Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q533_LEIMA

TriTrypDb:

LmjF.32.2420 , LMJLV39_320031400 , LMJSD75_320031500

Length:

885

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q533

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q533

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	609	613	PF00656	0.648
CLV_C14_Caspase3-7	74	78	PF00656	0.624
CLV_NRD_NRD_1	107	109	PF00675	0.530
CLV_NRD_NRD_1	223	225	PF00675	0.656
CLV_NRD_NRD_1	240	242	PF00675	0.735
CLV_NRD_NRD_1	328	330	PF00675	0.482
CLV_NRD_NRD_1	380	382	PF00675	0.468
CLV_NRD_NRD_1	464	466	PF00675	0.685
CLV_NRD_NRD_1	539	541	PF00675	0.606
CLV_NRD_NRD_1	567	569	PF00675	0.556
CLV_NRD_NRD_1	659	661	PF00675	0.746
CLV_NRD_NRD_1	662	664	PF00675	0.769
CLV_NRD_NRD_1	710	712	PF00675	0.800
CLV_NRD_NRD_1	745	747	PF00675	0.659
CLV_PCSK_FUR_1	660	664	PF00082	0.793
CLV_PCSK_KEX2_1	106	108	PF00082	0.545
CLV_PCSK_KEX2_1	223	225	PF00082	0.656
CLV_PCSK_KEX2_1	240	242	PF00082	0.735
CLV_PCSK_KEX2_1	328	330	PF00082	0.482
CLV_PCSK_KEX2_1	380	382	PF00082	0.468
CLV_PCSK_KEX2_1	399	401	PF00082	0.597
CLV_PCSK_KEX2_1	464	466	PF00082	0.685
CLV_PCSK_KEX2_1	539	541	PF00082	0.606
CLV_PCSK_KEX2_1	567	569	PF00082	0.556
CLV_PCSK_KEX2_1	659	661	PF00082	0.691
CLV_PCSK_KEX2_1	662	664	PF00082	0.718
CLV_PCSK_KEX2_1	710	712	PF00082	0.800
CLV_PCSK_KEX2_1	745	747	PF00082	0.659
CLV_PCSK_PC1ET2_1	399	401	PF00082	0.699
CLV_PCSK_PC7_1	376	382	PF00082	0.524
CLV_PCSK_SKI1_1	432	436	PF00082	0.542
CLV_PCSK_SKI1_1	591	595	PF00082	0.614
CLV_PCSK_SKI1_1	646	650	PF00082	0.611
CLV_PCSK_SKI1_1	674	678	PF00082	0.590
CLV_PCSK_SKI1_1	711	715	PF00082	0.616
CLV_PCSK_SKI1_1	808	812	PF00082	0.582
CLV_PCSK_SKI1_1	814	818	PF00082	0.573
CLV_PCSK_SKI1_1	841	845	PF00082	0.625
DEG_APCC_DBOX_1	380	388	PF00400	0.477
DEG_APCC_DBOX_1	645	653	PF00400	0.576
DEG_APCC_DBOX_1	673	681	PF00400	0.584
DEG_SCF_FBW7_1	579	585	PF00400	0.766
DOC_CDC14_PxL_1	382	390	PF14671	0.464
DOC_CKS1_1	405	410	PF01111	0.631
DOC_CKS1_1	579	584	PF01111	0.772
DOC_CYCLIN_RxL_1	808	821	PF00134	0.581
DOC_CYCLIN_yCln2_LP_2	518	524	PF00134	0.775
DOC_CYCLIN_yCln2_LP_2	594	600	PF00134	0.627
DOC_MAPK_DCC_7	380	390	PF00069	0.472
DOC_MAPK_gen_1	380	387	PF00069	0.581
DOC_MAPK_gen_1	504	514	PF00069	0.668
DOC_MAPK_MEF2A_6	381	390	PF00069	0.467
DOC_MAPK_MEF2A_6	591	598	PF00069	0.606
DOC_MAPK_MEF2A_6	642	651	PF00069	0.574
DOC_PP2B_LxvP_1	459	462	PF13499	0.567
DOC_PP2B_LxvP_1	594	597	PF13499	0.605
DOC_PP2B_LxvP_1	601	604	PF13499	0.605
DOC_PP4_FxxP_1	338	341	PF00568	0.620
DOC_PP4_FxxP_1	790	793	PF00568	0.640
DOC_USP7_MATH_1	126	130	PF00917	0.829
DOC_USP7_MATH_1	146	150	PF00917	0.736
DOC_USP7_MATH_1	212	216	PF00917	0.544
DOC_USP7_MATH_1	231	235	PF00917	0.575
DOC_USP7_MATH_1	252	256	PF00917	0.675
DOC_USP7_MATH_1	365	369	PF00917	0.551
DOC_USP7_MATH_1	5	9	PF00917	0.700
DOC_USP7_MATH_1	526	530	PF00917	0.744
DOC_USP7_MATH_1	563	567	PF00917	0.678
DOC_USP7_MATH_1	665	669	PF00917	0.816
DOC_USP7_MATH_1	691	695	PF00917	0.760
DOC_USP7_MATH_1	741	745	PF00917	0.757
DOC_USP7_MATH_1	85	89	PF00917	0.628
DOC_WW_Pin1_4	127	132	PF00397	0.755
DOC_WW_Pin1_4	150	155	PF00397	0.810
DOC_WW_Pin1_4	158	163	PF00397	0.642
DOC_WW_Pin1_4	235	240	PF00397	0.646
DOC_WW_Pin1_4	279	284	PF00397	0.619
DOC_WW_Pin1_4	399	404	PF00397	0.602
DOC_WW_Pin1_4	414	419	PF00397	0.626
DOC_WW_Pin1_4	45	50	PF00397	0.655
DOC_WW_Pin1_4	578	583	PF00397	0.773
DOC_WW_Pin1_4	602	607	PF00397	0.734
DOC_WW_Pin1_4	626	631	PF00397	0.630
DOC_WW_Pin1_4	696	701	PF00397	0.735
DOC_WW_Pin1_4	858	863	PF00397	0.654
LIG_14-3-3_CanoR_1	125	131	PF00244	0.756
LIG_14-3-3_CanoR_1	241	249	PF00244	0.700
LIG_14-3-3_CanoR_1	256	262	PF00244	0.487
LIG_14-3-3_CanoR_1	631	637	PF00244	0.720
LIG_14-3-3_CanoR_1	663	671	PF00244	0.729
LIG_14-3-3_CanoR_1	730	739	PF00244	0.580
LIG_14-3-3_CanoR_1	874	878	PF00244	0.581
LIG_Actin_WH2_2	309	327	PF00022	0.555
LIG_Actin_WH2_2	825	843	PF00022	0.650
LIG_APCC_ABBA_1	816	821	PF00400	0.684
LIG_BIR_III_4	77	81	PF00653	0.552
LIG_BRCT_BRCA1_1	186	190	PF00533	0.587
LIG_BRCT_BRCA1_1	346	350	PF00533	0.685
LIG_BRCT_BRCA1_1	528	532	PF00533	0.738
LIG_BRCT_BRCA1_1	598	602	PF00533	0.647
LIG_CaM_IQ_9	827	843	PF13499	0.582
LIG_deltaCOP1_diTrp_1	425	435	PF00928	0.540
LIG_deltaCOP1_diTrp_1	43	50	PF00928	0.710
LIG_EH1_1	177	185	PF00400	0.480
LIG_FHA_1	155	161	PF00498	0.738
LIG_FHA_1	168	174	PF00498	0.527
LIG_FHA_1	179	185	PF00498	0.409
LIG_FHA_1	243	249	PF00498	0.672
LIG_FHA_1	279	285	PF00498	0.610
LIG_FHA_1	400	406	PF00498	0.651
LIG_FHA_1	555	561	PF00498	0.826
LIG_FHA_1	757	763	PF00498	0.681
LIG_FHA_1	782	788	PF00498	0.681
LIG_FHA_2	193	199	PF00498	0.526
LIG_FHA_2	38	44	PF00498	0.653
LIG_FHA_2	492	498	PF00498	0.672
LIG_FHA_2	824	830	PF00498	0.681
LIG_GBD_Chelix_1	534	542	PF00786	0.627
LIG_GBD_Chelix_1	752	760	PF00786	0.567
LIG_GBD_Chelix_1	798	806	PF00786	0.601
LIG_Integrin_RGD_1	571	573	PF01839	0.673
LIG_LIR_Apic_2	11	17	PF02991	0.583
LIG_LIR_Apic_2	335	341	PF02991	0.617
LIG_LIR_Gen_1	260	270	PF02991	0.429
LIG_LIR_Gen_1	451	461	PF02991	0.515
LIG_LIR_Nem_3	101	105	PF02991	0.538
LIG_LIR_Nem_3	260	266	PF02991	0.433
LIG_LIR_Nem_3	451	456	PF02991	0.507
LIG_LIR_Nem_3	88	93	PF02991	0.500
LIG_NRBOX	497	503	PF00104	0.729
LIG_NRBOX	643	649	PF00104	0.609
LIG_PCNA_yPIPBox_3	591	602	PF02747	0.591
LIG_PCNA_yPIPBox_3	642	652	PF02747	0.590
LIG_PDZ_Class_1	880	885	PF00595	0.701
LIG_Pex14_2	537	541	PF04695	0.634
LIG_PTAP_UEV_1	155	160	PF05743	0.605
LIG_Rb_pABgroove_1	841	849	PF01858	0.466
LIG_SH2_CRK	14	18	PF00017	0.631
LIG_SH2_CRK	346	350	PF00017	0.685
LIG_SH2_CRK	590	594	PF00017	0.615
LIG_SH2_PTP2	24	27	PF00017	0.604
LIG_SH2_STAP1	294	298	PF00017	0.522
LIG_SH2_STAP1	346	350	PF00017	0.583
LIG_SH2_STAT3	847	850	PF00017	0.660
LIG_SH2_STAT5	24	27	PF00017	0.604
LIG_SH3_3	153	159	PF00018	0.646
LIG_SH3_3	246	252	PF00018	0.690
LIG_SH3_3	402	408	PF00018	0.675
LIG_SH3_3	415	421	PF00018	0.731
LIG_SH3_3	46	52	PF00018	0.736
LIG_SH3_3	513	519	PF00018	0.738
LIG_SH3_3	546	552	PF00018	0.706
LIG_SH3_3	685	691	PF00018	0.666
LIG_SUMO_SIM_anti_2	179	184	PF11976	0.479
LIG_SUMO_SIM_anti_2	320	325	PF11976	0.542
LIG_SUMO_SIM_par_1	842	848	PF11976	0.697
LIG_TYR_ITIM	22	27	PF00017	0.662
LIG_UBA3_1	438	444	PF00899	0.554
LIG_WRC_WIRS_1	534	539	PF05994	0.721
LIG_WRC_WIRS_1	87	92	PF05994	0.532
LIG_WW_3	373	377	PF00397	0.571
MOD_CDC14_SPxK_1	238	241	PF00782	0.574
MOD_CDK_SPK_2	235	240	PF00069	0.582
MOD_CDK_SPK_2	602	607	PF00069	0.617
MOD_CDK_SPK_2	626	631	PF00069	0.607
MOD_CDK_SPxK_1	235	241	PF00069	0.581
MOD_CDK_SPxxK_3	127	134	PF00069	0.760
MOD_CDK_SPxxK_3	626	633	PF00069	0.605
MOD_CK1_1	129	135	PF00069	0.723
MOD_CK1_1	147	153	PF00069	0.698
MOD_CK1_1	230	236	PF00069	0.705
MOD_CK1_1	354	360	PF00069	0.762
MOD_CK1_1	416	422	PF00069	0.689
MOD_CK1_1	550	556	PF00069	0.803
MOD_CK1_1	574	580	PF00069	0.710
MOD_CK1_1	672	678	PF00069	0.722
MOD_CK1_1	696	702	PF00069	0.786
MOD_CK1_1	704	710	PF00069	0.709
MOD_CK1_1	8	14	PF00069	0.748
MOD_CK2_1	188	194	PF00069	0.524
MOD_CK2_1	37	43	PF00069	0.652
MOD_CK2_1	491	497	PF00069	0.655
MOD_CK2_1	672	678	PF00069	0.687
MOD_CK2_1	737	743	PF00069	0.693
MOD_CK2_1	823	829	PF00069	0.621
MOD_CK2_1	852	858	PF00069	0.664
MOD_Cter_Amidation	326	329	PF01082	0.640
MOD_Cter_Amidation	708	711	PF01082	0.730
MOD_GlcNHglycan	145	149	PF01048	0.769
MOD_GlcNHglycan	186	189	PF01048	0.584
MOD_GlcNHglycan	205	208	PF01048	0.260
MOD_GlcNHglycan	214	217	PF01048	0.544
MOD_GlcNHglycan	229	232	PF01048	0.542
MOD_GlcNHglycan	233	236	PF01048	0.779
MOD_GlcNHglycan	268	271	PF01048	0.371
MOD_GlcNHglycan	429	432	PF01048	0.538
MOD_GlcNHglycan	484	487	PF01048	0.721
MOD_GlcNHglycan	52	55	PF01048	0.777
MOD_GlcNHglycan	527	531	PF01048	0.710
MOD_GlcNHglycan	573	576	PF01048	0.674
MOD_GlcNHglycan	598	601	PF01048	0.691
MOD_GlcNHglycan	615	618	PF01048	0.568
MOD_GlcNHglycan	667	670	PF01048	0.740
MOD_GlcNHglycan	671	674	PF01048	0.780
MOD_GlcNHglycan	681	684	PF01048	0.599
MOD_GlcNHglycan	695	698	PF01048	0.716
MOD_GlcNHglycan	7	10	PF01048	0.673
MOD_GlcNHglycan	706	709	PF01048	0.661
MOD_GlcNHglycan	739	742	PF01048	0.769
MOD_GSK3_1	140	147	PF00069	0.783
MOD_GSK3_1	148	155	PF00069	0.734
MOD_GSK3_1	167	174	PF00069	0.569
MOD_GSK3_1	184	191	PF00069	0.304
MOD_GSK3_1	227	234	PF00069	0.646
MOD_GSK3_1	32	39	PF00069	0.676
MOD_GSK3_1	351	358	PF00069	0.724
MOD_GSK3_1	388	395	PF00069	0.466
MOD_GSK3_1	476	483	PF00069	0.710
MOD_GSK3_1	543	550	PF00069	0.740
MOD_GSK3_1	571	578	PF00069	0.658
MOD_GSK3_1	602	609	PF00069	0.657
MOD_GSK3_1	622	629	PF00069	0.460
MOD_GSK3_1	665	672	PF00069	0.703
MOD_GSK3_1	691	698	PF00069	0.775
MOD_GSK3_1	699	706	PF00069	0.697
MOD_GSK3_1	731	738	PF00069	0.743
MOD_GSK3_1	772	779	PF00069	0.797
MOD_GSK3_1	861	868	PF00069	0.648
MOD_N-GLC_1	127	132	PF02516	0.719
MOD_N-GLC_1	227	232	PF02516	0.700
MOD_N-GLC_1	354	359	PF02516	0.681
MOD_N-GLC_1	491	496	PF02516	0.759
MOD_N-GLC_1	756	761	PF02516	0.482
MOD_NEK2_1	173	178	PF00069	0.521
MOD_NEK2_1	184	189	PF00069	0.438
MOD_NEK2_1	205	210	PF00069	0.486
MOD_NEK2_1	229	234	PF00069	0.615
MOD_NEK2_1	278	283	PF00069	0.729
MOD_NEK2_1	388	393	PF00069	0.460
MOD_NEK2_1	448	453	PF00069	0.479
MOD_NEK2_1	542	547	PF00069	0.648
MOD_NEK2_1	562	567	PF00069	0.696
MOD_NEK2_1	756	761	PF00069	0.529
MOD_NEK2_1	806	811	PF00069	0.693
MOD_NEK2_1	836	841	PF00069	0.639
MOD_NEK2_1	880	885	PF00069	0.599
MOD_NEK2_2	37	42	PF00069	0.651
MOD_PIKK_1	120	126	PF00454	0.706
MOD_PIKK_1	140	146	PF00454	0.844
MOD_PIKK_1	171	177	PF00454	0.591
MOD_PIKK_1	287	293	PF00454	0.692
MOD_PIKK_1	392	398	PF00454	0.456
MOD_PIKK_1	476	482	PF00454	0.740
MOD_PIKK_1	731	737	PF00454	0.720
MOD_PKA_2	140	146	PF00069	0.624
MOD_PKA_2	554	560	PF00069	0.781
MOD_PKA_2	632	638	PF00069	0.698
MOD_PKA_2	781	787	PF00069	0.664
MOD_PKA_2	873	879	PF00069	0.577
MOD_Plk_1	306	312	PF00069	0.435
MOD_Plk_1	424	430	PF00069	0.705
MOD_Plk_1	448	454	PF00069	0.522
MOD_Plk_1	491	497	PF00069	0.757
MOD_Plk_1	691	697	PF00069	0.691
MOD_Plk_1	756	762	PF00069	0.479
MOD_Plk_1	836	842	PF00069	0.645
MOD_Plk_1	85	91	PF00069	0.522
MOD_Plk_4	173	179	PF00069	0.493
MOD_Plk_4	205	211	PF00069	0.454
MOD_Plk_4	344	350	PF00069	0.638
MOD_Plk_4	388	394	PF00069	0.462
MOD_Plk_4	533	539	PF00069	0.722
MOD_ProDKin_1	127	133	PF00069	0.758
MOD_ProDKin_1	150	156	PF00069	0.808
MOD_ProDKin_1	158	164	PF00069	0.629
MOD_ProDKin_1	235	241	PF00069	0.645
MOD_ProDKin_1	279	285	PF00069	0.610
MOD_ProDKin_1	399	405	PF00069	0.613
MOD_ProDKin_1	414	420	PF00069	0.626
MOD_ProDKin_1	45	51	PF00069	0.656
MOD_ProDKin_1	578	584	PF00069	0.772
MOD_ProDKin_1	602	608	PF00069	0.739
MOD_ProDKin_1	626	632	PF00069	0.629
MOD_ProDKin_1	696	702	PF00069	0.735
MOD_ProDKin_1	858	864	PF00069	0.649
MOD_SUMO_rev_2	469	479	PF00179	0.696
TRG_DiLeu_BaEn_1	497	502	PF01217	0.630
TRG_DiLeu_BaEn_1	639	644	PF01217	0.608
TRG_DiLeu_BaLyEn_6	196	201	PF01217	0.496
TRG_DiLeu_BaLyEn_6	293	298	PF01217	0.529
TRG_DiLeu_BaLyEn_6	383	388	PF01217	0.515
TRG_DiLeu_BaLyEn_6	643	648	PF01217	0.579
TRG_DiLeu_BaLyEn_6	811	816	PF01217	0.671
TRG_DiLeu_LyEn_5	639	644	PF01217	0.633
TRG_ENDOCYTIC_2	24	27	PF00928	0.658
TRG_ENDOCYTIC_2	294	297	PF00928	0.527
TRG_ENDOCYTIC_2	346	349	PF00928	0.528
TRG_ENDOCYTIC_2	590	593	PF00928	0.614
TRG_ER_diArg_1	105	108	PF00400	0.536
TRG_ER_diArg_1	223	226	PF00400	0.664
TRG_ER_diArg_1	239	241	PF00400	0.731
TRG_ER_diArg_1	380	382	PF00400	0.468
TRG_ER_diArg_1	538	540	PF00400	0.596
TRG_ER_diArg_1	567	569	PF00400	0.556
TRG_ER_diArg_1	630	633	PF00400	0.730
TRG_ER_diArg_1	659	662	PF00400	0.768
TRG_NES_CRM1_1	751	763	PF08389	0.454
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	800	804	PF00026	0.595

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW56	Leptomonas seymouri	35%	87%
A0A3S7X5R7	Leishmania donovani	88%	87%
A4HKN3	Leishmania braziliensis	69%	87%
A4I864	Leishmania infantum	88%	87%
E9B322	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%