Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q515_LEIMA

TriTrypDb:

LmjF.32.2600 , LMJLV39_320033300 , LMJSD75_320033600

Length:

640

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q515

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q515

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	532	536	PF00656	0.656
CLV_NRD_NRD_1	217	219	PF00675	0.523
CLV_NRD_NRD_1	346	348	PF00675	0.614
CLV_NRD_NRD_1	365	367	PF00675	0.465
CLV_NRD_NRD_1	440	442	PF00675	0.601
CLV_NRD_NRD_1	466	468	PF00675	0.509
CLV_NRD_NRD_1	613	615	PF00675	0.686
CLV_PCSK_KEX2_1	217	219	PF00082	0.389
CLV_PCSK_KEX2_1	346	348	PF00082	0.594
CLV_PCSK_KEX2_1	365	367	PF00082	0.461
CLV_PCSK_KEX2_1	440	442	PF00082	0.482
CLV_PCSK_KEX2_1	466	468	PF00082	0.509
CLV_PCSK_SKI1_1	163	167	PF00082	0.393
CLV_PCSK_SKI1_1	217	221	PF00082	0.402
CLV_PCSK_SKI1_1	365	369	PF00082	0.447
CLV_PCSK_SKI1_1	452	456	PF00082	0.433
CLV_PCSK_SKI1_1	458	462	PF00082	0.591
CLV_Separin_Metazoa	300	304	PF03568	0.407
DEG_APCC_DBOX_1	216	224	PF00400	0.399
DEG_SCF_FBW7_1	600	607	PF00400	0.574
DEG_SCF_TRCP1_1	632	637	PF00400	0.518
DEG_SPOP_SBC_1	326	330	PF00917	0.750
DEG_SPOP_SBC_1	335	339	PF00917	0.505
DEG_SPOP_SBC_1	514	518	PF00917	0.701
DEG_SPOP_SBC_1	590	594	PF00917	0.694
DEG_SPOP_SBC_1	604	608	PF00917	0.543
DOC_CYCLIN_RxL_1	343	352	PF00134	0.542
DOC_CYCLIN_RxL_1	362	371	PF00134	0.452
DOC_CYCLIN_RxL_1	452	465	PF00134	0.562
DOC_CYCLIN_yCln2_LP_2	166	172	PF00134	0.397
DOC_MAPK_gen_1	217	225	PF00069	0.438
DOC_MAPK_MEF2A_6	23	32	PF00069	0.457
DOC_MAPK_MEF2A_6	397	404	PF00069	0.389
DOC_PP2B_LxvP_1	28	31	PF13499	0.375
DOC_PP2B_LxvP_1	348	351	PF13499	0.631
DOC_PP2B_LxvP_1	407	410	PF13499	0.382
DOC_PP4_FxxP_1	42	45	PF00568	0.446
DOC_USP7_MATH_1	247	251	PF00917	0.570
DOC_USP7_MATH_1	254	258	PF00917	0.561
DOC_USP7_MATH_1	262	266	PF00917	0.558
DOC_USP7_MATH_1	280	284	PF00917	0.634
DOC_USP7_MATH_1	291	295	PF00917	0.576
DOC_USP7_MATH_1	320	324	PF00917	0.743
DOC_USP7_MATH_1	326	330	PF00917	0.713
DOC_USP7_MATH_1	333	337	PF00917	0.578
DOC_USP7_MATH_1	421	425	PF00917	0.454
DOC_USP7_MATH_1	431	435	PF00917	0.450
DOC_USP7_MATH_1	494	498	PF00917	0.804
DOC_USP7_MATH_1	510	514	PF00917	0.655
DOC_USP7_MATH_1	571	575	PF00917	0.609
DOC_USP7_MATH_1	590	594	PF00917	0.643
DOC_USP7_MATH_1	602	606	PF00917	0.688
DOC_USP7_MATH_1	62	66	PF00917	0.679
DOC_USP7_UBL2_3	615	619	PF12436	0.542
DOC_WW_Pin1_4	316	321	PF00397	0.650
DOC_WW_Pin1_4	349	354	PF00397	0.787
DOC_WW_Pin1_4	544	549	PF00397	0.637
DOC_WW_Pin1_4	564	569	PF00397	0.520
DOC_WW_Pin1_4	596	601	PF00397	0.620
DOC_WW_Pin1_4	608	613	PF00397	0.793
DOC_WW_Pin1_4	67	72	PF00397	0.595
LIG_14-3-3_CanoR_1	198	205	PF00244	0.428
LIG_14-3-3_CanoR_1	246	254	PF00244	0.702
LIG_14-3-3_CanoR_1	365	374	PF00244	0.430
LIG_14-3-3_CanoR_1	482	490	PF00244	0.666
LIG_14-3-3_CanoR_1	55	60	PF00244	0.557
LIG_14-3-3_CanoR_1	588	598	PF00244	0.683
LIG_Actin_WH2_2	100	115	PF00022	0.367
LIG_Actin_WH2_2	233	248	PF00022	0.509
LIG_Actin_WH2_2	294	311	PF00022	0.431
LIG_BRCT_BRCA1_1	293	297	PF00533	0.589
LIG_BRCT_BRCA1_1	38	42	PF00533	0.427
LIG_BRCT_BRCA1_1	488	492	PF00533	0.557
LIG_BRCT_BRCA1_1	535	539	PF00533	0.673
LIG_BRCT_BRCA1_1	559	563	PF00533	0.605
LIG_CaM_IQ_9	368	384	PF13499	0.453
LIG_deltaCOP1_diTrp_1	423	432	PF00928	0.437
LIG_DLG_GKlike_1	614	621	PF00625	0.637
LIG_EH1_1	138	146	PF00400	0.431
LIG_EH1_1	147	155	PF00400	0.281
LIG_eIF4E_1	139	145	PF01652	0.311
LIG_FHA_1	101	107	PF00498	0.397
LIG_FHA_1	150	156	PF00498	0.269
LIG_FHA_1	192	198	PF00498	0.443
LIG_FHA_1	227	233	PF00498	0.459
LIG_FHA_1	326	332	PF00498	0.640
LIG_FHA_1	340	346	PF00498	0.639
LIG_FHA_1	369	375	PF00498	0.583
LIG_FHA_1	485	491	PF00498	0.676
LIG_FHA_1	87	93	PF00498	0.345
LIG_FHA_2	291	297	PF00498	0.625
LIG_FHA_2	448	454	PF00498	0.566
LIG_FHA_2	532	538	PF00498	0.617
LIG_Integrin_RGD_1	354	356	PF01839	0.582
LIG_LIR_Apic_2	39	45	PF02991	0.441
LIG_LIR_Gen_1	136	145	PF02991	0.281
LIG_LIR_Gen_1	36	46	PF02991	0.303
LIG_LIR_LC3C_4	152	156	PF02991	0.265
LIG_LIR_LC3C_4	89	93	PF02991	0.403
LIG_LIR_Nem_3	136	142	PF02991	0.352
LIG_LIR_Nem_3	167	173	PF02991	0.401
LIG_LIR_Nem_3	36	41	PF02991	0.448
LIG_LIR_Nem_3	396	401	PF02991	0.466
LIG_LYPXL_yS_3	170	173	PF13949	0.397
LIG_NRBOX	215	221	PF00104	0.431
LIG_Pex14_2	559	563	PF04695	0.567
LIG_Rb_pABgroove_1	383	391	PF01858	0.460
LIG_SH2_CRK	139	143	PF00017	0.442
LIG_SH2_CRK	38	42	PF00017	0.427
LIG_SH2_STAP1	21	25	PF00017	0.503
LIG_SH2_STAP1	38	42	PF00017	0.250
LIG_SH2_STAT5	13	16	PF00017	0.387
LIG_SH2_STAT5	139	142	PF00017	0.318
LIG_SH2_STAT5	180	183	PF00017	0.351
LIG_SH3_3	565	571	PF00018	0.605
LIG_SH3_4	615	622	PF00018	0.531
LIG_SH3_CIN85_PxpxPR_1	349	354	PF14604	0.618
LIG_SUMO_SIM_anti_2	103	108	PF11976	0.450
LIG_SUMO_SIM_par_1	152	158	PF11976	0.357
LIG_TRAF2_1	133	136	PF00917	0.366
LIG_UBA3_1	219	226	PF00899	0.485
LIG_WW_3	547	551	PF00397	0.642
MOD_CDC14_SPxK_1	547	550	PF00782	0.640
MOD_CDK_SPK_2	349	354	PF00069	0.738
MOD_CDK_SPK_2	596	601	PF00069	0.569
MOD_CDK_SPxK_1	544	550	PF00069	0.648
MOD_CDK_SPxK_1	608	614	PF00069	0.759
MOD_CDK_SPxxK_3	608	615	PF00069	0.726
MOD_CK1_1	115	121	PF00069	0.361
MOD_CK1_1	273	279	PF00069	0.681
MOD_CK1_1	325	331	PF00069	0.672
MOD_CK1_1	336	342	PF00069	0.690
MOD_CK1_1	434	440	PF00069	0.570
MOD_CK1_1	446	452	PF00069	0.467
MOD_CK1_1	478	484	PF00069	0.632
MOD_CK1_1	485	491	PF00069	0.695
MOD_CK1_1	513	519	PF00069	0.753
MOD_CK1_1	527	533	PF00069	0.597
MOD_CK1_1	555	561	PF00069	0.641
MOD_CK1_1	591	597	PF00069	0.668
MOD_CK1_1	605	611	PF00069	0.658
MOD_CK1_1	65	71	PF00069	0.618
MOD_CK2_1	130	136	PF00069	0.412
MOD_CK2_1	155	161	PF00069	0.381
MOD_CK2_1	280	286	PF00069	0.577
MOD_CK2_1	447	453	PF00069	0.561
MOD_CK2_1	531	537	PF00069	0.629
MOD_CK2_1	614	620	PF00069	0.738
MOD_GlcNHglycan	233	236	PF01048	0.540
MOD_GlcNHglycan	256	259	PF01048	0.562
MOD_GlcNHglycan	282	285	PF01048	0.551
MOD_GlcNHglycan	322	325	PF01048	0.680
MOD_GlcNHglycan	338	341	PF01048	0.625
MOD_GlcNHglycan	521	524	PF01048	0.588
MOD_GlcNHglycan	573	576	PF01048	0.660
MOD_GlcNHglycan	632	635	PF01048	0.689
MOD_GlcNHglycan	64	67	PF01048	0.634
MOD_GlcNHglycan	77	81	PF01048	0.425
MOD_GSK3_1	248	255	PF00069	0.580
MOD_GSK3_1	280	287	PF00069	0.621
MOD_GSK3_1	316	323	PF00069	0.636
MOD_GSK3_1	334	341	PF00069	0.791
MOD_GSK3_1	443	450	PF00069	0.491
MOD_GSK3_1	474	481	PF00069	0.723
MOD_GSK3_1	482	489	PF00069	0.601
MOD_GSK3_1	510	517	PF00069	0.755
MOD_GSK3_1	524	531	PF00069	0.615
MOD_GSK3_1	555	562	PF00069	0.678
MOD_GSK3_1	578	585	PF00069	0.781
MOD_GSK3_1	588	595	PF00069	0.671
MOD_GSK3_1	596	603	PF00069	0.661
MOD_GSK3_1	604	611	PF00069	0.792
MOD_GSK3_1	630	637	PF00069	0.604
MOD_N-GLC_1	308	313	PF02516	0.532
MOD_N-GLC_2	261	263	PF02516	0.509
MOD_NEK2_1	112	117	PF00069	0.352
MOD_NEK2_1	191	196	PF00069	0.417
MOD_NEK2_1	231	236	PF00069	0.471
MOD_NEK2_1	308	313	PF00069	0.629
MOD_NEK2_1	368	373	PF00069	0.571
MOD_NEK2_1	402	407	PF00069	0.515
MOD_NEK2_1	475	480	PF00069	0.620
MOD_NEK2_1	515	520	PF00069	0.650
MOD_NEK2_1	559	564	PF00069	0.558
MOD_PIKK_1	284	290	PF00454	0.682
MOD_PIKK_1	368	374	PF00454	0.450
MOD_PIKK_1	606	612	PF00454	0.683
MOD_PK_1	376	382	PF00069	0.453
MOD_PK_1	55	61	PF00069	0.481
MOD_PKA_1	466	472	PF00069	0.550
MOD_PKA_1	614	620	PF00069	0.612
MOD_PKA_2	112	118	PF00069	0.350
MOD_PKA_2	443	449	PF00069	0.438
MOD_PKA_2	466	472	PF00069	0.564
MOD_PKA_2	481	487	PF00069	0.582
MOD_PKA_2	510	516	PF00069	0.696
MOD_PKA_2	519	525	PF00069	0.700
MOD_Plk_1	376	382	PF00069	0.453
MOD_Plk_4	100	106	PF00069	0.543
MOD_Plk_4	112	118	PF00069	0.241
MOD_Plk_4	137	143	PF00069	0.478
MOD_Plk_4	149	155	PF00069	0.274
MOD_Plk_4	510	516	PF00069	0.654
MOD_Plk_4	593	599	PF00069	0.635
MOD_ProDKin_1	316	322	PF00069	0.648
MOD_ProDKin_1	349	355	PF00069	0.780
MOD_ProDKin_1	544	550	PF00069	0.637
MOD_ProDKin_1	564	570	PF00069	0.521
MOD_ProDKin_1	596	602	PF00069	0.620
MOD_ProDKin_1	608	614	PF00069	0.759
MOD_ProDKin_1	67	73	PF00069	0.593
TRG_DiLeu_BaEn_1	100	105	PF01217	0.455
TRG_DiLeu_BaLyEn_6	215	220	PF01217	0.569
TRG_DiLeu_BaLyEn_6	28	33	PF01217	0.459
TRG_DiLeu_BaLyEn_6	363	368	PF01217	0.441
TRG_DiLeu_BaLyEn_6	397	402	PF01217	0.378
TRG_DiLeu_BaLyEn_6	42	47	PF01217	0.301
TRG_ENDOCYTIC_2	139	142	PF00928	0.439
TRG_ENDOCYTIC_2	170	173	PF00928	0.397
TRG_ENDOCYTIC_2	21	24	PF00928	0.508
TRG_ENDOCYTIC_2	38	41	PF00928	0.252
TRG_ER_diArg_1	216	218	PF00400	0.478
TRG_ER_diArg_1	228	231	PF00400	0.363
TRG_ER_diArg_1	345	347	PF00400	0.675
TRG_ER_diArg_1	365	367	PF00400	0.475
TRG_ER_diArg_1	440	442	PF00400	0.535
TRG_ER_diArg_1	466	468	PF00400	0.518
TRG_NES_CRM1_1	22	36	PF08389	0.405
TRG_Pf-PMV_PEXEL_1	382	387	PF00026	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1K7	Leptomonas seymouri	45%	93%
A0A3Q8IGY3	Leishmania donovani	90%	100%
A4HKQ0	Leishmania braziliensis	63%	90%
A4I881	Leishmania infantum	89%	100%
E9B339	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%