Putative sphingosine-1-phosphate phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

sphingosine-1-phosphate phosphatase, putative

Species:

Leishmania major

UniProt:

Q4Q546_LEIMA

TriTrypDb:

LmjF.32.2290 , LMJLV39_320029800 , LMJSD75_320029900

Length:

639

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	2
GO:0016020	membrane	2	7
GO:0031090	organelle membrane	3	2
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4Q546

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q546

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016311	dephosphorylation	5	2
GO:0030258	lipid modification	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0046839	phospholipid dephosphorylation	5	2
GO:0071704	organic substance metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0016787	hydrolase activity	2	5
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016791	phosphatase activity	5	2
GO:0042392	sphingosine-1-phosphate phosphatase activity	7	2
GO:0042577	lipid phosphatase activity	6	2
GO:0042578	phosphoric ester hydrolase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	120	124	PF00656	0.715
CLV_C14_Caspase3-7	258	262	PF00656	0.222
CLV_C14_Caspase3-7	35	39	PF00656	0.633
CLV_C14_Caspase3-7	566	570	PF00656	0.664
CLV_NRD_NRD_1	36	38	PF00675	0.433
CLV_PCSK_KEX2_1	278	280	PF00082	0.486
CLV_PCSK_KEX2_1	36	38	PF00082	0.433
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.527
CLV_PCSK_SKI1_1	260	264	PF00082	0.596
CLV_PCSK_SKI1_1	476	480	PF00082	0.323
CLV_PCSK_SKI1_1	553	557	PF00082	0.463
DEG_COP1_1	16	27	PF00400	0.710
DEG_MDM2_SWIB_1	361	369	PF02201	0.333
DEG_Nend_Nbox_1	1	3	PF02207	0.678
DOC_AGCK_PIF_1	214	219	PF00069	0.370
DOC_CKS1_1	146	151	PF01111	0.679
DOC_CYCLIN_yCln2_LP_2	494	500	PF00134	0.525
DOC_MAPK_DCC_7	201	211	PF00069	0.542
DOC_MAPK_gen_1	514	522	PF00069	0.668
DOC_MAPK_gen_1	94	102	PF00069	0.729
DOC_MAPK_JIP1_4	96	102	PF00069	0.702
DOC_MAPK_MEF2A_6	267	275	PF00069	0.261
DOC_MAPK_MEF2A_6	492	501	PF00069	0.603
DOC_MAPK_MEF2A_6	94	102	PF00069	0.729
DOC_PP1_RVXF_1	173	180	PF00149	0.616
DOC_PP2B_LxvP_1	209	212	PF13499	0.646
DOC_PP2B_LxvP_1	228	231	PF13499	0.302
DOC_PP2B_LxvP_1	236	239	PF13499	0.288
DOC_PP4_FxxP_1	12	15	PF00568	0.754
DOC_PP4_FxxP_1	263	266	PF00568	0.335
DOC_USP7_MATH_1	119	123	PF00917	0.717
DOC_USP7_MATH_1	150	154	PF00917	0.724
DOC_USP7_MATH_1	239	243	PF00917	0.302
DOC_USP7_MATH_1	327	331	PF00917	0.411
DOC_USP7_MATH_1	524	528	PF00917	0.708
DOC_USP7_MATH_1	529	533	PF00917	0.792
DOC_USP7_MATH_1	555	559	PF00917	0.795
DOC_USP7_UBL2_3	476	480	PF12436	0.576
DOC_WW_Pin1_4	145	150	PF00397	0.715
DOC_WW_Pin1_4	156	161	PF00397	0.714
DOC_WW_Pin1_4	19	24	PF00397	0.769
DOC_WW_Pin1_4	372	377	PF00397	0.393
DOC_WW_Pin1_4	393	398	PF00397	0.465
DOC_WW_Pin1_4	630	635	PF00397	0.543
LIG_14-3-3_CanoR_1	434	443	PF00244	0.280
LIG_14-3-3_CanoR_1	489	495	PF00244	0.563
LIG_14-3-3_CanoR_1	514	522	PF00244	0.687
LIG_14-3-3_CanoR_1	559	568	PF00244	0.681
LIG_14-3-3_CanoR_1	594	599	PF00244	0.463
LIG_Actin_WH2_2	462	478	PF00022	0.470
LIG_Actin_WH2_2	601	616	PF00022	0.407
LIG_APCC_ABBAyCdc20_2	175	181	PF00400	0.539
LIG_BRCT_BRCA1_1	295	299	PF00533	0.261
LIG_BRCT_BRCA1_1	406	410	PF00533	0.484
LIG_BRCT_BRCA1_1	445	449	PF00533	0.302
LIG_BRCT_BRCA1_1	531	535	PF00533	0.791
LIG_CSL_BTD_1	631	634	PF09270	0.424
LIG_CtBP_PxDLS_1	97	101	PF00389	0.702
LIG_deltaCOP1_diTrp_1	181	187	PF00928	0.534
LIG_EH1_1	338	346	PF00400	0.482
LIG_eIF4E_1	384	390	PF01652	0.411
LIG_FHA_1	231	237	PF00498	0.338
LIG_FHA_1	384	390	PF00498	0.451
LIG_FHA_1	409	415	PF00498	0.407
LIG_FHA_1	53	59	PF00498	0.622
LIG_FHA_1	560	566	PF00498	0.691
LIG_FHA_1	614	620	PF00498	0.389
LIG_FHA_2	160	166	PF00498	0.653
LIG_FHA_2	256	262	PF00498	0.254
LIG_FHA_2	33	39	PF00498	0.743
LIG_FHA_2	394	400	PF00498	0.575
LIG_FHA_2	47	53	PF00498	0.635
LIG_FHA_2	562	568	PF00498	0.674
LIG_GSK3_LRP6_1	634	639	PF00069	0.477
LIG_LIR_Apic_2	10	15	PF02991	0.748
LIG_LIR_Apic_2	261	266	PF02991	0.335
LIG_LIR_Apic_2	283	289	PF02991	0.261
LIG_LIR_Apic_2	74	79	PF02991	0.635
LIG_LIR_Gen_1	224	234	PF02991	0.304
LIG_LIR_Gen_1	296	307	PF02991	0.276
LIG_LIR_Gen_1	330	338	PF02991	0.395
LIG_LIR_Gen_1	375	385	PF02991	0.330
LIG_LIR_Gen_1	446	455	PF02991	0.291
LIG_LIR_Gen_1	595	605	PF02991	0.379
LIG_LIR_Nem_3	20	24	PF02991	0.762
LIG_LIR_Nem_3	222	228	PF02991	0.365
LIG_LIR_Nem_3	296	302	PF02991	0.276
LIG_LIR_Nem_3	330	334	PF02991	0.395
LIG_LIR_Nem_3	374	380	PF02991	0.324
LIG_LIR_Nem_3	446	450	PF02991	0.291
LIG_MYND_1	208	212	PF01753	0.570
LIG_PCNA_PIPBox_1	295	304	PF02747	0.287
LIG_Pex14_1	250	254	PF04695	0.309
LIG_Pex14_2	225	229	PF04695	0.277
LIG_Pex14_2	361	365	PF04695	0.311
LIG_Pex14_2	445	449	PF04695	0.304
LIG_Pex14_2	535	539	PF04695	0.693
LIG_Pex14_2	603	607	PF04695	0.347
LIG_RPA_C_Fungi	459	471	PF08784	0.391
LIG_SH2_CRK	286	290	PF00017	0.302
LIG_SH2_CRK	304	308	PF00017	0.302
LIG_SH2_CRK	428	432	PF00017	0.428
LIG_SH2_GRB2like	571	574	PF00017	0.524
LIG_SH2_PTP2	384	387	PF00017	0.393
LIG_SH2_SRC	404	407	PF00017	0.367
LIG_SH2_SRC	571	574	PF00017	0.435
LIG_SH2_STAT5	183	186	PF00017	0.367
LIG_SH2_STAT5	213	216	PF00017	0.309
LIG_SH2_STAT5	226	229	PF00017	0.302
LIG_SH2_STAT5	254	257	PF00017	0.302
LIG_SH2_STAT5	304	307	PF00017	0.407
LIG_SH2_STAT5	325	328	PF00017	0.446
LIG_SH2_STAT5	335	338	PF00017	0.306
LIG_SH2_STAT5	380	383	PF00017	0.332
LIG_SH2_STAT5	384	387	PF00017	0.308
LIG_SH2_STAT5	404	407	PF00017	0.186
LIG_SH2_STAT5	498	501	PF00017	0.439
LIG_SH2_STAT5	571	574	PF00017	0.524
LIG_SH3_3	143	149	PF00018	0.571
LIG_SH3_3	154	160	PF00018	0.614
LIG_SH3_3	202	208	PF00018	0.477
LIG_SH3_3	21	27	PF00018	0.790
LIG_SH3_3	263	269	PF00018	0.307
LIG_SH3_3	394	400	PF00018	0.462
LIG_SH3_3	485	491	PF00018	0.370
LIG_SH3_3	628	634	PF00018	0.684
LIG_SUMO_SIM_anti_2	465	470	PF11976	0.306
LIG_SUMO_SIM_par_1	159	165	PF11976	0.572
LIG_SxIP_EBH_1	514	526	PF03271	0.607
LIG_TRAF2_1	564	567	PF00917	0.624
LIG_TYR_ITIM	211	216	PF00017	0.395
LIG_TYR_ITIM	302	307	PF00017	0.240
LIG_TYR_ITIM	382	387	PF00017	0.407
LIG_Vh1_VBS_1	459	477	PF01044	0.429
LIG_WRC_WIRS_1	216	221	PF05994	0.327
LIG_WRC_WIRS_1	298	303	PF05994	0.435
LIG_WRC_WIRS_1	444	449	PF05994	0.306
LIG_WRC_WIRS_1	604	609	PF05994	0.395
MOD_CK1_1	113	119	PF00069	0.735
MOD_CK1_1	124	130	PF00069	0.678
MOD_CK1_1	159	165	PF00069	0.555
MOD_CK1_1	290	296	PF00069	0.304
MOD_CK1_1	579	585	PF00069	0.428
MOD_CK1_1	92	98	PF00069	0.706
MOD_CK2_1	159	165	PF00069	0.590
MOD_CK2_1	557	563	PF00069	0.732
MOD_CMANNOS	586	589	PF00535	0.362
MOD_Cter_Amidation	276	279	PF01082	0.338
MOD_DYRK1A_RPxSP_1	372	376	PF00069	0.415
MOD_DYRK1A_RPxSP_1	630	634	PF00069	0.531
MOD_GlcNHglycan	137	140	PF01048	0.624
MOD_GlcNHglycan	16	19	PF01048	0.773
MOD_GlcNHglycan	295	298	PF01048	0.395
MOD_GlcNHglycan	416	419	PF01048	0.416
MOD_GlcNHglycan	46	49	PF01048	0.797
MOD_GlcNHglycan	482	485	PF01048	0.508
MOD_GlcNHglycan	73	76	PF01048	0.756
MOD_GlcNHglycan	91	94	PF01048	0.740
MOD_GSK3_1	19	26	PF00069	0.799
MOD_GSK3_1	27	34	PF00069	0.702
MOD_GSK3_1	293	300	PF00069	0.333
MOD_GSK3_1	3	10	PF00069	0.683
MOD_GSK3_1	404	411	PF00069	0.419
MOD_GSK3_1	44	51	PF00069	0.694
MOD_GSK3_1	460	467	PF00069	0.454
MOD_GSK3_1	520	527	PF00069	0.672
MOD_GSK3_1	555	562	PF00069	0.674
MOD_GSK3_1	630	637	PF00069	0.691
MOD_GSK3_1	92	99	PF00069	0.653
MOD_LATS_1	592	598	PF00433	0.395
MOD_N-GLC_1	524	529	PF02516	0.586
MOD_N-GLC_1	71	76	PF02516	0.680
MOD_N-GLC_1	87	92	PF02516	0.614
MOD_NEK2_1	2	7	PF00069	0.681
MOD_NEK2_1	32	37	PF00069	0.741
MOD_NEK2_1	383	388	PF00069	0.327
MOD_NEK2_1	408	413	PF00069	0.381
MOD_NEK2_1	445	450	PF00069	0.379
MOD_NEK2_1	603	608	PF00069	0.377
MOD_NEK2_1	613	618	PF00069	0.406
MOD_NEK2_2	182	187	PF00069	0.467
MOD_NEK2_2	404	409	PF00069	0.332
MOD_PIKK_1	571	577	PF00454	0.598
MOD_PKA_2	408	414	PF00069	0.395
MOD_PKA_2	513	519	PF00069	0.651
MOD_PKA_2	613	619	PF00069	0.406
MOD_Plk_1	365	371	PF00069	0.433
MOD_Plk_1	464	470	PF00069	0.468
MOD_Plk_1	621	627	PF00069	0.440
MOD_Plk_4	142	148	PF00069	0.633
MOD_Plk_4	244	250	PF00069	0.340
MOD_Plk_4	351	357	PF00069	0.362
MOD_Plk_4	365	371	PF00069	0.348
MOD_Plk_4	464	470	PF00069	0.373
MOD_Plk_4	603	609	PF00069	0.354
MOD_ProDKin_1	145	151	PF00069	0.657
MOD_ProDKin_1	156	162	PF00069	0.647
MOD_ProDKin_1	19	25	PF00069	0.731
MOD_ProDKin_1	372	378	PF00069	0.489
MOD_ProDKin_1	393	399	PF00069	0.461
MOD_ProDKin_1	630	636	PF00069	0.681
TRG_DiLeu_BaEn_1	465	470	PF01217	0.406
TRG_DiLeu_BaLyEn_6	205	210	PF01217	0.424
TRG_ENDOCYTIC_2	213	216	PF00928	0.302
TRG_ENDOCYTIC_2	226	229	PF00928	0.304
TRG_ENDOCYTIC_2	304	307	PF00928	0.302
TRG_ENDOCYTIC_2	335	338	PF00928	0.395
TRG_ENDOCYTIC_2	380	383	PF00928	0.411
TRG_ENDOCYTIC_2	384	387	PF00928	0.377
TRG_ENDOCYTIC_2	428	431	PF00928	0.425
TRG_ENDOCYTIC_2	498	501	PF00928	0.463
TRG_ENDOCYTIC_2	598	601	PF00928	0.311

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9L1	Leptomonas seymouri	53%	100%
A0A1X0NUR9	Trypanosomatidae	35%	100%
A0A3Q8IGA4	Leishmania donovani	89%	100%
A0A422MU49	Trypanosoma rangeli	39%	100%
A4HKM0	Leishmania braziliensis	64%	100%
A4I852	Leishmania infantum	89%	100%