Aquaporin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aquaporin-like protein

Species:

Leishmania major

UniProt:

Q4Q537_LEIMA

TriTrypDb:

LmjF.32.2380 , LMJLV39_320030700 , LMJSD75_320030800

Length:

593

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4Q537

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q537

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	7
GO:0015267	channel activity	4	7
GO:0022803	passive transmembrane transporter activity	3	7
GO:0022857	transmembrane transporter activity	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	543	547	PF00656	0.741
CLV_C14_Caspase3-7	553	557	PF00656	0.722
CLV_C14_Caspase3-7	559	563	PF00656	0.675
CLV_NRD_NRD_1	164	166	PF00675	0.492
CLV_NRD_NRD_1	214	216	PF00675	0.481
CLV_NRD_NRD_1	463	465	PF00675	0.485
CLV_NRD_NRD_1	503	505	PF00675	0.445
CLV_PCSK_KEX2_1	164	166	PF00082	0.492
CLV_PCSK_KEX2_1	495	497	PF00082	0.482
CLV_PCSK_PC1ET2_1	495	497	PF00082	0.482
CLV_PCSK_SKI1_1	308	312	PF00082	0.370
CLV_PCSK_SKI1_1	340	344	PF00082	0.526
CLV_PCSK_SKI1_1	464	468	PF00082	0.471
CLV_PCSK_SKI1_1	528	532	PF00082	0.586
CLV_PCSK_SKI1_1	579	583	PF00082	0.497
DEG_APCC_DBOX_1	566	574	PF00400	0.663
DEG_Nend_UBRbox_2	1	3	PF02207	0.698
DEG_ODPH_VHL_1	436	449	PF01847	0.310
DEG_SCF_FBW7_1	88	93	PF00400	0.656
DEG_SPOP_SBC_1	143	147	PF00917	0.734
DEG_SPOP_SBC_1	506	510	PF00917	0.706
DEG_SPOP_SBC_1	580	584	PF00917	0.704
DOC_MAPK_gen_1	218	226	PF00069	0.595
DOC_MAPK_MEF2A_6	180	187	PF00069	0.590
DOC_PP2B_LxvP_1	224	227	PF13499	0.576
DOC_PP4_FxxP_1	32	35	PF00568	0.699
DOC_USP7_MATH_1	109	113	PF00917	0.624
DOC_USP7_MATH_1	136	140	PF00917	0.745
DOC_USP7_MATH_1	254	258	PF00917	0.310
DOC_USP7_MATH_1	298	302	PF00917	0.481
DOC_USP7_MATH_1	345	349	PF00917	0.288
DOC_USP7_MATH_1	35	39	PF00917	0.702
DOC_USP7_MATH_1	410	414	PF00917	0.388
DOC_USP7_MATH_1	48	52	PF00917	0.748
DOC_USP7_MATH_1	506	510	PF00917	0.752
DOC_USP7_MATH_1	581	585	PF00917	0.760
DOC_USP7_MATH_1	90	94	PF00917	0.711
DOC_WW_Pin1_4	113	118	PF00397	0.683
DOC_WW_Pin1_4	25	30	PF00397	0.667
DOC_WW_Pin1_4	270	275	PF00397	0.233
DOC_WW_Pin1_4	49	54	PF00397	0.707
DOC_WW_Pin1_4	535	540	PF00397	0.721
DOC_WW_Pin1_4	86	91	PF00397	0.731
LIG_14-3-3_CanoR_1	101	109	PF00244	0.786
LIG_14-3-3_CanoR_1	515	521	PF00244	0.760
LIG_Actin_WH2_2	414	431	PF00022	0.274
LIG_AP2alpha_2	199	201	PF02296	0.640
LIG_BRCT_BRCA1_1	282	286	PF00533	0.305
LIG_BRCT_BRCA1_1	292	296	PF00533	0.299
LIG_BRCT_BRCA1_1	353	357	PF00533	0.310
LIG_BRCT_BRCA1_1	378	382	PF00533	0.474
LIG_FHA_1	180	186	PF00498	0.578
LIG_FHA_1	250	256	PF00498	0.337
LIG_FHA_1	280	286	PF00498	0.319
LIG_FHA_1	31	37	PF00498	0.630
LIG_FHA_1	347	353	PF00498	0.266
LIG_FHA_1	456	462	PF00498	0.618
LIG_FHA_1	75	81	PF00498	0.651
LIG_FHA_1	87	93	PF00498	0.612
LIG_FHA_2	149	155	PF00498	0.689
LIG_FHA_2	509	515	PF00498	0.726
LIG_FHA_2	581	587	PF00498	0.758
LIG_GBD_Chelix_1	302	310	PF00786	0.262
LIG_GBD_Chelix_1	444	452	PF00786	0.373
LIG_LIR_Apic_2	31	35	PF02991	0.700
LIG_LIR_Apic_2	582	588	PF02991	0.669
LIG_LIR_Gen_1	219	227	PF02991	0.604
LIG_LIR_Gen_1	228	236	PF02991	0.565
LIG_LIR_Gen_1	238	247	PF02991	0.336
LIG_LIR_Gen_1	354	365	PF02991	0.310
LIG_LIR_Nem_3	219	224	PF02991	0.642
LIG_LIR_Nem_3	228	232	PF02991	0.586
LIG_LIR_Nem_3	238	243	PF02991	0.429
LIG_LIR_Nem_3	246	250	PF02991	0.308
LIG_LIR_Nem_3	287	291	PF02991	0.310
LIG_LIR_Nem_3	354	360	PF02991	0.310
LIG_MAD2	169	177	PF02301	0.680
LIG_MAD2	192	200	PF02301	0.559
LIG_NBox_RRM_1	296	306	PF00076	0.499
LIG_NRP_CendR_1	592	593	PF00754	0.464
LIG_Pex14_2	382	386	PF04695	0.310
LIG_PTB_Apo_2	369	376	PF02174	0.310
LIG_PTB_Phospho_1	369	375	PF10480	0.310
LIG_SH2_CRK	221	225	PF00017	0.607
LIG_SH2_STAP1	181	185	PF00017	0.620
LIG_SH2_STAP1	221	225	PF00017	0.603
LIG_SH2_STAT3	375	378	PF00017	0.474
LIG_SH2_STAT5	181	184	PF00017	0.628
LIG_SH2_STAT5	239	242	PF00017	0.310
LIG_SH2_STAT5	290	293	PF00017	0.310
LIG_SH2_STAT5	318	321	PF00017	0.310
LIG_SH2_STAT5	351	354	PF00017	0.274
LIG_SH3_3	167	173	PF00018	0.657
LIG_SH3_3	37	43	PF00018	0.743
LIG_SH3_3	47	53	PF00018	0.625
LIG_SUMO_SIM_anti_2	252	257	PF11976	0.294
LIG_SUMO_SIM_par_1	181	186	PF11976	0.614
LIG_SUMO_SIM_par_1	251	257	PF11976	0.310
LIG_TRFH_1	434	438	PF08558	0.310
LIG_WRC_WIRS_1	244	249	PF05994	0.310
LIG_WRC_WIRS_1	285	290	PF05994	0.310
LIG_WRC_WIRS_1	361	366	PF05994	0.310
MOD_CDK_SPK_2	535	540	PF00069	0.718
MOD_CK1_1	112	118	PF00069	0.693
MOD_CK1_1	141	147	PF00069	0.792
MOD_CK1_1	267	273	PF00069	0.287
MOD_CK1_1	346	352	PF00069	0.273
MOD_CK1_1	376	382	PF00069	0.472
MOD_CK1_1	393	399	PF00069	0.294
MOD_CK1_1	508	514	PF00069	0.738
MOD_CK1_1	51	57	PF00069	0.812
MOD_CK1_1	518	524	PF00069	0.710
MOD_CK1_1	563	569	PF00069	0.789
MOD_CK2_1	497	503	PF00069	0.695
MOD_CK2_1	508	514	PF00069	0.695
MOD_CK2_1	571	577	PF00069	0.746
MOD_CK2_1	580	586	PF00069	0.721
MOD_CK2_1	72	78	PF00069	0.729
MOD_CMANNOS	432	435	PF00535	0.310
MOD_Cter_Amidation	162	165	PF01082	0.492
MOD_GlcNHglycan	140	143	PF01048	0.604
MOD_GlcNHglycan	146	149	PF01048	0.512
MOD_GlcNHglycan	23	26	PF01048	0.624
MOD_GlcNHglycan	353	356	PF01048	0.317
MOD_GlcNHglycan	37	40	PF01048	0.502
MOD_GlcNHglycan	378	381	PF01048	0.270
MOD_GlcNHglycan	392	395	PF01048	0.338
MOD_GlcNHglycan	397	400	PF01048	0.467
MOD_GlcNHglycan	402	405	PF01048	0.514
MOD_GlcNHglycan	412	415	PF01048	0.418
MOD_GlcNHglycan	499	502	PF01048	0.484
MOD_GlcNHglycan	562	565	PF01048	0.534
MOD_GlcNHglycan	74	77	PF01048	0.510
MOD_GlcNHglycan	80	83	PF01048	0.469
MOD_GlcNHglycan	92	95	PF01048	0.414
MOD_GlcNHglycan	96	99	PF01048	0.463
MOD_GSK3_1	109	116	PF00069	0.742
MOD_GSK3_1	126	133	PF00069	0.769
MOD_GSK3_1	138	145	PF00069	0.781
MOD_GSK3_1	179	186	PF00069	0.624
MOD_GSK3_1	21	28	PF00069	0.699
MOD_GSK3_1	264	271	PF00069	0.413
MOD_GSK3_1	280	287	PF00069	0.305
MOD_GSK3_1	346	353	PF00069	0.270
MOD_GSK3_1	48	55	PF00069	0.702
MOD_GSK3_1	505	512	PF00069	0.724
MOD_GSK3_1	515	522	PF00069	0.811
MOD_GSK3_1	74	81	PF00069	0.696
MOD_GSK3_1	86	93	PF00069	0.686
MOD_N-GLC_1	136	141	PF02516	0.525
MOD_N-GLC_1	259	264	PF02516	0.474
MOD_N-GLC_1	78	83	PF02516	0.515
MOD_NEK2_1	119	124	PF00069	0.756
MOD_NEK2_1	179	184	PF00069	0.612
MOD_NEK2_1	235	240	PF00069	0.474
MOD_NEK2_1	243	248	PF00069	0.310
MOD_NEK2_1	279	284	PF00069	0.319
MOD_NEK2_1	323	328	PF00069	0.339
MOD_NEK2_1	360	365	PF00069	0.340
MOD_NEK2_1	390	395	PF00069	0.310
MOD_NEK2_2	254	259	PF00069	0.310
MOD_PIKK_1	101	107	PF00454	0.723
MOD_PIKK_1	447	453	PF00454	0.400
MOD_PIKK_1	455	461	PF00454	0.615
MOD_PIKK_1	551	557	PF00454	0.739
MOD_PK_1	259	265	PF00069	0.274
MOD_PKA_2	100	106	PF00069	0.725
MOD_PKA_2	376	382	PF00069	0.474
MOD_PKA_2	400	406	PF00069	0.262
MOD_PKA_2	485	491	PF00069	0.657
MOD_Plk_1	136	142	PF00069	0.732
MOD_Plk_1	259	265	PF00069	0.274
MOD_Plk_1	267	273	PF00069	0.274
MOD_Plk_4	235	241	PF00069	0.474
MOD_Plk_4	259	265	PF00069	0.274
MOD_Plk_4	280	286	PF00069	0.310
MOD_Plk_4	427	433	PF00069	0.274
MOD_ProDKin_1	113	119	PF00069	0.683
MOD_ProDKin_1	25	31	PF00069	0.667
MOD_ProDKin_1	270	276	PF00069	0.233
MOD_ProDKin_1	49	55	PF00069	0.707
MOD_ProDKin_1	535	541	PF00069	0.721
MOD_ProDKin_1	86	92	PF00069	0.732
MOD_SUMO_rev_2	186	194	PF00179	0.580
MOD_SUMO_rev_2	426	431	PF00179	0.299
MOD_SUMO_rev_2	457	467	PF00179	0.620
MOD_SUMO_rev_2	500	507	PF00179	0.635
MOD_SUMO_rev_2	574	581	PF00179	0.688
TRG_DiLeu_BaLyEn_6	231	236	PF01217	0.560
TRG_ENDOCYTIC_2	221	224	PF00928	0.636
TRG_ER_diArg_1	217	220	PF00400	0.586
TRG_ER_diArg_1	475	478	PF00400	0.647

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I348	Leptomonas seymouri	59%	98%
A0A3Q8IFK5	Leishmania donovani	90%	99%
A4HKM9	Leishmania braziliensis	76%	100%
A4I858	Leishmania infantum	91%	99%
E9B317	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%