LeishMANIAdb
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Membrane associated protein-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Membrane associated protein-like protein
Gene product:
membrane associated protein-like protein
Species:
Leishmania major
UniProt:
Q4Q548_LEIMA
TriTrypDb:
LmjF.32.2270 , LMJLV39_320029600 * , LMJSD75_320029700 *
Length:
887

Annotations

LeishMANIAdb annotations

A family of very long coiled-coil proteins, likely performing cytoskeletal functions.. Two varieties have evolved, one with an N-terminal FYVE domain (Non-TM) and another with a C-terminal PDZ domain (might be TM)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 4
NetGPI no yes: 0, no: 4
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q548
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q548

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 157 159 PF00675 0.359
CLV_NRD_NRD_1 194 196 PF00675 0.563
CLV_NRD_NRD_1 59 61 PF00675 0.467
CLV_NRD_NRD_1 732 734 PF00675 0.555
CLV_NRD_NRD_1 796 798 PF00675 0.554
CLV_NRD_NRD_1 803 805 PF00675 0.558
CLV_PCSK_KEX2_1 157 159 PF00082 0.359
CLV_PCSK_KEX2_1 194 196 PF00082 0.387
CLV_PCSK_KEX2_1 732 734 PF00082 0.557
CLV_PCSK_KEX2_1 796 798 PF00082 0.554
CLV_PCSK_KEX2_1 872 874 PF00082 0.563
CLV_PCSK_PC1ET2_1 872 874 PF00082 0.556
CLV_PCSK_PC7_1 153 159 PF00082 0.336
CLV_PCSK_SKI1_1 283 287 PF00082 0.557
CLV_PCSK_SKI1_1 71 75 PF00082 0.514
CLV_PCSK_SKI1_1 87 91 PF00082 0.331
DEG_Nend_Nbox_1 1 3 PF02207 0.510
DEG_SCF_FBW7_1 324 331 PF00400 0.523
DEG_SCF_FBW7_1 686 692 PF00400 0.553
DEG_SPOP_SBC_1 26 30 PF00917 0.593
DEG_SPOP_SBC_1 32 36 PF00917 0.557
DOC_CKS1_1 686 691 PF01111 0.552
DOC_CKS1_1 774 779 PF01111 0.523
DOC_CYCLIN_yCln2_LP_2 771 777 PF00134 0.517
DOC_MAPK_gen_1 659 669 PF00069 0.460
DOC_MAPK_gen_1 796 803 PF00069 0.552
DOC_MAPK_gen_1 804 812 PF00069 0.523
DOC_MAPK_gen_1 869 877 PF00069 0.551
DOC_MAPK_MEF2A_6 662 671 PF00069 0.438
DOC_MAPK_MEF2A_6 804 812 PF00069 0.542
DOC_PP2B_LxvP_1 771 774 PF13499 0.509
DOC_PP4_FxxP_1 861 864 PF00568 0.544
DOC_PP4_MxPP_1 696 699 PF00568 0.516
DOC_USP7_MATH_1 171 175 PF00917 0.459
DOC_USP7_MATH_1 20 24 PF00917 0.583
DOC_USP7_MATH_1 235 239 PF00917 0.706
DOC_USP7_MATH_1 255 259 PF00917 0.526
DOC_USP7_MATH_1 274 278 PF00917 0.534
DOC_USP7_MATH_1 322 326 PF00917 0.568
DOC_USP7_MATH_1 739 743 PF00917 0.539
DOC_USP7_MATH_1 764 768 PF00917 0.519
DOC_USP7_MATH_1 825 829 PF00917 0.542
DOC_USP7_MATH_1 856 860 PF00917 0.566
DOC_USP7_MATH_1 95 99 PF00917 0.391
DOC_WW_Pin1_4 173 178 PF00397 0.448
DOC_WW_Pin1_4 260 265 PF00397 0.558
DOC_WW_Pin1_4 286 291 PF00397 0.506
DOC_WW_Pin1_4 324 329 PF00397 0.572
DOC_WW_Pin1_4 685 690 PF00397 0.566
DOC_WW_Pin1_4 726 731 PF00397 0.548
DOC_WW_Pin1_4 743 748 PF00397 0.516
DOC_WW_Pin1_4 753 758 PF00397 0.531
DOC_WW_Pin1_4 769 774 PF00397 0.482
DOC_WW_Pin1_4 804 809 PF00397 0.540
DOC_WW_Pin1_4 815 820 PF00397 0.519
DOC_WW_Pin1_4 82 87 PF00397 0.495
DOC_WW_Pin1_4 834 839 PF00397 0.500
DOC_WW_Pin1_4 860 865 PF00397 0.547
LIG_14-3-3_CanoR_1 194 200 PF00244 0.545
LIG_14-3-3_CanoR_1 732 737 PF00244 0.538
LIG_14-3-3_CanoR_1 761 767 PF00244 0.525
LIG_14-3-3_CanoR_1 826 830 PF00244 0.540
LIG_14-3-3_CanoR_1 87 92 PF00244 0.382
LIG_14-3-3_CanoR_1 96 105 PF00244 0.358
LIG_APCC_ABBA_1 669 674 PF00400 0.471
LIG_CtBP_PxDLS_1 800 805 PF00389 0.555
LIG_deltaCOP1_diTrp_1 705 715 PF00928 0.548
LIG_deltaCOP1_diTrp_1 878 887 PF00928 0.531
LIG_FHA_1 196 202 PF00498 0.373
LIG_FHA_1 264 270 PF00498 0.575
LIG_FHA_1 300 306 PF00498 0.589
LIG_FHA_1 50 56 PF00498 0.460
LIG_FHA_1 722 728 PF00498 0.536
LIG_FHA_1 785 791 PF00498 0.536
LIG_FHA_1 83 89 PF00498 0.364
LIG_FHA_2 186 192 PF00498 0.320
LIG_FHA_2 238 244 PF00498 0.562
LIG_FHA_2 302 308 PF00498 0.602
LIG_FHA_2 700 706 PF00498 0.565
LIG_LIR_Apic_2 859 864 PF02991 0.545
LIG_LIR_Gen_1 213 224 PF02991 0.440
LIG_LIR_Gen_1 712 723 PF02991 0.535
LIG_LIR_Nem_3 213 219 PF02991 0.605
LIG_LIR_Nem_3 712 718 PF02991 0.538
LIG_NRBOX 103 109 PF00104 0.356
LIG_SH2_CRK 216 220 PF00017 0.616
LIG_SH2_STAT3 278 281 PF00017 0.561
LIG_SH2_STAT5 262 265 PF00017 0.600
LIG_SH2_STAT5 278 281 PF00017 0.558
LIG_SH2_STAT5 57 60 PF00017 0.421
LIG_SH2_STAT5 726 729 PF00017 0.536
LIG_SH3_3 12 18 PF00018 0.533
LIG_SH3_3 692 698 PF00018 0.541
LIG_SH3_3 771 777 PF00018 0.517
LIG_SUMO_SIM_anti_2 103 110 PF11976 0.351
LIG_SUMO_SIM_anti_2 188 194 PF11976 0.318
LIG_TRAF2_1 304 307 PF00917 0.562
LIG_TRAF2_1 330 333 PF00917 0.542
LIG_UBA3_1 55 61 PF00899 0.467
LIG_WRC_WIRS_1 1 6 PF05994 0.491
LIG_WRPW_2 282 285 PF00400 0.561
MOD_CDC14_SPxK_1 729 732 PF00782 0.541
MOD_CDK_SPK_2 82 87 PF00069 0.392
MOD_CDK_SPxK_1 726 732 PF00069 0.546
MOD_CDK_SPxxK_3 726 733 PF00069 0.547
MOD_CDK_SPxxK_3 804 811 PF00069 0.554
MOD_CK1_1 113 119 PF00069 0.365
MOD_CK1_1 21 27 PF00069 0.753
MOD_CK1_1 239 245 PF00069 0.563
MOD_CK1_1 258 264 PF00069 0.567
MOD_CK1_1 658 664 PF00069 0.426
MOD_CK1_1 742 748 PF00069 0.536
MOD_CK1_1 828 834 PF00069 0.551
MOD_CK1_1 847 853 PF00069 0.512
MOD_CK1_1 859 865 PF00069 0.521
MOD_CK1_1 868 874 PF00069 0.534
MOD_CK2_1 301 307 PF00069 0.589
MOD_CK2_1 327 333 PF00069 0.554
MOD_CK2_1 76 82 PF00069 0.519
MOD_CK2_1 95 101 PF00069 0.396
MOD_Cter_Amidation 794 797 PF01082 0.531
MOD_GlcNHglycan 299 302 PF01048 0.551
MOD_GlcNHglycan 758 761 PF01048 0.532
MOD_GlcNHglycan 778 781 PF01048 0.505
MOD_GlcNHglycan 820 823 PF01048 0.553
MOD_GlcNHglycan 846 849 PF01048 0.555
MOD_GlcNHglycan 864 867 PF01048 0.495
MOD_GSK3_1 20 27 PF00069 0.787
MOD_GSK3_1 235 242 PF00069 0.707
MOD_GSK3_1 258 265 PF00069 0.580
MOD_GSK3_1 28 35 PF00069 0.690
MOD_GSK3_1 295 302 PF00069 0.589
MOD_GSK3_1 324 331 PF00069 0.573
MOD_GSK3_1 651 658 PF00069 0.433
MOD_GSK3_1 661 668 PF00069 0.440
MOD_GSK3_1 685 692 PF00069 0.572
MOD_GSK3_1 739 746 PF00069 0.558
MOD_GSK3_1 769 776 PF00069 0.530
MOD_GSK3_1 784 791 PF00069 0.512
MOD_GSK3_1 795 802 PF00069 0.512
MOD_GSK3_1 824 831 PF00069 0.554
MOD_GSK3_1 856 863 PF00069 0.542
MOD_NEK2_1 128 133 PF00069 0.372
MOD_NEK2_1 218 223 PF00069 0.447
MOD_NEK2_1 285 290 PF00069 0.550
MOD_NEK2_1 297 302 PF00069 0.588
MOD_NEK2_1 308 313 PF00069 0.555
MOD_NEK2_1 829 834 PF00069 0.536
MOD_NEK2_2 76 81 PF00069 0.521
MOD_NEK2_2 799 804 PF00069 0.554
MOD_NEK2_2 856 861 PF00069 0.539
MOD_PIKK_1 110 116 PF00454 0.352
MOD_PIKK_1 185 191 PF00454 0.344
MOD_PIKK_1 195 201 PF00454 0.360
MOD_PIKK_1 322 328 PF00454 0.594
MOD_PKA_1 194 200 PF00069 0.379
MOD_PKA_1 732 738 PF00069 0.574
MOD_PKA_2 194 200 PF00069 0.555
MOD_PKA_2 21 27 PF00069 0.577
MOD_PKA_2 274 280 PF00069 0.615
MOD_PKA_2 661 667 PF00069 0.439
MOD_PKA_2 731 737 PF00069 0.569
MOD_PKA_2 795 801 PF00069 0.557
MOD_PKA_2 8 14 PF00069 0.675
MOD_PKA_2 825 831 PF00069 0.554
MOD_PKA_2 95 101 PF00069 0.388
MOD_Plk_1 151 157 PF00069 0.336
MOD_Plk_1 258 264 PF00069 0.597
MOD_Plk_1 651 657 PF00069 0.414
MOD_Plk_1 665 671 PF00069 0.441
MOD_Plk_4 179 185 PF00069 0.391
MOD_Plk_4 274 280 PF00069 0.540
MOD_Plk_4 699 705 PF00069 0.559
MOD_Plk_4 856 862 PF00069 0.541
MOD_ProDKin_1 173 179 PF00069 0.439
MOD_ProDKin_1 260 266 PF00069 0.556
MOD_ProDKin_1 286 292 PF00069 0.508
MOD_ProDKin_1 324 330 PF00069 0.564
MOD_ProDKin_1 685 691 PF00069 0.570
MOD_ProDKin_1 726 732 PF00069 0.549
MOD_ProDKin_1 743 749 PF00069 0.511
MOD_ProDKin_1 753 759 PF00069 0.532
MOD_ProDKin_1 769 775 PF00069 0.487
MOD_ProDKin_1 804 810 PF00069 0.540
MOD_ProDKin_1 815 821 PF00069 0.520
MOD_ProDKin_1 82 88 PF00069 0.482
MOD_ProDKin_1 834 840 PF00069 0.500
MOD_ProDKin_1 860 866 PF00069 0.546
TRG_DiLeu_BaEn_1 103 108 PF01217 0.352
TRG_DiLeu_BaEn_1 125 130 PF01217 0.369
TRG_DiLeu_BaEn_1 214 219 PF01217 0.410
TRG_DiLeu_BaEn_1 353 358 PF01217 0.423
TRG_DiLeu_BaEn_1 363 368 PF01217 0.393
TRG_DiLeu_BaEn_1 383 388 PF01217 0.386
TRG_DiLeu_BaEn_1 393 398 PF01217 0.405
TRG_DiLeu_BaEn_1 403 408 PF01217 0.394
TRG_DiLeu_BaEn_1 423 428 PF01217 0.413
TRG_DiLeu_BaEn_1 553 558 PF01217 0.470
TRG_DiLeu_BaEn_1 573 578 PF01217 0.429
TRG_DiLeu_BaEn_1 613 618 PF01217 0.432
TRG_DiLeu_BaEn_4 342 348 PF01217 0.474
TRG_DiLeu_BaEn_4 372 378 PF01217 0.415
TRG_DiLeu_BaEn_4 412 418 PF01217 0.437
TRG_DiLeu_BaEn_4 432 438 PF01217 0.473
TRG_DiLeu_BaEn_4 442 448 PF01217 0.462
TRG_DiLeu_BaEn_4 452 458 PF01217 0.423
TRG_DiLeu_BaEn_4 462 468 PF01217 0.423
TRG_DiLeu_BaEn_4 472 478 PF01217 0.441
TRG_DiLeu_BaEn_4 482 488 PF01217 0.455
TRG_DiLeu_BaEn_4 492 498 PF01217 0.493
TRG_DiLeu_BaEn_4 502 508 PF01217 0.519
TRG_DiLeu_BaEn_4 512 518 PF01217 0.447
TRG_DiLeu_BaEn_4 522 528 PF01217 0.431
TRG_DiLeu_BaEn_4 532 538 PF01217 0.472
TRG_DiLeu_BaEn_4 542 548 PF01217 0.501
TRG_DiLeu_BaEn_4 562 568 PF01217 0.439
TRG_DiLeu_BaEn_4 582 588 PF01217 0.454
TRG_DiLeu_BaEn_4 592 598 PF01217 0.458
TRG_DiLeu_BaEn_4 602 608 PF01217 0.453
TRG_DiLeu_BaEn_4 622 628 PF01217 0.424
TRG_DiLeu_BaEn_4 632 638 PF01217 0.431
TRG_DiLeu_BaEn_4 642 648 PF01217 0.390
TRG_DiLeu_BaLyEn_6 155 160 PF01217 0.333
TRG_DiLeu_BaLyEn_6 206 211 PF01217 0.365
TRG_ENDOCYTIC_2 216 219 PF00928 0.612
TRG_ENDOCYTIC_2 672 675 PF00928 0.505
TRG_ER_diArg_1 157 159 PF00400 0.335
TRG_ER_diArg_1 193 195 PF00400 0.377
TRG_ER_diArg_1 207 210 PF00400 0.348
TRG_NLS_MonoExtC_3 803 808 PF00514 0.547
TRG_Pf-PMV_PEXEL_1 209 213 PF00026 0.380

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IJE1 Leishmania donovani 89% 95%
A4I2L3 Leishmania infantum 46% 100%
A4I850 Leishmania infantum 89% 75%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS