SAM_MT_RSMB_NOP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NOL1/NOP2/sun family, putative

Species:

Leishmania major

UniProt:

Q4Q532_LEIMA

TriTrypDb:

LmjF.32.2430 , LMJLV39_320031500 , LMJSD75_320031600

Length:

414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000315	organellar large ribosomal subunit	5	2
GO:0005762	mitochondrial large ribosomal subunit	3	2
GO:0015934	large ribosomal subunit	4	2
GO:0032991	protein-containing complex	1	2
GO:0044391	ribosomal subunit	3	2
GO:0098798	mitochondrial protein-containing complex	2	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4Q532

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q532

Function

Biological processes
Term	Name	Level	Count
GO:0000154	rRNA modification	6	2
GO:0001510	RNA methylation	4	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	2
GO:0031167	rRNA methylation	5	2
GO:0032259	methylation	2	12
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043414	macromolecule methylation	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0008168	methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	229	233	PF00656	0.491
CLV_C14_Caspase3-7	347	351	PF00656	0.733
CLV_MEL_PAP_1	65	71	PF00089	0.496
CLV_NRD_NRD_1	212	214	PF00675	0.275
CLV_NRD_NRD_1	60	62	PF00675	0.479
CLV_PCSK_FUR_1	210	214	PF00082	0.261
CLV_PCSK_KEX2_1	212	214	PF00082	0.260
CLV_PCSK_SKI1_1	255	259	PF00082	0.261
CLV_PCSK_SKI1_1	284	288	PF00082	0.279
CLV_PCSK_SKI1_1	328	332	PF00082	0.344
CLV_PCSK_SKI1_1	346	350	PF00082	0.425
CLV_PCSK_SKI1_1	378	382	PF00082	0.467
CLV_PCSK_SKI1_1	62	66	PF00082	0.420
DEG_SPOP_SBC_1	405	409	PF00917	0.744
DOC_CKS1_1	364	369	PF01111	0.548
DOC_CYCLIN_RxL_1	375	384	PF00134	0.490
DOC_MAPK_gen_1	322	329	PF00069	0.456
DOC_PP2B_LxvP_1	379	382	PF13499	0.462
DOC_PP4_FxxP_1	191	194	PF00568	0.511
DOC_USP7_MATH_1	250	254	PF00917	0.510
DOC_USP7_MATH_1	28	32	PF00917	0.638
DOC_USP7_MATH_1	351	355	PF00917	0.742
DOC_USP7_UBL2_3	119	123	PF12436	0.507
DOC_USP7_UBL2_3	29	33	PF12436	0.656
DOC_WW_Pin1_4	190	195	PF00397	0.511
DOC_WW_Pin1_4	261	266	PF00397	0.485
DOC_WW_Pin1_4	305	310	PF00397	0.461
DOC_WW_Pin1_4	330	335	PF00397	0.620
DOC_WW_Pin1_4	363	368	PF00397	0.644
LIG_14-3-3_CanoR_1	299	309	PF00244	0.461
LIG_14-3-3_CanoR_1	48	53	PF00244	0.324
LIG_14-3-3_CanoR_1	68	74	PF00244	0.525
LIG_BIR_III_4	145	149	PF00653	0.494
LIG_BIR_III_4	355	359	PF00653	0.686
LIG_CtBP_PxDLS_1	265	269	PF00389	0.528
LIG_FHA_1	100	106	PF00498	0.548
LIG_FHA_1	12	18	PF00498	0.678
LIG_FHA_1	274	280	PF00498	0.494
LIG_FHA_1	291	297	PF00498	0.503
LIG_FHA_1	302	308	PF00498	0.354
LIG_FHA_1	364	370	PF00498	0.601
LIG_FHA_1	76	82	PF00498	0.509
LIG_FHA_2	171	177	PF00498	0.555
LIG_FHA_2	197	203	PF00498	0.491
LIG_FHA_2	227	233	PF00498	0.479
LIG_FHA_2	321	327	PF00498	0.516
LIG_FHA_2	34	40	PF00498	0.479
LIG_FHA_2	345	351	PF00498	0.749
LIG_LIR_Apic_2	235	239	PF02991	0.463
LIG_LIR_Nem_3	36	40	PF02991	0.373
LIG_LIR_Nem_3	374	379	PF02991	0.397
LIG_Pex14_1	388	392	PF04695	0.454
LIG_Rb_LxCxE_1	193	206	PF01857	0.536
LIG_SH2_CRK	376	380	PF00017	0.484
LIG_SH2_SRC	237	240	PF00017	0.521
LIG_SH2_STAT5	153	156	PF00017	0.364
LIG_SH2_STAT5	223	226	PF00017	0.477
LIG_SH3_3	244	250	PF00018	0.450
LIG_SH3_3	339	345	PF00018	0.716
LIG_SH3_3	361	367	PF00018	0.647
LIG_SUMO_SIM_par_1	264	270	PF11976	0.528
LIG_TRAF2_1	73	76	PF00917	0.575
MOD_CK1_1	261	267	PF00069	0.551
MOD_CK1_1	272	278	PF00069	0.517
MOD_CK1_1	303	309	PF00069	0.461
MOD_CK1_1	354	360	PF00069	0.707
MOD_CK1_1	406	412	PF00069	0.675
MOD_CK2_1	196	202	PF00069	0.463
MOD_CK2_1	264	270	PF00069	0.495
MOD_CK2_1	305	311	PF00069	0.475
MOD_CK2_1	320	326	PF00069	0.528
MOD_CK2_1	33	39	PF00069	0.532
MOD_CK2_1	354	360	PF00069	0.755
MOD_CK2_1	404	410	PF00069	0.605
MOD_CK2_1	79	85	PF00069	0.546
MOD_GlcNHglycan	158	161	PF01048	0.410
MOD_GlcNHglycan	260	263	PF01048	0.301
MOD_GlcNHglycan	355	359	PF01048	0.754
MOD_GSK3_1	269	276	PF00069	0.480
MOD_GSK3_1	301	308	PF00069	0.450
MOD_GSK3_1	75	82	PF00069	0.543
MOD_GSK3_1	95	102	PF00069	0.350
MOD_N-GLC_1	11	16	PF02516	0.708
MOD_N-GLC_1	99	104	PF02516	0.667
MOD_NEK2_1	258	263	PF00069	0.503
MOD_NEK2_1	320	325	PF00069	0.437
MOD_NEK2_2	28	33	PF00069	0.612
MOD_NEK2_2	290	295	PF00069	0.482
MOD_PIKK_1	226	232	PF00454	0.461
MOD_PIKK_1	67	73	PF00454	0.506
MOD_PIKK_1	93	99	PF00454	0.476
MOD_PKA_2	226	232	PF00069	0.560
MOD_PKA_2	67	73	PF00069	0.454
MOD_PKB_1	9	17	PF00069	0.707
MOD_Plk_1	272	278	PF00069	0.454
MOD_Plk_1	371	377	PF00069	0.435
MOD_Plk_2-3	232	238	PF00069	0.536
MOD_Plk_4	170	176	PF00069	0.429
MOD_Plk_4	232	238	PF00069	0.479
MOD_Plk_4	365	371	PF00069	0.589
MOD_Plk_4	85	91	PF00069	0.486
MOD_ProDKin_1	190	196	PF00069	0.511
MOD_ProDKin_1	261	267	PF00069	0.485
MOD_ProDKin_1	305	311	PF00069	0.461
MOD_ProDKin_1	330	336	PF00069	0.626
MOD_ProDKin_1	363	369	PF00069	0.633
MOD_SUMO_rev_2	114	120	PF00179	0.515
MOD_SUMO_rev_2	397	405	PF00179	0.579
TRG_DiLeu_BaEn_1	85	90	PF01217	0.576
TRG_DiLeu_BaLyEn_6	375	380	PF01217	0.458
TRG_ENDOCYTIC_2	152	155	PF00928	0.372
TRG_ENDOCYTIC_2	376	379	PF00928	0.404
TRG_ENDOCYTIC_2	41	44	PF00928	0.400
TRG_ER_diArg_1	210	213	PF00400	0.475
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.543
TRG_Pf-PMV_PEXEL_1	213	217	PF00026	0.253
TRG_Pf-PMV_PEXEL_1	244	248	PF00026	0.250
TRG_Pf-PMV_PEXEL_1	255	259	PF00026	0.250
TRG_Pf-PMV_PEXEL_1	284	288	PF00026	0.355
TRG_Pf-PMV_PEXEL_1	378	383	PF00026	0.421

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK00	Leptomonas seymouri	67%	100%
A0A0S4J448	Bodo saltans	40%	100%
A0A1X0NJV9	Trypanosomatidae	29%	73%
A0A1X0NRJ9	Trypanosomatidae	41%	100%
A0A3Q8ID92	Leishmania donovani	92%	100%
A0A3R7K4S3	Trypanosoma rangeli	47%	100%
A4HKN4	Leishmania braziliensis	80%	98%
A4I865	Leishmania infantum	92%	100%
D0AAD3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9B323	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q0P5D8	Bos taurus	29%	100%
Q0V8R7	Bos taurus	31%	100%
Q4KMK0	Danio rerio	31%	100%
Q5M7E3	Xenopus laevis	29%	100%
Q66KI9	Xenopus tropicalis	29%	100%
Q8CCT7	Mus musculus	29%	100%
Q96CB9	Homo sapiens	26%	100%
Q9CZ57	Mus musculus	26%	100%
V5B8C1	Trypanosoma cruzi	43%	100%