Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q518_LEIMA

TriTrypDb:

LmjF.32.2570 , LMJLV39_320033000 , LMJSD75_320033300

Length:

718

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q518

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q518

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	581	585	PF00656	0.564
CLV_NRD_NRD_1	144	146	PF00675	0.633
CLV_NRD_NRD_1	151	153	PF00675	0.558
CLV_NRD_NRD_1	304	306	PF00675	0.471
CLV_NRD_NRD_1	335	337	PF00675	0.619
CLV_NRD_NRD_1	371	373	PF00675	0.557
CLV_NRD_NRD_1	399	401	PF00675	0.556
CLV_NRD_NRD_1	433	435	PF00675	0.663
CLV_NRD_NRD_1	449	451	PF00675	0.488
CLV_NRD_NRD_1	505	507	PF00675	0.665
CLV_NRD_NRD_1	508	510	PF00675	0.603
CLV_NRD_NRD_1	566	568	PF00675	0.565
CLV_NRD_NRD_1	617	619	PF00675	0.526
CLV_NRD_NRD_1	81	83	PF00675	0.706
CLV_NRD_NRD_1	88	90	PF00675	0.583
CLV_PCSK_FUR_1	447	451	PF00082	0.517
CLV_PCSK_FUR_1	506	510	PF00082	0.543
CLV_PCSK_KEX2_1	144	146	PF00082	0.607
CLV_PCSK_KEX2_1	150	152	PF00082	0.543
CLV_PCSK_KEX2_1	335	337	PF00082	0.619
CLV_PCSK_KEX2_1	371	373	PF00082	0.557
CLV_PCSK_KEX2_1	398	400	PF00082	0.561
CLV_PCSK_KEX2_1	433	435	PF00082	0.663
CLV_PCSK_KEX2_1	449	451	PF00082	0.488
CLV_PCSK_KEX2_1	505	507	PF00082	0.553
CLV_PCSK_KEX2_1	508	510	PF00082	0.569
CLV_PCSK_KEX2_1	522	524	PF00082	0.601
CLV_PCSK_KEX2_1	566	568	PF00082	0.710
CLV_PCSK_KEX2_1	617	619	PF00082	0.526
CLV_PCSK_KEX2_1	83	85	PF00082	0.663
CLV_PCSK_KEX2_1	88	90	PF00082	0.617
CLV_PCSK_PC1ET2_1	522	524	PF00082	0.652
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.581
CLV_PCSK_PC7_1	331	337	PF00082	0.587
CLV_PCSK_PC7_1	84	90	PF00082	0.677
CLV_PCSK_SKI1_1	40	44	PF00082	0.611
CLV_PCSK_SKI1_1	679	683	PF00082	0.611
CLV_Separin_Metazoa	172	176	PF03568	0.597
CLV_Separin_Metazoa	302	306	PF03568	0.543
DEG_APCC_DBOX_1	522	530	PF00400	0.648
DEG_Nend_UBRbox_1	1	4	PF02207	0.577
DEG_SPOP_SBC_1	114	118	PF00917	0.647
DEG_SPOP_SBC_1	546	550	PF00917	0.531
DOC_CKS1_1	121	126	PF01111	0.712
DOC_CKS1_1	221	226	PF01111	0.657
DOC_CKS1_1	250	255	PF01111	0.719
DOC_MAPK_gen_1	522	528	PF00069	0.697
DOC_MAPK_gen_1	566	576	PF00069	0.681
DOC_PP4_FxxP_1	475	478	PF00568	0.623
DOC_USP7_MATH_1	114	118	PF00917	0.647
DOC_USP7_MATH_1	124	128	PF00917	0.613
DOC_USP7_MATH_1	157	161	PF00917	0.529
DOC_USP7_MATH_1	205	209	PF00917	0.574
DOC_USP7_MATH_1	258	262	PF00917	0.735
DOC_USP7_MATH_1	606	610	PF00917	0.576
DOC_USP7_MATH_1	667	671	PF00917	0.660
DOC_USP7_MATH_1	694	698	PF00917	0.525
DOC_USP7_MATH_1	8	12	PF00917	0.627
DOC_WW_Pin1_4	120	125	PF00397	0.716
DOC_WW_Pin1_4	201	206	PF00397	0.664
DOC_WW_Pin1_4	220	225	PF00397	0.692
DOC_WW_Pin1_4	249	254	PF00397	0.713
DOC_WW_Pin1_4	3	8	PF00397	0.699
DOC_WW_Pin1_4	315	320	PF00397	0.720
DOC_WW_Pin1_4	365	370	PF00397	0.664
DOC_WW_Pin1_4	556	561	PF00397	0.750
DOC_WW_Pin1_4	565	570	PF00397	0.651
DOC_WW_Pin1_4	608	613	PF00397	0.689
DOC_WW_Pin1_4	633	638	PF00397	0.777
DOC_WW_Pin1_4	653	658	PF00397	0.467
LIG_14-3-3_CanoR_1	129	134	PF00244	0.604
LIG_14-3-3_CanoR_1	158	162	PF00244	0.633
LIG_14-3-3_CanoR_1	167	173	PF00244	0.569
LIG_14-3-3_CanoR_1	315	319	PF00244	0.615
LIG_14-3-3_CanoR_1	335	344	PF00244	0.677
LIG_14-3-3_CanoR_1	371	379	PF00244	0.554
LIG_14-3-3_CanoR_1	433	441	PF00244	0.524
LIG_14-3-3_CanoR_1	508	518	PF00244	0.612
LIG_14-3-3_CanoR_1	542	546	PF00244	0.791
LIG_14-3-3_CanoR_1	9	13	PF00244	0.633
LIG_14-3-3_CanoR_1	91	100	PF00244	0.762
LIG_APCC_ABBA_1	416	421	PF00400	0.590
LIG_APCC_ABBAyCdc20_2	306	312	PF00400	0.492
LIG_BIR_III_2	584	588	PF00653	0.643
LIG_BIR_III_4	659	663	PF00653	0.607
LIG_BRCT_BRCA1_1	191	195	PF00533	0.657
LIG_CSL_BTD_1	574	577	PF09270	0.624
LIG_EVH1_2	280	284	PF00568	0.615
LIG_FHA_1	221	227	PF00498	0.694
LIG_FHA_1	371	377	PF00498	0.558
LIG_FHA_1	490	496	PF00498	0.563
LIG_FHA_1	546	552	PF00498	0.574
LIG_FHA_1	556	562	PF00498	0.613
LIG_FHA_1	684	690	PF00498	0.530
LIG_FHA_2	151	157	PF00498	0.529
LIG_FHA_2	174	180	PF00498	0.639
LIG_FHA_2	27	33	PF00498	0.580
LIG_FHA_2	327	333	PF00498	0.709
LIG_FHA_2	382	388	PF00498	0.638
LIG_FHA_2	443	449	PF00498	0.589
LIG_FHA_2	579	585	PF00498	0.650
LIG_FHA_2	707	713	PF00498	0.497
LIG_Integrin_isoDGR_2	200	202	PF01839	0.544
LIG_LIR_Apic_2	472	478	PF02991	0.604
LIG_LIR_Gen_1	384	391	PF02991	0.541
LIG_LIR_Gen_1	602	612	PF02991	0.665
LIG_LIR_Nem_3	192	198	PF02991	0.578
LIG_LIR_Nem_3	384	389	PF02991	0.540
LIG_LIR_Nem_3	413	419	PF02991	0.598
LIG_LIR_Nem_3	602	607	PF02991	0.664
LIG_MYND_1	72	76	PF01753	0.559
LIG_NRBOX	490	496	PF00104	0.563
LIG_Pex14_2	284	288	PF04695	0.607
LIG_SH2_GRB2like	198	201	PF00017	0.541
LIG_SH2_SRC	198	201	PF00017	0.541
LIG_SH2_STAT3	177	180	PF00017	0.566
LIG_SH2_STAT3	699	702	PF00017	0.488
LIG_SH2_STAT5	198	201	PF00017	0.650
LIG_SH2_STAT5	699	702	PF00017	0.522
LIG_SH3_2	612	617	PF14604	0.521
LIG_SH3_3	108	114	PF00018	0.573
LIG_SH3_3	218	224	PF00018	0.802
LIG_SH3_3	247	253	PF00018	0.628
LIG_SH3_3	275	281	PF00018	0.659
LIG_SH3_3	341	347	PF00018	0.646
LIG_SH3_3	557	563	PF00018	0.798
LIG_SH3_3	609	615	PF00018	0.665
LIG_SH3_3	631	637	PF00018	0.514
LIG_SH3_3	651	657	PF00018	0.475
LIG_SH3_3	7	13	PF00018	0.580
LIG_SxIP_EBH_1	158	171	PF03271	0.555
LIG_TRAF2_1	153	156	PF00917	0.496
LIG_TRAF2_1	76	79	PF00917	0.711
LIG_UBA3_1	490	497	PF00899	0.563
LIG_WW_3	172	176	PF00397	0.597
LIG_WW_3	368	372	PF00397	0.627
MOD_CDC14_SPxK_1	368	371	PF00782	0.626
MOD_CDC14_SPxK_1	6	9	PF00782	0.703
MOD_CDC14_SPxK_1	614	617	PF00782	0.518
MOD_CDK_SPK_2	220	225	PF00069	0.618
MOD_CDK_SPK_2	565	570	PF00069	0.704
MOD_CDK_SPK_2	653	658	PF00069	0.550
MOD_CDK_SPxK_1	120	126	PF00069	0.642
MOD_CDK_SPxK_1	3	9	PF00069	0.703
MOD_CDK_SPxK_1	365	371	PF00069	0.630
MOD_CDK_SPxK_1	611	617	PF00069	0.527
MOD_CDK_SPxxK_3	365	372	PF00069	0.557
MOD_CDK_SPxxK_3	559	566	PF00069	0.667
MOD_CDK_SPxxK_3	611	618	PF00069	0.527
MOD_CK1_1	125	131	PF00069	0.639
MOD_CK1_1	160	166	PF00069	0.664
MOD_CK1_1	168	174	PF00069	0.592
MOD_CK1_1	21	27	PF00069	0.607
MOD_CK1_1	240	246	PF00069	0.809
MOD_CK1_1	512	518	PF00069	0.606
MOD_CK1_1	578	584	PF00069	0.603
MOD_CK1_1	611	617	PF00069	0.587
MOD_CK1_1	643	649	PF00069	0.667
MOD_CK2_1	150	156	PF00069	0.529
MOD_CK2_1	173	179	PF00069	0.641
MOD_CK2_1	406	412	PF00069	0.526
MOD_CK2_1	442	448	PF00069	0.602
MOD_CK2_1	514	520	PF00069	0.634
MOD_CK2_1	633	639	PF00069	0.538
MOD_CK2_1	706	712	PF00069	0.497
MOD_Cter_Amidation	520	523	PF01082	0.646
MOD_DYRK1A_RPxSP_1	315	319	PF00069	0.560
MOD_DYRK1A_RPxSP_1	608	612	PF00069	0.642
MOD_GlcNHglycan	10	13	PF01048	0.616
MOD_GlcNHglycan	117	120	PF01048	0.760
MOD_GlcNHglycan	243	246	PF01048	0.630
MOD_GlcNHglycan	260	263	PF01048	0.628
MOD_GlcNHglycan	323	326	PF01048	0.681
MOD_GlcNHglycan	337	340	PF01048	0.763
MOD_GlcNHglycan	498	501	PF01048	0.595
MOD_GlcNHglycan	577	580	PF01048	0.647
MOD_GlcNHglycan	649	652	PF01048	0.594
MOD_GlcNHglycan	669	672	PF01048	0.590
MOD_GlcNHglycan	696	699	PF01048	0.489
MOD_GlcNHglycan	93	96	PF01048	0.839
MOD_GSK3_1	120	127	PF00069	0.699
MOD_GSK3_1	14	21	PF00069	0.640
MOD_GSK3_1	156	163	PF00069	0.636
MOD_GSK3_1	201	208	PF00069	0.670
MOD_GSK3_1	237	244	PF00069	0.645
MOD_GSK3_1	264	271	PF00069	0.652
MOD_GSK3_1	313	320	PF00069	0.633
MOD_GSK3_1	406	413	PF00069	0.548
MOD_GSK3_1	429	436	PF00069	0.546
MOD_GSK3_1	473	480	PF00069	0.629
MOD_GSK3_1	512	519	PF00069	0.700
MOD_GSK3_1	541	548	PF00069	0.539
MOD_GSK3_1	555	562	PF00069	0.707
MOD_GSK3_1	575	582	PF00069	0.573
MOD_GSK3_1	643	650	PF00069	0.542
MOD_GSK3_1	66	73	PF00069	0.675
MOD_GSK3_1	702	709	PF00069	0.479
MOD_N-GLC_1	40	45	PF02516	0.570
MOD_N-GLC_1	66	71	PF02516	0.614
MOD_NEK2_1	115	120	PF00069	0.676
MOD_NEK2_1	14	19	PF00069	0.656
MOD_NEK2_1	206	211	PF00069	0.559
MOD_NEK2_1	219	224	PF00069	0.674
MOD_NEK2_1	313	318	PF00069	0.707
MOD_NEK2_1	514	519	PF00069	0.553
MOD_NEK2_1	593	598	PF00069	0.616
MOD_NEK2_2	442	447	PF00069	0.617
MOD_NEK2_2	66	71	PF00069	0.638
MOD_PIKK_1	473	479	PF00454	0.629
MOD_PIKK_1	509	515	PF00454	0.712
MOD_PIKK_1	640	646	PF00454	0.626
MOD_PIKK_1	712	718	PF00454	0.483
MOD_PK_1	129	135	PF00069	0.521
MOD_PKA_1	150	156	PF00069	0.501
MOD_PKA_1	335	341	PF00069	0.618
MOD_PKA_1	433	439	PF00069	0.596
MOD_PKA_1	84	90	PF00069	0.685
MOD_PKA_2	106	112	PF00069	0.676
MOD_PKA_2	125	131	PF00069	0.569
MOD_PKA_2	150	156	PF00069	0.612
MOD_PKA_2	157	163	PF00069	0.646
MOD_PKA_2	288	294	PF00069	0.591
MOD_PKA_2	314	320	PF00069	0.558
MOD_PKA_2	334	340	PF00069	0.729
MOD_PKA_2	370	376	PF00069	0.554
MOD_PKA_2	433	439	PF00069	0.620
MOD_PKA_2	541	547	PF00069	0.631
MOD_PKA_2	8	14	PF00069	0.630
MOD_PKB_1	82	90	PF00069	0.653
MOD_Plk_1	14	20	PF00069	0.642
MOD_Plk_1	60	66	PF00069	0.548
MOD_Plk_4	227	233	PF00069	0.613
MOD_Plk_4	381	387	PF00069	0.566
MOD_ProDKin_1	120	126	PF00069	0.714
MOD_ProDKin_1	201	207	PF00069	0.663
MOD_ProDKin_1	220	226	PF00069	0.694
MOD_ProDKin_1	249	255	PF00069	0.712
MOD_ProDKin_1	3	9	PF00069	0.703
MOD_ProDKin_1	315	321	PF00069	0.723
MOD_ProDKin_1	365	371	PF00069	0.666
MOD_ProDKin_1	556	562	PF00069	0.749
MOD_ProDKin_1	565	571	PF00069	0.651
MOD_ProDKin_1	608	614	PF00069	0.686
MOD_ProDKin_1	633	639	PF00069	0.778
MOD_ProDKin_1	653	659	PF00069	0.463
TRG_ENDOCYTIC_2	604	607	PF00928	0.668
TRG_ER_diArg_1	143	145	PF00400	0.648
TRG_ER_diArg_1	149	152	PF00400	0.602
TRG_ER_diArg_1	370	372	PF00400	0.560
TRG_ER_diArg_1	398	400	PF00400	0.537
TRG_ER_diArg_1	423	426	PF00400	0.585
TRG_ER_diArg_1	433	435	PF00400	0.583
TRG_ER_diArg_1	449	452	PF00400	0.478
TRG_ER_diArg_1	505	508	PF00400	0.539
TRG_ER_diArg_1	565	567	PF00400	0.685
TRG_ER_diArg_1	88	91	PF00400	0.681
TRG_NLS_MonoCore_2	81	86	PF00514	0.578
TRG_NLS_MonoExtC_3	81	86	PF00514	0.578
TRG_NLS_MonoExtN_4	82	87	PF00514	0.579
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.630
TRG_Pf-PMV_PEXEL_1	425	429	PF00026	0.540
TRG_Pf-PMV_PEXEL_1	433	437	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	701	706	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGB2	Leptomonas seymouri	32%	76%
A0A3S7X5S6	Leishmania donovani	83%	99%
A4HKP7	Leishmania braziliensis	51%	93%
A4I878	Leishmania infantum	83%	76%
E9B336	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	99%