Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q539_LEIMA

TriTrypDb:

LmjF.32.2360 , LMJLV39_320030500 , LMJSD75_320030600

Length:

813

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q539

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q539

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	647	651	PF00656	0.401
CLV_C14_Caspase3-7	84	88	PF00656	0.633
CLV_NRD_NRD_1	127	129	PF00675	0.438
CLV_NRD_NRD_1	255	257	PF00675	0.476
CLV_NRD_NRD_1	294	296	PF00675	0.403
CLV_NRD_NRD_1	409	411	PF00675	0.535
CLV_NRD_NRD_1	549	551	PF00675	0.508
CLV_NRD_NRD_1	567	569	PF00675	0.558
CLV_NRD_NRD_1	689	691	PF00675	0.449
CLV_NRD_NRD_1	718	720	PF00675	0.509
CLV_PCSK_KEX2_1	127	129	PF00082	0.438
CLV_PCSK_KEX2_1	255	257	PF00082	0.476
CLV_PCSK_KEX2_1	294	296	PF00082	0.440
CLV_PCSK_KEX2_1	409	411	PF00082	0.570
CLV_PCSK_KEX2_1	549	551	PF00082	0.508
CLV_PCSK_KEX2_1	560	562	PF00082	0.629
CLV_PCSK_KEX2_1	689	691	PF00082	0.449
CLV_PCSK_KEX2_1	718	720	PF00082	0.509
CLV_PCSK_KEX2_1	788	790	PF00082	0.427
CLV_PCSK_PC1ET2_1	560	562	PF00082	0.629
CLV_PCSK_PC1ET2_1	788	790	PF00082	0.427
CLV_PCSK_SKI1_1	161	165	PF00082	0.450
CLV_PCSK_SKI1_1	202	206	PF00082	0.526
CLV_PCSK_SKI1_1	215	219	PF00082	0.464
CLV_PCSK_SKI1_1	311	315	PF00082	0.486
CLV_PCSK_SKI1_1	718	722	PF00082	0.399
DEG_APCC_DBOX_1	717	725	PF00400	0.321
DEG_SCF_FBW7_1	240	247	PF00400	0.447
DEG_SPOP_SBC_1	176	180	PF00917	0.573
DOC_CYCLIN_yCln2_LP_2	39	45	PF00134	0.549
DOC_MAPK_gen_1	331	339	PF00069	0.454
DOC_MAPK_gen_1	481	491	PF00069	0.423
DOC_MAPK_gen_1	568	579	PF00069	0.445
DOC_MAPK_MEF2A_6	568	577	PF00069	0.447
DOC_PP2B_LxvP_1	450	453	PF13499	0.586
DOC_PP2B_LxvP_1	505	508	PF13499	0.401
DOC_USP7_MATH_1	176	180	PF00917	0.612
DOC_USP7_MATH_1	181	185	PF00917	0.651
DOC_USP7_MATH_1	191	195	PF00917	0.532
DOC_USP7_MATH_1	244	248	PF00917	0.464
DOC_USP7_MATH_1	388	392	PF00917	0.595
DOC_USP7_MATH_1	482	486	PF00917	0.400
DOC_USP7_MATH_1	52	56	PF00917	0.682
DOC_USP7_MATH_1	588	592	PF00917	0.575
DOC_USP7_MATH_1	601	605	PF00917	0.443
DOC_USP7_MATH_1	65	69	PF00917	0.527
DOC_USP7_MATH_1	70	74	PF00917	0.518
DOC_USP7_MATH_1	757	761	PF00917	0.400
DOC_WW_Pin1_4	141	146	PF00397	0.486
DOC_WW_Pin1_4	177	182	PF00397	0.663
DOC_WW_Pin1_4	240	245	PF00397	0.447
DOC_WW_Pin1_4	452	457	PF00397	0.607
DOC_WW_Pin1_4	458	463	PF00397	0.518
DOC_WW_Pin1_4	47	52	PF00397	0.488
DOC_WW_Pin1_4	615	620	PF00397	0.590
DOC_WW_Pin1_4	661	666	PF00397	0.585
DOC_WW_Pin1_4	753	758	PF00397	0.501
LIG_14-3-3_CanoR_1	128	138	PF00244	0.392
LIG_14-3-3_CanoR_1	182	188	PF00244	0.658
LIG_14-3-3_CanoR_1	202	210	PF00244	0.479
LIG_14-3-3_CanoR_1	25	35	PF00244	0.437
LIG_14-3-3_CanoR_1	255	262	PF00244	0.525
LIG_14-3-3_CanoR_1	301	309	PF00244	0.496
LIG_14-3-3_CanoR_1	350	357	PF00244	0.400
LIG_14-3-3_CanoR_1	732	738	PF00244	0.489
LIG_14-3-3_CanoR_1	81	86	PF00244	0.609
LIG_Actin_WH2_2	336	352	PF00022	0.454
LIG_Actin_WH2_2	68	83	PF00022	0.603
LIG_APCC_ABBA_1	765	770	PF00400	0.434
LIG_BIR_II_1	1	5	PF00653	0.489
LIG_BRCT_BRCA1_1	324	328	PF00533	0.443
LIG_BRCT_BRCA1_1	353	357	PF00533	0.430
LIG_BRCT_BRCA1_1	428	432	PF00533	0.589
LIG_BRCT_BRCA1_1	603	607	PF00533	0.439
LIG_Clathr_ClatBox_1	139	143	PF01394	0.482
LIG_Clathr_ClatBox_1	363	367	PF01394	0.364
LIG_CtBP_PxDLS_1	623	628	PF00389	0.514
LIG_EH1_1	721	729	PF00400	0.293
LIG_FHA_1	158	164	PF00498	0.380
LIG_FHA_1	178	184	PF00498	0.618
LIG_FHA_1	244	250	PF00498	0.489
LIG_FHA_1	343	349	PF00498	0.364
LIG_FHA_1	358	364	PF00498	0.324
LIG_FHA_1	502	508	PF00498	0.451
LIG_FHA_1	512	518	PF00498	0.306
LIG_FHA_1	607	613	PF00498	0.667
LIG_FHA_1	630	636	PF00498	0.609
LIG_FHA_1	699	705	PF00498	0.425
LIG_FHA_1	738	744	PF00498	0.554
LIG_FHA_2	183	189	PF00498	0.507
LIG_FHA_2	276	282	PF00498	0.362
LIG_FHA_2	354	360	PF00498	0.520
LIG_FHA_2	419	425	PF00498	0.606
LIG_FHA_2	434	440	PF00498	0.477
LIG_LIR_Gen_1	463	474	PF02991	0.429
LIG_LIR_Gen_1	574	583	PF02991	0.419
LIG_LIR_Gen_1	591	602	PF02991	0.451
LIG_LIR_Gen_1	636	646	PF02991	0.423
LIG_LIR_Nem_3	162	168	PF02991	0.598
LIG_LIR_Nem_3	29	35	PF02991	0.434
LIG_LIR_Nem_3	463	469	PF02991	0.391
LIG_LIR_Nem_3	574	579	PF02991	0.423
LIG_LIR_Nem_3	591	597	PF02991	0.434
LIG_LIR_Nem_3	636	642	PF02991	0.428
LIG_NRBOX	377	383	PF00104	0.415
LIG_PAM2_1	708	720	PF00658	0.436
LIG_PTB_Apo_2	163	170	PF02174	0.524
LIG_PTB_Phospho_1	163	169	PF10480	0.517
LIG_RPA_C_Fungi	326	338	PF08784	0.429
LIG_RPA_C_Fungi	585	597	PF08784	0.382
LIG_SH2_CRK	466	470	PF00017	0.427
LIG_SH2_CRK	594	598	PF00017	0.445
LIG_SH2_CRK	600	604	PF00017	0.496
LIG_SH2_CRK	639	643	PF00017	0.430
LIG_SH2_GRB2like	35	38	PF00017	0.305
LIG_SH2_NCK_1	600	604	PF00017	0.423
LIG_SH2_PTP2	493	496	PF00017	0.397
LIG_SH2_SRC	691	694	PF00017	0.417
LIG_SH2_STAP1	438	442	PF00017	0.587
LIG_SH2_STAT5	10	13	PF00017	0.538
LIG_SH2_STAT5	493	496	PF00017	0.348
LIG_SH2_STAT5	691	694	PF00017	0.640
LIG_SH2_STAT5	709	712	PF00017	0.373
LIG_SH3_2	453	458	PF14604	0.585
LIG_SH3_3	108	114	PF00018	0.641
LIG_SH3_3	139	145	PF00018	0.503
LIG_SH3_3	42	48	PF00018	0.569
LIG_SH3_3	450	456	PF00018	0.717
LIG_SUMO_SIM_par_1	362	368	PF11976	0.375
LIG_SUMO_SIM_par_1	503	511	PF11976	0.389
LIG_TYR_ITIM	491	496	PF00017	0.344
MOD_CDC14_SPxK_1	455	458	PF00782	0.664
MOD_CDK_SPK_2	177	182	PF00069	0.615
MOD_CDK_SPxK_1	452	458	PF00069	0.668
MOD_CK1_1	157	163	PF00069	0.415
MOD_CK1_1	352	358	PF00069	0.419
MOD_CK1_1	444	450	PF00069	0.613
MOD_CK1_1	461	467	PF00069	0.547
MOD_CK1_1	645	651	PF00069	0.423
MOD_CK1_1	779	785	PF00069	0.440
MOD_CK2_1	143	149	PF00069	0.477
MOD_CK2_1	182	188	PF00069	0.621
MOD_CK2_1	244	250	PF00069	0.459
MOD_CK2_1	302	308	PF00069	0.530
MOD_CK2_1	418	424	PF00069	0.657
MOD_CK2_1	52	58	PF00069	0.641
MOD_Cter_Amidation	292	295	PF01082	0.423
MOD_DYRK1A_RPxSP_1	458	462	PF00069	0.616
MOD_GlcNHglycan	131	134	PF01048	0.522
MOD_GlcNHglycan	2	5	PF01048	0.526
MOD_GlcNHglycan	224	227	PF01048	0.510
MOD_GlcNHglycan	246	249	PF01048	0.480
MOD_GlcNHglycan	290	293	PF01048	0.509
MOD_GlcNHglycan	304	307	PF01048	0.441
MOD_GlcNHglycan	446	449	PF01048	0.598
MOD_GlcNHglycan	54	57	PF01048	0.670
MOD_GlcNHglycan	590	593	PF01048	0.571
MOD_GlcNHglycan	603	606	PF01048	0.528
MOD_GlcNHglycan	62	66	PF01048	0.578
MOD_GlcNHglycan	644	647	PF01048	0.427
MOD_GlcNHglycan	67	70	PF01048	0.517
MOD_GlcNHglycan	710	713	PF01048	0.426
MOD_GlcNHglycan	784	787	PF01048	0.417
MOD_GSK3_1	155	162	PF00069	0.443
MOD_GSK3_1	177	184	PF00069	0.627
MOD_GSK3_1	240	247	PF00069	0.471
MOD_GSK3_1	349	356	PF00069	0.556
MOD_GSK3_1	433	440	PF00069	0.630
MOD_GSK3_1	472	479	PF00069	0.525
MOD_GSK3_1	52	59	PF00069	0.682
MOD_GSK3_1	582	589	PF00069	0.362
MOD_GSK3_1	601	608	PF00069	0.375
MOD_GSK3_1	61	68	PF00069	0.745
MOD_GSK3_1	613	620	PF00069	0.539
MOD_GSK3_1	629	636	PF00069	0.547
MOD_GSK3_1	733	740	PF00069	0.466
MOD_GSK3_1	753	760	PF00069	0.286
MOD_GSK3_1	76	83	PF00069	0.509
MOD_GSK3_1	775	782	PF00069	0.553
MOD_GSK3_1	87	94	PF00069	0.611
MOD_N-GLC_1	357	362	PF02516	0.389
MOD_NEK2_1	154	159	PF00069	0.482
MOD_NEK2_1	205	210	PF00069	0.475
MOD_NEK2_1	27	32	PF00069	0.446
MOD_NEK2_1	321	326	PF00069	0.409
MOD_NEK2_1	349	354	PF00069	0.443
MOD_NEK2_1	357	362	PF00069	0.389
MOD_NEK2_1	520	525	PF00069	0.505
MOD_NEK2_1	582	587	PF00069	0.427
MOD_NEK2_1	624	629	PF00069	0.570
MOD_NEK2_1	659	664	PF00069	0.581
MOD_NEK2_1	80	85	PF00069	0.666
MOD_NEK2_2	433	438	PF00069	0.485
MOD_NEK2_2	733	738	PF00069	0.487
MOD_PKA_2	181	187	PF00069	0.661
MOD_PKA_2	254	260	PF00069	0.452
MOD_PKA_2	27	33	PF00069	0.410
MOD_PKA_2	300	306	PF00069	0.477
MOD_PKA_2	349	355	PF00069	0.412
MOD_PKA_2	418	424	PF00069	0.639
MOD_PKA_2	659	665	PF00069	0.622
MOD_PKA_2	733	739	PF00069	0.482
MOD_PKA_2	80	86	PF00069	0.630
MOD_PKA_2	90	96	PF00069	0.619
MOD_Plk_1	149	155	PF00069	0.398
MOD_Plk_1	357	363	PF00069	0.389
MOD_Plk_1	57	63	PF00069	0.548
MOD_Plk_1	76	82	PF00069	0.527
MOD_Plk_1	779	785	PF00069	0.551
MOD_Plk_2-3	143	149	PF00069	0.494
MOD_Plk_4	27	33	PF00069	0.401
MOD_Plk_4	323	329	PF00069	0.546
MOD_Plk_4	433	439	PF00069	0.618
MOD_Plk_4	446	452	PF00069	0.651
MOD_Plk_4	461	467	PF00069	0.393
MOD_Plk_4	617	623	PF00069	0.515
MOD_Plk_4	733	739	PF00069	0.466
MOD_ProDKin_1	141	147	PF00069	0.478
MOD_ProDKin_1	177	183	PF00069	0.663
MOD_ProDKin_1	240	246	PF00069	0.440
MOD_ProDKin_1	452	458	PF00069	0.607
MOD_ProDKin_1	47	53	PF00069	0.492
MOD_ProDKin_1	615	621	PF00069	0.592
MOD_ProDKin_1	661	667	PF00069	0.593
MOD_ProDKin_1	753	759	PF00069	0.492
MOD_SUMO_rev_2	671	679	PF00179	0.611
TRG_DiLeu_BaEn_1	19	24	PF01217	0.468
TRG_DiLeu_BaEn_4	149	155	PF01217	0.458
TRG_ENDOCYTIC_2	466	469	PF00928	0.422
TRG_ENDOCYTIC_2	493	496	PF00928	0.348
TRG_ENDOCYTIC_2	594	597	PF00928	0.438
TRG_ENDOCYTIC_2	639	642	PF00928	0.434
TRG_ER_diArg_1	254	256	PF00400	0.472
TRG_ER_diArg_1	408	410	PF00400	0.555
TRG_ER_diArg_1	483	486	PF00400	0.456
TRG_ER_diArg_1	549	551	PF00400	0.459
TRG_ER_diArg_1	688	690	PF00400	0.455
TRG_ER_diArg_1	717	719	PF00400	0.513
TRG_NES_CRM1_1	495	510	PF08389	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXT3	Leptomonas seymouri	47%	100%
A0A3Q8IGW2	Leishmania donovani	90%	100%
A4HKM7	Leishmania braziliensis	70%	98%
A4I860	Leishmania infantum	90%	100%
D0AAC6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9B315	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	95%