Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q536_LEIMA

TriTrypDb:

LmjF.32.2390 , LMJLV39_320030800 , LMJSD75_320030900

Length:

523

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q536

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q536

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	294	298	PF00656	0.753
CLV_C14_Caspase3-7	519	523	PF00656	0.654
CLV_NRD_NRD_1	123	125	PF00675	0.722
CLV_NRD_NRD_1	139	141	PF00675	0.608
CLV_NRD_NRD_1	143	145	PF00675	0.542
CLV_NRD_NRD_1	147	149	PF00675	0.623
CLV_NRD_NRD_1	226	228	PF00675	0.687
CLV_NRD_NRD_1	318	320	PF00675	0.609
CLV_NRD_NRD_1	455	457	PF00675	0.579
CLV_NRD_NRD_1	67	69	PF00675	0.627
CLV_PCSK_FUR_1	140	144	PF00082	0.673
CLV_PCSK_FUR_1	65	69	PF00082	0.564
CLV_PCSK_KEX2_1	123	125	PF00082	0.810
CLV_PCSK_KEX2_1	141	143	PF00082	0.576
CLV_PCSK_KEX2_1	146	148	PF00082	0.662
CLV_PCSK_KEX2_1	167	169	PF00082	0.482
CLV_PCSK_KEX2_1	226	228	PF00082	0.688
CLV_PCSK_KEX2_1	320	322	PF00082	0.559
CLV_PCSK_KEX2_1	33	35	PF00082	0.597
CLV_PCSK_KEX2_1	384	386	PF00082	0.672
CLV_PCSK_KEX2_1	455	457	PF00082	0.589
CLV_PCSK_KEX2_1	465	467	PF00082	0.485
CLV_PCSK_KEX2_1	67	69	PF00082	0.627
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.730
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.482
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.536
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.623
CLV_PCSK_PC1ET2_1	384	386	PF00082	0.672
CLV_PCSK_PC1ET2_1	465	467	PF00082	0.523
CLV_PCSK_PC7_1	142	148	PF00082	0.723
CLV_PCSK_SKI1_1	227	231	PF00082	0.629
CLV_PCSK_SKI1_1	332	336	PF00082	0.649
CLV_PCSK_SKI1_1	339	343	PF00082	0.621
CLV_PCSK_SKI1_1	384	388	PF00082	0.545
CLV_PCSK_SKI1_1	456	460	PF00082	0.507
CLV_PCSK_SKI1_1	465	469	PF00082	0.381
CLV_PCSK_SKI1_1	67	71	PF00082	0.632
CLV_Separin_Metazoa	149	153	PF03568	0.670
DEG_Kelch_Keap1_1	104	109	PF01344	0.674
DEG_ODPH_VHL_1	159	171	PF01847	0.478
DEG_SCF_FBW7_1	24	31	PF00400	0.535
DEG_SCF_FBW7_2	171	178	PF00400	0.658
DEG_SPOP_SBC_1	210	214	PF00917	0.710
DEG_SPOP_SBC_1	28	32	PF00917	0.715
DOC_CKS1_1	172	177	PF01111	0.574
DOC_CKS1_1	405	410	PF01111	0.727
DOC_MAPK_gen_1	141	153	PF00069	0.700
DOC_MAPK_gen_1	226	232	PF00069	0.672
DOC_MAPK_gen_1	384	392	PF00069	0.666
DOC_MAPK_gen_1	455	463	PF00069	0.459
DOC_MAPK_MEF2A_6	384	392	PF00069	0.698
DOC_PP2B_LxvP_1	187	190	PF13499	0.614
DOC_PP4_FxxP_1	158	161	PF00568	0.525
DOC_PP4_FxxP_1	354	357	PF00568	0.750
DOC_USP7_MATH_1	132	136	PF00917	0.774
DOC_USP7_MATH_1	20	24	PF00917	0.714
DOC_USP7_MATH_1	208	212	PF00917	0.689
DOC_USP7_MATH_1	26	30	PF00917	0.729
DOC_USP7_MATH_1	260	264	PF00917	0.743
DOC_USP7_MATH_1	330	334	PF00917	0.583
DOC_USP7_MATH_1	360	364	PF00917	0.573
DOC_USP7_MATH_1	391	395	PF00917	0.662
DOC_USP7_MATH_1	423	427	PF00917	0.741
DOC_USP7_MATH_1	432	436	PF00917	0.736
DOC_USP7_MATH_1	475	479	PF00917	0.573
DOC_USP7_UBL2_3	271	275	PF12436	0.609
DOC_USP7_UBL2_3	380	384	PF12436	0.727
DOC_USP7_UBL2_3	465	469	PF12436	0.482
DOC_WW_Pin1_4	171	176	PF00397	0.562
DOC_WW_Pin1_4	24	29	PF00397	0.659
DOC_WW_Pin1_4	404	409	PF00397	0.741
LIG_14-3-3_CanoR_1	13	21	PF00244	0.601
LIG_14-3-3_CanoR_1	170	175	PF00244	0.541
LIG_14-3-3_CanoR_1	236	243	PF00244	0.638
LIG_14-3-3_CanoR_1	385	391	PF00244	0.681
LIG_14-3-3_CanoR_1	400	406	PF00244	0.525
LIG_14-3-3_CanoR_1	455	461	PF00244	0.520
LIG_14-3-3_CanoR_1	86	92	PF00244	0.600
LIG_BRCT_BRCA1_1	88	92	PF00533	0.629
LIG_eIF4E_1	91	97	PF01652	0.495
LIG_FHA_1	164	170	PF00498	0.643
LIG_FHA_1	181	187	PF00498	0.441
LIG_FHA_1	205	211	PF00498	0.715
LIG_FHA_1	385	391	PF00498	0.709
LIG_FHA_1	405	411	PF00498	0.588
LIG_FHA_1	445	451	PF00498	0.582
LIG_FHA_2	125	131	PF00498	0.623
LIG_FHA_2	457	463	PF00498	0.544
LIG_FHA_2	484	490	PF00498	0.503
LIG_FHA_2	50	56	PF00498	0.528
LIG_FHA_2	517	523	PF00498	0.517
LIG_LIR_Apic_2	156	161	PF02991	0.520
LIG_LIR_Apic_2	352	357	PF02991	0.743
LIG_LIR_Gen_1	177	187	PF02991	0.523
LIG_LIR_Gen_1	473	481	PF02991	0.535
LIG_LIR_Nem_3	154	158	PF02991	0.593
LIG_LIR_Nem_3	177	182	PF02991	0.554
LIG_MLH1_MIPbox_1	88	92	PF16413	0.629
LIG_SH2_CRK	5	9	PF00017	0.677
LIG_SH2_STAT5	44	47	PF00017	0.590
LIG_SH2_STAT5	91	94	PF00017	0.659
LIG_SH3_3	169	175	PF00018	0.703
LIG_SH3_3	385	391	PF00018	0.634
LIG_SH3_3	402	408	PF00018	0.605
LIG_SH3_3	42	48	PF00018	0.626
LIG_SH3_3	426	432	PF00018	0.669
LIG_TRAF2_1	279	282	PF00917	0.503
LIG_TRAF2_1	486	489	PF00917	0.557
LIG_UBA3_1	460	465	PF00899	0.509
LIG_WRC_WIRS_1	331	336	PF05994	0.574
LIG_WW_3	80	84	PF00397	0.583
MOD_CK1_1	117	123	PF00069	0.809
MOD_CK1_1	177	183	PF00069	0.620
MOD_CK1_1	211	217	PF00069	0.700
MOD_CK1_1	247	253	PF00069	0.678
MOD_CK1_1	29	35	PF00069	0.692
MOD_CK1_1	393	399	PF00069	0.794
MOD_CK1_1	404	410	PF00069	0.707
MOD_CK1_1	437	443	PF00069	0.619
MOD_CK1_1	483	489	PF00069	0.539
MOD_CK1_1	514	520	PF00069	0.531
MOD_CK1_1	99	105	PF00069	0.671
MOD_CK2_1	100	106	PF00069	0.631
MOD_CK2_1	456	462	PF00069	0.557
MOD_CK2_1	483	489	PF00069	0.511
MOD_CK2_1	49	55	PF00069	0.543
MOD_GlcNHglycan	106	109	PF01048	0.754
MOD_GlcNHglycan	136	139	PF01048	0.684
MOD_GlcNHglycan	16	19	PF01048	0.673
MOD_GlcNHglycan	252	255	PF01048	0.631
MOD_GlcNHglycan	257	260	PF01048	0.543
MOD_GlcNHglycan	305	308	PF01048	0.681
MOD_GlcNHglycan	314	317	PF01048	0.694
MOD_GlcNHglycan	369	372	PF01048	0.813
MOD_GlcNHglycan	374	378	PF01048	0.743
MOD_GlcNHglycan	393	396	PF01048	0.638
MOD_GlcNHglycan	419	422	PF01048	0.681
MOD_GlcNHglycan	426	429	PF01048	0.649
MOD_GlcNHglycan	433	437	PF01048	0.608
MOD_GSK3_1	114	121	PF00069	0.736
MOD_GSK3_1	132	139	PF00069	0.762
MOD_GSK3_1	170	177	PF00069	0.659
MOD_GSK3_1	20	27	PF00069	0.701
MOD_GSK3_1	204	211	PF00069	0.793
MOD_GSK3_1	249	256	PF00069	0.618
MOD_GSK3_1	28	35	PF00069	0.656
MOD_GSK3_1	386	393	PF00069	0.731
MOD_GSK3_1	396	403	PF00069	0.630
MOD_GSK3_1	410	417	PF00069	0.576
MOD_GSK3_1	437	444	PF00069	0.516
MOD_GSK3_1	96	103	PF00069	0.639
MOD_N-GLC_1	24	29	PF02516	0.659
MOD_N-GLC_1	288	293	PF02516	0.722
MOD_N-GLC_1	59	64	PF02516	0.592
MOD_NEK2_1	219	224	PF00069	0.547
MOD_NEK2_1	267	272	PF00069	0.566
MOD_NEK2_1	441	446	PF00069	0.479
MOD_NEK2_1	481	486	PF00069	0.552
MOD_NEK2_1	494	499	PF00069	0.406
MOD_NEK2_1	85	90	PF00069	0.619
MOD_NEK2_1	96	101	PF00069	0.659
MOD_PIKK_1	475	481	PF00454	0.639
MOD_PIKK_1	494	500	PF00454	0.291
MOD_PKA_1	384	390	PF00069	0.542
MOD_PKA_2	235	241	PF00069	0.728
MOD_PKA_2	384	390	PF00069	0.556
MOD_PKA_2	401	407	PF00069	0.582
MOD_PKA_2	85	91	PF00069	0.583
MOD_PKB_1	168	176	PF00069	0.472
MOD_Plk_1	177	183	PF00069	0.632
MOD_Plk_1	324	330	PF00069	0.489
MOD_Plk_2-3	273	279	PF00069	0.665
MOD_Plk_4	441	447	PF00069	0.509
MOD_Plk_4	456	462	PF00069	0.532
MOD_ProDKin_1	171	177	PF00069	0.565
MOD_ProDKin_1	24	30	PF00069	0.661
MOD_ProDKin_1	404	410	PF00069	0.741
MOD_SUMO_rev_2	270	277	PF00179	0.630
TRG_DiLeu_BaEn_2	153	159	PF01217	0.542
TRG_DiLeu_BaLyEn_6	215	220	PF01217	0.620
TRG_ENDOCYTIC_2	155	158	PF00928	0.608
TRG_ENDOCYTIC_2	179	182	PF00928	0.554
TRG_ENDOCYTIC_2	5	8	PF00928	0.678
TRG_ER_diArg_1	140	143	PF00400	0.674
TRG_ER_diArg_1	144	147	PF00400	0.655
TRG_ER_diArg_1	168	171	PF00400	0.472
TRG_ER_diArg_1	225	227	PF00400	0.676
TRG_ER_diArg_1	67	69	PF00400	0.627
TRG_NLS_Bipartite_1	123	145	PF00514	0.693
TRG_NLS_MonoCore_2	139	144	PF00514	0.750
TRG_NLS_MonoExtC_3	139	144	PF00514	0.724
TRG_NLS_MonoExtN_4	140	145	PF00514	0.735
TRG_Pf-PMV_PEXEL_1	227	231	PF00026	0.629
TRG_Pf-PMV_PEXEL_1	466	470	PF00026	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P596	Leptomonas seymouri	41%	96%
A0A1X0NRH9	Trypanosomatidae	24%	100%
A0A3Q8IL99	Leishmania donovani	89%	100%
A4HKN0	Leishmania braziliensis	71%	99%
A4I857	Leishmania infantum	89%	100%
D0AAC7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9B318	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%