	162	166	PF00244	0.668
LIG_14-3-3_CanoR_1	45	51	PF00244	0.282
LIG_14-3-3_CanoR_1	71	77	PF00244	0.368
LIG_14-3-3_CanoR_1	92	100	PF00244	0.399
LIG_14-3-3_CterR_2	204	206	PF00244	0.762
LIG_Actin_WH2_2	138	156	PF00022	0.652
LIG_Actin_WH2_2	6	21	PF00022	0.261
LIG_BIR_II_1	1	5	PF00653	0.400
LIG_eIF4E_1	105	111	PF01652	0.430
LIG_FHA_1	122	128	PF00498	0.676
LIG_FHA_1	19	25	PF00498	0.350
LIG_FHA_1	73	79	PF00498	0.371
LIG_LIR_Apic_2	181	186	PF02991	0.649
LIG_LIR_Gen_1	102	111	PF02991	0.301
LIG_LIR_Nem_3	102	108	PF02991	0.301
LIG_NRBOX	105	111	PF00104	0.369
LIG_PCNA_PIPBox_1	176	185	PF02747	0.632
LIG_SH2_CRK	183	187	PF00017	0.742
LIG_SH2_GRB2like	77	80	PF00017	0.356
LIG_SH2_NCK_1	183	187	PF00017	0.660
LIG_SH2_STAT5	105	108	PF00017	0.353
LIG_SH2_STAT5	17	20	PF00017	0.271
LIG_SH2_STAT5	77	80	PF00017	0.356
LIG_SH3_1	183	189	PF00018	0.661
LIG_SH3_3	183	189	PF00018	0.679
LIG_SUMO_SIM_anti_2	104	110	PF11976	0.408
LIG_SUMO_SIM_anti_2	115	120	PF11976	0.425
LIG_SUMO_SIM_anti_2	63	70	PF11976	0.434
LIG_SUMO_SIM_anti_2	7	14	PF11976	0.277
LIG_TRAF2_1	149	152	PF00917	0.588
LIG_WRC_WIRS_1	179	184	PF05994	0.494
MOD_CK2_1	146	152	PF00069	0.490
MOD_GlcNHglycan	1	4	PF01048	0.521
MOD_GlcNHglycan	38	41	PF01048	0.316
MOD_GlcNHglycan	50	53	PF01048	0.375
MOD_GSK3_1	185	192	PF00069	0.622
MOD_N-GLC_1	25	30	PF02516	0.306
MOD_N-GLC_1	45	50	PF02516	0.150
MOD_NEK2_1	18	23	PF00069	0.430
MOD_NEK2_1	72	77	PF00069	0.458
MOD_NEK2_2	196	201	PF00069	0.686
MOD_NEK2_2	25	30	PF00069	0.306
MOD_PIKK_1	99	105	PF00454	0.472
MOD_PKA_2	161	167	PF00069	0.595
MOD_PKA_2	70	76	PF00069	0.467
MOD_PKA_2	91	97	PF00069	0.500
MOD_PKB_1	43	51	PF00069	0.348
MOD_Plk_1	25	31	PF00069	0.306
MOD_Plk_1	45	51	PF00069	0.150
MOD_Plk_4	101	107	PF00069	0.431
MOD_Plk_4	178	184	PF00069	0.550
MOD_ProDKin_1	146	152	PF00069	0.526
MOD_ProDKin_1	185	191	PF00069	0.669
MOD_SUMO_rev_2	146	156	PF00179	0.676
TRG_ENDOCYTIC_2	105	108	PF00928	0.371
TRG_ER_diArg_1	130	132	PF00400	0.519
TRG_ER_diArg_1	14	16	PF00400	0.306
TRG_ER_diArg_1	91	93	PF00400	0.482
TRG_NES_CRM1_1	133	146	PF08389	0.488
TRG_Pf-PMV_PEXEL_1	30	35	PF00026	0.306
TRG_Pf-PMV_PEXEL_1	54	59	PF00026	0.306

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4J0	Leptomonas seymouri	81%	100%
A0A0S4JR38	Bodo saltans	54%	100%
A0A1X0NU58	Trypanosomatidae	70%	100%
A0A3Q8IL84	Leishmania donovani	94%	100%
A4HKL1	Leishmania braziliensis	86%	100%
A4I844	Leishmania infantum	95%	100%
D0AAB1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
E9B302	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BKR8	Trypanosoma cruzi	70%	100%