Putative GPI transamidase component Tta1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GPI transamidase component Tta1, putative

Species:

Leishmania major

UniProt:

Q4Q519_LEIMA

TriTrypDb:

LmjF.32.2560 , LMJLV39_320032900 , LMJSD75_320033200

Length:

418

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0008303	caspase complex	5	2
GO:0032991	protein-containing complex	1	2
GO:0042765	GPI-anchor transamidase complex	3	2
GO:0098796	membrane protein complex	2	2
GO:0140534	endoplasmic reticulum protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1905368	peptidase complex	3	2
GO:1905369	endopeptidase complex	4	2
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4Q519

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q519

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0003923	GPI-anchor transamidase activity	6	2
GO:0004175	endopeptidase activity	4	2
GO:0004197	cysteine-type endopeptidase activity	5	2
GO:0008233	peptidase activity	3	2
GO:0008234	cysteine-type peptidase activity	4	2
GO:0016787	hydrolase activity	2	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	233	237	PF00656	0.485
CLV_C14_Caspase3-7	410	414	PF00656	0.610
CLV_NRD_NRD_1	21	23	PF00675	0.440
CLV_NRD_NRD_1	6	8	PF00675	0.460
CLV_PCSK_KEX2_1	161	163	PF00082	0.596
CLV_PCSK_KEX2_1	21	23	PF00082	0.424
CLV_PCSK_KEX2_1	295	297	PF00082	0.562
CLV_PCSK_KEX2_1	6	8	PF00082	0.497
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.596
CLV_PCSK_PC1ET2_1	295	297	PF00082	0.580
CLV_PCSK_SKI1_1	182	186	PF00082	0.654
CLV_PCSK_SKI1_1	270	274	PF00082	0.566
DEG_APCC_DBOX_1	269	277	PF00400	0.383
DEG_SCF_FBW7_1	70	77	PF00400	0.471
DOC_CKS1_1	360	365	PF01111	0.343
DOC_CYCLIN_yCln2_LP_2	365	371	PF00134	0.446
DOC_MAPK_gen_1	347	357	PF00069	0.379
DOC_MAPK_MEF2A_6	49	56	PF00069	0.370
DOC_PP2B_LxvP_1	176	179	PF13499	0.439
DOC_PP2B_LxvP_1	365	368	PF13499	0.366
DOC_PP2B_LxvP_1	379	382	PF13499	0.391
DOC_PP4_FxxP_1	201	204	PF00568	0.325
DOC_SPAK_OSR1_1	392	396	PF12202	0.529
DOC_USP7_MATH_1	14	18	PF00917	0.749
DOC_USP7_MATH_1	235	239	PF00917	0.507
DOC_USP7_MATH_1	382	386	PF00917	0.425
DOC_USP7_MATH_1	75	79	PF00917	0.469
DOC_WW_Pin1_4	1	6	PF00397	0.756
DOC_WW_Pin1_4	251	256	PF00397	0.485
DOC_WW_Pin1_4	359	364	PF00397	0.498
DOC_WW_Pin1_4	70	75	PF00397	0.475
DOC_WW_Pin1_4	91	96	PF00397	0.420
LIG_14-3-3_CanoR_1	162	168	PF00244	0.338
LIG_14-3-3_CanoR_1	21	29	PF00244	0.565
LIG_14-3-3_CanoR_1	245	255	PF00244	0.466
LIG_14-3-3_CanoR_1	261	266	PF00244	0.480
LIG_Actin_WH2_2	300	317	PF00022	0.374
LIG_Actin_WH2_2	333	349	PF00022	0.392
LIG_Actin_WH2_2	56	73	PF00022	0.290
LIG_BRCT_BRCA1_1	153	157	PF00533	0.429
LIG_BRCT_BRCA1_1	341	345	PF00533	0.401
LIG_FHA_1	125	131	PF00498	0.444
LIG_FHA_1	309	315	PF00498	0.450
LIG_FHA_1	360	366	PF00498	0.481
LIG_FHA_1	71	77	PF00498	0.500
LIG_FHA_2	67	73	PF00498	0.338
LIG_GBD_Chelix_1	373	381	PF00786	0.366
LIG_LIR_Apic_2	199	204	PF02991	0.320
LIG_LIR_Gen_1	132	140	PF02991	0.424
LIG_LIR_Gen_1	25	36	PF02991	0.547
LIG_LIR_Gen_1	330	340	PF02991	0.458
LIG_LIR_Nem_3	132	136	PF02991	0.415
LIG_LIR_Nem_3	25	31	PF02991	0.551
LIG_LIR_Nem_3	32	37	PF02991	0.437
LIG_LIR_Nem_3	330	336	PF02991	0.468
LIG_LIR_Nem_3	354	360	PF02991	0.379
LIG_MYND_1	359	363	PF01753	0.421
LIG_MYND_1	95	99	PF01753	0.404
LIG_SH2_CRK	227	231	PF00017	0.306
LIG_SH2_STAT5	227	230	PF00017	0.289
LIG_SH2_STAT5	366	369	PF00017	0.353
LIG_SH3_2	2	7	PF14604	0.632
LIG_SH3_3	2	8	PF00018	0.770
LIG_SH3_3	49	55	PF00018	0.442
LIG_SH3_3	89	95	PF00018	0.368
LIG_SUMO_SIM_anti_2	375	381	PF11976	0.408
LIG_SUMO_SIM_par_1	93	100	PF11976	0.257
LIG_TRAF2_1	231	234	PF00917	0.422
LIG_WRC_WIRS_1	130	135	PF05994	0.399
LIG_WRC_WIRS_1	283	288	PF05994	0.324
MOD_CDC14_SPxK_1	4	7	PF00782	0.672
MOD_CDK_SPK_2	1	6	PF00069	0.615
MOD_CDK_SPxK_1	1	7	PF00069	0.750
MOD_CK1_1	16	22	PF00069	0.646
MOD_CK1_1	199	205	PF00069	0.376
MOD_CK1_1	24	30	PF00069	0.501
MOD_CK1_1	243	249	PF00069	0.488
MOD_CK1_1	309	315	PF00069	0.384
MOD_CK1_1	372	378	PF00069	0.408
MOD_CK1_1	66	72	PF00069	0.380
MOD_GlcNHglycan	151	156	PF01048	0.740
MOD_GlcNHglycan	158	161	PF01048	0.708
MOD_GlcNHglycan	205	208	PF01048	0.525
MOD_GlcNHglycan	242	245	PF01048	0.676
MOD_GlcNHglycan	248	251	PF01048	0.711
MOD_GlcNHglycan	31	34	PF01048	0.351
MOD_GlcNHglycan	341	344	PF01048	0.563
MOD_GlcNHglycan	77	80	PF01048	0.703
MOD_GSK3_1	147	154	PF00069	0.453
MOD_GSK3_1	199	206	PF00069	0.353
MOD_GSK3_1	235	242	PF00069	0.479
MOD_GSK3_1	306	313	PF00069	0.402
MOD_GSK3_1	66	73	PF00069	0.436
MOD_N-GLC_1	22	27	PF02516	0.438
MOD_NEK2_1	196	201	PF00069	0.357
MOD_NEK2_1	63	68	PF00069	0.434
MOD_NEK2_2	282	287	PF00069	0.346
MOD_PIKK_1	135	141	PF00454	0.387
MOD_PIKK_1	372	378	PF00454	0.408
MOD_PKA_1	21	27	PF00069	0.629
MOD_PKA_2	21	27	PF00069	0.584
MOD_PKA_2	244	250	PF00069	0.528
MOD_PKB_1	259	267	PF00069	0.430
MOD_Plk_1	369	375	PF00069	0.334
MOD_Plk_4	129	135	PF00069	0.406
MOD_Plk_4	196	202	PF00069	0.337
MOD_Plk_4	24	30	PF00069	0.506
MOD_Plk_4	272	278	PF00069	0.283
MOD_Plk_4	341	347	PF00069	0.377
MOD_Plk_4	369	375	PF00069	0.279
MOD_Plk_4	384	390	PF00069	0.230
MOD_ProDKin_1	1	7	PF00069	0.756
MOD_ProDKin_1	251	257	PF00069	0.479
MOD_ProDKin_1	359	365	PF00069	0.489
MOD_ProDKin_1	70	76	PF00069	0.477
MOD_ProDKin_1	91	97	PF00069	0.417
TRG_DiLeu_BaLyEn_6	356	361	PF01217	0.342
TRG_ENDOCYTIC_2	227	230	PF00928	0.285
TRG_ER_diArg_1	20	22	PF00400	0.608
TRG_ER_diArg_1	258	261	PF00400	0.462
TRG_ER_diArg_1	5	7	PF00400	0.760
TRG_ER_diLys_1	415	418	PF00400	0.658
TRG_Pf-PMV_PEXEL_1	392	396	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	58	62	PF00026	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I345	Leptomonas seymouri	58%	97%
A0A1X0NT15	Trypanosomatidae	28%	100%
A0A3S5IR84	Trypanosoma rangeli	31%	100%
A0A3S7X5V4	Leishmania donovani	90%	100%
A4HKP6	Leishmania braziliensis	77%	95%
A4I877	Leishmania infantum	90%	100%
D0AAE7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9B335	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5AUS2	Trypanosoma cruzi	31%	96%