HDc domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HD domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q521_LEIMA

TriTrypDb:

LmjF.32.2540 , LMJLV39_320032700 , LMJSD75_320032900

Length:

673

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4Q521

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q521

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	3
GO:0006163	purine nucleotide metabolic process	5	3
GO:0006195	purine nucleotide catabolic process	6	3
GO:0006203	dGTP catabolic process	7	3
GO:0006725	cellular aromatic compound metabolic process	3	3
GO:0006753	nucleoside phosphate metabolic process	4	3
GO:0006793	phosphorus metabolic process	3	3
GO:0006796	phosphate-containing compound metabolic process	4	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0009056	catabolic process	2	3
GO:0009117	nucleotide metabolic process	5	3
GO:0009141	nucleoside triphosphate metabolic process	5	3
GO:0009143	nucleoside triphosphate catabolic process	6	3
GO:0009144	purine nucleoside triphosphate metabolic process	6	3
GO:0009146	purine nucleoside triphosphate catabolic process	7	3
GO:0009151	purine deoxyribonucleotide metabolic process	6	3
GO:0009155	purine deoxyribonucleotide catabolic process	6	3
GO:0009166	nucleotide catabolic process	6	3
GO:0009200	deoxyribonucleoside triphosphate metabolic process	6	3
GO:0009204	deoxyribonucleoside triphosphate catabolic process	7	3
GO:0009215	purine deoxyribonucleoside triphosphate metabolic process	7	3
GO:0009217	purine deoxyribonucleoside triphosphate catabolic process	8	3
GO:0009262	deoxyribonucleotide metabolic process	4	3
GO:0009264	deoxyribonucleotide catabolic process	5	3
GO:0009394	2'-deoxyribonucleotide metabolic process	5	3
GO:0009987	cellular process	1	3
GO:0019439	aromatic compound catabolic process	4	3
GO:0019637	organophosphate metabolic process	3	3
GO:0019692	deoxyribose phosphate metabolic process	4	3
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0034655	nucleobase-containing compound catabolic process	4	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044248	cellular catabolic process	3	3
GO:0044270	cellular nitrogen compound catabolic process	4	3
GO:0044281	small molecule metabolic process	2	3
GO:0046070	dGTP metabolic process	7	3
GO:0046386	deoxyribose phosphate catabolic process	5	3
GO:0046434	organophosphate catabolic process	4	3
GO:0046483	heterocycle metabolic process	3	3
GO:0046700	heterocycle catabolic process	4	3
GO:0055086	nucleobase-containing small molecule metabolic process	3	3
GO:0071704	organic substance metabolic process	2	3
GO:0072521	purine-containing compound metabolic process	4	3
GO:0072523	purine-containing compound catabolic process	5	3
GO:1901135	carbohydrate derivative metabolic process	3	3
GO:1901136	carbohydrate derivative catabolic process	4	3
GO:1901292	nucleoside phosphate catabolic process	5	3
GO:1901360	organic cyclic compound metabolic process	3	3
GO:1901361	organic cyclic compound catabolic process	4	3
GO:1901564	organonitrogen compound metabolic process	3	3
GO:1901565	organonitrogen compound catabolic process	4	3
GO:1901575	organic substance catabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0008832	dGTPase activity	6	3
GO:0016787	hydrolase activity	2	3
GO:0016788	hydrolase activity, acting on ester bonds	3	3
GO:0016793	triphosphoric monoester hydrolase activity	5	3
GO:0042578	phosphoric ester hydrolase activity	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	278	282	PF00656	0.468
CLV_C14_Caspase3-7	92	96	PF00656	0.378
CLV_NRD_NRD_1	157	159	PF00675	0.391
CLV_NRD_NRD_1	170	172	PF00675	0.345
CLV_NRD_NRD_1	376	378	PF00675	0.557
CLV_NRD_NRD_1	620	622	PF00675	0.590
CLV_PCSK_FUR_1	618	622	PF00082	0.512
CLV_PCSK_KEX2_1	227	229	PF00082	0.443
CLV_PCSK_KEX2_1	24	26	PF00082	0.451
CLV_PCSK_KEX2_1	376	378	PF00082	0.567
CLV_PCSK_KEX2_1	426	428	PF00082	0.476
CLV_PCSK_KEX2_1	608	610	PF00082	0.652
CLV_PCSK_KEX2_1	620	622	PF00082	0.596
CLV_PCSK_PC1ET2_1	227	229	PF00082	0.443
CLV_PCSK_PC1ET2_1	24	26	PF00082	0.524
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.476
CLV_PCSK_PC1ET2_1	608	610	PF00082	0.652
CLV_PCSK_SKI1_1	44	48	PF00082	0.452
CLV_PCSK_SKI1_1	56	60	PF00082	0.301
DEG_APCC_DBOX_1	290	298	PF00400	0.440
DEG_COP1_1	99	109	PF00400	0.315
DEG_SPOP_SBC_1	638	642	PF00917	0.558
DOC_ANK_TNKS_1	90	97	PF00023	0.315
DOC_CKS1_1	247	252	PF01111	0.466
DOC_CKS1_1	528	533	PF01111	0.481
DOC_CYCLIN_RxL_1	605	616	PF00134	0.616
DOC_MAPK_gen_1	227	233	PF00069	0.430
DOC_MAPK_gen_1	302	312	PF00069	0.420
DOC_MAPK_gen_1	608	614	PF00069	0.713
DOC_MAPK_MEF2A_6	534	541	PF00069	0.560
DOC_PP1_RVXF_1	536	542	PF00149	0.427
DOC_PP2B_PxIxI_1	40	46	PF00149	0.362
DOC_PP4_FxxP_1	104	107	PF00568	0.378
DOC_PP4_FxxP_1	488	491	PF00568	0.496
DOC_PP4_MxPP_1	1	4	PF00568	0.626
DOC_USP7_MATH_1	23	27	PF00917	0.508
DOC_USP7_MATH_1	333	337	PF00917	0.367
DOC_USP7_MATH_1	4	8	PF00917	0.668
DOC_USP7_MATH_1	491	495	PF00917	0.553
DOC_USP7_MATH_1	517	521	PF00917	0.490
DOC_USP7_MATH_1	567	571	PF00917	0.787
DOC_USP7_MATH_1	586	590	PF00917	0.484
DOC_USP7_MATH_1	638	642	PF00917	0.578
DOC_USP7_MATH_1	71	75	PF00917	0.421
DOC_USP7_MATH_2	531	537	PF00917	0.436
DOC_WW_Pin1_4	246	251	PF00397	0.464
DOC_WW_Pin1_4	46	51	PF00397	0.391
DOC_WW_Pin1_4	527	532	PF00397	0.503
DOC_WW_Pin1_4	556	561	PF00397	0.544
DOC_WW_Pin1_4	582	587	PF00397	0.766
LIG_14-3-3_CanoR_1	147	155	PF00244	0.348
LIG_14-3-3_CanoR_1	158	167	PF00244	0.363
LIG_14-3-3_CanoR_1	218	224	PF00244	0.409
LIG_14-3-3_CanoR_1	25	30	PF00244	0.495
LIG_14-3-3_CanoR_1	393	402	PF00244	0.464
LIG_14-3-3_CanoR_1	403	410	PF00244	0.495
LIG_14-3-3_CanoR_1	414	419	PF00244	0.570
LIG_14-3-3_CanoR_1	492	501	PF00244	0.574
LIG_14-3-3_CanoR_1	538	548	PF00244	0.463
LIG_14-3-3_CanoR_1	595	601	PF00244	0.630
LIG_Actin_WH2_2	177	194	PF00022	0.442
LIG_Actin_WH2_2	300	318	PF00022	0.420
LIG_BRCT_BRCA1_1	138	142	PF00533	0.344
LIG_BRCT_BRCA1_1	255	259	PF00533	0.339
LIG_Clathr_ClatBox_1	309	313	PF01394	0.405
LIG_FHA_1	218	224	PF00498	0.413
LIG_FHA_1	302	308	PF00498	0.476
LIG_FHA_1	506	512	PF00498	0.559
LIG_FHA_1	513	519	PF00498	0.534
LIG_FHA_1	595	601	PF00498	0.690
LIG_FHA_1	638	644	PF00498	0.500
LIG_FHA_1	665	671	PF00498	0.634
LIG_FHA_2	185	191	PF00498	0.475
LIG_FHA_2	360	366	PF00498	0.488
LIG_FHA_2	439	445	PF00498	0.485
LIG_FHA_2	458	464	PF00498	0.318
LIG_FHA_2	470	476	PF00498	0.521
LIG_FHA_2	528	534	PF00498	0.504
LIG_LIR_Apic_2	103	107	PF02991	0.315
LIG_LIR_Apic_2	486	491	PF02991	0.488
LIG_LIR_Apic_2	64	69	PF02991	0.421
LIG_LIR_Gen_1	139	150	PF02991	0.344
LIG_LIR_Gen_1	190	201	PF02991	0.311
LIG_LIR_Gen_1	249	259	PF02991	0.460
LIG_LIR_Gen_1	348	356	PF02991	0.396
LIG_LIR_Gen_1	540	548	PF02991	0.540
LIG_LIR_LC3C_4	519	523	PF02991	0.403
LIG_LIR_Nem_3	139	145	PF02991	0.323
LIG_LIR_Nem_3	190	196	PF02991	0.283
LIG_LIR_Nem_3	31	37	PF02991	0.450
LIG_LIR_Nem_3	348	353	PF02991	0.423
LIG_LIR_Nem_3	38	42	PF02991	0.371
LIG_LIR_Nem_3	540	544	PF02991	0.530
LIG_LIR_Nem_3	64	68	PF02991	0.425
LIG_LIR_Nem_3	88	93	PF02991	0.378
LIG_PCNA_yPIPBox_3	296	307	PF02747	0.458
LIG_PTB_Apo_2	60	67	PF02174	0.398
LIG_PTB_Phospho_1	60	66	PF10480	0.428
LIG_SH2_CRK	396	400	PF00017	0.373
LIG_SH2_CRK	651	655	PF00017	0.594
LIG_SH2_CRK	90	94	PF00017	0.378
LIG_SH2_NCK_1	396	400	PF00017	0.394
LIG_SH2_PTP2	193	196	PF00017	0.402
LIG_SH2_PTP2	66	69	PF00017	0.462
LIG_SH2_SRC	344	347	PF00017	0.342
LIG_SH2_SRC	66	69	PF00017	0.403
LIG_SH2_STAT5	193	196	PF00017	0.402
LIG_SH2_STAT5	238	241	PF00017	0.379
LIG_SH2_STAT5	344	347	PF00017	0.359
LIG_SH2_STAT5	396	399	PF00017	0.407
LIG_SH2_STAT5	487	490	PF00017	0.424
LIG_SH2_STAT5	66	69	PF00017	0.403
LIG_SH2_STAT5	84	87	PF00017	0.378
LIG_SH3_3	208	214	PF00018	0.378
LIG_SH3_3	335	341	PF00018	0.433
LIG_SH3_3	525	531	PF00018	0.461
LIG_SUMO_SIM_anti_2	166	171	PF11976	0.322
LIG_SUMO_SIM_anti_2	519	525	PF11976	0.378
LIG_SUMO_SIM_anti_2	639	647	PF11976	0.560
LIG_SUMO_SIM_par_1	304	311	PF11976	0.346
LIG_TRAF2_1	421	424	PF00917	0.624
LIG_TRAF2_1	530	533	PF00917	0.442
LIG_TYR_ITIM	191	196	PF00017	0.407
LIG_UBA3_1	167	172	PF00899	0.405
LIG_UBA3_1	197	205	PF00899	0.392
LIG_WRC_WIRS_1	142	147	PF05994	0.378
MOD_CDK_SPxxK_3	527	534	PF00069	0.499
MOD_CK1_1	359	365	PF00069	0.497
MOD_CK1_1	366	372	PF00069	0.464
MOD_CK1_1	405	411	PF00069	0.493
MOD_CK1_1	540	546	PF00069	0.489
MOD_CK1_1	554	560	PF00069	0.613
MOD_CK1_1	582	588	PF00069	0.694
MOD_CK1_1	598	604	PF00069	0.622
MOD_CK2_1	359	365	PF00069	0.558
MOD_CK2_1	4	10	PF00069	0.611
MOD_CK2_1	418	424	PF00069	0.658
MOD_CK2_1	433	439	PF00069	0.288
MOD_CK2_1	457	463	PF00069	0.327
MOD_CK2_1	527	533	PF00069	0.497
MOD_CK2_1	638	644	PF00069	0.578
MOD_CK2_1	71	77	PF00069	0.388
MOD_GlcNHglycan	148	151	PF01048	0.315
MOD_GlcNHglycan	228	231	PF01048	0.423
MOD_GlcNHglycan	368	371	PF01048	0.520
MOD_GlcNHglycan	483	486	PF01048	0.511
MOD_GlcNHglycan	580	584	PF01048	0.658
MOD_GlcNHglycan	600	603	PF01048	0.554
MOD_GSK3_1	141	148	PF00069	0.329
MOD_GSK3_1	25	32	PF00069	0.499
MOD_GSK3_1	359	366	PF00069	0.434
MOD_GSK3_1	394	401	PF00069	0.419
MOD_GSK3_1	4	11	PF00069	0.614
MOD_GSK3_1	414	421	PF00069	0.420
MOD_GSK3_1	501	508	PF00069	0.543
MOD_GSK3_1	512	519	PF00069	0.505
MOD_GSK3_1	533	540	PF00069	0.514
MOD_GSK3_1	548	555	PF00069	0.464
MOD_GSK3_1	582	589	PF00069	0.677
MOD_GSK3_1	594	601	PF00069	0.595
MOD_GSK3_1	664	671	PF00069	0.633
MOD_N-GLC_1	110	115	PF02516	0.395
MOD_N-GLC_1	176	181	PF02516	0.393
MOD_N-GLC_1	359	364	PF02516	0.472
MOD_N-GLC_1	505	510	PF02516	0.520
MOD_N-GLC_1	586	591	PF02516	0.569
MOD_NEK2_1	141	146	PF00069	0.378
MOD_NEK2_1	289	294	PF00069	0.465
MOD_NEK2_1	322	327	PF00069	0.409
MOD_NEK2_1	356	361	PF00069	0.458
MOD_NEK2_1	363	368	PF00069	0.460
MOD_NEK2_1	395	400	PF00069	0.460
MOD_NEK2_1	443	448	PF00069	0.408
MOD_NEK2_1	512	517	PF00069	0.524
MOD_NEK2_1	537	542	PF00069	0.515
MOD_NEK2_1	596	601	PF00069	0.675
MOD_NEK2_1	61	66	PF00069	0.397
MOD_NEK2_1	76	81	PF00069	0.344
MOD_NEK2_1	89	94	PF00069	0.405
MOD_PIKK_1	419	425	PF00454	0.589
MOD_PIKK_1	467	473	PF00454	0.496
MOD_PIKK_1	559	565	PF00454	0.645
MOD_PIKK_1	568	574	PF00454	0.632
MOD_PIKK_1	613	619	PF00454	0.523
MOD_PK_1	25	31	PF00069	0.487
MOD_PK_1	414	420	PF00069	0.565
MOD_PK_1	8	14	PF00069	0.663
MOD_PKA_1	158	164	PF00069	0.315
MOD_PKA_2	146	152	PF00069	0.303
MOD_PKA_2	217	223	PF00069	0.436
MOD_PKA_2	240	246	PF00069	0.384
MOD_PKA_2	29	35	PF00069	0.411
MOD_PKA_2	301	307	PF00069	0.429
MOD_PKA_2	402	408	PF00069	0.551
MOD_PKA_2	491	497	PF00069	0.576
MOD_PKA_2	537	543	PF00069	0.434
MOD_PKA_2	594	600	PF00069	0.642
MOD_Plk_1	269	275	PF00069	0.468
MOD_Plk_1	359	365	PF00069	0.576
MOD_Plk_1	405	411	PF00069	0.567
MOD_Plk_1	443	449	PF00069	0.438
MOD_Plk_1	551	557	PF00069	0.632
MOD_Plk_1	586	592	PF00069	0.556
MOD_Plk_1	76	82	PF00069	0.344
MOD_Plk_2-3	308	314	PF00069	0.343
MOD_Plk_2-3	433	439	PF00069	0.412
MOD_Plk_4	141	147	PF00069	0.378
MOD_Plk_4	163	169	PF00069	0.378
MOD_Plk_4	248	254	PF00069	0.477
MOD_Plk_4	29	35	PF00069	0.574
MOD_Plk_4	405	411	PF00069	0.526
MOD_Plk_4	483	489	PF00069	0.448
MOD_Plk_4	507	513	PF00069	0.542
MOD_Plk_4	517	523	PF00069	0.372
MOD_Plk_4	61	67	PF00069	0.394
MOD_ProDKin_1	246	252	PF00069	0.459
MOD_ProDKin_1	46	52	PF00069	0.387
MOD_ProDKin_1	527	533	PF00069	0.497
MOD_ProDKin_1	556	562	PF00069	0.545
MOD_ProDKin_1	582	588	PF00069	0.767
MOD_SUMO_for_1	425	428	PF00179	0.476
MOD_SUMO_rev_2	16	26	PF00179	0.640
TRG_DiLeu_BaEn_3	15	21	PF01217	0.554
TRG_DiLeu_BaEn_4	665	671	PF01217	0.634
TRG_ENDOCYTIC_2	193	196	PF00928	0.350
TRG_ENDOCYTIC_2	34	37	PF00928	0.421
TRG_ENDOCYTIC_2	396	399	PF00928	0.344
TRG_ENDOCYTIC_2	651	654	PF00928	0.711
TRG_ENDOCYTIC_2	84	87	PF00928	0.378
TRG_ENDOCYTIC_2	90	93	PF00928	0.378
TRG_ER_diArg_1	609	612	PF00400	0.585
TRG_ER_diArg_1	618	621	PF00400	0.590
TRG_NLS_MonoExtC_3	607	613	PF00514	0.684
TRG_NLS_MonoExtN_4	605	612	PF00514	0.668
TRG_Pf-PMV_PEXEL_1	56	60	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	91	95	PF00026	0.378

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD02	Leptomonas seymouri	68%	100%
A0A0S4J714	Bodo saltans	34%	95%
A0A3Q8IGB9	Leishmania donovani	96%	100%
A0A3R7LQB8	Trypanosoma rangeli	34%	89%
A0A3S7WPC5	Leishmania donovani	34%	100%
A4H4I2	Leishmania braziliensis	35%	100%
A4HKP4	Leishmania braziliensis	88%	100%
A4HSQ7	Leishmania infantum	34%	100%
A4I875	Leishmania infantum	96%	100%
C9ZTA3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AKP4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9B333	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q09374	Caenorhabditis elegans	27%	100%
Q4QJ63	Leishmania major	34%	100%
Q6INN8	Xenopus laevis	31%	100%