Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q523_LEIMA

TriTrypDb:

LmjF.32.2520 , LMJLV39_320032500 , LMJSD75_320032700

Length:

926

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q523

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q523

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	266	270	PF00656	0.665
CLV_C14_Caspase3-7	640	644	PF00656	0.718
CLV_C14_Caspase3-7	709	713	PF00656	0.711
CLV_NRD_NRD_1	177	179	PF00675	0.698
CLV_NRD_NRD_1	208	210	PF00675	0.836
CLV_NRD_NRD_1	278	280	PF00675	0.739
CLV_NRD_NRD_1	288	290	PF00675	0.624
CLV_NRD_NRD_1	311	313	PF00675	0.705
CLV_NRD_NRD_1	453	455	PF00675	0.769
CLV_NRD_NRD_1	459	461	PF00675	0.756
CLV_NRD_NRD_1	511	513	PF00675	0.742
CLV_NRD_NRD_1	514	516	PF00675	0.724
CLV_NRD_NRD_1	517	519	PF00675	0.688
CLV_NRD_NRD_1	520	522	PF00675	0.650
CLV_NRD_NRD_1	524	526	PF00675	0.616
CLV_NRD_NRD_1	575	577	PF00675	0.698
CLV_NRD_NRD_1	705	707	PF00675	0.669
CLV_NRD_NRD_1	863	865	PF00675	0.667
CLV_NRD_NRD_1	879	881	PF00675	0.808
CLV_PCSK_FUR_1	175	179	PF00082	0.687
CLV_PCSK_FUR_1	273	277	PF00082	0.730
CLV_PCSK_FUR_1	504	508	PF00082	0.726
CLV_PCSK_FUR_1	509	513	PF00082	0.705
CLV_PCSK_FUR_1	515	519	PF00082	0.650
CLV_PCSK_FUR_1	876	880	PF00082	0.725
CLV_PCSK_KEX2_1	177	179	PF00082	0.681
CLV_PCSK_KEX2_1	208	210	PF00082	0.843
CLV_PCSK_KEX2_1	273	275	PF00082	0.736
CLV_PCSK_KEX2_1	276	278	PF00082	0.697
CLV_PCSK_KEX2_1	287	289	PF00082	0.584
CLV_PCSK_KEX2_1	310	312	PF00082	0.707
CLV_PCSK_KEX2_1	452	454	PF00082	0.775
CLV_PCSK_KEX2_1	459	461	PF00082	0.753
CLV_PCSK_KEX2_1	506	508	PF00082	0.729
CLV_PCSK_KEX2_1	509	511	PF00082	0.717
CLV_PCSK_KEX2_1	514	516	PF00082	0.685
CLV_PCSK_KEX2_1	517	519	PF00082	0.649
CLV_PCSK_KEX2_1	520	522	PF00082	0.611
CLV_PCSK_KEX2_1	524	526	PF00082	0.577
CLV_PCSK_KEX2_1	575	577	PF00082	0.674
CLV_PCSK_KEX2_1	705	707	PF00082	0.669
CLV_PCSK_KEX2_1	792	794	PF00082	0.694
CLV_PCSK_KEX2_1	863	865	PF00082	0.658
CLV_PCSK_KEX2_1	878	880	PF00082	0.819
CLV_PCSK_PC1ET2_1	792	794	PF00082	0.622
CLV_PCSK_PC7_1	273	279	PF00082	0.728
CLV_PCSK_PC7_1	504	510	PF00082	0.696
CLV_PCSK_PC7_1	520	526	PF00082	0.564
CLV_PCSK_PC7_1	859	865	PF00082	0.619
CLV_PCSK_PC7_1	874	880	PF00082	0.633
CLV_PCSK_SKI1_1	45	49	PF00082	0.743
CLV_PCSK_SKI1_1	697	701	PF00082	0.687
CLV_PCSK_SKI1_1	751	755	PF00082	0.682
DEG_Nend_Nbox_1	1	3	PF02207	0.665
DEG_SCF_FBW7_1	383	390	PF00400	0.606
DEG_SPOP_SBC_1	216	220	PF00917	0.603
DEG_SPOP_SBC_1	372	376	PF00917	0.664
DEG_SPOP_SBC_1	444	448	PF00917	0.690
DEG_SPOP_SBC_1	464	468	PF00917	0.629
DEG_SPOP_SBC_1	530	534	PF00917	0.625
DEG_SPOP_SBC_1	733	737	PF00917	0.583
DEG_SPOP_SBC_1	893	897	PF00917	0.688
DOC_ANK_TNKS_1	277	284	PF00023	0.658
DOC_CKS1_1	758	763	PF01111	0.654
DOC_CYCLIN_yCln2_LP_2	820	826	PF00134	0.600
DOC_MAPK_gen_1	424	432	PF00069	0.585
DOC_MAPK_RevD_3	779	793	PF00069	0.590
DOC_PP2B_LxvP_1	605	608	PF13499	0.665
DOC_PP4_FxxP_1	108	111	PF00568	0.660
DOC_USP7_MATH_1	11	15	PF00917	0.694
DOC_USP7_MATH_1	145	149	PF00917	0.659
DOC_USP7_MATH_1	157	161	PF00917	0.610
DOC_USP7_MATH_1	191	195	PF00917	0.776
DOC_USP7_MATH_1	239	243	PF00917	0.688
DOC_USP7_MATH_1	29	33	PF00917	0.619
DOC_USP7_MATH_1	291	295	PF00917	0.761
DOC_USP7_MATH_1	345	349	PF00917	0.809
DOC_USP7_MATH_1	370	374	PF00917	0.689
DOC_USP7_MATH_1	379	383	PF00917	0.604
DOC_USP7_MATH_1	462	466	PF00917	0.700
DOC_USP7_MATH_1	499	503	PF00917	0.701
DOC_USP7_MATH_1	530	534	PF00917	0.745
DOC_USP7_MATH_1	543	547	PF00917	0.602
DOC_USP7_MATH_1	63	67	PF00917	0.697
DOC_USP7_MATH_1	654	658	PF00917	0.670
DOC_USP7_MATH_1	660	664	PF00917	0.637
DOC_USP7_MATH_1	719	723	PF00917	0.680
DOC_USP7_MATH_1	734	738	PF00917	0.583
DOC_USP7_MATH_1	739	743	PF00917	0.546
DOC_USP7_MATH_1	788	792	PF00917	0.744
DOC_USP7_UBL2_3	901	905	PF12436	0.667
DOC_WW_Pin1_4	127	132	PF00397	0.615
DOC_WW_Pin1_4	146	151	PF00397	0.685
DOC_WW_Pin1_4	159	164	PF00397	0.583
DOC_WW_Pin1_4	167	172	PF00397	0.671
DOC_WW_Pin1_4	183	188	PF00397	0.659
DOC_WW_Pin1_4	192	197	PF00397	0.711
DOC_WW_Pin1_4	289	294	PF00397	0.744
DOC_WW_Pin1_4	34	39	PF00397	0.525
DOC_WW_Pin1_4	360	365	PF00397	0.719
DOC_WW_Pin1_4	383	388	PF00397	0.685
DOC_WW_Pin1_4	435	440	PF00397	0.631
DOC_WW_Pin1_4	458	463	PF00397	0.691
DOC_WW_Pin1_4	650	655	PF00397	0.689
DOC_WW_Pin1_4	66	71	PF00397	0.704
DOC_WW_Pin1_4	757	762	PF00397	0.719
DOC_WW_Pin1_4	779	784	PF00397	0.599
DOC_WW_Pin1_4	819	824	PF00397	0.599
DOC_WW_Pin1_4	848	853	PF00397	0.737
DOC_WW_Pin1_4	869	874	PF00397	0.678
DOC_WW_Pin1_4	878	883	PF00397	0.712
LIG_14-3-3_CanoR_1	287	296	PF00244	0.806
LIG_14-3-3_CanoR_1	424	432	PF00244	0.595
LIG_14-3-3_CanoR_1	453	462	PF00244	0.779
LIG_14-3-3_CanoR_1	471	477	PF00244	0.583
LIG_14-3-3_CanoR_1	478	488	PF00244	0.633
LIG_14-3-3_CanoR_1	528	538	PF00244	0.660
LIG_14-3-3_CanoR_1	738	746	PF00244	0.656
LIG_14-3-3_CanoR_1	856	866	PF00244	0.603
LIG_APCC_ABBA_1	36	41	PF00400	0.522
LIG_BIR_III_4	643	647	PF00653	0.673
LIG_CtBP_PxDLS_1	59	63	PF00389	0.560
LIG_CtBP_PxDLS_1	778	782	PF00389	0.691
LIG_FHA_1	131	137	PF00498	0.775
LIG_FHA_1	387	393	PF00498	0.745
LIG_FHA_1	402	408	PF00498	0.657
LIG_FHA_1	427	433	PF00498	0.635
LIG_FHA_1	747	753	PF00498	0.661
LIG_FHA_1	758	764	PF00498	0.616
LIG_FHA_2	231	237	PF00498	0.691
LIG_FHA_2	578	584	PF00498	0.571
LIG_Integrin_isoDGR_2	173	175	PF01839	0.607
LIG_Integrin_RGD_1	178	180	PF01839	0.724
LIG_LIR_Apic_2	358	364	PF02991	0.593
LIG_LIR_Apic_2	85	89	PF02991	0.747
LIG_LIR_Nem_3	231	237	PF02991	0.685
LIG_LIR_Nem_3	37	42	PF02991	0.519
LIG_Pex14_2	234	238	PF04695	0.725
LIG_Pex14_2	700	704	PF04695	0.684
LIG_PTB_Apo_2	41	48	PF02174	0.524
LIG_REV1ctd_RIR_1	571	580	PF16727	0.700
LIG_SH2_CRK	100	104	PF00017	0.613
LIG_SH2_CRK	86	90	PF00017	0.776
LIG_SH2_NCK_1	222	226	PF00017	0.678
LIG_SH2_STAP1	484	488	PF00017	0.659
LIG_SH2_STAP1	613	617	PF00017	0.650
LIG_SH2_STAT5	222	225	PF00017	0.653
LIG_SH3_1	811	817	PF00018	0.661
LIG_SH3_2	193	198	PF14604	0.665
LIG_SH3_2	761	766	PF14604	0.654
LIG_SH3_3	118	124	PF00018	0.719
LIG_SH3_3	190	196	PF00018	0.717
LIG_SH3_3	248	254	PF00018	0.683
LIG_SH3_3	290	296	PF00018	0.741
LIG_SH3_3	392	398	PF00018	0.827
LIG_SH3_3	404	410	PF00018	0.636
LIG_SH3_3	414	420	PF00018	0.625
LIG_SH3_3	434	440	PF00018	0.637
LIG_SH3_3	53	59	PF00018	0.698
LIG_SH3_3	545	551	PF00018	0.673
LIG_SH3_3	64	70	PF00018	0.611
LIG_SH3_3	75	81	PF00018	0.668
LIG_SH3_3	758	764	PF00018	0.657
LIG_SH3_3	811	817	PF00018	0.661
LIG_SH3_3	85	91	PF00018	0.576
LIG_SUMO_SIM_par_1	397	404	PF11976	0.714
LIG_TRAF2_1	595	598	PF00917	0.672
LIG_TYR_ITSM	35	42	PF00017	0.523
LIG_UBA3_1	699	708	PF00899	0.647
LIG_WRC_WIRS_1	570	575	PF05994	0.627
LIG_WW_3	768	772	PF00397	0.655
MOD_CDC14_SPxK_1	195	198	PF00782	0.666
MOD_CDC14_SPxK_1	363	366	PF00782	0.712
MOD_CDK_SPK_2	167	172	PF00069	0.688
MOD_CDK_SPK_2	869	874	PF00069	0.598
MOD_CDK_SPxK_1	192	198	PF00069	0.667
MOD_CDK_SPxK_1	360	366	PF00069	0.720
MOD_CDK_SPxK_1	650	656	PF00069	0.691
MOD_CDK_SPxK_1	878	884	PF00069	0.593
MOD_CDK_SPxxK_3	159	166	PF00069	0.616
MOD_CDK_SPxxK_3	869	876	PF00069	0.601
MOD_CK1_1	148	154	PF00069	0.635
MOD_CK1_1	218	224	PF00069	0.686
MOD_CK1_1	292	298	PF00069	0.718
MOD_CK1_1	373	379	PF00069	0.670
MOD_CK1_1	400	406	PF00069	0.577
MOD_CK1_1	463	469	PF00069	0.735
MOD_CK1_1	482	488	PF00069	0.543
MOD_CK1_1	489	495	PF00069	0.664
MOD_CK1_1	500	506	PF00069	0.573
MOD_CK1_1	529	535	PF00069	0.729
MOD_CK1_1	546	552	PF00069	0.551
MOD_CK1_1	639	645	PF00069	0.735
MOD_CK1_1	66	72	PF00069	0.667
MOD_CK1_1	663	669	PF00069	0.680
MOD_CK1_1	693	699	PF00069	0.656
MOD_CK1_1	727	733	PF00069	0.705
MOD_CK1_1	737	743	PF00069	0.653
MOD_CK1_1	888	894	PF00069	0.823
MOD_CK1_1	895	901	PF00069	0.750
MOD_CK2_1	230	236	PF00069	0.691
MOD_CK2_1	292	298	PF00069	0.741
MOD_CK2_1	487	493	PF00069	0.679
MOD_CK2_1	554	560	PF00069	0.692
MOD_CK2_1	577	583	PF00069	0.598
MOD_Cter_Amidation	206	209	PF01082	0.603
MOD_Cter_Amidation	271	274	PF01082	0.740
MOD_Cter_Amidation	450	453	PF01082	0.580
MOD_Cter_Amidation	515	518	PF01082	0.739
MOD_Cter_Amidation	522	525	PF01082	0.665
MOD_Cter_Amidation	861	864	PF01082	0.747
MOD_Cter_Amidation	876	879	PF01082	0.684
MOD_GlcNHglycan	13	16	PF01048	0.661
MOD_GlcNHglycan	143	146	PF01048	0.681
MOD_GlcNHglycan	159	162	PF01048	0.617
MOD_GlcNHglycan	188	191	PF01048	0.693
MOD_GlcNHglycan	205	208	PF01048	0.661
MOD_GlcNHglycan	31	34	PF01048	0.522
MOD_GlcNHglycan	336	339	PF01048	0.775
MOD_GlcNHglycan	366	369	PF01048	0.643
MOD_GlcNHglycan	432	435	PF01048	0.698
MOD_GlcNHglycan	462	465	PF01048	0.728
MOD_GlcNHglycan	468	471	PF01048	0.693
MOD_GlcNHglycan	499	502	PF01048	0.699
MOD_GlcNHglycan	528	531	PF01048	0.692
MOD_GlcNHglycan	545	548	PF01048	0.614
MOD_GlcNHglycan	585	588	PF01048	0.688
MOD_GlcNHglycan	620	623	PF01048	0.555
MOD_GlcNHglycan	663	666	PF01048	0.739
MOD_GlcNHglycan	692	695	PF01048	0.621
MOD_GlcNHglycan	720	724	PF01048	0.705
MOD_GlcNHglycan	729	732	PF01048	0.677
MOD_GlcNHglycan	741	744	PF01048	0.653
MOD_GlcNHglycan	766	769	PF01048	0.677
MOD_GlcNHglycan	834	837	PF01048	0.692
MOD_GlcNHglycan	860	863	PF01048	0.832
MOD_GlcNHglycan	9	12	PF01048	0.572
MOD_GlcNHglycan	907	910	PF01048	0.756
MOD_GSK3_1	126	133	PF00069	0.698
MOD_GSK3_1	137	144	PF00069	0.626
MOD_GSK3_1	216	223	PF00069	0.718
MOD_GSK3_1	224	231	PF00069	0.631
MOD_GSK3_1	287	294	PF00069	0.761
MOD_GSK3_1	350	357	PF00069	0.693
MOD_GSK3_1	360	367	PF00069	0.630
MOD_GSK3_1	379	386	PF00069	0.662
MOD_GSK3_1	387	394	PF00069	0.651
MOD_GSK3_1	397	404	PF00069	0.594
MOD_GSK3_1	426	433	PF00069	0.639
MOD_GSK3_1	454	461	PF00069	0.718
MOD_GSK3_1	462	469	PF00069	0.677
MOD_GSK3_1	478	485	PF00069	0.555
MOD_GSK3_1	487	494	PF00069	0.586
MOD_GSK3_1	526	533	PF00069	0.675
MOD_GSK3_1	65	72	PF00069	0.754
MOD_GSK3_1	650	657	PF00069	0.702
MOD_GSK3_1	676	683	PF00069	0.730
MOD_GSK3_1	7	14	PF00069	0.564
MOD_GSK3_1	733	740	PF00069	0.685
MOD_GSK3_1	742	749	PF00069	0.640
MOD_GSK3_1	796	803	PF00069	0.687
MOD_GSK3_1	858	865	PF00069	0.626
MOD_GSK3_1	883	890	PF00069	0.840
MOD_GSK3_1	891	898	PF00069	0.714
MOD_LATS_1	458	464	PF00433	0.711
MOD_N-GLC_1	370	375	PF02516	0.697
MOD_N-GLC_1	554	559	PF02516	0.718
MOD_N-GLC_1	576	581	PF02516	0.630
MOD_N-GLC_1	676	681	PF02516	0.668
MOD_N-GLC_1	724	729	PF02516	0.674
MOD_N-GLC_1	746	751	PF02516	0.685
MOD_N-GLC_1	843	848	PF02516	0.695
MOD_N-GLC_2	44	46	PF02516	0.622
MOD_N-GLC_2	887	889	PF02516	0.691
MOD_NEK2_1	2	7	PF00069	0.567
MOD_NEK2_1	344	349	PF00069	0.694
MOD_NEK2_1	391	396	PF00069	0.601
MOD_NEK2_1	612	617	PF00069	0.671
MOD_NEK2_1	883	888	PF00069	0.730
MOD_NEK2_2	569	574	PF00069	0.626
MOD_PIKK_1	137	143	PF00454	0.720
MOD_PIKK_1	224	230	PF00454	0.674
MOD_PIKK_1	654	660	PF00454	0.705
MOD_PIKK_1	827	833	PF00454	0.649
MOD_PKA_1	287	293	PF00069	0.692
MOD_PKA_2	287	293	PF00069	0.847
MOD_PKA_2	426	432	PF00069	0.584
MOD_PKA_2	470	476	PF00069	0.615
MOD_PKA_2	737	743	PF00069	0.661
MOD_PKA_2	797	803	PF00069	0.683
MOD_PKA_2	858	864	PF00069	0.699
MOD_PKB_1	452	460	PF00069	0.588
MOD_PKB_1	841	849	PF00069	0.646
MOD_Plk_1	554	560	PF00069	0.719
MOD_Plk_1	613	619	PF00069	0.571
MOD_Plk_1	724	730	PF00069	0.675
MOD_Plk_4	387	393	PF00069	0.678
MOD_Plk_4	401	407	PF00069	0.585
MOD_Plk_4	569	575	PF00069	0.628
MOD_Plk_4	613	619	PF00069	0.571
MOD_ProDKin_1	127	133	PF00069	0.615
MOD_ProDKin_1	146	152	PF00069	0.687
MOD_ProDKin_1	159	165	PF00069	0.583
MOD_ProDKin_1	167	173	PF00069	0.674
MOD_ProDKin_1	183	189	PF00069	0.660
MOD_ProDKin_1	192	198	PF00069	0.713
MOD_ProDKin_1	289	295	PF00069	0.743
MOD_ProDKin_1	34	40	PF00069	0.525
MOD_ProDKin_1	360	366	PF00069	0.720
MOD_ProDKin_1	383	389	PF00069	0.684
MOD_ProDKin_1	435	441	PF00069	0.629
MOD_ProDKin_1	458	464	PF00069	0.692
MOD_ProDKin_1	650	656	PF00069	0.691
MOD_ProDKin_1	66	72	PF00069	0.708
MOD_ProDKin_1	757	763	PF00069	0.718
MOD_ProDKin_1	779	785	PF00069	0.594
MOD_ProDKin_1	819	825	PF00069	0.600
MOD_ProDKin_1	848	854	PF00069	0.736
MOD_ProDKin_1	869	875	PF00069	0.679
MOD_ProDKin_1	878	884	PF00069	0.710
MOD_SUMO_rev_2	298	308	PF00179	0.693
MOD_SUMO_rev_2	328	336	PF00179	0.597
TRG_DiLeu_BaEn_4	303	309	PF01217	0.581
TRG_ENDOCYTIC_2	100	103	PF00928	0.723
TRG_ENDOCYTIC_2	39	42	PF00928	0.574
TRG_ER_diArg_1	175	178	PF00400	0.693
TRG_ER_diArg_1	273	276	PF00400	0.738
TRG_ER_diArg_1	277	279	PF00400	0.685
TRG_ER_diArg_1	287	289	PF00400	0.584
TRG_ER_diArg_1	310	312	PF00400	0.690
TRG_ER_diArg_1	452	454	PF00400	0.720
TRG_ER_diArg_1	506	509	PF00400	0.733
TRG_ER_diArg_1	510	512	PF00400	0.720
TRG_ER_diArg_1	514	517	PF00400	0.678
TRG_ER_diArg_1	518	521	PF00400	0.631
TRG_ER_diArg_1	524	526	PF00400	0.570
TRG_ER_diArg_1	535	538	PF00400	0.568
TRG_ER_diArg_1	574	576	PF00400	0.700
TRG_ER_diArg_1	704	706	PF00400	0.659
TRG_ER_diArg_1	873	876	PF00400	0.712
TRG_ER_diArg_1	878	880	PF00400	0.688
TRG_NLS_MonoExtN_4	798	805	PF00514	0.690
TRG_Pf-PMV_PEXEL_1	610	614	PF00026	0.547

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IJG2	Leishmania donovani	85%	100%
A4HKP2	Leishmania braziliensis	50%	100%
A4I873	Leishmania infantum	85%	100%
E9B331	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%