Cyclic nucleotide-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclic nucleotide-binding domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q522_LEIMA

TriTrypDb:

LmjF.32.2530 , LMJLV39_320032600 , LMJSD75_320032800

Length:

958

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005929	cilium	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4Q522

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q522

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	275	279	PF00656	0.587
CLV_C14_Caspase3-7	94	98	PF00656	0.647
CLV_NRD_NRD_1	202	204	PF00675	0.620
CLV_NRD_NRD_1	213	215	PF00675	0.613
CLV_NRD_NRD_1	230	232	PF00675	0.511
CLV_NRD_NRD_1	361	363	PF00675	0.511
CLV_NRD_NRD_1	431	433	PF00675	0.395
CLV_NRD_NRD_1	50	52	PF00675	0.428
CLV_NRD_NRD_1	631	633	PF00675	0.554
CLV_NRD_NRD_1	774	776	PF00675	0.352
CLV_NRD_NRD_1	795	797	PF00675	0.374
CLV_NRD_NRD_1	896	898	PF00675	0.550
CLV_PCSK_KEX2_1	202	204	PF00082	0.620
CLV_PCSK_KEX2_1	230	232	PF00082	0.634
CLV_PCSK_KEX2_1	361	363	PF00082	0.414
CLV_PCSK_KEX2_1	431	433	PF00082	0.395
CLV_PCSK_KEX2_1	631	633	PF00082	0.595
CLV_PCSK_KEX2_1	774	776	PF00082	0.352
CLV_PCSK_KEX2_1	795	797	PF00082	0.382
CLV_PCSK_KEX2_1	896	898	PF00082	0.550
CLV_PCSK_SKI1_1	100	104	PF00082	0.753
CLV_PCSK_SKI1_1	133	137	PF00082	0.450
CLV_PCSK_SKI1_1	149	153	PF00082	0.517
CLV_PCSK_SKI1_1	361	365	PF00082	0.433
CLV_PCSK_SKI1_1	439	443	PF00082	0.660
CLV_PCSK_SKI1_1	481	485	PF00082	0.407
CLV_PCSK_SKI1_1	54	58	PF00082	0.530
CLV_PCSK_SKI1_1	631	635	PF00082	0.596
CLV_PCSK_SKI1_1	718	722	PF00082	0.403
CLV_PCSK_SKI1_1	796	800	PF00082	0.365
CLV_PCSK_SKI1_1	896	900	PF00082	0.614
CLV_PCSK_SKI1_1	917	921	PF00082	0.604
CLV_Separin_Metazoa	476	480	PF03568	0.575
DEG_APCC_DBOX_1	896	904	PF00400	0.611
DEG_SPOP_SBC_1	285	289	PF00917	0.614
DOC_ANK_TNKS_1	585	592	PF00023	0.576
DOC_CYCLIN_RxL_1	478	486	PF00134	0.535
DOC_CYCLIN_RxL_1	715	724	PF00134	0.385
DOC_CYCLIN_yCln2_LP_2	531	537	PF00134	0.354
DOC_MAPK_gen_1	431	437	PF00069	0.330
DOC_MAPK_gen_1	49	57	PF00069	0.464
DOC_MAPK_gen_1	597	606	PF00069	0.612
DOC_MAPK_gen_1	702	710	PF00069	0.454
DOC_MAPK_gen_1	777	785	PF00069	0.425
DOC_MAPK_gen_1	795	802	PF00069	0.242
DOC_PP1_RVXF_1	716	723	PF00149	0.416
DOC_PP2B_LxvP_1	309	312	PF13499	0.352
DOC_PP2B_LxvP_1	40	43	PF13499	0.458
DOC_PP2B_LxvP_1	406	409	PF13499	0.431
DOC_PP2B_LxvP_1	475	478	PF13499	0.626
DOC_PP4_FxxP_1	609	612	PF00568	0.683
DOC_USP7_MATH_1	182	186	PF00917	0.464
DOC_USP7_MATH_1	194	198	PF00917	0.473
DOC_USP7_MATH_1	2	6	PF00917	0.584
DOC_USP7_MATH_1	272	276	PF00917	0.608
DOC_USP7_MATH_1	284	288	PF00917	0.560
DOC_USP7_MATH_1	294	298	PF00917	0.662
DOC_USP7_MATH_1	612	616	PF00917	0.568
DOC_USP7_MATH_1	627	631	PF00917	0.518
DOC_USP7_MATH_1	678	682	PF00917	0.433
DOC_USP7_MATH_1	745	749	PF00917	0.677
DOC_USP7_MATH_1	761	765	PF00917	0.492
DOC_USP7_MATH_1	840	844	PF00917	0.682
DOC_WW_Pin1_4	331	336	PF00397	0.410
DOC_WW_Pin1_4	456	461	PF00397	0.763
DOC_WW_Pin1_4	604	609	PF00397	0.684
DOC_WW_Pin1_4	623	628	PF00397	0.509
DOC_WW_Pin1_4	752	757	PF00397	0.445
LIG_14-3-3_CanoR_1	202	210	PF00244	0.617
LIG_14-3-3_CanoR_1	214	219	PF00244	0.566
LIG_14-3-3_CanoR_1	230	237	PF00244	0.531
LIG_14-3-3_CanoR_1	270	277	PF00244	0.724
LIG_14-3-3_CanoR_1	394	403	PF00244	0.554
LIG_14-3-3_CanoR_1	479	484	PF00244	0.498
LIG_14-3-3_CanoR_1	504	511	PF00244	0.401
LIG_14-3-3_CanoR_1	665	674	PF00244	0.528
LIG_14-3-3_CanoR_1	879	884	PF00244	0.574
LIG_14-3-3_CanoR_1	896	901	PF00244	0.547
LIG_14-3-3_CanoR_1	932	937	PF00244	0.645
LIG_Actin_RPEL_3	44	63	PF02755	0.404
LIG_Actin_WH2_2	14	32	PF00022	0.439
LIG_APCC_ABBA_1	633	638	PF00400	0.620
LIG_APCC_ABBA_1	719	724	PF00400	0.424
LIG_APCC_ABBAyCdc20_2	632	638	PF00400	0.620
LIG_APCC_ABBAyCdc20_2	718	724	PF00400	0.425
LIG_BRCT_BRCA1_1	493	497	PF00533	0.576
LIG_Clathr_ClatBox_1	720	724	PF01394	0.389
LIG_deltaCOP1_diTrp_1	153	156	PF00928	0.486
LIG_deltaCOP1_diTrp_1	547	555	PF00928	0.568
LIG_deltaCOP1_diTrp_1	790	799	PF00928	0.316
LIG_FHA_1	254	260	PF00498	0.570
LIG_FHA_1	262	268	PF00498	0.518
LIG_FHA_1	304	310	PF00498	0.454
LIG_FHA_1	395	401	PF00498	0.388
LIG_FHA_1	491	497	PF00498	0.404
LIG_FHA_1	549	555	PF00498	0.582
LIG_FHA_1	777	783	PF00498	0.369
LIG_FHA_1	80	86	PF00498	0.411
LIG_FHA_1	803	809	PF00498	0.530
LIG_FHA_1	814	820	PF00498	0.374
LIG_FHA_1	87	93	PF00498	0.433
LIG_FHA_1	935	941	PF00498	0.727
LIG_FHA_2	129	135	PF00498	0.331
LIG_FHA_2	487	493	PF00498	0.340
LIG_FHA_2	507	513	PF00498	0.326
LIG_FHA_2	632	638	PF00498	0.620
LIG_FHA_2	64	70	PF00498	0.456
LIG_FHA_2	709	715	PF00498	0.473
LIG_FHA_2	858	864	PF00498	0.503
LIG_FHA_2	92	98	PF00498	0.526
LIG_HP1_1	678	682	PF01393	0.474
LIG_LIR_Apic_2	512	517	PF02991	0.295
LIG_LIR_Apic_2	607	612	PF02991	0.617
LIG_LIR_Gen_1	138	147	PF02991	0.407
LIG_LIR_Gen_1	503	513	PF02991	0.435
LIG_LIR_Gen_1	66	76	PF02991	0.398
LIG_LIR_Nem_3	138	143	PF02991	0.419
LIG_LIR_Nem_3	503	508	PF02991	0.416
LIG_LIR_Nem_3	66	71	PF02991	0.404
LIG_LIR_Nem_3	73	79	PF02991	0.327
LIG_LIR_Nem_3	833	837	PF02991	0.545
LIG_MYND_1	836	840	PF01753	0.477
LIG_PDZ_Class_3	953	958	PF00595	0.580
LIG_PTAP_UEV_1	295	300	PF05743	0.589
LIG_PTB_Apo_2	134	141	PF02174	0.424
LIG_PTB_Phospho_1	134	140	PF10480	0.430
LIG_REV1ctd_RIR_1	426	436	PF16727	0.337
LIG_REV1ctd_RIR_1	720	730	PF16727	0.422
LIG_RPA_C_Fungi	357	369	PF08784	0.412
LIG_SH2_CRK	505	509	PF00017	0.388
LIG_SH2_CRK	770	774	PF00017	0.320
LIG_SH2_CRK	834	838	PF00017	0.549
LIG_SH2_NCK_1	505	509	PF00017	0.388
LIG_SH2_NCK_1	93	97	PF00017	0.528
LIG_SH2_PTP2	140	143	PF00017	0.416
LIG_SH2_STAT5	140	143	PF00017	0.428
LIG_SH2_STAT5	326	329	PF00017	0.370
LIG_SH2_STAT5	347	350	PF00017	0.392
LIG_SH2_STAT5	377	380	PF00017	0.404
LIG_SH2_STAT5	505	508	PF00017	0.391
LIG_SH2_STAT5	514	517	PF00017	0.250
LIG_SH2_STAT5	770	773	PF00017	0.317
LIG_SH2_STAT5	84	87	PF00017	0.440
LIG_SH2_STAT5	93	96	PF00017	0.587
LIG_SH3_3	112	118	PF00018	0.491
LIG_SH3_3	293	299	PF00018	0.598
LIG_SH3_3	329	335	PF00018	0.409
LIG_SH3_3	337	343	PF00018	0.388
LIG_SH3_3	454	460	PF00018	0.666
LIG_SH3_3	5	11	PF00018	0.480
LIG_SH3_3	605	611	PF00018	0.545
LIG_SH3_3	816	822	PF00018	0.545
LIG_SH3_3	862	868	PF00018	0.608
LIG_SUMO_SIM_anti_2	160	167	PF11976	0.365
LIG_SUMO_SIM_par_1	678	684	PF11976	0.400
LIG_SUMO_SIM_par_1	781	787	PF11976	0.351
LIG_SUMO_SIM_par_1	855	860	PF11976	0.518
LIG_TRAF2_1	24	27	PF00917	0.468
LIG_TRAF2_1	538	541	PF00917	0.487
LIG_TRAF2_1	67	70	PF00917	0.471
LIG_TRAF2_1	712	715	PF00917	0.456
LIG_TRAF2_1	860	863	PF00917	0.540
LIG_TYR_ITIM	768	773	PF00017	0.318
LIG_TYR_ITIM	832	837	PF00017	0.556
LIG_ULM_U2AF65_1	774	779	PF00076	0.448
MOD_CK1_1	213	219	PF00069	0.736
MOD_CK1_1	239	245	PF00069	0.664
MOD_CK1_1	257	263	PF00069	0.614
MOD_CK1_1	287	293	PF00069	0.576
MOD_CK1_1	331	337	PF00069	0.405
MOD_CK1_1	64	70	PF00069	0.604
MOD_CK1_1	681	687	PF00069	0.370
MOD_CK1_1	902	908	PF00069	0.746
MOD_CK1_1	934	940	PF00069	0.530
MOD_CK1_1	946	952	PF00069	0.465
MOD_CK2_1	486	492	PF00069	0.347
MOD_CK2_1	535	541	PF00069	0.509
MOD_CK2_1	63	69	PF00069	0.474
MOD_CK2_1	631	637	PF00069	0.662
MOD_CK2_1	669	675	PF00069	0.497
MOD_CK2_1	708	714	PF00069	0.399
MOD_CK2_1	857	863	PF00069	0.504
MOD_CK2_1	879	885	PF00069	0.656
MOD_Cter_Amidation	894	897	PF01082	0.661
MOD_GlcNHglycan	100	103	PF01048	0.691
MOD_GlcNHglycan	11	14	PF01048	0.456
MOD_GlcNHglycan	111	114	PF01048	0.515
MOD_GlcNHglycan	204	207	PF01048	0.590
MOD_GlcNHglycan	232	235	PF01048	0.674
MOD_GlcNHglycan	248	251	PF01048	0.608
MOD_GlcNHglycan	256	259	PF01048	0.579
MOD_GlcNHglycan	272	275	PF01048	0.629
MOD_GlcNHglycan	296	299	PF01048	0.622
MOD_GlcNHglycan	537	540	PF01048	0.491
MOD_GlcNHglycan	612	615	PF01048	0.758
MOD_GlcNHglycan	654	657	PF01048	0.655
MOD_GlcNHglycan	667	670	PF01048	0.513
MOD_GlcNHglycan	671	674	PF01048	0.454
MOD_GlcNHglycan	683	686	PF01048	0.369
MOD_GlcNHglycan	711	714	PF01048	0.414
MOD_GlcNHglycan	747	750	PF01048	0.650
MOD_GlcNHglycan	752	755	PF01048	0.584
MOD_GlcNHglycan	76	79	PF01048	0.410
MOD_GlcNHglycan	763	766	PF01048	0.331
MOD_GlcNHglycan	891	894	PF01048	0.681
MOD_GlcNHglycan	917	920	PF01048	0.720
MOD_GlcNHglycan	924	927	PF01048	0.691
MOD_GSK3_1	105	112	PF00069	0.700
MOD_GSK3_1	183	190	PF00069	0.617
MOD_GSK3_1	194	201	PF00069	0.773
MOD_GSK3_1	210	217	PF00069	0.500
MOD_GSK3_1	239	246	PF00069	0.670
MOD_GSK3_1	253	260	PF00069	0.519
MOD_GSK3_1	268	275	PF00069	0.522
MOD_GSK3_1	303	310	PF00069	0.502
MOD_GSK3_1	349	356	PF00069	0.430
MOD_GSK3_1	390	397	PF00069	0.394
MOD_GSK3_1	452	459	PF00069	0.607
MOD_GSK3_1	486	493	PF00069	0.390
MOD_GSK3_1	623	630	PF00069	0.627
MOD_GSK3_1	665	672	PF00069	0.552
MOD_GSK3_1	681	688	PF00069	0.473
MOD_GSK3_1	857	864	PF00069	0.444
MOD_GSK3_1	898	905	PF00069	0.781
MOD_GSK3_1	927	934	PF00069	0.669
MOD_GSK3_1	939	946	PF00069	0.720
MOD_N-GLC_1	136	141	PF02516	0.424
MOD_N-GLC_1	452	457	PF02516	0.520
MOD_N-GLC_1	471	476	PF02516	0.534
MOD_N-GLC_1	479	484	PF02516	0.430
MOD_NEK2_1	136	141	PF00069	0.470
MOD_NEK2_1	198	203	PF00069	0.591
MOD_NEK2_1	237	242	PF00069	0.584
MOD_NEK2_1	286	291	PF00069	0.612
MOD_NEK2_1	330	335	PF00069	0.319
MOD_NEK2_1	497	502	PF00069	0.489
MOD_NEK2_1	61	66	PF00069	0.511
MOD_NEK2_1	79	84	PF00069	0.273
MOD_NEK2_1	802	807	PF00069	0.474
MOD_NEK2_1	884	889	PF00069	0.673
MOD_NEK2_1	915	920	PF00069	0.594
MOD_NEK2_1	922	927	PF00069	0.537
MOD_PK_1	214	220	PF00069	0.582
MOD_PK_1	879	885	PF00069	0.628
MOD_PK_1	907	913	PF00069	0.735
MOD_PK_1	932	938	PF00069	0.576
MOD_PKA_1	202	208	PF00069	0.627
MOD_PKA_1	214	220	PF00069	0.613
MOD_PKA_1	230	236	PF00069	0.523
MOD_PKA_1	631	637	PF00069	0.551
MOD_PKA_1	896	902	PF00069	0.565
MOD_PKA_2	128	134	PF00069	0.339
MOD_PKA_2	202	208	PF00069	0.627
MOD_PKA_2	213	219	PF00069	0.584
MOD_PKA_2	230	236	PF00069	0.496
MOD_PKA_2	237	243	PF00069	0.601
MOD_PKA_2	503	509	PF00069	0.396
MOD_PKA_2	631	637	PF00069	0.536
MOD_PKA_2	664	670	PF00069	0.660
MOD_PKA_2	776	782	PF00069	0.429
MOD_PKA_2	896	902	PF00069	0.560
MOD_PKA_2	931	937	PF00069	0.755
MOD_PKA_2	946	952	PF00069	0.499
MOD_Plk_1	136	142	PF00069	0.426
MOD_Plk_1	439	445	PF00069	0.621
MOD_Plk_1	471	477	PF00069	0.592
MOD_Plk_1	479	485	PF00069	0.423
MOD_Plk_1	491	497	PF00069	0.241
MOD_Plk_1	540	546	PF00069	0.498
MOD_Plk_1	602	608	PF00069	0.621
MOD_Plk_1	861	867	PF00069	0.627
MOD_Plk_2-3	486	492	PF00069	0.347
MOD_Plk_2-3	91	97	PF00069	0.514
MOD_Plk_4	136	142	PF00069	0.426
MOD_Plk_4	2	8	PF00069	0.540
MOD_Plk_4	214	220	PF00069	0.656
MOD_Plk_4	287	293	PF00069	0.776
MOD_Plk_4	540	546	PF00069	0.489
MOD_Plk_4	631	637	PF00069	0.612
MOD_Plk_4	678	684	PF00069	0.475
MOD_Plk_4	80	86	PF00069	0.432
MOD_Plk_4	841	847	PF00069	0.536
MOD_Plk_4	861	867	PF00069	0.675
MOD_Plk_4	879	885	PF00069	0.640
MOD_ProDKin_1	331	337	PF00069	0.405
MOD_ProDKin_1	456	462	PF00069	0.765
MOD_ProDKin_1	604	610	PF00069	0.684
MOD_ProDKin_1	623	629	PF00069	0.507
MOD_ProDKin_1	752	758	PF00069	0.436
MOD_SUMO_for_1	525	528	PF00179	0.431
TRG_DiLeu_BaEn_1	161	166	PF01217	0.415
TRG_DiLeu_BaEn_1	715	720	PF01217	0.375
TRG_DiLeu_BaLyEn_6	359	364	PF01217	0.423
TRG_DiLeu_BaLyEn_6	370	375	PF01217	0.324
TRG_DiLeu_BaLyEn_6	387	392	PF01217	0.332
TRG_DiLeu_BaLyEn_6	833	838	PF01217	0.474
TRG_DiLeu_LyEn_5	715	720	PF01217	0.375
TRG_ENDOCYTIC_2	140	143	PF00928	0.517
TRG_ENDOCYTIC_2	347	350	PF00928	0.322
TRG_ENDOCYTIC_2	505	508	PF00928	0.385
TRG_ENDOCYTIC_2	770	773	PF00928	0.317
TRG_ENDOCYTIC_2	834	837	PF00928	0.567
TRG_ER_diArg_1	361	363	PF00400	0.465
TRG_ER_diArg_1	383	386	PF00400	0.394
TRG_ER_diArg_1	430	432	PF00400	0.386
TRG_ER_diArg_1	478	481	PF00400	0.594
TRG_ER_diArg_1	48	51	PF00400	0.421
TRG_ER_diArg_1	631	633	PF00400	0.591
TRG_ER_diArg_1	773	775	PF00400	0.347
TRG_ER_diArg_1	794	796	PF00400	0.415
TRG_NES_CRM1_1	818	833	PF08389	0.378
TRG_NLS_MonoExtN_4	49	55	PF00514	0.422
TRG_Pf-PMV_PEXEL_1	361	366	PF00026	0.462
TRG_Pf-PMV_PEXEL_1	481	486	PF00026	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I352	Leptomonas seymouri	50%	100%
A0A1X0NRJ2	Trypanosomatidae	31%	100%
A0A3S7X5T2	Leishmania donovani	92%	100%
A4I874	Leishmania infantum	92%	100%
D0AAE4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B332	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%