Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q524_LEIMA

TriTrypDb:

LmjF.32.2510 , LMJLV39_320032400 , LMJSD75_320032600

Length:

665

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q524

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q524

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	1
GO:0006518	peptide metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	1
GO:0043043	peptide biosynthetic process	5	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043603	amide metabolic process	3	1
GO:0043604	amide biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	1
GO:0005198	structural molecule activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	160	164	PF00656	0.591
CLV_C14_Caspase3-7	272	276	PF00656	0.652
CLV_C14_Caspase3-7	387	391	PF00656	0.446
CLV_C14_Caspase3-7	79	83	PF00656	0.686
CLV_NRD_NRD_1	138	140	PF00675	0.620
CLV_NRD_NRD_1	16	18	PF00675	0.748
CLV_NRD_NRD_1	184	186	PF00675	0.616
CLV_NRD_NRD_1	255	257	PF00675	0.596
CLV_NRD_NRD_1	304	306	PF00675	0.480
CLV_NRD_NRD_1	618	620	PF00675	0.461
CLV_PCSK_FUR_1	302	306	PF00082	0.476
CLV_PCSK_KEX2_1	137	139	PF00082	0.754
CLV_PCSK_KEX2_1	16	18	PF00082	0.748
CLV_PCSK_KEX2_1	184	186	PF00082	0.616
CLV_PCSK_KEX2_1	254	256	PF00082	0.595
CLV_PCSK_KEX2_1	267	269	PF00082	0.618
CLV_PCSK_KEX2_1	302	304	PF00082	0.516
CLV_PCSK_KEX2_1	348	350	PF00082	0.581
CLV_PCSK_KEX2_1	618	620	PF00082	0.470
CLV_PCSK_PC1ET2_1	267	269	PF00082	0.676
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.436
CLV_PCSK_PC7_1	134	140	PF00082	0.613
CLV_PCSK_PC7_1	344	350	PF00082	0.486
CLV_PCSK_SKI1_1	125	129	PF00082	0.612
CLV_PCSK_SKI1_1	305	309	PF00082	0.419
CLV_PCSK_SKI1_1	312	316	PF00082	0.526
CLV_PCSK_SKI1_1	34	38	PF00082	0.483
CLV_PCSK_SKI1_1	344	348	PF00082	0.471
CLV_PCSK_SKI1_1	374	378	PF00082	0.471
CLV_PCSK_SKI1_1	511	515	PF00082	0.474
CLV_PCSK_SKI1_1	519	523	PF00082	0.423
CLV_PCSK_SKI1_1	618	622	PF00082	0.491
CLV_PCSK_SKI1_1	94	98	PF00082	0.738
DEG_APCC_DBOX_1	114	122	PF00400	0.587
DEG_COP1_1	582	591	PF00400	0.446
DOC_CKS1_1	463	468	PF01111	0.538
DOC_CYCLIN_RxL_1	120	132	PF00134	0.548
DOC_CYCLIN_RxL_1	511	523	PF00134	0.297
DOC_MAPK_gen_1	120	129	PF00069	0.456
DOC_MAPK_gen_1	426	435	PF00069	0.408
DOC_MAPK_gen_1	618	624	PF00069	0.394
DOC_MAPK_MEF2A_6	123	131	PF00069	0.533
DOC_MAPK_MEF2A_6	174	183	PF00069	0.535
DOC_MAPK_RevD_3	605	619	PF00069	0.387
DOC_PP1_RVXF_1	517	523	PF00149	0.429
DOC_PP2B_LxvP_1	455	458	PF13499	0.638
DOC_PP2B_LxvP_1	581	584	PF13499	0.410
DOC_PP2B_LxvP_1	586	589	PF13499	0.479
DOC_PP4_FxxP_1	231	234	PF00568	0.688
DOC_USP7_MATH_1	217	221	PF00917	0.797
DOC_USP7_MATH_1	273	277	PF00917	0.702
DOC_USP7_MATH_1	380	384	PF00917	0.480
DOC_USP7_MATH_1	444	448	PF00917	0.483
DOC_USP7_MATH_1	480	484	PF00917	0.649
DOC_USP7_MATH_1	495	499	PF00917	0.500
DOC_USP7_MATH_1	80	84	PF00917	0.657
DOC_WW_Pin1_4	259	264	PF00397	0.731
DOC_WW_Pin1_4	326	331	PF00397	0.453
DOC_WW_Pin1_4	459	464	PF00397	0.793
DOC_WW_Pin1_4	489	494	PF00397	0.629
DOC_WW_Pin1_4	496	501	PF00397	0.412
LIG_14-3-3_CanoR_1	34	43	PF00244	0.442
LIG_14-3-3_CanoR_1	428	433	PF00244	0.371
LIG_14-3-3_CanoR_1	618	623	PF00244	0.424
LIG_14-3-3_CanoR_1	94	103	PF00244	0.630
LIG_Actin_WH2_2	198	213	PF00022	0.515
LIG_APCC_ABBAyCdc20_2	137	143	PF00400	0.574
LIG_BIR_II_1	1	5	PF00653	0.782
LIG_Clathr_ClatBox_1	566	570	PF01394	0.433
LIG_FHA_1	140	146	PF00498	0.639
LIG_FHA_1	27	33	PF00498	0.547
LIG_FHA_1	420	426	PF00498	0.456
LIG_FHA_1	51	57	PF00498	0.580
LIG_FHA_1	543	549	PF00498	0.287
LIG_FHA_1	602	608	PF00498	0.379
LIG_FHA_1	615	621	PF00498	0.354
LIG_FHA_1	624	630	PF00498	0.378
LIG_FHA_2	105	111	PF00498	0.555
LIG_FHA_2	153	159	PF00498	0.501
LIG_FHA_2	645	651	PF00498	0.347
LIG_FHA_2	95	101	PF00498	0.767
LIG_LIR_Gen_1	395	404	PF02991	0.447
LIG_LIR_Gen_1	46	56	PF02991	0.440
LIG_LIR_Gen_1	502	508	PF02991	0.533
LIG_LIR_Nem_3	290	296	PF02991	0.408
LIG_LIR_Nem_3	395	401	PF02991	0.376
LIG_LIR_Nem_3	46	52	PF02991	0.444
LIG_LIR_Nem_3	502	506	PF02991	0.541
LIG_MYND_1	230	234	PF01753	0.666
LIG_Pex14_2	58	62	PF04695	0.559
LIG_PTAP_UEV_1	588	593	PF05743	0.443
LIG_SH2_PTP2	327	330	PF00017	0.541
LIG_SH2_STAP1	309	313	PF00017	0.635
LIG_SH2_STAP1	39	43	PF00017	0.420
LIG_SH2_STAP1	398	402	PF00017	0.443
LIG_SH2_STAP1	423	427	PF00017	0.542
LIG_SH2_STAT3	39	42	PF00017	0.448
LIG_SH2_STAT5	309	312	PF00017	0.448
LIG_SH2_STAT5	327	330	PF00017	0.541
LIG_SH3_3	4	10	PF00018	0.597
LIG_SH3_3	460	466	PF00018	0.663
LIG_SH3_3	586	592	PF00018	0.584
LIG_SH3_3	617	623	PF00018	0.450
LIG_SUMO_SIM_par_1	603	608	PF11976	0.381
LIG_TRAF2_1	331	334	PF00917	0.495
LIG_WRC_WIRS_1	381	386	PF05994	0.376
LIG_WRC_WIRS_1	543	548	PF05994	0.362
LIG_WRC_WIRS_1	576	581	PF05994	0.430
MOD_CK1_1	152	158	PF00069	0.643
MOD_CK1_1	169	175	PF00069	0.528
MOD_CK1_1	243	249	PF00069	0.602
MOD_CK1_1	276	282	PF00069	0.702
MOD_CK1_1	447	453	PF00069	0.582
MOD_CK1_1	556	562	PF00069	0.588
MOD_CK1_1	57	63	PF00069	0.491
MOD_CK1_1	644	650	PF00069	0.362
MOD_CK2_1	151	157	PF00069	0.648
MOD_CK2_1	215	221	PF00069	0.639
MOD_CK2_1	337	343	PF00069	0.601
MOD_CK2_1	380	386	PF00069	0.415
MOD_CK2_1	57	63	PF00069	0.588
MOD_CK2_1	579	585	PF00069	0.480
MOD_CK2_1	80	86	PF00069	0.625
MOD_Cter_Amidation	265	268	PF01082	0.694
MOD_GlcNHglycan	131	134	PF01048	0.616
MOD_GlcNHglycan	151	154	PF01048	0.631
MOD_GlcNHglycan	217	220	PF01048	0.644
MOD_GlcNHglycan	242	245	PF01048	0.610
MOD_GlcNHglycan	275	278	PF01048	0.621
MOD_GlcNHglycan	442	445	PF01048	0.495
MOD_GlcNHglycan	482	485	PF01048	0.635
MOD_GlcNHglycan	489	492	PF01048	0.700
MOD_GlcNHglycan	527	530	PF01048	0.357
MOD_GlcNHglycan	589	592	PF01048	0.626
MOD_GlcNHglycan	59	62	PF01048	0.495
MOD_GlcNHglycan	631	634	PF01048	0.575
MOD_GlcNHglycan	661	664	PF01048	0.545
MOD_GlcNHglycan	75	79	PF01048	0.590
MOD_GlcNHglycan	82	85	PF01048	0.630
MOD_GSK3_1	145	152	PF00069	0.677
MOD_GSK3_1	215	222	PF00069	0.740
MOD_GSK3_1	23	30	PF00069	0.585
MOD_GSK3_1	255	262	PF00069	0.627
MOD_GSK3_1	273	280	PF00069	0.599
MOD_GSK3_1	380	387	PF00069	0.574
MOD_GSK3_1	440	447	PF00069	0.485
MOD_GSK3_1	480	487	PF00069	0.687
MOD_GSK3_1	495	502	PF00069	0.529
MOD_GSK3_1	50	57	PF00069	0.595
MOD_GSK3_1	549	556	PF00069	0.456
MOD_GSK3_1	575	582	PF00069	0.406
MOD_GSK3_1	610	617	PF00069	0.446
MOD_GSK3_1	625	632	PF00069	0.459
MOD_GSK3_1	638	645	PF00069	0.587
MOD_GSK3_1	76	83	PF00069	0.648
MOD_GSK3_1	84	91	PF00069	0.794
MOD_NEK2_1	149	154	PF00069	0.687
MOD_NEK2_1	193	198	PF00069	0.645
MOD_NEK2_1	384	389	PF00069	0.533
MOD_NEK2_1	440	445	PF00069	0.474
MOD_NEK2_1	448	453	PF00069	0.527
MOD_NEK2_1	553	558	PF00069	0.459
MOD_NEK2_1	579	584	PF00069	0.467
MOD_NEK2_1	624	629	PF00069	0.531
MOD_NEK2_2	54	59	PF00069	0.560
MOD_PIKK_1	384	390	PF00454	0.497
MOD_PIKK_1	448	454	PF00454	0.565
MOD_PKA_1	16	22	PF00069	0.602
MOD_PKA_1	255	261	PF00069	0.604
MOD_PKA_1	618	624	PF00069	0.397
MOD_PKA_2	16	22	PF00069	0.651
MOD_PKA_2	255	261	PF00069	0.691
MOD_PKA_2	610	616	PF00069	0.432
MOD_PKA_2	618	624	PF00069	0.370
MOD_PKB_1	137	145	PF00069	0.551
MOD_PKB_1	426	434	PF00069	0.411
MOD_Plk_1	419	425	PF00069	0.323
MOD_Plk_4	145	151	PF00069	0.701
MOD_Plk_4	444	450	PF00069	0.501
MOD_Plk_4	499	505	PF00069	0.520
MOD_Plk_4	553	559	PF00069	0.466
MOD_Plk_4	572	578	PF00069	0.419
MOD_Plk_4	601	607	PF00069	0.330
MOD_Plk_4	625	631	PF00069	0.559
MOD_Plk_4	644	650	PF00069	0.403
MOD_ProDKin_1	259	265	PF00069	0.734
MOD_ProDKin_1	326	332	PF00069	0.454
MOD_ProDKin_1	459	465	PF00069	0.795
MOD_ProDKin_1	489	495	PF00069	0.626
MOD_ProDKin_1	496	502	PF00069	0.404
MOD_SUMO_for_1	70	73	PF00179	0.662
TRG_DiLeu_BaEn_1	341	346	PF01217	0.362
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.518
TRG_DiLeu_BaLyEn_6	474	479	PF01217	0.599
TRG_ENDOCYTIC_2	293	296	PF00928	0.569
TRG_ENDOCYTIC_2	398	401	PF00928	0.462
TRG_ER_diArg_1	115	118	PF00400	0.621
TRG_ER_diArg_1	137	139	PF00400	0.624
TRG_ER_diArg_1	183	185	PF00400	0.622
TRG_ER_diArg_1	253	256	PF00400	0.593
TRG_ER_diArg_1	302	305	PF00400	0.475
TRG_ER_diArg_1	425	428	PF00400	0.581
TRG_ER_diArg_1	618	620	PF00400	0.505
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5A1	Leptomonas seymouri	45%	100%
A0A1X0NRK2	Trypanosomatidae	31%	100%
A0A3Q8IG27	Leishmania donovani	91%	100%
A4HKP1	Leishmania braziliensis	72%	100%
A4I872	Leishmania infantum	90%	100%
D0AAE1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9B330	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5AUP9	Trypanosoma cruzi	33%	100%