NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Complex1_LYR-like, putative

Species:

Leishmania major

UniProt:

Q4Q513_LEIMA

TriTrypDb:

LmjF.32.2620 , LMJLV39_320033500 , LMJSD75_320033800

Length:

302

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005747	mitochondrial respiratory chain complex I	4	2
GO:0030964	NADH dehydrogenase complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0045271	respiratory chain complex I	4	2
GO:0098796	membrane protein complex	2	2
GO:0098798	mitochondrial protein-containing complex	2	2
GO:0098800	inner mitochondrial membrane protein complex	3	2
GO:0098803	respiratory chain complex	3	2
GO:1902494	catalytic complex	2	2
GO:1902495	transmembrane transporter complex	3	2
GO:1990204	oxidoreductase complex	3	2
GO:1990351	transporter complex	2	2
GO:0005743	mitochondrial inner membrane	5	8
GO:0016020	membrane	2	8
GO:0019866	organelle inner membrane	4	8
GO:0031090	organelle membrane	3	8
GO:0031966	mitochondrial membrane	4	8
GO:0070469	respirasome	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4Q513

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q513

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	10
GO:0006120	mitochondrial electron transport, NADH to ubiquinone	7	10
GO:0008152	metabolic process	1	10
GO:0009060	aerobic respiration	6	10
GO:0009987	cellular process	1	10
GO:0015980	energy derivation by oxidation of organic compounds	4	10
GO:0019646	aerobic electron transport chain	6	10
GO:0022900	electron transport chain	4	10
GO:0022904	respiratory electron transport chain	5	10
GO:0044237	cellular metabolic process	2	10
GO:0045333	cellular respiration	5	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	282	286	PF00656	0.531
CLV_NRD_NRD_1	105	107	PF00675	0.362
CLV_NRD_NRD_1	140	142	PF00675	0.433
CLV_NRD_NRD_1	3	5	PF00675	0.441
CLV_PCSK_KEX2_1	104	106	PF00082	0.368
CLV_PCSK_KEX2_1	140	142	PF00082	0.433
CLV_PCSK_KEX2_1	3	5	PF00082	0.441
CLV_PCSK_SKI1_1	111	115	PF00082	0.360
DEG_APCC_DBOX_1	77	85	PF00400	0.531
DOC_CDC14_PxL_1	204	212	PF14671	0.648
DOC_CYCLIN_yCln2_LP_2	152	158	PF00134	0.616
DOC_MAPK_gen_1	3	9	PF00069	0.694
DOC_PP1_RVXF_1	209	216	PF00149	0.529
DOC_USP7_MATH_1	159	163	PF00917	0.643
DOC_USP7_UBL2_3	39	43	PF12436	0.639
DOC_WW_Pin1_4	142	147	PF00397	0.619
LIG_14-3-3_CanoR_1	111	116	PF00244	0.563
LIG_14-3-3_CanoR_1	124	130	PF00244	0.563
LIG_14-3-3_CanoR_1	140	146	PF00244	0.564
LIG_14-3-3_CanoR_1	183	191	PF00244	0.685
LIG_14-3-3_CanoR_1	264	270	PF00244	0.473
LIG_14-3-3_CanoR_1	289	295	PF00244	0.529
LIG_14-3-3_CanoR_1	3	8	PF00244	0.645
LIG_14-3-3_CanoR_1	66	73	PF00244	0.556
LIG_14-3-3_CanoR_1	78	82	PF00244	0.530
LIG_Actin_WH2_2	69	84	PF00022	0.637
LIG_BRCT_BRCA1_1	197	201	PF00533	0.655
LIG_deltaCOP1_diTrp_1	166	175	PF00928	0.593
LIG_deltaCOP1_diTrp_1	242	248	PF00928	0.431
LIG_FHA_1	147	153	PF00498	0.621
LIG_FHA_2	167	173	PF00498	0.592
LIG_Integrin_RGD_1	271	273	PF01839	0.725
LIG_Integrin_RGDW_4	271	274	PF00362	0.725
LIG_LIR_Apic_2	166	171	PF02991	0.592
LIG_LIR_Gen_1	273	280	PF02991	0.424
LIG_LIR_Nem_3	108	113	PF02991	0.549
LIG_LIR_Nem_3	144	150	PF02991	0.651
LIG_LIR_Nem_3	273	277	PF02991	0.421
LIG_LIR_Nem_3	30	35	PF02991	0.624
LIG_PDZ_Class_2	297	302	PF00595	0.536
LIG_Pex14_1	244	248	PF04695	0.416
LIG_Pex14_2	218	222	PF04695	0.387
LIG_PTB_Apo_2	151	158	PF02174	0.616
LIG_PTB_Apo_2	34	41	PF02174	0.625
LIG_PTB_Phospho_1	34	40	PF10480	0.623
LIG_SH2_CRK	110	114	PF00017	0.596
LIG_SH2_CRK	191	195	PF00017	0.732
LIG_SH2_CRK	227	231	PF00017	0.434
LIG_SH2_NCK_1	150	154	PF00017	0.652
LIG_SH2_SRC	176	179	PF00017	0.606
LIG_SH2_STAT5	112	115	PF00017	0.547
LIG_SH2_STAT5	129	132	PF00017	0.569
LIG_SH2_STAT5	150	153	PF00017	0.664
LIG_SH2_STAT5	47	50	PF00017	0.641
LIG_SH3_3	110	116	PF00018	0.561
LIG_UBA3_1	88	95	PF00899	0.663
MOD_CK1_1	145	151	PF00069	0.614
MOD_CK1_1	265	271	PF00069	0.494
MOD_CK2_1	166	172	PF00069	0.610
MOD_CK2_1	77	83	PF00069	0.608
MOD_GlcNHglycan	9	12	PF01048	0.443
MOD_GSK3_1	111	118	PF00069	0.615
MOD_GSK3_1	141	148	PF00069	0.620
MOD_GSK3_1	3	10	PF00069	0.673
MOD_N-GLC_1	141	146	PF02516	0.421
MOD_N-GLC_1	290	295	PF02516	0.727
MOD_NEK2_1	2	7	PF00069	0.654
MOD_NEK2_1	278	283	PF00069	0.519
MOD_NEK2_1	51	56	PF00069	0.665
MOD_NEK2_2	77	82	PF00069	0.610
MOD_PIKK_1	123	129	PF00454	0.554
MOD_PKA_1	3	9	PF00069	0.694
MOD_PKA_2	123	129	PF00069	0.557
MOD_PKA_2	182	188	PF00069	0.632
MOD_PKA_2	2	8	PF00069	0.661
MOD_PKA_2	260	266	PF00069	0.446
MOD_PKA_2	65	71	PF00069	0.571
MOD_PKA_2	77	83	PF00069	0.528
MOD_Plk_1	159	165	PF00069	0.687
MOD_Plk_1	290	296	PF00069	0.540
MOD_Plk_4	159	165	PF00069	0.687
MOD_Plk_4	265	271	PF00069	0.457
MOD_Plk_4	290	296	PF00069	0.513
MOD_Plk_4	3	9	PF00069	0.683
MOD_ProDKin_1	142	148	PF00069	0.615
MOD_SUMO_for_1	38	41	PF00179	0.662
MOD_SUMO_rev_2	172	181	PF00179	0.603
MOD_SUMO_rev_2	36	44	PF00179	0.639
TRG_DiLeu_BaLyEn_6	21	26	PF01217	0.651
TRG_ENDOCYTIC_2	110	113	PF00928	0.582
TRG_ENDOCYTIC_2	227	230	PF00928	0.403
TRG_ENDOCYTIC_2	49	52	PF00928	0.711
TRG_ER_diArg_1	103	106	PF00400	0.532
TRG_ER_diArg_1	139	141	PF00400	0.628
TRG_ER_diArg_1	2	4	PF00400	0.650

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8L7	Leptomonas seymouri	85%	100%
A0A0S4JPN7	Bodo saltans	65%	100%
A0A1X0NRJ8	Trypanosomatidae	74%	100%
A0A3Q8IFL7	Leishmania donovani	98%	100%
A4I883	Leishmania infantum	98%	100%
D0AAF3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	99%
E9B341	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5BA67	Trypanosoma cruzi	75%	100%