WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q517_LEIMA

TriTrypDb:

LmjF.32.2580 , LMJLV39_320033100 , LMJSD75_320033400

Length:

391

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q517

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q517

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	281	285	PF00656	0.561
CLV_C14_Caspase3-7	365	369	PF00656	0.808
CLV_PCSK_SKI1_1	318	322	PF00082	0.420
DEG_Nend_Nbox_1	1	3	PF02207	0.476
DOC_CKS1_1	89	94	PF01111	0.561
DOC_MAPK_gen_1	252	262	PF00069	0.479
DOC_MAPK_gen_1	303	313	PF00069	0.555
DOC_MAPK_HePTP_8	217	229	PF00069	0.489
DOC_MAPK_MEF2A_6	220	229	PF00069	0.493
DOC_MAPK_MEF2A_6	306	315	PF00069	0.461
DOC_PP1_RVXF_1	114	121	PF00149	0.469
DOC_PP1_RVXF_1	173	179	PF00149	0.363
DOC_USP7_MATH_1	129	133	PF00917	0.446
DOC_USP7_MATH_1	22	26	PF00917	0.450
DOC_USP7_MATH_1	93	97	PF00917	0.459
DOC_WW_Pin1_4	134	139	PF00397	0.384
DOC_WW_Pin1_4	18	23	PF00397	0.751
DOC_WW_Pin1_4	88	93	PF00397	0.497
LIG_14-3-3_CanoR_1	157	163	PF00244	0.420
LIG_14-3-3_CanoR_1	252	262	PF00244	0.323
LIG_BIR_III_2	284	288	PF00653	0.539
LIG_FHA_1	228	234	PF00498	0.426
LIG_FHA_1	24	30	PF00498	0.501
LIG_FHA_1	296	302	PF00498	0.468
LIG_FHA_1	59	65	PF00498	0.470
LIG_FHA_1	80	86	PF00498	0.427
LIG_FHA_2	319	325	PF00498	0.370
LIG_FHA_2	33	39	PF00498	0.479
LIG_LIR_Apic_2	237	243	PF02991	0.377
LIG_LIR_Gen_1	156	165	PF02991	0.512
LIG_LIR_Gen_1	264	272	PF02991	0.486
LIG_LIR_Nem_3	156	162	PF02991	0.533
LIG_LIR_Nem_3	256	261	PF02991	0.524
LIG_LIR_Nem_3	264	268	PF02991	0.465
LIG_PROFILIN_1	8	14	PF00235	0.464
LIG_PTAP_UEV_1	137	142	PF05743	0.523
LIG_SH2_PTP2	240	243	PF00017	0.443
LIG_SH2_SRC	37	40	PF00017	0.581
LIG_SH2_STAP1	67	71	PF00017	0.540
LIG_SH2_STAT3	67	70	PF00017	0.469
LIG_SH2_STAT3	99	102	PF00017	0.385
LIG_SH2_STAT5	240	243	PF00017	0.391
LIG_SH2_STAT5	261	264	PF00017	0.382
LIG_SH2_STAT5	42	45	PF00017	0.401
LIG_SH3_1	7	13	PF00018	0.465
LIG_SH3_3	135	141	PF00018	0.515
LIG_SH3_3	5	11	PF00018	0.467
LIG_SH3_3	86	92	PF00018	0.454
LIG_TRAF2_1	197	200	PF00917	0.551
MOD_CK1_1	58	64	PF00069	0.409
MOD_CK2_1	183	189	PF00069	0.352
MOD_CK2_1	194	200	PF00069	0.382
MOD_CK2_1	253	259	PF00069	0.343
MOD_CK2_1	318	324	PF00069	0.369
MOD_CK2_1	32	38	PF00069	0.446
MOD_GlcNHglycan	126	129	PF01048	0.515
MOD_GlcNHglycan	138	141	PF01048	0.471
MOD_GlcNHglycan	185	188	PF01048	0.339
MOD_GlcNHglycan	268	271	PF01048	0.508
MOD_GlcNHglycan	275	278	PF01048	0.504
MOD_GlcNHglycan	280	284	PF01048	0.566
MOD_GlcNHglycan	347	350	PF01048	0.680
MOD_GlcNHglycan	368	371	PF01048	0.784
MOD_GlcNHglycan	378	381	PF01048	0.778
MOD_GSK3_1	130	137	PF00069	0.377
MOD_GSK3_1	14	21	PF00069	0.557
MOD_GSK3_1	336	343	PF00069	0.550
MOD_GSK3_1	345	352	PF00069	0.593
MOD_GSK3_1	51	58	PF00069	0.383
MOD_GSK3_1	66	73	PF00069	0.314
MOD_GSK3_1	93	100	PF00069	0.413
MOD_N-GLC_1	49	54	PF02516	0.494
MOD_NEK2_1	124	129	PF00069	0.463
MOD_NEK2_1	153	158	PF00069	0.420
MOD_NEK2_1	227	232	PF00069	0.518
MOD_NEK2_1	358	363	PF00069	0.752
MOD_NEK2_1	55	60	PF00069	0.392
MOD_NEK2_1	66	71	PF00069	0.422
MOD_NEK2_1	97	102	PF00069	0.440
MOD_PIKK_1	295	301	PF00454	0.528
MOD_PIKK_1	58	64	PF00454	0.501
MOD_PIKK_1	66	72	PF00454	0.505
MOD_PKA_2	248	254	PF00069	0.571
MOD_PKA_2	376	382	PF00069	0.730
MOD_Plk_1	171	177	PF00069	0.361
MOD_Plk_4	38	44	PF00069	0.458
MOD_Plk_4	70	76	PF00069	0.487
MOD_Plk_4	93	99	PF00069	0.403
MOD_ProDKin_1	134	140	PF00069	0.382
MOD_ProDKin_1	18	24	PF00069	0.741
MOD_ProDKin_1	88	94	PF00069	0.496
MOD_SUMO_rev_2	174	184	PF00179	0.434
TRG_DiLeu_BaLyEn_6	138	143	PF01217	0.524
TRG_DiLeu_BaLyEn_6	315	320	PF01217	0.486
TRG_ER_diArg_1	175	178	PF00400	0.348
TRG_ER_diArg_1	387	390	PF00400	0.714
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.382
TRG_Pf-PMV_PEXEL_1	83	87	PF00026	0.334

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8A3	Leptomonas seymouri	77%	100%
A0A0S4J2R9	Bodo saltans	43%	100%
A0A1X0NRV1	Trypanosomatidae	43%	100%
A0A3Q8IDA1	Leishmania donovani	96%	88%
A0A3R7L0G4	Trypanosoma rangeli	54%	100%
A4HKP8	Leishmania braziliensis	86%	100%
A4I879	Leishmania infantum	95%	88%
D0AAE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9B337	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5BET5	Trypanosoma cruzi	51%	94%