Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q545_LEIMA

TriTrypDb:

LmjF.32.2300 , LMJLV39_320029900 , LMJSD75_320030000

Length:

453

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q545

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q545

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	243	247	PF00656	0.771
CLV_NRD_NRD_1	118	120	PF00675	0.668
CLV_NRD_NRD_1	152	154	PF00675	0.675
CLV_NRD_NRD_1	34	36	PF00675	0.662
CLV_NRD_NRD_1	430	432	PF00675	0.811
CLV_NRD_NRD_1	439	441	PF00675	0.737
CLV_NRD_NRD_1	96	98	PF00675	0.689
CLV_PCSK_KEX2_1	118	120	PF00082	0.668
CLV_PCSK_KEX2_1	152	154	PF00082	0.675
CLV_PCSK_KEX2_1	263	265	PF00082	0.757
CLV_PCSK_KEX2_1	34	36	PF00082	0.662
CLV_PCSK_KEX2_1	362	364	PF00082	0.650
CLV_PCSK_KEX2_1	430	432	PF00082	0.811
CLV_PCSK_KEX2_1	439	441	PF00082	0.737
CLV_PCSK_KEX2_1	56	58	PF00082	0.556
CLV_PCSK_KEX2_1	96	98	PF00082	0.689
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.821
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.796
CLV_PCSK_PC1ET2_1	56	58	PF00082	0.465
CLV_PCSK_PC7_1	30	36	PF00082	0.663
CLV_PCSK_SKI1_1	153	157	PF00082	0.734
CLV_PCSK_SKI1_1	164	168	PF00082	0.608
CLV_PCSK_SKI1_1	221	225	PF00082	0.765
CLV_PCSK_SKI1_1	242	246	PF00082	0.778
CLV_PCSK_SKI1_1	348	352	PF00082	0.781
CLV_PCSK_SKI1_1	96	100	PF00082	0.675
DEG_APCC_DBOX_1	163	171	PF00400	0.546
DOC_CYCLIN_RxL_1	161	172	PF00134	0.462
DOC_CYCLIN_yCln2_LP_2	157	163	PF00134	0.665
DOC_CYCLIN_yCln2_LP_2	415	421	PF00134	0.765
DOC_MAPK_DCC_7	412	421	PF00069	0.762
DOC_MAPK_gen_1	171	180	PF00069	0.628
DOC_MAPK_gen_1	260	267	PF00069	0.759
DOC_MAPK_gen_1	412	421	PF00069	0.824
DOC_PP1_RVXF_1	261	268	PF00149	0.816
DOC_PP2B_LxvP_1	415	418	PF13499	0.722
DOC_USP7_MATH_1	117	121	PF00917	0.595
DOC_USP7_MATH_1	131	135	PF00917	0.762
DOC_USP7_MATH_1	136	140	PF00917	0.679
DOC_USP7_MATH_1	240	244	PF00917	0.673
DOC_USP7_MATH_1	300	304	PF00917	0.728
DOC_USP7_MATH_1	346	350	PF00917	0.783
DOC_USP7_MATH_1	372	376	PF00917	0.733
DOC_USP7_MATH_1	407	411	PF00917	0.571
DOC_USP7_MATH_1	82	86	PF00917	0.580
DOC_WW_Pin1_4	127	132	PF00397	0.769
DOC_WW_Pin1_4	225	230	PF00397	0.717
DOC_WW_Pin1_4	232	237	PF00397	0.824
DOC_WW_Pin1_4	254	259	PF00397	0.690
DOC_WW_Pin1_4	373	378	PF00397	0.823
DOC_WW_Pin1_4	420	425	PF00397	0.823
DOC_WW_Pin1_4	62	67	PF00397	0.523
LIG_14-3-3_CanoR_1	348	353	PF00244	0.754
LIG_14-3-3_CanoR_1	363	371	PF00244	0.539
LIG_14-3-3_CanoR_1	439	443	PF00244	0.842
LIG_FHA_1	302	308	PF00498	0.597
LIG_FHA_1	34	40	PF00498	0.572
LIG_FHA_1	340	346	PF00498	0.811
LIG_FHA_2	23	29	PF00498	0.653
LIG_FHA_2	447	453	PF00498	0.734
LIG_FHA_2	63	69	PF00498	0.627
LIG_LIR_Gen_1	270	281	PF02991	0.649
LIG_LIR_Nem_3	270	276	PF02991	0.644
LIG_LIR_Nem_3	9	15	PF02991	0.662
LIG_NRBOX	165	171	PF00104	0.493
LIG_Pex14_2	337	341	PF04695	0.566
LIG_Rb_LxCxE_1	42	59	PF01857	0.539
LIG_SH2_CRK	12	16	PF00017	0.544
LIG_SH2_STAT5	408	411	PF00017	0.697
LIG_SH3_2	114	119	PF14604	0.722
LIG_SH3_3	111	117	PF00018	0.703
LIG_SH3_3	120	126	PF00018	0.728
LIG_SH3_3	182	188	PF00018	0.624
LIG_SH3_3	191	197	PF00018	0.586
LIG_SH3_3	223	229	PF00018	0.786
LIG_SH3_3	233	239	PF00018	0.702
LIG_SH3_3	303	309	PF00018	0.811
LIG_SUMO_SIM_par_1	166	172	PF11976	0.548
LIG_SUMO_SIM_par_1	417	423	PF11976	0.769
LIG_TRAF2_1	7	10	PF00917	0.671
LIG_TRAF2_1	88	91	PF00917	0.685
LIG_UBA3_1	166	173	PF00899	0.667
LIG_WW_1	405	408	PF00397	0.641
LIG_WW_3	257	261	PF00397	0.608
MOD_CDC14_SPxK_1	257	260	PF00782	0.608
MOD_CDC14_SPxK_1	376	379	PF00782	0.837
MOD_CDK_SPK_2	420	425	PF00069	0.776
MOD_CDK_SPxK_1	254	260	PF00069	0.612
MOD_CDK_SPxK_1	373	379	PF00069	0.828
MOD_CK1_1	127	133	PF00069	0.700
MOD_CK1_1	140	146	PF00069	0.553
MOD_CK1_1	225	231	PF00069	0.760
MOD_CK1_1	423	429	PF00069	0.833
MOD_CK1_1	434	440	PF00069	0.664
MOD_CK2_1	4	10	PF00069	0.693
MOD_CK2_1	446	452	PF00069	0.736
MOD_Cter_Amidation	437	440	PF01082	0.651
MOD_GlcNHglycan	119	122	PF01048	0.625
MOD_GlcNHglycan	133	136	PF01048	0.707
MOD_GlcNHglycan	140	143	PF01048	0.639
MOD_GlcNHglycan	144	147	PF01048	0.611
MOD_GlcNHglycan	348	351	PF01048	0.655
MOD_GlcNHglycan	389	392	PF01048	0.793
MOD_GlcNHglycan	425	428	PF01048	0.796
MOD_GlcNHglycan	434	437	PF01048	0.653
MOD_GlcNHglycan	6	9	PF01048	0.687
MOD_GlcNHglycan	84	87	PF01048	0.579
MOD_GSK3_1	127	134	PF00069	0.720
MOD_GSK3_1	136	143	PF00069	0.600
MOD_GSK3_1	196	203	PF00069	0.777
MOD_GSK3_1	221	228	PF00069	0.773
MOD_GSK3_1	238	245	PF00069	0.576
MOD_GSK3_1	327	334	PF00069	0.814
MOD_GSK3_1	344	351	PF00069	0.655
MOD_GSK3_1	434	441	PF00069	0.747
MOD_GSK3_1	443	450	PF00069	0.636
MOD_N-GLC_1	127	132	PF02516	0.645
MOD_N-GLC_1	311	316	PF02516	0.740
MOD_N-GLC_1	327	332	PF02516	0.784
MOD_N-GLC_1	431	436	PF02516	0.783
MOD_N-GLC_2	323	325	PF02516	0.751
MOD_NEK2_2	339	344	PF00069	0.829
MOD_PIKK_1	22	28	PF00454	0.587
MOD_PIKK_1	331	337	PF00454	0.791
MOD_PKA_2	117	123	PF00069	0.625
MOD_PKA_2	210	216	PF00069	0.850
MOD_PKA_2	274	280	PF00069	0.804
MOD_PKA_2	285	291	PF00069	0.574
MOD_PKA_2	33	39	PF00069	0.656
MOD_PKA_2	364	370	PF00069	0.635
MOD_PKA_2	438	444	PF00069	0.677
MOD_PKA_2	446	452	PF00069	0.674
MOD_PKA_2	82	88	PF00069	0.698
MOD_Plk_1	153	159	PF00069	0.775
MOD_Plk_1	311	317	PF00069	0.737
MOD_Plk_4	153	159	PF00069	0.691
MOD_Plk_4	190	196	PF00069	0.574
MOD_Plk_4	222	228	PF00069	0.809
MOD_Plk_4	288	294	PF00069	0.737
MOD_Plk_4	348	354	PF00069	0.780
MOD_ProDKin_1	127	133	PF00069	0.769
MOD_ProDKin_1	225	231	PF00069	0.720
MOD_ProDKin_1	232	238	PF00069	0.821
MOD_ProDKin_1	254	260	PF00069	0.690
MOD_ProDKin_1	373	379	PF00069	0.828
MOD_ProDKin_1	420	426	PF00069	0.823
MOD_ProDKin_1	62	68	PF00069	0.522
MOD_SUMO_for_1	55	58	PF00179	0.458
MOD_SUMO_rev_2	255	265	PF00179	0.806
TRG_DiLeu_BaEn_1	10	15	PF01217	0.657
TRG_ENDOCYTIC_2	12	15	PF00928	0.656
TRG_ER_diArg_1	117	119	PF00400	0.658
TRG_ER_diArg_1	151	153	PF00400	0.675

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ITE5	Leishmania donovani	85%	100%
A4HKM1	Leishmania braziliensis	63%	100%
A4I853	Leishmania infantum	85%	100%
E9B310	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%