Nsp1_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoporin NUP53a

Species:

Leishmania major

UniProt:

Q4Q540_LEIMA

TriTrypDb:

LmjF.32.2350 , LMJLV39_320030400 , LMJSD75_320030500

Length:

644

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	6
GO:0032991	protein-containing complex	1	6
GO:0044613	nuclear pore central transport channel	3	2
GO:0140513	nuclear protein-containing complex	2	6

Expansion

Sequence features

Q4Q540

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q540

Function

Biological processes
Term	Name	Level	Count
GO:0006405	RNA export from nucleus	5	2
GO:0006606	protein import into nucleus	5	2
GO:0006810	transport	3	6
GO:0006886	intracellular protein transport	4	2
GO:0006913	nucleocytoplasmic transport	5	2
GO:0008104	protein localization	4	6
GO:0009987	cellular process	1	6
GO:0015031	protein transport	4	6
GO:0015931	nucleobase-containing compound transport	5	2
GO:0033036	macromolecule localization	2	6
GO:0033365	protein localization to organelle	5	2
GO:0034504	protein localization to nucleus	6	2
GO:0045184	establishment of protein localization	3	6
GO:0046907	intracellular transport	3	2
GO:0050657	nucleic acid transport	6	2
GO:0050658	RNA transport	4	2
GO:0051168	nuclear export	6	2
GO:0051169	nuclear transport	4	2
GO:0051170	import into nucleus	6	2
GO:0051179	localization	1	6
GO:0051234	establishment of localization	2	6
GO:0051236	establishment of RNA localization	3	2
GO:0051641	cellular localization	2	6
GO:0051649	establishment of localization in cell	3	2
GO:0070727	cellular macromolecule localization	3	6
GO:0071702	organic substance transport	4	6
GO:0071705	nitrogen compound transport	4	6
GO:0072594	establishment of protein localization to organelle	4	2

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	6
GO:0005488	binding	1	2
GO:0005543	phospholipid binding	3	2
GO:0008289	lipid binding	2	2
GO:0017056	structural constituent of nuclear pore	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	459	461	PF00675	0.530
CLV_PCSK_KEX2_1	428	430	PF00082	0.651
CLV_PCSK_PC1ET2_1	428	430	PF00082	0.651
CLV_PCSK_SKI1_1	502	506	PF00082	0.471
CLV_PCSK_SKI1_1	567	571	PF00082	0.494
DEG_APCC_DBOX_1	598	606	PF00400	0.702
DEG_SPOP_SBC_1	84	88	PF00917	0.720
DOC_CYCLIN_yCln2_LP_2	171	177	PF00134	0.766
DOC_MAPK_gen_1	460	468	PF00069	0.530
DOC_MAPK_MEF2A_6	460	468	PF00069	0.530
DOC_PP2B_LxvP_1	171	174	PF13499	0.760
DOC_PP2B_LxvP_1	313	316	PF13499	0.687
DOC_USP7_MATH_1	118	122	PF00917	0.757
DOC_USP7_MATH_1	126	130	PF00917	0.626
DOC_USP7_MATH_1	133	137	PF00917	0.527
DOC_USP7_MATH_1	196	200	PF00917	0.753
DOC_USP7_MATH_1	201	205	PF00917	0.700
DOC_USP7_MATH_1	262	266	PF00917	0.688
DOC_USP7_MATH_1	346	350	PF00917	0.569
DOC_USP7_MATH_1	369	373	PF00917	0.625
DOC_USP7_MATH_1	385	389	PF00917	0.643
DOC_USP7_MATH_1	444	448	PF00917	0.530
DOC_USP7_MATH_1	5	9	PF00917	0.787
DOC_USP7_MATH_1	507	511	PF00917	0.530
DOC_USP7_MATH_1	627	631	PF00917	0.607
DOC_USP7_MATH_1	69	73	PF00917	0.764
DOC_USP7_MATH_1	85	89	PF00917	0.600
DOC_USP7_MATH_1	90	94	PF00917	0.734
DOC_WW_Pin1_4	102	107	PF00397	0.750
DOC_WW_Pin1_4	127	132	PF00397	0.795
DOC_WW_Pin1_4	155	160	PF00397	0.695
DOC_WW_Pin1_4	16	21	PF00397	0.802
DOC_WW_Pin1_4	184	189	PF00397	0.719
DOC_WW_Pin1_4	318	323	PF00397	0.689
DOC_WW_Pin1_4	337	342	PF00397	0.471
DOC_WW_Pin1_4	357	362	PF00397	0.635
DOC_WW_Pin1_4	403	408	PF00397	0.669
DOC_WW_Pin1_4	442	447	PF00397	0.530
DOC_WW_Pin1_4	65	70	PF00397	0.739
LIG_14-3-3_CanoR_1	521	529	PF00244	0.452
LIG_14-3-3_CanoR_1	567	572	PF00244	0.507
LIG_BIR_II_1	1	5	PF00653	0.785
LIG_BRCT_BRCA1_1	128	132	PF00533	0.793
LIG_BRCT_BRCA1_1	373	377	PF00533	0.723
LIG_BRCT_BRCA1_1	446	450	PF00533	0.530
LIG_FHA_1	195	201	PF00498	0.671
LIG_FHA_1	262	268	PF00498	0.762
LIG_FHA_1	294	300	PF00498	0.559
LIG_FHA_1	418	424	PF00498	0.668
LIG_FHA_1	609	615	PF00498	0.516
LIG_FHA_2	512	518	PF00498	0.488
LIG_GBD_Chelix_1	628	636	PF00786	0.621
LIG_LIR_Nem_3	158	163	PF02991	0.731
LIG_LIR_Nem_3	73	79	PF02991	0.732
LIG_NRBOX	635	641	PF00104	0.644
LIG_PCNA_PIPBox_1	522	531	PF02747	0.530
LIG_PCNA_yPIPBox_3	519	529	PF02747	0.476
LIG_PTAP_UEV_1	33	38	PF05743	0.550
LIG_SH2_GRB2like	571	574	PF00017	0.649
LIG_SH2_SRC	571	574	PF00017	0.649
LIG_SH2_STAP1	571	575	PF00017	0.649
LIG_SH2_STAT3	539	542	PF00017	0.530
LIG_SH2_STAT5	528	531	PF00017	0.369
LIG_SH3_3	135	141	PF00018	0.718
LIG_SH3_3	31	37	PF00018	0.687
LIG_SH3_3	96	102	PF00018	0.731
LIG_SUMO_SIM_par_1	225	230	PF11976	0.712
LIG_TRAF2_1	446	449	PF00917	0.530
LIG_TRAF2_2	446	451	PF00917	0.452
MOD_CK1_1	104	110	PF00069	0.628
MOD_CK1_1	199	205	PF00069	0.688
MOD_CK1_1	248	254	PF00069	0.736
MOD_CK1_1	308	314	PF00069	0.724
MOD_CK1_1	401	407	PF00069	0.713
MOD_CK1_1	415	421	PF00069	0.586
MOD_CK1_1	49	55	PF00069	0.698
MOD_CK1_1	59	65	PF00069	0.706
MOD_CK1_1	93	99	PF00069	0.815
MOD_CK2_1	511	517	PF00069	0.530
MOD_CK2_1	595	601	PF00069	0.559
MOD_CK2_1	603	609	PF00069	0.624
MOD_CK2_1	627	633	PF00069	0.497
MOD_GlcNHglycan	111	114	PF01048	0.522
MOD_GlcNHglycan	120	123	PF01048	0.650
MOD_GlcNHglycan	142	145	PF01048	0.814
MOD_GlcNHglycan	153	156	PF01048	0.638
MOD_GlcNHglycan	201	204	PF01048	0.596
MOD_GlcNHglycan	231	234	PF01048	0.734
MOD_GlcNHglycan	247	250	PF01048	0.616
MOD_GlcNHglycan	253	256	PF01048	0.686
MOD_GlcNHglycan	264	267	PF01048	0.574
MOD_GlcNHglycan	276	280	PF01048	0.608
MOD_GlcNHglycan	307	310	PF01048	0.721
MOD_GlcNHglycan	348	351	PF01048	0.594
MOD_GlcNHglycan	357	360	PF01048	0.673
MOD_GlcNHglycan	373	376	PF01048	0.530
MOD_GlcNHglycan	400	403	PF01048	0.833
MOD_GlcNHglycan	414	417	PF01048	0.537
MOD_GlcNHglycan	425	428	PF01048	0.653
MOD_GlcNHglycan	436	439	PF01048	0.594
MOD_GlcNHglycan	48	51	PF01048	0.783
MOD_GlcNHglycan	509	512	PF01048	0.379
MOD_GlcNHglycan	52	55	PF01048	0.714
MOD_GlcNHglycan	58	61	PF01048	0.640
MOD_GlcNHglycan	625	628	PF01048	0.617
MOD_GlcNHglycan	629	632	PF01048	0.540
MOD_GlcNHglycan	79	82	PF01048	0.667
MOD_GlcNHglycan	92	95	PF01048	0.729
MOD_GSK3_1	151	158	PF00069	0.792
MOD_GSK3_1	178	185	PF00069	0.716
MOD_GSK3_1	247	254	PF00069	0.581
MOD_GSK3_1	293	300	PF00069	0.606
MOD_GSK3_1	371	378	PF00069	0.765
MOD_GSK3_1	386	393	PF00069	0.592
MOD_GSK3_1	46	53	PF00069	0.733
MOD_GSK3_1	503	510	PF00069	0.360
MOD_GSK3_1	623	630	PF00069	0.496
MOD_GSK3_1	65	72	PF00069	0.537
MOD_GSK3_1	90	97	PF00069	0.786
MOD_N-GLC_1	318	323	PF02516	0.689
MOD_N-GLC_1	595	600	PF02516	0.681
MOD_NEK2_1	109	114	PF00069	0.840
MOD_NEK2_1	354	359	PF00069	0.769
MOD_NEK2_1	379	384	PF00069	0.799
MOD_NEK2_1	6	11	PF00069	0.785
MOD_PIKK_1	444	450	PF00454	0.530
MOD_PKA_2	520	526	PF00069	0.452
MOD_Plk_1	464	470	PF00069	0.452
MOD_Plk_1	511	517	PF00069	0.379
MOD_Plk_4	496	502	PF00069	0.530
MOD_ProDKin_1	102	108	PF00069	0.743
MOD_ProDKin_1	127	133	PF00069	0.796
MOD_ProDKin_1	155	161	PF00069	0.695
MOD_ProDKin_1	16	22	PF00069	0.802
MOD_ProDKin_1	184	190	PF00069	0.721
MOD_ProDKin_1	318	324	PF00069	0.684
MOD_ProDKin_1	337	343	PF00069	0.472
MOD_ProDKin_1	357	363	PF00069	0.632
MOD_ProDKin_1	403	409	PF00069	0.670
MOD_ProDKin_1	442	448	PF00069	0.530
MOD_ProDKin_1	65	71	PF00069	0.739
MOD_SUMO_rev_2	445	455	PF00179	0.452
MOD_SUMO_rev_2	527	536	PF00179	0.530
MOD_SUMO_rev_2	579	588	PF00179	0.649
TRG_DiLeu_BaEn_1	635	640	PF01217	0.643
TRG_DiLeu_BaLyEn_6	610	615	PF01217	0.644
TRG_DiLeu_LyEn_5	635	640	PF01217	0.643
TRG_Pf-PMV_PEXEL_1	460	465	PF00026	0.530
TRG_Pf-PMV_PEXEL_1	492	496	PF00026	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X5T9	Leishmania donovani	84%	99%
A4HKM6	Leishmania braziliensis	63%	100%
A4I861	Leishmania infantum	84%	99%
E9B314	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%