Cysteine desulfhydrase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cysteine desulfhydrase

Species:

Leishmania major

UniProt:

Q4Q511_LEIMA

TriTrypDb:

LmjF.32.2640 , LMJLV39_320033700 , LMJSD75_320034000

Length:

399

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q511

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q511

Function

Biological processes
Term	Name	Level	Count
GO:0000096	sulfur amino acid metabolic process	4	8
GO:0000098	sulfur amino acid catabolic process	5	2
GO:0006082	organic acid metabolic process	3	8
GO:0006090	pyruvate metabolic process	7	2
GO:0006520	amino acid metabolic process	3	8
GO:0006534	cysteine metabolic process	5	8
GO:0006790	sulfur compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009056	catabolic process	2	2
GO:0009058	biosynthetic process	2	2
GO:0009063	amino acid catabolic process	4	2
GO:0009069	serine family amino acid metabolic process	5	8
GO:0009071	serine family amino acid catabolic process	6	2
GO:0009092	homoserine metabolic process	6	8
GO:0009093	cysteine catabolic process	5	2
GO:0009987	cellular process	1	8
GO:0016054	organic acid catabolic process	4	2
GO:0019346	transsulfuration	6	8
GO:0019448	L-cysteine catabolic process	6	2
GO:0019450	L-cysteine catabolic process to pyruvate	7	2
GO:0019752	carboxylic acid metabolic process	5	8
GO:0032787	monocarboxylic acid metabolic process	6	2
GO:0043436	oxoacid metabolic process	4	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044248	cellular catabolic process	3	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044272	sulfur compound biosynthetic process	4	2
GO:0044273	sulfur compound catabolic process	4	2
GO:0044281	small molecule metabolic process	2	8
GO:0044282	small molecule catabolic process	3	2
GO:0046395	carboxylic acid catabolic process	5	2
GO:0046439	L-cysteine metabolic process	6	2
GO:0050667	homocysteine metabolic process	5	8
GO:0070813	hydrogen sulfide metabolic process	4	2
GO:0070814	hydrogen sulfide biosynthetic process	5	2
GO:0071704	organic substance metabolic process	2	8
GO:1901564	organonitrogen compound metabolic process	3	8
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2
GO:1901605	alpha-amino acid metabolic process	4	8
GO:1901606	alpha-amino acid catabolic process	5	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004121	cystathionine beta-lyase activity	4	8
GO:0004123	cystathionine gamma-lyase activity	4	5
GO:0005488	binding	1	8
GO:0016829	lyase activity	2	8
GO:0016846	carbon-sulfur lyase activity	3	8
GO:0019148	D-cysteine desulfhydrase activity	4	2
GO:0019842	vitamin binding	3	8
GO:0030170	pyridoxal phosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0044540	L-cystine L-cysteine-lyase (deaminating)	4	5
GO:0070279	vitamin B6 binding	3	8
GO:0080146	L-cysteine desulfhydrase activity	4	5
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.306
CLV_C14_Caspase3-7	43	47	PF00656	0.246
CLV_NRD_NRD_1	280	282	PF00675	0.323
CLV_NRD_NRD_1	302	304	PF00675	0.309
CLV_PCSK_KEX2_1	302	304	PF00082	0.306
CLV_PCSK_SKI1_1	125	129	PF00082	0.457
CLV_PCSK_SKI1_1	142	146	PF00082	0.224
CLV_PCSK_SKI1_1	282	286	PF00082	0.294
CLV_PCSK_SKI1_1	303	307	PF00082	0.306
CLV_PCSK_SKI1_1	357	361	PF00082	0.309
DOC_CKS1_1	189	194	PF01111	0.296
DOC_MAPK_gen_1	233	240	PF00069	0.373
DOC_MAPK_gen_1	255	264	PF00069	0.316
DOC_MAPK_gen_1	281	287	PF00069	0.266
DOC_MAPK_HePTP_8	252	264	PF00069	0.365
DOC_MAPK_MEF2A_6	255	264	PF00069	0.365
DOC_PP1_RVXF_1	49	56	PF00149	0.246
DOC_SPAK_OSR1_1	370	374	PF12202	0.331
DOC_USP7_MATH_1	2	6	PF00917	0.618
DOC_USP7_MATH_1	291	295	PF00917	0.331
DOC_USP7_UBL2_3	229	233	PF12436	0.309
DOC_USP7_UBL2_3	282	286	PF12436	0.288
DOC_WW_Pin1_4	155	160	PF00397	0.306
DOC_WW_Pin1_4	188	193	PF00397	0.306
LIG_14-3-3_CanoR_1	235	241	PF00244	0.320
LIG_14-3-3_CanoR_1	255	261	PF00244	0.252
LIG_14-3-3_CanoR_1	35	40	PF00244	0.467
LIG_14-3-3_CanoR_1	357	363	PF00244	0.365
LIG_Actin_WH2_2	250	267	PF00022	0.365
LIG_Actin_WH2_2	37	53	PF00022	0.246
LIG_BIR_III_4	196	200	PF00653	0.343
LIG_BRCT_BRCA1_1	160	164	PF00533	0.306
LIG_BRCT_BRCA1_1	308	312	PF00533	0.365
LIG_BRCT_BRCA1_1	335	339	PF00533	0.331
LIG_deltaCOP1_diTrp_1	186	195	PF00928	0.306
LIG_deltaCOP1_diTrp_1	228	237	PF00928	0.331
LIG_deltaCOP1_diTrp_1	23	28	PF00928	0.309
LIG_deltaCOP1_diTrp_1	299	305	PF00928	0.373
LIG_EH1_1	178	186	PF00400	0.373
LIG_FHA_1	112	118	PF00498	0.415
LIG_FHA_1	122	128	PF00498	0.438
LIG_FHA_1	149	155	PF00498	0.336
LIG_FHA_1	161	167	PF00498	0.382
LIG_FHA_1	180	186	PF00498	0.306
LIG_FHA_1	208	214	PF00498	0.319
LIG_FHA_1	257	263	PF00498	0.395
LIG_FHA_2	128	134	PF00498	0.369
LIG_FHA_2	135	141	PF00498	0.331
LIG_FHA_2	181	187	PF00498	0.322
LIG_LIR_Apic_2	128	134	PF02991	0.306
LIG_LIR_Apic_2	186	192	PF02991	0.306
LIG_LIR_Gen_1	259	267	PF02991	0.390
LIG_LIR_Gen_1	309	320	PF02991	0.306
LIG_LIR_Nem_3	228	234	PF02991	0.373
LIG_LIR_Nem_3	23	29	PF02991	0.320
LIG_LIR_Nem_3	248	254	PF02991	0.301
LIG_LIR_Nem_3	259	264	PF02991	0.353
LIG_LIR_Nem_3	309	315	PF02991	0.306
LIG_LIR_Nem_3	330	335	PF02991	0.328
LIG_LIR_Nem_3	340	344	PF02991	0.278
LIG_LIR_Nem_3	38	44	PF02991	0.289
LIG_LYPXL_yS_3	231	234	PF13949	0.365
LIG_NRBOX	140	146	PF00104	0.306
LIG_Pex14_1	301	305	PF04695	0.306
LIG_Pex14_2	335	339	PF04695	0.365
LIG_SH2_CRK	41	45	PF00017	0.390
LIG_SH2_CRK	92	96	PF00017	0.373
LIG_SH2_PTP2	261	264	PF00017	0.373
LIG_SH2_STAP1	92	96	PF00017	0.343
LIG_SH2_STAT3	320	323	PF00017	0.343
LIG_SH2_STAT5	111	114	PF00017	0.365
LIG_SH2_STAT5	212	215	PF00017	0.306
LIG_SH2_STAT5	251	254	PF00017	0.352
LIG_SH2_STAT5	261	264	PF00017	0.299
LIG_SH2_STAT6	331	335	PF00017	0.246
LIG_SH3_3	107	113	PF00018	0.373
LIG_SH3_3	284	290	PF00018	0.306
LIG_SH3_3	312	318	PF00018	0.306
LIG_Sin3_3	91	98	PF02671	0.373
LIG_TRAF2_1	5	8	PF00917	0.455
LIG_TYR_ITAM	248	264	PF00017	0.331
LIG_TYR_ITIM	39	44	PF00017	0.352
LIG_TYR_ITIM	90	95	PF00017	0.373
LIG_UBA3_1	220	229	PF00899	0.309
MOD_CK1_1	10	16	PF00069	0.319
MOD_CK1_1	158	164	PF00069	0.306
MOD_CK1_1	243	249	PF00069	0.275
MOD_CK2_1	134	140	PF00069	0.338
MOD_CK2_1	2	8	PF00069	0.576
MOD_CK2_1	222	228	PF00069	0.365
MOD_CK2_1	277	283	PF00069	0.365
MOD_GlcNHglycan	224	227	PF01048	0.350
MOD_GlcNHglycan	308	311	PF01048	0.365
MOD_GlcNHglycan	84	87	PF01048	0.306
MOD_GlcNHglycan	99	102	PF01048	0.306
MOD_GSK3_1	121	128	PF00069	0.490
MOD_GSK3_1	236	243	PF00069	0.312
MOD_GSK3_1	306	313	PF00069	0.306
MOD_GSK3_1	333	340	PF00069	0.467
MOD_GSK3_1	351	358	PF00069	0.231
MOD_GSK3_1	77	84	PF00069	0.306
MOD_LATS_1	146	152	PF00433	0.309
MOD_N-GLC_1	149	154	PF02516	0.365
MOD_N-GLC_1	179	184	PF02516	0.365
MOD_N-GLC_1	2	7	PF02516	0.451
MOD_N-GLC_2	116	118	PF02516	0.331
MOD_NEK2_1	121	126	PF00069	0.365
MOD_NEK2_1	179	184	PF00069	0.319
MOD_NEK2_1	240	245	PF00069	0.383
MOD_NEK2_1	277	282	PF00069	0.314
MOD_NEK2_1	305	310	PF00069	0.306
MOD_NEK2_1	351	356	PF00069	0.408
MOD_NEK2_1	40	45	PF00069	0.334
MOD_NEK2_1	94	99	PF00069	0.379
MOD_NEK2_2	256	261	PF00069	0.306
MOD_PIKK_1	158	164	PF00454	0.306
MOD_PK_1	333	339	PF00069	0.331
MOD_PK_1	49	55	PF00069	0.246
MOD_PKA_2	34	40	PF00069	0.345
MOD_Plk_1	149	155	PF00069	0.365
MOD_Plk_1	179	185	PF00069	0.333
MOD_Plk_1	2	8	PF00069	0.559
MOD_Plk_1	202	208	PF00069	0.306
MOD_Plk_2-3	7	13	PF00069	0.463
MOD_Plk_4	127	133	PF00069	0.346
MOD_Plk_4	149	155	PF00069	0.373
MOD_Plk_4	180	186	PF00069	0.344
MOD_Plk_4	236	242	PF00069	0.263
MOD_Plk_4	343	349	PF00069	0.286
MOD_Plk_4	35	41	PF00069	0.369
MOD_Plk_4	77	83	PF00069	0.327
MOD_ProDKin_1	155	161	PF00069	0.306
MOD_ProDKin_1	188	194	PF00069	0.306
MOD_SUMO_rev_2	7	15	PF00179	0.447
TRG_DiLeu_BaEn_1	140	145	PF01217	0.306
TRG_DiLeu_BaEn_2	23	29	PF01217	0.306
TRG_DiLeu_BaEn_2	272	278	PF01217	0.365
TRG_ENDOCYTIC_2	231	234	PF00928	0.365
TRG_ENDOCYTIC_2	251	254	PF00928	0.182
TRG_ENDOCYTIC_2	261	264	PF00928	0.322
TRG_ENDOCYTIC_2	332	335	PF00928	0.365
TRG_ENDOCYTIC_2	41	44	PF00928	0.422
TRG_ENDOCYTIC_2	92	95	PF00928	0.365
TRG_ER_diArg_1	301	303	PF00400	0.309
TRG_Pf-PMV_PEXEL_1	115	119	PF00026	0.373
TRG_Pf-PMV_PEXEL_1	142	147	PF00026	0.343

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0D2YG02	Fusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC 9935 / NRRL 34936)	24%	92%
A0A0J6G7P5	Pseudomonas deceptionensis	28%	100%
A0A0N0P3U0	Leptomonas seymouri	29%	78%
A0A0N0P8H0	Leptomonas seymouri	68%	100%
A0A0N1HW05	Leptomonas seymouri	27%	97%
A0A0N1PG90	Leptomonas seymouri	68%	91%
A0A0S4IZX4	Bodo saltans	28%	97%
A0A1X0NP01	Trypanosomatidae	26%	82%
A0A1X0P5N4	Trypanosomatidae	27%	98%
A0A3Q8ILD8	Leishmania donovani	93%	100%
A0A3R7R3B5	Trypanosoma rangeli	26%	98%
A0A3S7WSY5	Leishmania donovani	29%	87%
A0A3S7X9N0	Leishmania donovani	27%	98%
A2RM21	Lactococcus lactis subsp. cremoris (strain MG1363)	32%	100%
A4H7K6	Leishmania braziliensis	27%	78%
A4HKQ5	Leishmania braziliensis	81%	100%
A4HMZ0	Leishmania braziliensis	30%	97%
A4HVY9	Leishmania infantum	29%	77%
A4I885	Leishmania infantum	94%	100%
A4IBL4	Leishmania infantum	27%	98%
C9ZZ26	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	89%
E9AFE7	Leishmania major	27%	98%
E9APP1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	87%
E9B343	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9B6K2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	97%
O05394	Bacillus subtilis (strain 168)	30%	100%
O13326	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	93%
O31631	Bacillus subtilis (strain 168)	30%	100%
O31632	Bacillus subtilis (strain 168)	31%	100%
O42851	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
O94350	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
P00935	Escherichia coli (strain K12)	31%	100%
P06106	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	90%
P06721	Escherichia coli (strain K12)	37%	100%
P0A4K2	Lactococcus lactis subsp. lactis (strain IL1403)	32%	100%
P0C2T9	Lactococcus lactis subsp. cremoris	32%	100%
P13254	Pseudomonas putida	25%	100%
P18757	Rattus norvegicus	31%	100%
P18949	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	37%	100%
P24601	Herpetosiphon aurantiacus	33%	100%
P31373	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
P32929	Homo sapiens	34%	99%
P38716	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
P43623	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	56%	100%
P44502	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	28%	100%
P44527	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	36%	100%
P46807	Mycobacterium leprae (strain TN)	31%	100%
P50125	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	23%	91%
P53101	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	86%
P53780	Arabidopsis thaliana	27%	86%
P55216	Caenorhabditis elegans	31%	100%
P55217	Arabidopsis thaliana	29%	71%
P55218	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	28%	99%
P56069	Helicobacter pylori (strain ATCC 700392 / 26695)	33%	100%
P66876	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	31%	100%
P94890	Leptospira meyeri	24%	90%
P9WGB4	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	25%	98%
P9WGB5	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	25%	98%
P9WGB6	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	31%	100%
P9WGB7	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	31%	100%
Q07703	Bordetella avium	36%	100%
Q19QT7	Sus scrofa	31%	99%
Q1K8G0	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	27%	87%
Q1M0P5	Helicobacter pylori	33%	100%
Q4L332	Staphylococcus haemolyticus (strain JCSC1435)	27%	100%
Q4QFT8	Leishmania major	29%	87%
Q52811	Rhizobium leguminosarum bv. viciae (strain 3841)	41%	100%
Q55DV9	Dictyostelium discoideum	28%	100%
Q58DW2	Bos taurus	32%	99%
Q59829	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	26%	100%
Q5MNH8	Epichloe uncinata	22%	84%
Q5SJ58	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	24%	97%
Q5SK88	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	26%	95%
Q60HG7	Macaca fascicularis	31%	99%
Q73GL9	Wolbachia pipientis wMel	36%	99%
Q73KL7	Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)	26%	100%
Q79VI4	Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)	26%	91%
Q7MX71	Porphyromonas gingivalis (strain ATCC BAA-308 / W83)	27%	100%
Q826W3	Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)	28%	97%
Q83A83	Coxiella burnetii (strain RSA 493 / Nine Mile phase I)	27%	100%
Q8J0B2	Epichloe uncinata	22%	84%
Q8L0X4	Fusobacterium nucleatum subsp. polymorphum	29%	100%
Q8RDT4	Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355)	29%	100%
Q8VCN5	Mus musculus	31%	100%
Q92441	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	24%	90%
Q9C876	Arabidopsis thaliana	29%	97%
Q9SGU9	Arabidopsis thaliana	28%	90%
Q9WZY4	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	26%	93%
Q9X0Z7	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	29%	100%
Q9ZMW7	Helicobacter pylori (strain J99 / ATCC 700824)	34%	100%
S0DUX5	Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)	24%	92%
V5DUQ5	Trypanosoma cruzi	29%	98%
W7MS09	Gibberella moniliformis (strain M3125 / FGSC 7600)	24%	92%