Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q535_LEIMA

TriTrypDb:

LmjF.32.2400 , LMJLV39_320030900 , LMJSD75_320031000

Length:

344

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q535

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q535

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	164	166	PF00675	0.397
CLV_NRD_NRD_1	3	5	PF00675	0.565
CLV_PCSK_KEX2_1	3	5	PF00082	0.565
CLV_PCSK_SKI1_1	223	227	PF00082	0.423
DOC_MAPK_gen_1	221	229	PF00069	0.365
DOC_MAPK_gen_1	3	11	PF00069	0.255
DOC_MAPK_MEF2A_6	3	11	PF00069	0.361
DOC_PP2B_LxvP_1	208	211	PF13499	0.452
DOC_USP7_MATH_1	234	238	PF00917	0.510
DOC_USP7_MATH_1	276	280	PF00917	0.595
DOC_WW_Pin1_4	193	198	PF00397	0.714
DOC_WW_Pin1_4	200	205	PF00397	0.534
DOC_WW_Pin1_4	255	260	PF00397	0.360
LIG_14-3-3_CanoR_1	102	111	PF00244	0.523
LIG_14-3-3_CanoR_1	245	254	PF00244	0.574
LIG_14-3-3_CanoR_1	29	33	PF00244	0.481
LIG_14-3-3_CanoR_1	4	10	PF00244	0.428
LIG_CaM_IQ_9	158	173	PF13499	0.348
LIG_FHA_1	19	25	PF00498	0.478
LIG_FHA_1	320	326	PF00498	0.488
LIG_FHA_2	107	113	PF00498	0.344
LIG_FHA_2	87	93	PF00498	0.540
LIG_LIR_Apic_2	251	257	PF02991	0.445
LIG_LIR_Gen_1	137	145	PF02991	0.408
LIG_LIR_Gen_1	30	38	PF02991	0.453
LIG_LIR_Gen_1	8	18	PF02991	0.338
LIG_LIR_Gen_1	95	105	PF02991	0.392
LIG_LIR_Nem_3	137	142	PF02991	0.426
LIG_LIR_Nem_3	30	35	PF02991	0.444
LIG_LIR_Nem_3	322	326	PF02991	0.377
LIG_LIR_Nem_3	8	14	PF02991	0.331
LIG_LIR_Nem_3	95	100	PF02991	0.370
LIG_SH2_CRK	254	258	PF00017	0.433
LIG_SH2_NCK_1	105	109	PF00017	0.367
LIG_SH2_NCK_1	254	258	PF00017	0.433
LIG_SH2_STAP1	32	36	PF00017	0.397
LIG_SH2_STAT5	105	108	PF00017	0.362
LIG_SH2_STAT5	139	142	PF00017	0.445
LIG_SH3_3	191	197	PF00018	0.621
LIG_SUMO_SIM_par_1	5	10	PF11976	0.348
LIG_TRAF2_1	54	57	PF00917	0.440
LIG_TRAF2_1	89	92	PF00917	0.482
LIG_WRC_WIRS_1	32	37	PF05994	0.414
LIG_WRC_WIRS_1	93	98	PF05994	0.470
MOD_CK1_1	196	202	PF00069	0.579
MOD_CK1_1	31	37	PF00069	0.378
MOD_CK2_1	170	176	PF00069	0.531
MOD_CK2_1	86	92	PF00069	0.497
MOD_GlcNHglycan	175	179	PF01048	0.585
MOD_GlcNHglycan	198	201	PF01048	0.587
MOD_GlcNHglycan	236	239	PF01048	0.512
MOD_GlcNHglycan	247	250	PF01048	0.354
MOD_GlcNHglycan	338	341	PF01048	0.604
MOD_GlcNHglycan	76	79	PF01048	0.643
MOD_GSK3_1	145	152	PF00069	0.515
MOD_GSK3_1	170	177	PF00069	0.602
MOD_GSK3_1	183	190	PF00069	0.683
MOD_GSK3_1	196	203	PF00069	0.680
MOD_GSK3_1	241	248	PF00069	0.413
MOD_GSK3_1	27	34	PF00069	0.466
MOD_N-GLC_1	48	53	PF02516	0.484
MOD_NEK2_1	101	106	PF00069	0.440
MOD_NEK2_1	145	150	PF00069	0.450
MOD_NEK2_1	183	188	PF00069	0.542
MOD_NEK2_1	213	218	PF00069	0.484
MOD_NEK2_1	336	341	PF00069	0.535
MOD_NEK2_1	43	48	PF00069	0.472
MOD_OFUCOSY	47	52	PF10250	0.471
MOD_PKA_2	101	107	PF00069	0.370
MOD_PKA_2	249	255	PF00069	0.374
MOD_PKA_2	28	34	PF00069	0.479
MOD_Plk_1	174	180	PF00069	0.495
MOD_Plk_4	106	112	PF00069	0.368
MOD_Plk_4	13	19	PF00069	0.381
MOD_Plk_4	31	37	PF00069	0.387
MOD_ProDKin_1	193	199	PF00069	0.710
MOD_ProDKin_1	200	206	PF00069	0.518
MOD_ProDKin_1	255	261	PF00069	0.356
TRG_DiLeu_BaLyEn_6	238	243	PF01217	0.486
TRG_ENDOCYTIC_2	139	142	PF00928	0.397
TRG_ENDOCYTIC_2	32	35	PF00928	0.369
TRG_ER_diArg_1	2	4	PF00400	0.602
TRG_ER_diArg_1	220	223	PF00400	0.468
TRG_Pf-PMV_PEXEL_1	22	27	PF00026	0.327
TRG_Pf-PMV_PEXEL_1	99	103	PF00026	0.376

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5N9	Leptomonas seymouri	54%	100%
A0A1X0NS57	Trypanosomatidae	29%	100%
A0A3Q8IG17	Leishmania donovani	91%	97%
A0A422N888	Trypanosoma rangeli	29%	100%
A4HKN1	Leishmania braziliensis	76%	99%
D0AAC8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B319	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%
V5BCW8	Trypanosoma cruzi	29%	100%