CS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

heat shock protein Hsp20, putative

Species:

Leishmania major

UniProt:

Q4Q549_LEIMA

TriTrypDb:

LmjF.32.2260 , LMJLV39_320029500 , LMJSD75_320029600

Length:

187

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q549

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q549

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0005515	protein binding	2	6
GO:0008092	cytoskeletal protein binding	3	6
GO:0015631	tubulin binding	4	6
GO:0019899	enzyme binding	3	6
GO:0031625	ubiquitin protein ligase binding	5	6
GO:0044389	ubiquitin-like protein ligase binding	4	6
GO:0044548	S100 protein binding	3	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	173	177	PF00656	0.690
CLV_C14_Caspase3-7	182	186	PF00656	0.642
CLV_PCSK_KEX2_1	135	137	PF00082	0.588
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.588
CLV_PCSK_SKI1_1	156	160	PF00082	0.438
DOC_CKS1_1	47	52	PF01111	0.644
DOC_MAPK_gen_1	123	131	PF00069	0.512
DOC_MAPK_gen_1	147	155	PF00069	0.583
DOC_MAPK_gen_1	156	166	PF00069	0.590
DOC_MAPK_MEF2A_6	125	133	PF00069	0.491
DOC_MAPK_MEF2A_6	149	157	PF00069	0.597
DOC_MAPK_MEF2A_6	159	168	PF00069	0.599
DOC_PP1_RVXF_1	110	116	PF00149	0.556
DOC_USP7_MATH_1	178	182	PF00917	0.653
DOC_USP7_MATH_1	67	71	PF00917	0.649
DOC_USP7_UBL2_3	135	139	PF12436	0.593
DOC_USP7_UBL2_3	145	149	PF12436	0.568
DOC_USP7_UBL2_3	36	40	PF12436	0.582
DOC_WW_Pin1_4	46	51	PF00397	0.625
LIG_14-3-3_CanoR_1	125	130	PF00244	0.561
LIG_14-3-3_CanoR_1	141	148	PF00244	0.633
LIG_APCC_ABBA_1	83	88	PF00400	0.445
LIG_BIR_II_1	1	5	PF00653	0.820
LIG_FHA_1	148	154	PF00498	0.566
LIG_FHA_1	47	53	PF00498	0.640
LIG_FHA_1	66	72	PF00498	0.581
LIG_FHA_2	115	121	PF00498	0.578
LIG_FHA_2	94	100	PF00498	0.680
LIG_LIR_Gen_1	162	172	PF02991	0.501
LIG_LIR_Gen_1	80	90	PF02991	0.553
LIG_LIR_Nem_3	162	168	PF02991	0.479
LIG_LIR_Nem_3	80	85	PF02991	0.540
LIG_Pex14_2	111	115	PF04695	0.578
LIG_SH2_STAT3	30	33	PF00017	0.650
LIG_SH2_STAT5	51	54	PF00017	0.648
LIG_SH2_STAT5	86	89	PF00017	0.450
LIG_SH3_3	61	67	PF00018	0.730
LIG_SH3_4	147	154	PF00018	0.627
LIG_SUMO_SIM_par_1	67	72	PF11976	0.649
LIG_TRAF2_1	2	5	PF00917	0.647
LIG_UBA3_1	153	160	PF00899	0.564
MOD_CK1_1	72	78	PF00069	0.570
MOD_CK2_1	114	120	PF00069	0.610
MOD_CK2_1	93	99	PF00069	0.633
MOD_GlcNHglycan	176	179	PF01048	0.722
MOD_GSK3_1	107	114	PF00069	0.564
MOD_GSK3_1	121	128	PF00069	0.659
MOD_GSK3_1	170	177	PF00069	0.595
MOD_GSK3_1	65	72	PF00069	0.543
MOD_GSK3_1	93	100	PF00069	0.708
MOD_NEK2_1	111	116	PF00069	0.408
MOD_NEK2_1	97	102	PF00069	0.665
MOD_PIKK_1	147	153	PF00454	0.636
MOD_PIKK_1	6	12	PF00454	0.737
MOD_PK_1	127	133	PF00069	0.614
MOD_PK_1	160	166	PF00069	0.607
MOD_PK_1	81	87	PF00069	0.560
MOD_PKA_2	131	137	PF00069	0.533
MOD_PKA_2	140	146	PF00069	0.632
MOD_PKB_1	123	131	PF00069	0.560
MOD_Plk_1	97	103	PF00069	0.604
MOD_Plk_2-3	93	99	PF00069	0.692
MOD_Plk_4	160	166	PF00069	0.497
MOD_Plk_4	24	30	PF00069	0.625
MOD_Plk_4	81	87	PF00069	0.431
MOD_ProDKin_1	46	52	PF00069	0.626

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4H6	Leptomonas seymouri	67%	85%
A0A0S4KMW7	Bodo saltans	39%	100%
A0A1X0NU46	Trypanosomatidae	44%	88%
A0A3G1S267	Trypanosoma rangeli	41%	91%
A0A3S7X5U5	Leishmania donovani	98%	100%
A4HKL7	Leishmania braziliensis	83%	100%
A4I849	Leishmania infantum	98%	100%
D0AAB5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	90%
E9B307	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5DCC8	Trypanosoma cruzi	44%	90%